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1
المؤلفون: Yanchun, Ji, Zhipeng, Nie, Feilong, Meng, Cuifang, Hu, Hui, Chen, Lihao, Jin, Mengquan, Chen, Minglian, Zhang, Juanjuan, Zhang, Min, Liang, Meng, Wang, Min-Xin, Guan
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: autophagy, RNA, Mitochondrial, RNA Stability, PARP, poly ADP ribose polymerase, oxidative phosphorylation, Apoptosis, RNA, Transfer, Ala, LAMP1, lysosome-associated membrane glycoprotein 1, LHON, Leber’s hereditary optic neuropathy, Electron Transport, Mitochondrial Proteins, Adenosine Triphosphate, ROS, reactive oxidative species, Humans, OCR, oxygen consumption rate, RNA Processing, Post-Transcriptional, A73, adenosine at position 73, mDNA, mitochondrial DNA, Membrane Potential, Mitochondrial, mitochondrial tRNA 3’-end metabolisms, Base Sequence, OXPHOS, oxidative phosphorylation system, Mitophagy, Cytochromes c, TBE, Tris-borate-EDTA, RGC, retinal ganglion cell, Mitochondria, Mutation, Nucleic Acid Conformation, Transfer RNA Aminoacylation, Leber’s hereditary optic neuropathy, Reactive Oxygen Species, TRNT1, tRNA nucleotidyltransferase, Research Article
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2
المؤلفون: Meng Liang, Ke Fan, Jiahui Zhang, Qin Tian, Dapeng Shi, Zhihua Sun, Hao Ding, Ling Wang, Wen Qin
المصدر: NeuroImage : Clinical
NeuroImage: Clinical, Vol 30, Iss, Pp 102619-(2021)مصطلحات موضوعية: genetic structures, Nerve fiber layer, LHON, Leber’s hereditary optic neuropathy, Optic neuropathy, chemistry.chemical_compound, 0302 clinical medicine, Basal ganglia, Medicine, NBS, network-based statistic, FA, fractional anisotropy, Rich club, 05 social sciences, Leber's hereditary optic neuropathy, Brain, Regular Article, AD, axial diffusion, medicine.anatomical_structure, Diffusion tensor imaging, Retinal nerve fiber layer, Neurology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Cognitive Neuroscience, Computer applications to medicine. Medical informatics, R858-859.7, Optic Atrophy, Hereditary, Leber, 050105 experimental psychology, Retina, RD, radial diffusion, 03 medical and health sciences, Ophthalmology, Fractional anisotropy, MS, mean sensitivity, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, In patient, RNFL, retinal nerve fiber layer, RC346-429, MD, mean defect, business.industry, nutritional and metabolic diseases, Retinal, medicine.disease, eye diseases, nervous system diseases, mtDNA, mitochondrial DNA, Duration, chemistry, LV, loss of variance, Structural network, Anisotropy, Neurology (clinical), Neurology. Diseases of the nervous system, Leber’s hereditary optic neuropathy, business, 030217 neurology & neurosurgery, Diffusion MRI
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3
المؤلفون: Abdullah A.Y. Gibriel, Ola Adel
المصدر: Mutation Research. Reviews in Mutation Research
مصطلحات موضوعية: 0301 basic medicine, Chemiluminescence, CFTR, Cystic Fibrosis Transmembrane Conductance Regulator, Genotyping Techniques, Cost effectiveness, Health, Toxicology and Mutagenesis, SAPE, Streptavidin-R-phycoerythrin, Metal Nanoparticles, ICP-MS, Inductively Coupled Plasma-Mass Spectrometry, Biosensing Techniques, Polymerase Chain Reaction, 01 natural sciences, LSAW, Leaky Surface Acoustic Wave, BRCA1, Breast Cancer1, SARS, Severe Acute Respiratory Syndrome, CRET, Chemiluminescence Resonance Energy Transfer, Multiplex, PCR, Polymerase Chain Reaction, Ligase chain reaction, HRP-SA, Horse-Radish Peroxidase-Streptavidin, PRNP, PRioN Protein, MOL-PCR, Multiplexed Oligonucleotide Ligation PCR, SSCP, Single Stranded Conformational Polymorphism, RT-MLPA, Reverse Transcriptase-Multiplex Ligation Dependent Probe Amplification, eLCR, electrochemical Ligase Chain Reaction, MEIA, Microparticle Capture Enzyme Immunoassay, NAT2, N-acetyltransferase-2 gene, SNP genotyping, AG-LCR, Asymmetric Gap-Ligase Chain Reaction, CTV, Citrus tristeza virus, HBV, Hepatitis B Virus, WNV, West Nile virus, CE, Capillary Electrophoresis, cDNA, Complementary DNA, QCM, Quartz Crystal Microbalance, G-LCR, Gap-Ligase Chain Reaction, LCR, LIF, Laser Induced Fluorescence, MTBC, Mycobacterium tuberculosis complex, SDA, Strand Displacement Amplification, cPLP, circular Padlock Probe, HCC, Hepatocellular Carinoma, LSO, Locus Specific Oligonucleotide, DNA Ligases, CE-fSSCP, Capillary Electrophoresis- fluorescent Single Stranded Conformational Polymorphism, NP, Nanoparticles, PLP, Padlock Probe, Ligase Chain Reaction, SNP, Single Nucleotide Polymorphism, QG-LCR, Quantitative Gap-Ligase Chain Reaction, Computational biology, μ-eLCR, Microdevice based electrochemical LCR, Biology, Polymorphism, Single Nucleotide, Article, AuNP, Gold Nanoparticles, 03 medical and health sciences, Genetics, MLPA, Multiplex Ligation Dependent Probe Amplification, Humans, CCP, Cationic Conjugated Polymer, SERS, Surface Enhanced Raman Scattering, FO-SPR, Fiber Optic Surface Plasmon Resonance, Multiplex ligation-dependent probe amplification, Genotyping, CGE, Capillary Gel Electrophoresis, HRP, Horse-Radish Peroxidase, QD, Quantum Dots, SERS, Genome, Human, HRCA, Hyberbranching Rolling Circle Amplification, 010401 analytical chemistry, MS-MLPA, Methylation-Specific Multiplex Ligation Dependent Probe Amplification, Multiple displacement amplification, ACV, Altering Current Voltammetry, CP, Capture Probes, RCA, Rolling Circle Amplification, LDR, Ligase Detection Reaction, HFE, Human Hemochromatosis Protein, ONS, Oligonucleotide incorporated Nonfouling Surface, RSV, Respiratory Cyntical Virus, LCR, Ligase Chain Reaction, Molecular biology, 0104 chemical sciences, LHON, Leber’s Hereditary Optic Neuropathy, qPCR, quantitative Polymerase Chain Reaction, ASO, Allele Specific Oligonucleotide, Biosensors, 030104 developmental biology, FRET, Nanoparticles, Gold, DOL, Dye-labeled Oligonucleotide Ligation, FRET, Fluorescence Resonance Energy Transfer, Biosensor, ALP-SA, Alkaline Phosphatase-Streptavidin
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4
المؤلفون: Shuo Yang, Xing Wan, Han Pei, Si-qi Ma, Min-jian Zhao, Jiajia Yuan, Dao Wen Wang, Heng He, Chen Chen, Xiao-yan Dong, Bin Li
المصدر: EBioMedicine
EBioMedicine, Vol 10, Iss C, Pp 258-268 (2016)مصطلحات موضوعية: Male, Intraocular pressure, Visual acuity, genetic structures, Visual Acuity, lcsh:Medicine, Optic neuropathy, AAV, adeno-associated virus, 0302 clinical medicine, Leber's hereditary optic neuropathy, ERG, electroretinogram, Evoked potential, Child, lcsh:R5-920, OCT, optical coherence tomography, VFI, visual field index, General Medicine, Dependovirus, Middle Aged, Visual field, Treatment Outcome, Optic nerve, Female, medicine.symptom, lcsh:Medicine (General), Tomography, Optical Coherence, ND4, NADH–ubiquinone oxidoreductase, subunit 4, Research Paper, BCVA, best corrected visual acuity, Adult, medicine.medical_specialty, Adolescent, Genetic Vectors, Optic Atrophy, Hereditary, Leber, General Biochemistry, Genetics and Molecular Biology, Young Adult, MtDNA, mitochondrial DNA, 03 medical and health sciences, Gene therapy, Ophthalmology, medicine, Humans, HM, hand movement, RNFL, retinal nerve fiber layer, LHON, Leber's hereditary optic neuropathy, MD, mean defect, CF, counting fingers, VEP, visual evoked potential, business.industry, lcsh:R, rAAV2-ND4, recombinant adeno-associated virus carrying the ND4 gene, NADH Dehydrogenase, Genetic Therapy, medicine.disease, IOP, intraocular pressure, eye diseases, Clinical trial, Mutation, 030221 ophthalmology & optometry, Evoked Potentials, Visual, Optometry, sense organs, Visual Fields, business, Best-corrected visual acuity, 030217 neurology & neurosurgery
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المؤلفون: Amutha Boominathan, Carter J. Hall, Elizabeth Batiuk, Caitlin J. Lewis, Bhavna Dixit, Matthew S. O'Connor
المصدر: Redox Biology
Redox Biology, Vol 30, Iss, Pp-(2020)مصطلحات موضوعية: 0301 basic medicine, Mitochondrial respiratory chain complex, Mitochondrial Diseases, Clinical Biochemistry, Gene Expression, OxPhos, oxidative phosphorylation, Biochemistry, CV, Complex V, Mice, 0302 clinical medicine, Mitochondrial DNA (mtDNA), Respiratory function, o, optimized, Codon Usage, lcsh:QH301-705.5, TIM, translocase of the inner membrane, Genetics, lcsh:R5-920, IMS, intermembrane space, Mitochondrial Proton-Translocating ATPases, Codon optimization, Phenotype, Mitochondria, HEK293, human embryonic kidney cells, CIII, Complex III, ARMS qPCR, Amplification Refractory Mutation System-quantitative PCR, ATP synthase, lcsh:Medicine (General), Research Paper, Mitochondrial DNA, MELAS, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes, Mitochondrial disease, PIM, protease inhibitor cocktail, MPP, matrix processing peptidase, Biology, DNA, Mitochondrial, Models, Biological, Allotopic expression, Human mitochondrial genetics, Mitochondrial Proteins, 03 medical and health sciences, Gene therapy, NARP, Neuropathy, Ataxia and Retinitis Pigmentosa, r, minimally-recoded, medicine, Animals, Humans, MIB, mitochondria isolation buffer, Gene transfer, Gene, Organic Chemistry, Wild type, Computational Biology, NADH Dehydrogenase, medicine.disease, mtDNA, mitochondrial DNA, LHON, Leber’s Hereditary Optic Neuropathy, HEK293 Cells, 030104 developmental biology, lcsh:Biology (General), PMSF, phenylmethylsulfonyl fluoride, RSCU, relative synonymous codon use, Mutation, CIV, Complex IV, CI, Complex I, BN-PAGE, Blue Native-PAGE, Protein expression, MTS, mitochondrial targeting sequence, 030217 neurology & neurosurgery
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6ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I
المؤلفون: Amanda Birch, Alexander Galkin, Ilka Wittig, Matthew Fuszard, Catherine H. Botting, Paola Labarbuta, Heinrich Heide, Marion Babot, Sara Kee
المساهمون: University of St Andrews. School of Chemistry, University of St Andrews. EaSTCHEM, University of St Andrews. Biomedical Sciences Research Complex
المصدر: Babot, M, Labarbuta, P, Birch, A, Kee, S, Fuszard, M, Botting, C H, Wittig, I, Heide, H & Galkin, A 2014, ' ND3, ND1 and 39 kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I ', Biochimica et Biophysica Acta-Bioenergetics, vol. 1837, no. 6, pp. 929-939 . https://doi.org/10.1016/j.bbabio.2014.02.013
Biochimica et Biophysica Actaمصطلحات موضوعية: Conformational change, QH301 Biology, dSDS-PAGE, double SDS-PAGE, Mitochondrion, Biochemistry, Mass Spectrometry, NDUFA9, AH, amphipathic helix, Quinone binding, chemistry.chemical_classification, 0303 health sciences, Q1, ubiquinone-1,2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone, BN-PAGE, blue native polyacrylamide gel electrophoresis, 030302 biochemistry & molecular biology, NHS, N-hydroxysuccinimide, 3. Good health, Electron Transport Complex I, Electrophoresis, Polyacrylamide Gel, A/D transition, Oxidation-Reduction, Protein subunit, MELAS, mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, Molecular Sequence Data, Biophysics, N-hydroxysuccinimide, TMS, transmembrane segment, Article, Fluorescence, N -hydroxysuccinimide, A/D, active/de-active transition, NAI, N-acetylimidazole, NADH:ubiquinone oxidoreductase, 03 medical and health sciences, QH301, ROS, reactive oxygen species, Protein tyrosine modification, Complex I, nLC-ESI-MSMS, nano-HPLC electrospray ionisation tandem mass spectrometry, Animals, ddc:610, Amino Acid Sequence, Cysteine, DIGE, difference gel electrophoresis, hrCN-PAGE, high resolution clear native polyacrylamide gel electrophoresis, LHON, Leber's hereditary optic neuropathy, 030304 developmental biology, ubiquinone oxidoreductase [NADH], SMP, submitochondrial particles, Lysine, Cell Biology, NAD, NADH, dihydronicotinamide adenine dinucleotide, TNM, tetranitromethane, Enzyme, chemistry, DTT, dithiothreitol, NEM, N-ethylmaleimide, Cattle, F-NHS, fluorescein-N-hydroxysulfosuccinimide ester
وصف الملف: application/pdf; application/octet-stream
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7
المؤلفون: Valeria Petronilli, Anna Ghelli, Giorgio Lenaz, Valerio Carelli, Michela Rugolo, Valentina Giorgio, Paolo Bernardi
المساهمون: Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, Bernardi P
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: Ubiquinone, NQO1, NAD(P)H:quinone oxidoreductase 1, Drug Evaluation, Preclinical, TMRM, tetramethylrhodamine methyl ester, Mitochondria, Liver, Mitochondrion, Biochemistry, Antioxidants, FCCP, carbonylcyanide-p-trifluoromethoxyphenyl hydrazone, chemistry.chemical_compound, Mice, Adenosine Triphosphate, MITOCHONDRIA, Idebenone, OCR, oxygen consumption rate, ELECTRON TRANSFER, Cells, Cultured, Membrane Potential, Mitochondrial, Membrane potential, DMEM, Dulbecco's modified Eagle's medium, Cultured, Depolarization, MELAS, mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes, Cs, cyclosporin, Δψm, mitochondrial membrane potential difference, Preclinical, Mitochondrial, Liver, CRC, calcium retention capacity, medicine.drug, PERMEABILITY TRANSITION, Cellular respiration, Cells, Cell Respiration, Biophysics, Biology, Membrane Potential, Article, ROS, reactive oxygen species, Oxygen Consumption, medicine, Animals, LHON, Leber's hereditary optic neuropathy, ATP SYNTHESIS, Cell Biology, Dithiothreitol, chemistry, ATP synthesis, Electron transfer, Mitochondria, Permeability transition, Energy Metabolism, DTT, dithiothreitol, MOPS, 4-morpholinepropanesulfonic acid, Coenzyme Q – cytochrome c reductase, PTP, permeability transition pore, Drug Evaluation, IDEBENONE, NAD+ kinase, Adenosine triphosphate
وصف الملف: STAMPA