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المؤلفون: Melanie A. Kimm, Vanessa Franziska Schmidt, Max L.A. Ebert, Lena Pfaff, Anne von Thaden, Moritz Wildgruber
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: Vascular smooth muscle, medicine.medical_treatment, HDL, high-density lipoprotein, Cell, neointimal hyperplasia, Bioinformatics, PDGF, platelet-derived growth factor, VSMC, vascular smooth muscle cell, Fibroblast migration, restenosis, Restenosis, LDL, low-density lipoprotein, Angioplasty, medicine, VLDL, very low-density lipoprotein, TGF, transforming growth factor, Neointimal hyperplasia, business.industry, animal model, angioplasty, Stent, Lipid metabolism, medicine.disease, ECM, extracellular matrix, FGF, fibroblast growth factor, CETP, cholesteryl ester transferase protein, LDLr, LDL receptor, medicine.anatomical_structure, Apo, apolipoprotein, State-of-the-Art Review, Cardiology and Cardiovascular Medicine, business
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المؤلفون: Liang Han, Chen Jiang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PSMA, prostate-specific membrane antigen, Gd, gadolinium, BACE1, β-secretase 1, MMP9, metalloproteinase-9, PLGA, poly(lactic-co-glycolic acid), Disease, Review, Aβ, amyloid beta, ICAM-1, intercellular adhesion molecule-1, KCa, calcium-dependent potassium channels, PD, Parkinson's disease, LDL, low density lipoprotein, PEG, polyethyleneglycol, Epilepsy, 0302 clinical medicine, P-gp, P-glycoprotein, Medicine, LRP1, LDLR-related protein 1, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, siRNA, short interfering RNA, 0303 health sciences, ZO1, zona occludens 1, LAT1, L-type amino acid transporter 1, LDLR, LDL receptor, RBC, red blood cell, AMT, alpha-methyl-l-tryptophan, DTPA-Gd, Gd-diethyltriaminepentaacetic acid, RAGE, receptor for advanced glycosylation end products, VEGF, vascular endothelial growth factor, Drug delivery systems, KATP, ATP-sensitive potassium channels, medicine.anatomical_structure, TJ, tight junction, 030220 oncology & carcinogenesis, Drug delivery, cardiovascular system, AD, Alzheimer's disease, Brain diseases, RMT, receptor-mediated transcytosis, Traumatic brain injury, Brain tumor, BDNF, brain derived neurotrophic factor, Brain-targeting, TfR, transferrin receptor, RM1-950, Blood–brain barrier, TBI, traumatic brain injury, MFSD2A, major facilitator superfamily domain-containing protein 2a, 03 medical and health sciences, ROS, reactive oxygen species, EPR, enhanced permeability and retention, NPs, nanoparticles, 030304 developmental biology, CMT, carrier-mediated transportation, PEG-PLGA, polyethyleneglycol-poly(lactic-co-glycolic acid), business.industry, LFA-1, lymphocyte function associated antigen-1, GLUT1, glucose transporter-1, medicine.disease, tPA, tissue plasminogen activator, Brain targeting, BTB, blood–brain tumor barrier, nervous system, Nanoparticles, Nasal administration, Therapeutics. Pharmacology, business, Neuroscience, MRI, magnetic resonance imaging
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المؤلفون: Nabil G. Seidah
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100130-(2021)مصطلحات موضوعية: CHRD, Cys-His-rich domain, Apolipoprotein B, HEK293, human embryonic kidney 293, DENV, dengue virus, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, S1P, site 1 protease, Biochemistry, 0302 clinical medicine, Endocrinology, Thematic Review Series: The Science of FH, Neoplasms, lipid metabolism, GOF, gain-of-function, cancer/metastasis, Receptor, 0303 health sciences, biology, LDLR, LDL receptor, SKI-1, subtilisin-kexin isozyme 1, 3. Good health, Virus Diseases, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, furin, Endosome, Hypercholesterolemia, QD415-436, FH, familial hypercholesterolemia, ER, endoplasmic reticulum, 03 medical and health sciences, cDNA, complementary DNA, lysosomes, Zymogen, medicine, MHC, major histocompatibility complex, Animals, Humans, mAb, monoclonal antibody, LDL-C, 030304 developmental biology, PCSK9, proprotein convertases, Thematic Review Series, PC, proprotein convertase, Cell Biology, Proprotein convertase, medicine.disease, LDLR, inflammation, LDL receptor, Cancer research, biology.protein, viral infection, PCSK9, proprotein convertase subtilisin/kexin type 9, LOF, loss of function, NARC-1, neural apoptosis-regulated convertase 1
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المؤلفون: Emily J. Brown, Karan Kapoor, Kathleen Byrne, Seth S. Martin, Robert Derenbecker, Parvez M. Lokhandwala, Thorsten M Leucker, Steven R. Jones
المصدر: JACC: Case Reports, Vol 1, Iss 3, Pp 346-349 (2019)
JACC Case Reportsمصطلحات موضوعية: Apolipoprotein B, cascade screening, CAD, coronary artery disease, HeFH, heterozygous familial hypercholesterolemia, Dutch Lipid Clinic, LDL-C, low density lipoprotein-cholesterol, Case Report, Familial hypercholesterolemia, Southeast asia, chemistry.chemical_compound, Clinical Case, medicine, Diseases of the circulatory (Cardiovascular) system, NSTEMI, non–ST-segment elevation myocardial infarction, genetics, Gene, Uncertain significance, Genetics, HoFH, homozygous familial hypercholesterolemia, low-density lipoprotein cholesterol, PCSK9, proprotein convertase subtilsin-kexin type 9, biology, Cholesterol, business.industry, LDLR, LDL receptor, nutritional and metabolic diseases, cholesterol, VUS, variants of uncertain significance, medicine.disease, chemistry, LDL apheresis, RC666-701, LDL receptor, biology.protein, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, Cardiology and Cardiovascular Medicine, business, coronary artery disease, CABG, coronary artery bypass grafting
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المؤلفون: Yishi Shen, Shucun Qin, Bingxiang Wang, Yongfang Zhao, Lei Zhai, Boyan Liu, Xiaole Chang, Adekunle Alabi, Shijun Deng, Maggie Wang, Hong-mei Gu, Da-Wei Zhang, Xiao-dan Xia, Guiqing Wang, Sijie Xing
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100091-(2021)مصطلحات موضوعية: 0301 basic medicine, Alb, albumin, Very low-density lipoprotein, Apolipoprotein B, TANGO1, Transport and Golgi Organization 1, 030204 cardiovascular system & hematology, Lipoproteins, VLDL, Biochemistry, Microsomal triglyceride transfer protein, apoB100, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, AAV, adeno-associated virus, stearyl-CoA-1, lipid metabolism, COPII, classical coat protein complex II, Cells, Cultured, lipoprotein metabolism, Mice, Knockout, apoB, apolipoprotein B, biology, CE, cholesteryl ester, TG, triglyceride, LDLR, LDL receptor, Surf4, Surfeit 4, MTP, microsomal triglyceride transfer protein, Lipogenesis, Cholesteryl ester, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, Proprotein Convertase 9, Research Article, medicine.medical_specialty, apoB100, apolipoprotein B100, QD415-436, liver, LDL, 03 medical and health sciences, Internal medicine, ALT, alanine aminotransferase, medicine, Animals, Secretion, triglyceride, Cholesterol, Surf4LKO, Surf4 liver-specific knockout, nutritional and metabolic diseases, Membrane Proteins, SCD1, stearoyl-CoA desaturase-1, Cell Biology, Atherosclerosis, TC, total cholesterol, Mice, Inbred C57BL, 030104 developmental biology, LDLR, chemistry, Receptors, LDL, LDL receptor, biology.protein, VTV, VLDL transport vesicle, apolipoproteins, PCSK9, proprotein convertase subtilisin/kexin type 9
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المؤلفون: Juro Sakai, Masashi Muramatsu, Toshiya Tanaka, Suguru Nakagawa, Sandra Ryeom, Tatsuhiko Kodama, Yuri Miyamura, Takashi Minami, Hiroyuki Aburatani, Tsuyoshi Osawa
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, HFD, high-fat diet, Apolipoprotein B, proprotein convertase subtilisin/kexin type (PCSK)9, SREBP, sterol regulatory element-binding protein, Muscle Proteins, Biochemistry, PCSK, proprotein convertase subtilisin/kexin, chemistry.chemical_compound, Mice, LDL, low-density lipoprotein, Nonalcoholic fatty liver disease, nonalcoholic fatty liver disease (NAFLD), apolipoprotein (Apo)E, biology, LDLR, LDL receptor, HRP, horseradish peroxidase, NFAT, DSCR, Down syndrome critical region, VEGF, vascular endothelial growth factor, Cholesterol, Phenotype, regulator of calcineurin (RCAN)1, lipids (amino acids, peptides, and proteins), medicine.symptom, Research Article, medicine.medical_specialty, NFAT, nuclear factor for activated T cell, Down syndrome critical region (DSCR)-1, Hypercholesterolemia, Inflammation, ER, endoplasmic reticulum, 03 medical and health sciences, HEK, human embryonic kidney, Apolipoproteins E, Internal medicine, medicine, low-density lipoprotein (LDL), Animals, nuclear factor for activated T cells (NFAT), oxLDL, oxidative LDL, Molecular Biology, GO, gene ontology, 030102 biochemistry & molecular biology, business.industry, Calcium-Binding Proteins, Cell Biology, medicine.disease, WT, wild-type, Sterol regulatory element-binding protein, 030104 developmental biology, Endocrinology, chemistry, Apo, apolipoprotein, Gene Expression Regulation, LDL receptor, biology.protein, Hepatocytes, NAFLD, nonalcoholic fatty liver disease, business, Gene Deletion
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المؤلفون: Ebert, Max L A, Schmidt, Vanessa F, Pfaff, Lena, von Thaden, Anne, Kimm, Melanie A, Wildgruber, Moritz
المصدر: JACC Basic to translational science 6(11), 900-917 (2021). doi:10.1016/j.jacbts.2021.06.006
مصطلحات موضوعية: animal model, HDL, high-density lipoprotein, angioplasty, neointimal hyperplasia, PDGF, platelet-derived growth factor, VSMC, vascular smooth muscle cell, ECM, extracellular matrix, FGF, fibroblast growth factor, CETP, cholesteryl ester transferase protein, LDLr, LDL receptor, restenosis, Apo, apolipoprotein, LDL, low-density lipoprotein, VLDL, very low-density lipoprotein, ddc:610, TGF, transforming growth factor
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المؤلفون: Dirk J. Blom, César Martín, Kévin Chemello, Gilles Lambert, Antonio Gallo, Javier García-Nafría
المساهمون: Gestionnaire, Hal Sorbonne Université, Diabète athérothrombose et thérapies Réunion Océan Indien (DéTROI), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto de Biocomputación y Física de Sistemas Complejos = Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service d'Endocrinologie, Métabolisme et Prévention des Maladies Cardio-vasculaires [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), University of Cape Town, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR), Service d’Endocrinologie, Métabolisme et Prévention des Risques Cardio-Vasculaires [CHU Pitié-Salpêtrière], Interreg, Conseil Régional de la Réunion, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fondation pour la Recherche Médicale, Eusko Jaurlaritza, Agence Nationale de la Recherche (France), Fondation de France, Blom, Dirk
المصدر: Addi. Archivo Digital para la Docencia y la Investigación
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Journal of Lipid Research
Journal of Lipid Research, 2021, pp.100062. ⟨10.1016/j.jlr.2021.100062⟩
Journal of Lipid Research, Vol 62, Iss, Pp 100062-(2021)
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2021, pp.100062. ⟨10.1016/j.jlr.2021.100062⟩
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vascoمصطلحات موضوعية: 0301 basic medicine, Apolipoprotein B, [SDV]Life Sciences [q-bio], Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Biochemistry, 0302 clinical medicine, Endocrinology, ANGPTL3, GOF, gain-of-function, HoFH, homozygous familial hypercholesterolemia, apoB, apolipoprotein B, TRL, TG-rich lipoprotein, biology, TG, triglyceride, familial hypercholesterolemia, LDLR, LDL receptor, Lipoprotein(a), 3. Good health, [SDV] Life Sciences [q-bio], PCSK9, proprotein convertase subtilisin kexin type 9, Autosomal Recessive Hypercholesterolemia, Cardiovascular Diseases, LDL cholesterol, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, medicine.medical_specialty, ARH, autosomal recessive hypercholesterolemia, ANGPTL3, angiopoietin-like 3, apo(a), apolipoprotein (a), HeFH, heterozygous familial hypercholesterolemia, apoB100, apolipoprotein B100, QD415-436, apoA1, apolipoprotein A1, FH, familial hypercholesterolemia, 03 medical and health sciences, Internal medicine, medicine, CVDs, REDUCE-IT, Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial, LDL-C, FCR, fractional catabolic rate, business.industry, PCSK9, lipoprotein (a), FDB, familial defective apolipoprotein B, LDLRAP1, LDLR adapter protein 1, Thematic Review Series, Cell Biology, medicine.disease, JELIS, Japan EPA Lipid Intervention Study, Lp(a), lipoprotein (a), lipoproteins, 030104 developmental biology, ASCVD, atherosclerotic CVD, LDL receptor, biology.protein, business, TESLA, Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities, Lipoprotein
وصف الملف: application/pdf
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المؤلفون: Robert S. Rosenson
المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100060-(2021)
Journal of Lipid Researchمصطلحات موضوعية: 0301 basic medicine, Homozygous Familial Hypercholesterolemia, Apolipoprotein B, HeFH, heterozygous FH, angiopoietin-like protein 3, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Medicine, genetics, ANGPLT3, angiopoietin-like protein 3, Lp(a), lipoprotein a, biology, familial hypercholesterolemia, HoFH, homozygous FH, LDLR, LDL receptor, atherosclerotic cardiovascular disease, Lipoprotein(a), Low-density lipoprotein, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, medicine.drug, proprotein convertase subtilisin Kexin 9, medicine.medical_specialty, Statin, medicine.drug_class, QD415-436, FH, familial hypercholesterolemia, PCSK9, proprotein convertase subtilisin Kexin type 9, LDL, 03 medical and health sciences, cholesterol-lowering therapies, Ezetimibe, Internal medicine, LDLRAP1, low-density lipoprotein receptor adaptor protein 1, business.industry, PCSK9, lipoprotein (a), LDL receptor, Thematic Review Series, Cell Biology, medicine.disease, CI, confidence interval, 030104 developmental biology, chemistry, biology.protein, apo B, apolipoprotein B, business
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المؤلفون: Kaylin M. McMahon, Adam Yuh Lin, Reem Karmali, Andrea E. Calvert, Shuo Yang, C. Shad Thaxton, Jonathan Moreira, Jonathan S. Rink, Amir Behdad, Tim Taxter, Amy Chadburn, Leo I. Gordon
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Lymphoma, TFF, tangential flow filtration, SCARB1, scavenger receptor type B-1, Mice, SCID, Biochemistry, HMGCS1, HMG-CoA synthase 1, FL, follicular lymphoma, NF-kB, nuclear factor kappa-light-chain-enhancer of activated B cells, chemistry.chemical_compound, Jurkat Cells, Mice, FACS, fluorescent activated cell sorter, BCR, B cell receptor, LDL, low-density lipoprotein, DLBCL, diffuse large B cell lymphoma, ALCL, anaplastic large T cell lymphoma, STR, short tandem repeat, PI, propridium iodide, DFO, deferoxamine, MPER, mammalian protein extraction reagent, nanotechnology, LDLR, LDL receptor, scavenger receptor type B1 (SCARB1), Hepes, 4-(20hydroxyethyl)-1-piperasineethanesulfonic acid, lipid peroxidation, DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine, U937 Cells, Scavenger Receptors, Class B, ferroptosis, Neoplasm Proteins, high-density lipoprotein (HDL), Cholesterol, Low-density lipoprotein, AuNP, gold nanoparticles, GPX4, glutathione peroxidase 4, GC, germinal center, lipids (amino acids, peptides, and proteins), Oxidation-Reduction, IHC, immunohistochemistry, SREBP-1a, sterol response element binding protein-1a, Research Article, Membrane lipids, HCM, hepatocyte culture media, HDL, high-density lipoprotein, PDP PE, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate], glutathione peroxidase 4 (GPX4), L-OOH, lipid peroxides, PDX, patient-derived xenografts, 03 medical and health sciences, FBS, fetal bovine serum, PBS, phosphate buffered saline, SQLE, squalene epoxidase, Animals, Humans, Scavenger receptor, Molecular Biology, HSD17B7, 17β-hydroxysteroid dehydrogenase type 7, DHCR7, dehydrocholesterol reductase 7, BL, Burkitt’s lymphoma, 030102 biochemistry & molecular biology, INSIG1, insulin induced gene-1, ALK, anaplastic lymphoma kinase, L-OH, lipid alcohols, Cell Biology, ABC, activated B cell, Phospholipid Hydroperoxide Glutathione Peroxidase, SCARB1, 030104 developmental biology, DiI, 1,1’-dioctadecyl-3,3,3’,3’-tetramethylindocarbocyanine perchlorate, chemistry, Cancer cell, LDL receptor, Cancer research, C11-BODIPY, 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-indacene-3-undecanoic acid, HDL NPs, HDL-like nanoparticles, Lipoprotein
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المؤلفون: Moss, Joe W.E., Williams, Jessica O., Ramji, Dipak P.
المصدر: Biochimica et Biophysica Acta
مصطلحات موضوعية: ANCHOR, Effect of AMR101 (Icosapent Ethyl) on Triglyceride Levels in Patients on Statins With High Triglyceride Levels (≥200 and <500 mg/dL), FMD, flow-mediated dilation, TMAO, trimethylamine-N-oxide, VEAPS, Vitamin E Atherosclerosis Prevention Study, CHD, coronary heart disease, MAGMA, Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis, DGLA, dihomo-gamma-linolenic acid, OPTILIP, The Quantification of the Optimal n-6/n-3 ratio in the UK Diet, LDL, low-density lipoprotein, VLDL, very low-density lipoprotein, EUROLIVE, Effect of Olive Oils on Oxidative Damage in European Populations, ASAP, Antioxidant Supplementation in Atherosclerosis Prevention, LDLR, LDL receptor, FOURIER, Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk, Cardiovascular disease, ECM, extracellular matrix, TG, triacylglycerol, GPR, G-protein-coupled receptor, KIHD, Kuopio Ischaemic Heart Disease Risk Factor, ESRD, end stage renal disease, CoCoA, Cocoa, Cognition and Aging, CRP, C-reactive protein, MI, myocardial infarction, Fatty Acids, Unsaturated, REDUCE-IT, Reduction of Cardiovascular Events with EPA – Intervention Trial, Nutraceuticals, CIRT, Cardiovascular Inflammation Reduction Trial, SU.VI.MAX, Supplementation en Vitamines et Mineraux Antioxydant, HDL, high-density lipoprotein, CVD, cardiovascular disease, ORIGIN, Outcome Reduction with an Initial Glargine Intervention, Article, MRS-ROZE, Multicenter Randomized Study of ROsuvastatin and eZEtimibe, OMEGA, Effect of Omega 3-Fatty Acids on the Reduction of Sudden Cardiac Death After Myocardial Infarction, IMPROVE-IT, Improved Reduction of Outcomes: Vytorin Efficacy International Trial, PUFA, polyunsaturated fatty acid, PREDIMED, Prevención con Dieta Mediterránea, Animals, Humans, cardiovascular diseases, oxLDL, oxidized LDL, PRECISE-IVUS, Plaque Regression With Cholesterol Absorption Inhibitor or Synthesis Inhibitor Evaluated by Intravascular Ultrasound, GISSI, Gruppo Italiano per lo Studio della Sopravvivenza nell'infarlo, Flavonoids, MARINE, Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension, NO, nitric oxide, STRENGTH, STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia, GLA, gamma-linolenic acid, Polyphenols, CANTOS, Canakinumab Anti-inflammatory Thrombosis Outcomes Study, LDL-C, LDL-cholesterol, EPA, eicosapentaenoic acid, Atherosclerosis, CoQ10, coenzyme Q10, JELIS, Japan EPA Lipid Intervention Study, IL, interleukin, Apo, apolipoprotein, Dietary Supplements, Polyunsaturated fatty acids, PCSK9, proprotein convertase subtilisin/kexin type 9, PWV, pulse wave velocity
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المؤلفون: Linn K L, Øyri, Ingunn, Narverud, Martin P, Bogsrud, Patrik, Hansson, Lena, Leder, Marte G, Byfuglien, Marit B, Veierød, Magne, Thoresen, Stine M, Ulven, Kirsten B, Holven
المصدر: Journal of Nutritional Science
مصطلحات موضوعية: Adult, Male, Fat quality, Fatty Acids, LDLR, LDL receptor, food and beverages, Gene Expression, LDL receptor, LDL-C, LDL-cholesterol, SREBP, sterol regulatory element binding protein, Postprandial Period, Hyperlipoproteinemia Type II, Young Adult, Cholesterol, Receptors, LDL, PBMC, peripheral blood mononuclear cells, Homeostasis, Humans, lipids (amino acids, peptides, and proteins), Female, Postprandial responses, CT, cycle threshold, Familial hypercholesterolaemia, Research Article, FH, familial hypercholesterolaemia
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المصدر: Journal of Lipid Research, Vol 62, Iss, Pp 100139-(2021)
Journal of Lipid Researchمصطلحات موضوعية: RFLP, restriction fragment length polymorphism, DFH, definite FH, clinical utility, polygenic, LLT, lipid-lowering therapy, Familial hypercholesterolemia, CHD, coronary heart disease, PFH, possible FH, Biochemistry, ACGS, UK Association for Clinical Genomic Science, SNP score, Endocrinology, Thematic Review Series: The Science of FH, Index case, variants of unknown significance, Exome sequencing, Genetics, medicine.diagnostic_test, LDLR, LDL receptor, SSCP, single-strand conformation polymorphism, PRS, polygenic risk score, WES, whole exome sequencing, index case, WGS, whole genome sequencing, Locus (genetics), QD415-436, Biology, FH, familial hypercholesterolemia, Hyperlipoproteinemia Type II, monogenic, VUS, variants of unknown significance, medicine, Humans, Genetic Testing, Multiplex ligation-dependent probe amplification, coronary heart disease, CT, cascade testing, LDL-C, Genetic testing, PCSK9, dHPLC, denaturing HPLC, Thematic Review Series, ACMG, American College of Medical Genetics and Genomics, Single-strand conformation polymorphism, Cell Biology, MLPA, multiplex ligation-dependent probe amplification, medicine.disease, Lp(a), lipoprotein (a), NGS, next-generation sequencing, TC, total cholesterol, LDLR, next-generation sequencing
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المؤلفون: Niek Blomberg, Amanda C. M. Pronk, Robin van Eenige, Mario van der Stelt, Tamer Coskun, Martin Giera, Yanan Wang, Lauren L. Tambyrajah, Patrick C N Rensen, Sander Kooijman, Zhixiong Ying
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100070-(2021)
Journal of Lipid Research, 62. ELSEVIERمصطلحات موضوعية: 0301 basic medicine, Apolipoprotein E, medicine.medical_treatment, 030204 cardiovascular system & hematology, Biochemistry, 0302 clinical medicine, Endocrinology, Rimonabant, RCT, reverse cholesterol transport, cardiovascular disease, Cannabinoid receptor type 1, iBAT, interscapular BAT, CB1R, cannabinoid type 1 receptor, TG, triglyceride, Reverse cholesterol transport, bile acids and salts/metabolism, WAT, white adipose tissue, cannabinoid receptor type 1, Endocannabinoid system, adipose tissue, drug therapy, LDLr, LDL receptor, ZT, Zeitgeber time, BA, bile acid, TRL, triglyceride-rich lipoprotein, lipids (amino acids, peptides, and proteins), Research Article, medicine.drug, medicine.medical_specialty, sWAT, subcutaneous WAT, QD415-436, lipids, 03 medical and health sciences, lipoproteins/metabolism, Internal medicine, UCP1, uncoupling protein 1, medicine, E3L.CETP, APOE∗3-Leiden.CETP, CETP, cholesteryl ester transfer protein, endocannabinoids, gWAT, gonadal WAT, Cannabinoids, business.industry, Cell Biology, medicine.disease, BAT, brown adipose tissue, TC, total cholesterol, 030104 developmental biology, LDL receptor, Cannabinoid, atherosclerosis, business, Dyslipidemia
وصف الملف: application/pdf
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المؤلفون: Mingjiang Zhu, Mingming Zhao, Shanshan Zhong, Xinli Xue, Shuyuan Guo, L. L. Li, Jianhong Lu, Yongzhen Tao, Buxing Chen, Qun Chen, Mengqing Xiao, Yujuan Zhuo, Chunzhao Yin, Huiyong Yin, Lemin Zheng, Xia Shen
المصدر: Redox Biology, Vol 21, Iss, Pp-(2019)
Redox Biologyمصطلحات موضوعية: RT, retention time, Male, TLR4, Toll like receptor 4, BEP-CE, Bicyclic endoperoxide and hydroperoxide cholesterol ester, CHD, coronary heart disease, Biochemistry, Mass Spectrometry, Mice, 0302 clinical medicine, LXRα, liver X receptor α, oxLA-CE, oxidized LA-CE, Myocardial infarction, HMGCR, HMG-CoA reductase, CBD, cerebrovascular diseases, lcsh:QH301-705.5, chol-d7, cholesterol-d7, Idol, inducible degrader of the LDL receptor, AMVN, 2, 2′-azobis(2,4-dimethylvaleronitrile), GW, GW 3965, LDLR, LDL receptor, mmLDL, minimally modified LDL, Cholesterol, WT, wide type, Cardiovascular Diseases, Knockout mouse, MI, myocardial infarction, Cholesterol Esters, lcsh:Medicine (General), ch-HpETE, cholesteryl-hydroperoxy-eicosatetraenoate, medicine.medical_specialty, NH4OAc, ammonium acetate, LA-CEOH, LA-CE hydroxide, Lipid peroxidation, CVD, cardiovascular disease, SYK, spleen tyrosine kinase, 03 medical and health sciences, PUFA, polyunsaturated fatty acid, Humans, Aged, TLC, thin layer chromatography, Macrophages, ch-HpODE, cholesteryl-hydroperoxy-octadecadienoate, Lipid Metabolism, medicine.disease, Dil-LDL, 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate labeled LDL, 030104 developmental biology, Endocrinology, LA-CE, cholesteryl linoleate, LDL oxidation, Biomarkers, 030217 neurology & neurosurgery, MRM, multiple reaction monitoring, 0301 basic medicine, CE19:0, cholesteryl nonadecanoate, Clinical Biochemistry, ch-HODE, cholesteryl-hydroxy-octadecadienoate, Endogeny, LDL, low density lipoprotein, Pathogenesis, Cholesterol/metabolism, chemistry.chemical_compound, BSTFA+TMCS, Bis-(trimethylsilyl)-trifluoroacetamide+Trimethylchlorosilane, Cholesterol uptake, IS, internal standard, PPh3, triphenylphosphine, CEOH, CE hydroxide, Liver X Receptors, lcsh:R5-920, CEOOH, cholesterol ester hydroperoxide, Chemistry, BMDM, bone marrow-derived macrophage, Middle Aged, CVD, ch-13c,t-HpODE, cholesteryl-13(cis, trans)-hydroperoxy-octadecadienoate, ch-HETE, cholesteryl-hydroxy-eicosatetraenoate, Metabolome, LXR, Female, lipids (amino acids, peptides, and proteins), oxCE, oxidized CE, Research Paper, IPA, isopropanol, AA-CE, cholesteryl arachidonate, Cholesterol ester hydroperoxides, CE, cholesterol ester, T09, T0901317, ROS, reactive oxygen species, Internal medicine, BHT, butylated hydroxytoluene, medicine, Animals, oxLDL, oxidized LDL, Organic Chemistry, IP, intraperitoneal injection, Disease Models, Animal, LDLR, Receptors, LDL, lcsh:Biology (General), NaOMe, sodium methoxide, Lipidomics, LDL receptor, Hepatocytes, Chromatography, Liquid, Lipoprotein
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المؤلفون: Janine van Duijn, Maarten Swart, Bram Slütter, Johan Kuiper, Harm Smeets, Ilze Bot, Thomas van der Heijden, Eva Kritikou, Pasquale Maffia, Anouk Wezel
المساهمون: Kritikou, Eva, van der Heijden, Thoma, Swart, Maarten, van Duijn, Janine, Slütter, Bram, Wezel, Anouk, Smeets, Harm J, Maffia, Pasquale, Kuiper, Johan, Bot, Ilze
المصدر: Journal of Immunology, 202(5), 1531-1539
Journal of Immunologyمصطلحات موضوعية: Cell type, T cell, Immunology, Proinflammatory cytokine, LDL, LDLr, MC, mast cell, MHC-II, MHC class II, medicine, Immunology and Allergy, WTD, Westerntype diet, MC, oxLDL, oxidized LDL, MHC-II, Westerntype diet, oxLDL, CD86, MHC class II, Innate immune system, biology, Chemistry, Low-density lipoprotein, LDL receptor, Acquired immune system, Mast cell, humanities, Cell biology, LDLr, LDL receptor, medicine.anatomical_structure, oxidized LDL, biology.protein, WTD, mast cell
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المؤلفون: Joshua C. Neuman, Lin Zhu, John M. Stafford, Elijah Trefts, Jeanne Shi, Thao Luu, David H. Wasserman, MacRae F. Linton, Brian T. Palmisano, Sophia S.K. Yu
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 8, Iss, Pp 106-116 (2018)مصطلحات موضوعية: 0301 basic medicine, Male, WT, wild type, PLTP, phospholipid transfer protein, CHD, coronary heart disease, SAA1, serum amyloid A1, chemistry.chemical_compound, Mice, Cholesterol/metabolism, 0302 clinical medicine, RCT, reverse cholesterol transport, DG, diacylglycerol, Medicine, Cells, Cultured, 2. Zero hunger, TG, triglyceride, Fatty liver, Reverse cholesterol transport, LDLR, LDL receptor, medicine.anatomical_structure, Cholesterol, Hepatocyte, Female, Original Article, ERα, estrogen receptor alpha, lcsh:Internal medicine, medicine.medical_specialty, PON1, paraoxonase 1, medicine.drug_class, 030209 endocrinology & metabolism, LKO-ERα, deletion of hepatocyte estrogen receptor alpha, 03 medical and health sciences, Insulin resistance, Sex Factors, Internal medicine, Sex differences, FPLC, fast performance liquid chromatography, Animals, Obesity, CETP, cholesteryl ester transfer protein, lcsh:RC31-1245, Molecular Biology, WD, Western-type diet, business.industry, SR-BI, scavenger receptor class B member I, Macrophages, Estrogen Receptor alpha, Biological Transport, Cell Biology, medicine.disease, Atherosclerosis, Estrogen, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, chemistry, Diet, Western, Hepatocytes, PDZK1, PDZ domain containing 1, business, Estrogen receptor alpha, Dyslipidemia
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المصدر: Cytokine
مصطلحات موضوعية: Cellular differentiation, 030204 cardiovascular system & hematology, Matrix metalloproteinase, DR3, death receptor 3, TNF-α, tumour necrosis factor-α, Biochemistry, Monocytes, 0302 clinical medicine, Transforming Growth Factor beta, LDL, low-density lipoprotein, Immunology and Allergy, IFN-γ, interferon-γ, ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs, Foam cell, ApoE, apolipoprotein E, 0303 health sciences, HMDM, human monocyte-derived macrophages, biology, ADAMTS, Interleukin-17, LDLR, LDL receptor, TL1A, tumour necrosis factor-like protein 1A, Interleukin, Cell Differentiation, Hematology, ADAMTS4 Protein, Plaque, Atherosclerotic, Cell biology, ECM, extracellular matrix, MMP, matrix metalloproteinase, LPL, lipoprotein lipase, VSMC, vascular smooth muscle cells, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Cytokines, Interleukin 17, Tumor Necrosis Factor Ligand Superfamily Member 15, PMA, phorbol 12-myristate 13-acetate, Immunology, ADAMTS proteases, Article, 03 medical and health sciences, Interferon-gamma, ADAMTS1 Protein, Cell Line, Tumor, TGF-β, transforming growth factor-β, Humans, ApoB, apolipoprotein B, Molecular Biology, 030304 developmental biology, Macrophages, Transforming growth factor beta, Atherosclerosis, QP, IL, interleukin, ADAM Proteins, RT-qPCR, real-time quantitative polymerase chain reaction, biology.protein, ADAMTS5 Protein, Gene expression, Procollagen N-Endopeptidase
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المصدر: Bioscience Reports
مصطلحات موضوعية: Male, ldlr, LDL receptor, 030204 cardiovascular system & hematology, Sphingomyelin phosphodiesterase, Biochemistry, SPT, serine-palmitoyl transferase, Palmitic acid, Mice, chemistry.chemical_compound, bSMase, bacterial SMase, 0302 clinical medicine, LDL, low-density lipoprotein, 2. Zero hunger, 0303 health sciences, ESI, electrospray ionization, Fatty Acids, Lipoproteins, LDL, Sphingomyelin Phosphodiesterase, TBARS, thiobarbituric acid-reactive substances, Liver, Female, lipids (amino acids, peptides, and proteins), Sphingomyelin, medicine.medical_specialty, Ceramide, HDL, high-density lipoprotein, Biophysics, Biology, Ceramides, Diet, High-Fat, secretory sphingomyelinase, S4, sphingomyelin, ABV, aorta and blood vessel, 03 medical and health sciences, Internal medicine, medicine, Animals, ASMase, acid SMase, ceramide, C6-NBD-Cer, 6-[N-(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoylceramide, Molecular Biology, Receptors, Lipoprotein, 030304 developmental biology, Sphingolipids, Original Paper, SM, sphingomyelin, low-density lipoprotein aggregation, Cholesterol, Macrophages, apoE, apolipoprotein E, C6-NBD-SM, 6-[N-(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]hexanoylsphingosylphosphocholine, VLDL, very-low-density lipoprotein, Cell Biology, Sphingolipid, Mice, Mutant Strains, Mice, Inbred C57BL, Endocrinology, chemistry, L-SMase, lysosomal ASMase, LDL receptor, S-SMase, secretory SMase, Blood Vessels, Diet, Atherogenic, SMase, sphingomyelinase, atherosclerosis, Lipoprotein
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المؤلفون: Ian T. Kirby, Martin J. Scott, Christopher J. Duff, Steven Martin, Nigel M. Hooper, Sue Hutchinson
المصدر: Biochemical Journal
مصطلحات موضوعية: Models, Molecular, antibody-mediated disruption, Low-density lipoprotein receptor gene family, Insecta, Plasma protein binding, Biochemistry, Epitope, RU, resonance units, Epitopes, LDL, low-density lipoprotein, Receptor, MOI, multiplicity of infection, LDLR, LDL receptor, Serine Endopeptidases, low-density lipoprotein receptor, LDLc, LDL-cholesterol, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9, aa, amino acids, surface plasmon resonance, Research Article, Protein Binding, HEK-F cells, Freestyle™ suspension human embryonic kidney cells, proprotein convertase subtilisin/kexin type 9 (PCSK9), SPR, surface plasmon resonance, Biology, Antibodies, Cell Line, FBS, fetal bovine serum, IL1Ra, interleukin-1 receptor antagonist, Animals, Humans, Molecular Biology, BODIPY®, boron dipyrromethene (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene, CHRD, cysteine/histidine-rich domain, PCSK9, cholesterol, Reproducibility of Results, Cell Biology, Cholesterol, LDL, Proprotein convertase, Molecular biology, EGF-A, epidermal growth factor-like repeat A, Kinetics, protein–protein interaction, Receptors, LDL, LDL receptor, Mutant Proteins, Extracellular Space, PCSK9, proprotein convertase subtilisin/kexin type 9