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المؤلفون: Arun Upadhyay
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2995-3014 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Ubiquitin proteasome system, CASA, chaperone-assisted selective autophagy, DUBs, deubiquitinases, Review, 0302 clinical medicine, Ubiquitin, Natural molecules, Chaperones, General Pharmacology, Toxicology and Pharmaceutics, Ub, ubiquitin, Cancer, CAP, chaperone-assisted proteasomal degradation, EGCG, epigallocatechin-3-gallate, 0303 health sciences, biology, Drug discovery, Chemistry, HECT, homologous to the E6-AP carboxyl terminus, Neurodegeneration, CELL DEBRIS, CMA, chaperone-mediated autophagy, Cell biology, 030220 oncology & carcinogenesis, Proteinopathies, HSP, heat shock protein, LAMP2a, lysosome-associated membrane protein 2a, UPS, ubiquitin–proteasome system, 17-AAG, 17-allylamino-geldanamycin, BAG, BCL2-associated athanogene, HSF1, heat shock factor 1, RM1-950, RING, really interesting new gene, 03 medical and health sciences, ESCRT, endosomal sorting complexes required for transport, CHIP, carboxy-terminus of HSC70 interacting protein, medicine, Autophagy, HSC70, heat shock cognate 70, PQC, protein quality control, 030304 developmental biology, APC, anaphase-promoting complex, medicine.disease, NBR1, next to BRCA1 gene 1, KFERQ, lysine-phenylalanine-glutamate-arginine-glutamine, LC3, light chain 3, Ageing, Proteostasis, Proteasome, biology.protein, Therapeutics. Pharmacology
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المؤلفون: Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Target, ONRs, orphan nuclear receptors, Parkinson's disease, Small-molecule compound, MPP+, 1-methyl-4-phenylpyridinium, Autolysosome, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, GBA, glucocerebrosidase β acid, Review, MPTP, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, Disease, mTORC1, mTOR, the mammalian target of rapamycin, PD, Parkinson's disease, 0302 clinical medicine, CL, clearance rate, DAT, dopamine transporter, HDAC6, histone deacetylase 6, PD therapy, A2A, adenosine 2A, MYCBP2, MYC-binding protein 2, TFEB, transcription factor EB, AUTAC, autophagy targeting chimera, General Pharmacology, Toxicology and Pharmaceutics, SAS, solvent accessible surface, 0303 health sciences, α-syn, α-synuclein, ALP, autophagy-lysosomal pathway, AADC, aromatic amino acid decarboxylase, DJ-1, Parkinson protein 7, PI3K, phosphatidylinositol 3-kinase, COMT, catechol-O-methyltransferase, LUHMES, lund human mesencephalic, LRRK2, CMA, chaperone-mediated autophagy, KI, knockin, 030220 oncology & carcinogenesis, LRS, leucyl-tRNA synthetase, BBB, blood−brain barrier, SN, substantia nigra, IMPase, inositol monophosphatase, IPPase, inositol polyphosphate 1-phosphatase, HSPA8, heat shock 70 kDa protein 8, MAO-B, monoamine oxidase B, PREP, prolyl oligopeptidase, Parkinson's disease (PD), DR, dopamine receptor, PDE4, phosphodiesterase 4, AMPK, 5ʹAMP-activated protein kinase, 5-HT2C, serotonin 2C, SNCA, α-synuclein gene, TSC2, tuberous sclerosis complex 2, RM1-950, LIMP-2, lysosomal integrated membrane protein-2, CNS, central nervous system, 5-HT2A, Serotonin 2A, ER, endoplasmic reticulum, ATG, autophagy related protein, 03 medical and health sciences, PLC, phospholipase C, ROS, reactive oxygen species, ERRα, estrogen-related receptor alpha, SAR, structure–activity relationship, ULK1, UNC-51-like kinase 1, medicine, Autophagy, NMDA, N-methyl-d-aspartic acid, mAChR, muscarinic acetylcholine receptor, GWAS, genome-wide association study, LAMP2A, lysosome-associated membrane protein 2 A, Lamp2a, type 2A lysosomal-associated membrane protein, 030304 developmental biology, Parkin, parkin RBR E3 ubiquitin−protein ligase, PINK1, PTEN-induced kinase 1, ATTEC, autophagosome-tethering compound, ATP13A2, ATPase cation transporting 13A2, business.industry, ULK1, medicine.disease, LC3, light chain 3, PI3P, phosphatidylinositol 3-phosphate, SYT11, synaptotagmin 11, AUC, the area under the curve, UPS, ubiquitin−proteasome system, TFEB, DA, dopamine, Therapeutics. Pharmacology, business, BAF, bafilomycinA1, HSC70, heat shock cognate 71 kDa protein, Neuroscience, 3-MA, 3-methyladenine, F, oral bioavailability, LRRK2, leucine-rich repeat sequence kinase 2
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المؤلفون: Edmond Fleischer, Vincent Kam Wai Wong, Thorsten Berg, Sara Abdelfatah, Thomas Efferth, Anette Klinger, Li Jun Yang, Qi Huang, Sami Hamdoun, Henry Johannes Greten, Angela Berg
المصدر: Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 1021-1034 (2019)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PBD, Polo box domain, MTD, maximal tolerance dose, CDC25, cell division cycle 25, HIF-1α, hypoxia-inducible factor 1 α, MST, microscale thermophoresis, IC50, 50% inhibition concentration, MFP, M phase promoting factor, PARP-1, poly(ADP-ribose) polymerase-1, 0302 clinical medicine, FOXO, forkhead box O, Nec-1, necrostatin 1, CDC2, cell division cycle protein 2 homolog, General Pharmacology, Toxicology and Pharmaceutics, Mitotic catastrophe, CDK, cyclin-dependent kinase, 0303 health sciences, Chemistry, Polo-like kinase, Mono-targeted therapy, Cell cycle, BUBR1, budding uninhibited by benzimidazole-related 1, Polo box domain, 030220 oncology & carcinogenesis, PLK1, Polo-like kinase, Necroptosis, Spindle damage, PLK1, IHC, immunohistochemistry, Original article, APC/C, anaphase-promoting complex/cyclosome, PLK3, ABC, avidin-biotin complex, PI, propidium iodide, 03 medical and health sciences, FBS, fetal bovine serum, PDB, Protein Data Bank, Kd, the dissociation constant, Kinase activity, 030304 developmental biology, Akt/PKB signaling pathway, Cell growth, lcsh:RM1-950, LC3, light chain 3, lcsh:Therapeutics. Pharmacology, Cancer research, DAPKs, death-associated protein kinase, 3-MA, 3-methyladenine, DAPI, 4′,6-diamidino-2-phenylindole, SAC, spindle assembly checkpoint
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المؤلفون: Wen-Xing Ding, Hartmut Jaeschke, David S Umbaugh, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Nga T. Nguyen, Jephte Y. Akakpo, Anup Ramachandran
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3740-3755 (2021)مصطلحات موضوعية: GSSG, glutathione disulfide, LOOH, lipid hydroperoxides, NQO1, NAD(P)H:quinone oxidoreductase 1, TLR, toll like receptor, HNE, 4-hydroxynonenal, NAC, N-acetylcysteine, Apoptosis, Review, Bioinformatics, SMAC/DIABLO, second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI, GSH, glutathione, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, Innate immunity, BSO, buthionine sulfoximine, mTORC1, mammalian target of rapamycin complex 1, MCP-1, monocyte chemoattractant protein-1, Mitochondria, CYP, cytochrome P450 enzymes, GPX4, glutathione peroxidase 4, NRF2, nuclear factor erythroid 2-related factor 2, KEAP1, Kelch-like ECH-associated protein 1, LPO, lipid peroxidation, NF-κB, nuclear factor κB, medicine.drug, DMSO, dimethylsulfoxide, Inflammatory response, Gclm, glutamate–cysteine ligase modifier subunit, HMGB1, high mobility group box protein 1, APAP, acetaminophen, ARE, antioxidant response element, RM1-950, TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling, UGT, UDP-glucuronosyltransferases, Necrotic cell, MPT, mitochondrial permeability transition, Acetaminophen hepatotoxicity, NRF2, ROS, reactive oxygen species, EndoG, endonuclease G, medicine, Autophagy, Injury mechanisms, Ferroptosis, MnSOD, manganese superoxide dismutase, Antipyretic drugs, MDA, malondialdehyde, Drug metabolism, business.industry, ATG, autophagy-related genes, PUFAs, polyunsaturated fatty acids, Liver failure, medicine.disease, CAD, caspase-activated DNase, Gclc, glutamate–cysteine ligase catalytic subunit, Acetaminophen, LC3, light chain 3, AIF, apoptosis-inducing factor, AMPK, AMP-activated protein kinase, DAMPs, damage-associated molecular patterns, JNK, c-jun N-terminal kinase, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, NAPQI, N-acetyl-p-benzoquinone imine, FSP1, ferroptosis suppressing protein 1, MAP kinase, mitogen activated protein kinase
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المؤلفون: Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)مصطلحات موضوعية: Review, Mitochondrion, PD, Parkinson's disease, 0302 clinical medicine, FOXO, forkhead box O, Mitophagy, HD, Huntington's disease, TFEB, transcription factor EB, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, TIGAR, TP53-induced glycolysis and apoptosis regulator, Stroke, 0303 health sciences, AMPK, 5′-adenosine monophosphate-activated protein kinase, mTOR, mechanistic target of rapamycin, eIF2a, eukaryotic translation-initiation factor 2, PI3K, phosphatidylinositol 3-kinase, OGD/R, oxygen and glucose deprivation-reperfusion, Cerebral ischemia, ALS, amyotrophic lateral sclerosis, PERK, protein kinase R (PKR)-like endoplasmic reticulum kinase, Neuroprotection, Mitochondria, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, ULK, Unc-51- like kinase, AD, Alzheimer's disease, Intracellular, Programmed cell death, ATF6, activating transcription factor 6, IRE1, inositol-requiring enzyme 1, RM1-950, Natural compounds, IPC, ischemic preconditioning, ER, endoplasmic reticulum, 03 medical and health sciences, COPII, coat protein complex II, LKB1, liver kinase B1, ROS, reactive oxygen species, ΔΨm, mitochondrial membrane potential, medicine, Autophagy, Lysosomal activation, ATG, autophagy related genes, 030304 developmental biology, Uro-A, urolithin A, business.industry, FUNDC1, FUN14 domain containing 1, medicine.disease, LC3, light chain 3, GPCR, G-protein coupled receptor, BNIP3L, BCL2/adenovirus, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, Neuroscience, Homeostasis, Neurological disorders, BCL-2, B-cell lymphoma 2
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المؤلفون: Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)مصطلحات موضوعية: 0301 basic medicine, Esophageal Neoplasms, medicine.medical_treatment, Biopsy, Cell, CQ, chloroquine, IC50, half maximal inhibitory concentration, OPSCC, oropharyngeal squamous cell carcinoma, Mice, 0302 clinical medicine, SCCs, squamous cell carcinomas, CD44, Original Research, TE11R, 5-fluorouracil–resistant derivative of TE11, biology, Gastroenterology, Chemoradiotherapy, 3. Good health, Organoids, Oropharyngeal Neoplasms, 5FU, 5-fluorouracil, medicine.anatomical_structure, Hyaluronan Receptors, Carcinoma, Squamous Cell, 030211 gastroenterology & hepatology, Fluorouracil, ESCC, esophageal squamous cell carcinoma, EMT, epithelial-mesenchymal transition, IHC, immunohistochemistry, medicine.medical_specialty, 5-Fluorouracil, 3D Organoids, PI, propidium iodide, 03 medical and health sciences, FBS, fetal bovine serum, Cell Line, Tumor, 3D, 3-dimensional, medicine, Organoid, Autophagy, Animals, Humans, lcsh:RC799-869, AV, autophagy vesicle, Chemotherapy, Hepatology, business.industry, Cancer, Endoscopy, medicine.disease, CD44H, high expression of CD44, LC3, light chain 3, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer cell, biology.protein, Cancer research, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Histopathology, DMEM, Dulbecco’s modified Eagle medium, Personalized medicine, business
وصف الملف: application/pdf
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المؤلفون: Isaac M. Oderberg, Paul J. Wrighton, Wolfram Goessling
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 347-363 (2019)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Cirrhosis, LSEC, liver sinusoidal endothelial cell, ved/biology.organism_classification_rank.species, Review, Disease, Bioinformatics, 0302 clinical medicine, Tumor Microenvironment, Medicine, Gene Regulatory Networks, Wnt, Wingless, TGF, transforming growth factor, Zebrafish, GFP, green fluorescent protein, HCP, hepatitis C virus core protein, ICC, intrahepatic cholangiocarcinoma, lf:Yap, Tg[-2.8fabp10a:yap1-1βS87A, Yap, Yes-associated protein, biology, Liver Neoplasms, TME, tumor microenvironment, Gastroenterology, TAN, tumor-associated neutrophil, HSC, hepatic stellate cell, TERT, telomerase reverse transcriptase, 3. Good health, DILI, drug-induced liver injury, HCV, hepatitis C virus, Hepatocellular carcinoma, HBx, hepatitis B x antigen, TAM, tumor-associated macrophage, 030211 gastroenterology & hepatology, TP53, tumor protein 53, Liver cancer, E2, 17β-estradiol, medicine.drug, Sorafenib, Carcinoma, Hepatocellular, APAP, acetaminophen, 03 medical and health sciences, Model Organisms, ROS, reactive oxygen species, Autophagy, Animals, Humans, Genetic Predisposition to Disease, lcsh:RC799-869, Model organism, DMBA, 7,12-dimethylbenz[a]anthracene, Inflammation, Cancer prevention, Hepatology, business.industry, ved/biology, Drug-Induced Liver Injury, medicine.disease, biology.organism_classification, WT, wild-type, Hormones, digestive system diseases, Disease Models, Animal, HBV, hepatitis B virus, 030104 developmental biology, Lc3, Light Chain 3 Beta, Mutation, fabp10a, fatty acid binding protein 10a, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, HCC, hepatocellular carcinoma, business
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المؤلفون: Simona Simmen, Jesus Cosin-Roger, Cheryl de Valliere, Katharina Spanaus, Katharina Baebler, Chiaki Maeyashiki, Nikolaos Maliachovas, Jonas Zeitz, Gerhard Rogler, Pedro A. Ruiz, Hassan Melhem, Stephan R. Vavricka, Bruce Weder, Max Maane, Martin Hausmann, Michael Scharl
المساهمون: University of Zurich, Ruiz, Pedro A
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)مصطلحات موضوعية: 0301 basic medicine, DMT-1, divalent metal transporter 1, RNA Stability, Interleukin-1beta, IRE, iron-responsive elements, IEC, intestinal epithelial cell, 0302 clinical medicine, PCR, polymerase chain reaction, 540 Chemistry, IL1β, interleukin 1β, Intestinal Mucosa, Hypoxia, Promoter Regions, Genetic, 10038 Institute of Clinical Chemistry, Original Research, DFO, deferoxamine, Aged, 80 and over, TNF, tumor necrosis factor, biology, IBD, inflammatory bowel disease, Chemistry, TTP, tristetraprolin, Gastroenterology, NF-kappa B, Middle Aged, Intestinal epithelium, mRNA, messenger RNA, Cell biology, Oxygen tension, Deferoxamine, ChIP, chromatin immunoprecipitation, HIF, hypoxia-inducible transcription factor, 10219 Clinic for Gastroenterology and Hepatology, FPN, ferroportin, 030211 gastroenterology & hepatology, Tumor necrosis factor alpha, medicine.symptom, HT29 Cells, medicine.drug, Adult, Iron, NF-κB, nuclear factor-κB, 610 Medicine & health, Inflammation, mTOR, mammalian target of rapamycin, PHD, prolyl hydroxylase, Models, Biological, H2DCF-DA, 2′,7′-dichlorofluorescein diacetate, IRP, iron regulatory protein, 03 medical and health sciences, Young Adult, ROS, reactive oxygen species, Tf, transferrin, medicine, Autophagy, Humans, 2715 Gastroenterology, lcsh:RC799-869, Aged, Hepatology, Tumor Necrosis Factor-alpha, Inflammatory Bowel Disease, Transcription Factor RelA, Caco-2, Hypoxia (medical), LC3, light chain 3, Ferritin, FAC, ferric ammonion iron citrate, 030104 developmental biology, ARE, adenylate and uridylate-rich elements, biology.protein, 2721 Hepatology, lcsh:Diseases of the digestive system. Gastroenterology, Caco-2 Cells
وصف الملف: 1-s2.0-S2352345X18301528-main.pdf - application/pdf
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المؤلفون: Rui Song, Han Lei, Wanwen Cheng, Ling Ling Yao, Li Feng, Jie Liu, Ying Li
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Autophagosome, TF, transcription factor, LVIDd, diastolic LV internal dimension, CQ, chloroquine, ATG7, autophagy-related protein 7, mTORC1, HF, heart failure, Biochemistry, Muscle hypertrophy, Mice, RFP, red fluorescent protein, AAV, adeno-associated virus, Medicine, Myocytes, Cardiac, TFEB, transcription factor EB, MOI, multiplicity of infection, FS, fractional shortening, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, BW, body weight, BafA1, bafilomycin A1, IP, immunoprecipitation, mTORC1, mechanistic target of rapamycin kinase complex 1, NPPB, natriuretic peptide precursor B, Cell biology, LVIDs, systolic LV internal dimension, cardiovascular system, β-MHC, myosin heavy chain-β, TAC, transverse aortic constriction, hypertrophy, Research Article, autophagy, NRVM, neonatal rat ventricular myocyte, WGA, wheat germ agglutinin, Cardiomegaly, NIH, the National Institutes of Health, heart, MYH7B, myosin heavy chain 7B, ALP, autophagosome–lysosome pathway, GATA4, Downregulation and upregulation, Animals, Humans, EF, ejection fraction, PO, pressure overload, Autophagy-Related Protein 7, ANP, atrial natriuretic peptide, LV, left ventricular, Molecular Biology, PGC1α, peroxisome proliferator–activated receptor-gamma coactivator-1α, KD, knockdown, Pressure overload, TFEB, PE, phenylephrine, autophagosome–lysosome pathway, business.industry, Autophagy, Cell Biology, NPPA, natriuretic peptide precursor A, GATA4 Transcription Factor, LC3, light chain 3, Proteolysis, business
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المؤلفون: Elisabeth Sehn, Christian Behl, Christof Hiebel, Franz H. Grus, Vanessa Felzen, Uwe Wolfrum, Caroline Manicam, Natarajan Perumal, Debapriya Chakraborty, Elisabeth Stürner
المصدر: Redox Biology
Redox Biology, Vol 24, Iss, Pp-(2019)مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, LFQ, Label-free quantification, LETM, Leucine zipper and EF-hand containing transmembrane protein, medicine.disease_cause, Biochemistry, CHX, Cycloheximide, 0302 clinical medicine, BNIP3, Bcl-2 interacting protein 3, RAPA, Rapamycin, PIK3C3, Class III PI3‐kinase, Phosphorylation, lcsh:QH301-705.5, Neurons, lcsh:R5-920, PolyUB, Polyubiquitin, Chemistry, BAG3, OPA1, Optic atrophy 1, TOR Serine-Threonine Kinases, WIPI1, WD repeat domain phosphoinositide-interacting protein 1, ATG, Autophagy related, TFEB, Transcription factor EB, Cell biology, Mitochondria, siRNA, Small interfering RNA, DLP1, Dynamin-like protein 1, LAMP1, Lysosomal‐associated membrane protein 1, PURO, Puromycin, lcsh:Medicine (General), Protein homeostasis, Research Paper, BafA1, Bafilomycin A1, LAMP2, Lysosomal‐associated membrane protein 2, Proteasome Endopeptidase Complex, RAB18, Member RAS oncogene, TUB, Tubulin, LC3, Light chain 3 protein, Oxidative phosphorylation, CTSD, Cathepsin D, Models, Biological, Cell Line, 03 medical and health sciences, Downregulation and upregulation, Macroautophagy, medicine, Autophagy, Humans, Adaptation, BAG1, Bcl-2-associated athanogene 1, BECN1, Beclin1, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, TEM, Transmission electron microscopy, Hsp70, Heat shock protein 70, Organic Chemistry, Autophagosomes, mTOR, Mammalian target of rapamycin, Hsp70, Oxidative Stress, 030104 developmental biology, Proteostasis, lcsh:Biology (General), CV, Canavanine, BAG3, Bcl-2-associated athanogene 3, MTT, (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide), Apoptosis Regulatory Proteins, Lysosomes, 030217 neurology & neurosurgery, Oxidative stress
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المؤلفون: Bing He, Lana X. Garmire, Shankar Subramaniam, Mano Ram Maurya, Cameron Lassiter, Yu Liu, Hui Li, Paula Benny
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100118-(2021)مصطلحات موضوعية: Severity of Illness Index, Biochemistry, Cohort Studies, OxPE, oxidized phosphatidylethanolamine, Pathogenesis, PC, phosphatidylcholine, chemistry.chemical_compound, Endocrinology, Pre-Eclampsia, Pregnancy, reproductive and urinary physiology, CE, cholesteryl ester, WGCNA, weighted gene coexpression network analysis, Lipidome, Lipids, metabolomics, female genital diseases and pregnancy complications, machine learning, PL, phospholipid, RF, random forest, Lysophosphatidylcholine, classification, Cholesteryl ester, biomarker, Biomarker (medicine), Female, lipids (amino acids, peptides, and proteins), Research Article, Adult, LPE, lysophosphatidylethanolamine, medicine.medical_specialty, Ceramide, hypertension, TAG, triacylglycerol, Cer, ceramide, QD415-436, OxPL, oxidized phospholipid, PE, phosphatidylethanolamine, Preeclampsia, preeclampsia, Internal medicine, Lipidomics, medicine, Humans, SOV, source of variation, LPC, lysophosphatidylcholine, pathway, business.industry, KNN, K-nearest neighbor, Cell Biology, ACN, acetonitrile, medicine.disease, maternal blood, LC3, light chain 3, OxPC, oxidized PC, QC, quality control, chemistry, business
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المؤلفون: Li Chen, Ming Zhang, Fan Yao
المصدر: Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 20-25 (2016)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: 0301 basic medicine, CaMKK, Ca2+ calmodulin-dependent protein kinase kinase, FoxO, forkhead box class O, mTORC1, IκB kinase, Review, DEPTOR, DEP domain-containing mTOR-interacting protein, AMP-activated protein kinase, ERK, extracellular signal-regulated kinase, AMPK, 5′-monophosphate-activated protein kinase, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, SOGA, suppressor of glucose form autophagy, biology, Diabetes, JLDG, Jinlida granule, mTORC1, mammalian target of rapamycin (mTOR) complex 1, VPS34, vacuolar protein-sorting 34, AdipoR, adiponectin receptors, medicine.medical_specialty, ATP, adenosine triphosphate, ACC, carboxylase, PRAS40, proline-rich Akt substrate 40 kDa, mTOR, mammalian target of rapamycin, STZ, streptozotocin, JNK, janus kinase, Diabetic complications, 03 medical and health sciences, LKB1, liver kinase B1, Diabetes mellitus, Internal medicine, PKC, protein kinase C, medicine, Autophagy, PI3K/AKT/mTOR pathway, GFRs, glomerular filtration rates, business.industry, AMP-activated protein kinases, lcsh:RM1-950, AMPK, DM, Diabetes mellitus, DN, Diabetic nephropathy, ULK1, medicine.disease, ADP, adenosine diphosphate, ULK1, Unc-51-like kinase 1, LC3, light chain 3, 030104 developmental biology, Endocrinology, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, Cancer research, biology.protein, business, TSC, tuberous sclerosis complex, RAPTOR, regulator associated protein of mTOR
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المصدر: Redox Biology, Vol 4, Iss C, Pp 184-192 (2015)
Redox Biologyمصطلحات موضوعية: ATG8, autophagy related gene 8, Clinical Biochemistry, Autophagy-Related Proteins, mTORC1, mammalian target of rapamycin complex, Tumor initiation, AMP-Activated Protein Kinases, Biochemistry, Metastasis, Neoplasms, Tumor Microenvironment, Autophagy-Related Protein-1 Homolog, SQSTM1, sequestosome 1, HMGB1, high-mobility group protein B 1, lcsh:QH301-705.5, Cancer, lcsh:R5-920, Kelch-Like ECH-Associated Protein 1, GABARAPL2, GABARAP protein-like 2, Intracellular Signaling Peptides and Proteins, Mitophagy, ROS, Primary tumor, Mitochondria, Cell biology, NLRP3, NOD-like receptor family, pyrin domain containing 3, Gene Expression Regulation, Neoplastic, PINK1, PTEN induced putative kinase 1, Cysteine Endopeptidases, Cell Transformation, Neoplastic, Lymphatic Metastasis, NRF2, nuclear factor erythroid 2-related factor 2, KEAP1, Kelch-like ECH-associated protein 1, HSP, heat shock protein, Beclin-1, Antioxidant, EMT, epithelial-mesenchymal transition, lcsh:Medicine (General), Signal Transduction, Mini Review, ATG, autophagy related gene, Antineoplastic Agents, Protein Serine-Threonine Kinases, Biology, HIF-1α, hypoxia-inducible factor-1 α, ROS, reactive oxygen species, Cancer stem cell, Autophagy, medicine, Humans, GEC1, glandular epithelial cell 1, Tumor microenvironment, Organic Chemistry, Membrane Proteins, medicine.disease, LC3, light chain 3, ULK1, unc-51 like autophagy activating kinase 1, AMPK, AMP-activated protein kinase, GABARAPL1, GABARAP protein-like 1, lcsh:Biology (General), Cancer cell, BNIP3, BCL-2/adenovirus E1B 19-kDa-interacting protein 3, Apoptosis Regulatory Proteins, Reactive Oxygen Species, 3-MA, 3-methyladenine, GABARAP, GABAA receptor-associated protein
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المؤلفون: Wen-Xing Ding, Sharon Manley
المصدر: Acta Pharmaceutica Sinica B, Vol 5, Iss 2, Pp 158-167 (2015)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: WT, wild type, Alcoholic liver disease, Cirrhosis, NTCP, sodium taurocholate cotransporting polypeptide, IR-1, inverted repeat-1, Review, TLR4, toll-like receptor 4, SHP, small heterodimer partner, 0302 clinical medicine, NAD+, nicotinamide adenine dinucleotide, 6ECDCA, 6α-ethyl-chenodeoxycholic acid, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, FGFR4, fibroblast growth factor receptor 4, MRP4, multidrug resistance protein 4, 0303 health sciences, CA, cholic acid, SQSTM, sequestome-1, FGF15/19, fibroblast growth factor 15/19, 3. Good health, Atg, autophagy-related, WAY, WAY-362450, Hepatocellular carcinoma, CREBH, cAMP response element-binding protein, hepatocyte specific, FoxO3, FOXO3, CYP, cytochrome P450, 030211 gastroenterology & hepatology, FoxO3a, forkhead box-containing protein class O3a, BAAT, bile acid CoA:amino acid N-acyltransferase, RXRα, retinoid X receptor-alpha, BACS, bile acid CoA synthetase, medicine.medical_specialty, ALD, alcoholic liver disease, GGT, gamma-glutamyltranspeptidase, TCA, taurocholic acid, ASBT, apical sodium dependent bile acid transporter, Biology, PE, phosphatidylethanolamine, AKT, protein kinase B, ADH, alcohol dehydrogenase, UDCA, ursodeoxycholic acid, CDCA, chenodeoxycholic acid, 03 medical and health sciences, FXR, farnesoid X receptor, ROS, reactive oxygen species, Cholestasis, Farnesoid X receptor, TUDCA, tauro-ursodeoxycholic acid, Internal medicine, ALT, alanine aminotransferase, AF, activation function, medicine, Autophagy, BSEP, bile salt export pump, 030304 developmental biology, KO, knockout, PPARα, peroxisome proliferator-activated receptor alpha, SREBP1, sterol regulatory element-binding protein 1, lcsh:RM1-950, CB1R, cannabinoid receptor type 1, CRTC2, CREB regulated transcription coactivator 2, medicine.disease, Bile acids, LC3, light chain 3, OSTα/β, organic solute transporter α/β, Endocrinology, lcsh:Therapeutics. Pharmacology, DCA, deoxycholic acid, DR1, direct repeat 1, LRH-1, liver receptor homolog 1, CREB, cAMP response element-binding protein, Steatosis, LXR, liver X receptor, HCC, hepatocellular carcinoma, Sirt1, sirtuin 1
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المؤلفون: Munehiro Kitada, Shinji Kume, Ai Takeda-Watanabe, Keizo Kanasaki, Daisuke Koya
المصدر: Clinical Science (London, England : 1979)
مصطلحات موضوعية: Aging, IGF, insulin-like growth factor, PARP, poly(ADP-ribose) polymerase, Review Article, Bioinformatics, TNF-α, tumour necrosis factor α, Diabetic nephropathy, PTP1B, protein tyrosine phosphatase 1B, chemistry.chemical_compound, Sirtuin 1, FOXO, forkhead box O, Sirtuin 3, SIRT1 (sirtuin 1), Sirtuins, Atg, autophagy-related gene, Diabetic Nephropathies, AT1R, angiotensin type 1 receptor, TGF, transforming growth factor, ICAM-1, intercellular adhesion molecule 1, Kidney, WFR, Wistar fatty diabetic rat, AngII, angiotensin II, eNOS, endothelial NO synthase, General Medicine, PGC-1α, PPAR-γ co-activator-1α, MCP-1, monocyte chemotactic protein-1, SIRT1 etc., sirtuin 1 etc., SNP, single nucleotide polymorphism, HIF, hypoxia-inducible factor, sirtuin, Idh2, isocitrate dehydrogenase 2, BMAL1, brain and muscle ARNT (aryl hydrocarbon receptor nuclear translocator)-like 1, medicine.anatomical_structure, Sirtuin, CRP, C-reactive protein, IRS, insulin receptor substrate, Advanced glycation end-product, Kidney Diseases, Bnip3, BCL2/adenovirus E1V 19-kDa interacting protein 3, PPAR, peroxisome-proliferator-activated receptor, SREBP, sterol-regulatory-element-binding protein, SIRT6, medicine.medical_specialty, Calorie restriction, H3K9me3, H3K9 trimethylation, NF-κB, nuclear factor-κB, S6, mTOR, mammalian target of rapamycin, Biology, α-ENaC, epithelial Na+ channel α-subunit, S4, ER, endoplasmic reticulum, FXR, farnesoid X receptor, ROS, reactive oxygen species, RAS, renin–angiotensin system, Internal medicine, Diabetes mellitus, PKC, protein kinase C, medicine, CR, calorie restriction, Animals, Humans, Sir2, silent information regulator 2, UUO, unilateral ureteral obstruction, Caloric Restriction, Mn-SOD, manganese superoxide dismutase, diabetic nephropathy, CKD, chronic kidney disease, H3K9, histone H3 Lys9, medicine.disease, PER2, Period 2, Angiotensin II, LC3, light chain 3, VCAM-1, vascular cell adhesion protein 1, AMPK, AMP-activated protein kinase, Endocrinology, AGE, advanced glycation end-product, chemistry, COX2, cyclo-oxygenase 2, biology.protein, LXR, liver X receptor
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16
المؤلفون: Samantha Giordano, Jisun Lee, Jianhua Zhang
المصدر: Biochemical Journal
مصطلحات موضوعية: ULK, unc (unco-ordinated family member)-51-like kinase, Transcription, Genetic, Protein Deglycase DJ-1, BNIP, Bcl-2/adenovirus E18 19-kDa-interacting protein, Review Article, Biochemistry, IκB, inhibitor of nuclear factor κB, DNM1L, 0302 clinical medicine, mitochondrion, Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein, NOS, nitric oxide synthase, FIP200, focal adhesion kinase family-interacting protein of 200 kDa, GFP, green fluorescent protein, 0303 health sciences, TOR Serine-Threonine Kinases, ECH, enoyl-CoA hydratase, Intracellular Signaling Peptides and Proteins, BAG, Bcl-2-associated athanogene, ALS, amyotrophic lateral sclerosis, LRRK2, leucine-rich repeat kinase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, Cardiovascular Diseases, TNFα, tumour necrosis factor α, VDAC, voltage-dependent anion channel, UCP, uncoupling protein, NGF, nerve growth factor, mTOR, mammalian target of rapamycin, PE, phosphatidylethanolamine, Nitric Oxide, 03 medical and health sciences, Humans, AMPK, 5′-AMP-activated protein kinase, Vps34, vacuolar protein sorting 34, IKKβ, IκB kinase β, Molecular Biology, Drp1, dynamin-related protein 1, PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1, ATG, AuTophaGy-related, RLS, reactive lipid species, redox signalling, Hydrogen Peroxide, HIF-1, hypoxia-inducible factor 1, siRNA, small interfering RNA, tfLC3, tandem fluorescently tagged LC3, Reactive Oxygen Species, Protein Kinases, 3-MA, 3-methyladenine, 030217 neurology & neurosurgery, Mitochondrial Turnover, HNE, 4-hydroxynonenal, Mitochondrion, Tzb, trastuzumab, medicine.disease_cause, Nrf2, nuclear factor-erythroid 2-related factor 2, RFP, red fluorescent protein, Neoplasms, Mitophagy, oxidative stress, nitrative stress, NAC, N-acetyl-L-cysteine, Oncogene Proteins, neurodegeneration, TOR, target of rapamycin, Parkinson Disease, NOX, NADPH oxidase, Reactive Nitrogen Species, Mitochondria, NF-κB, nuclear factor κB, TAC, transverse aortic constriction, Oxidation-Reduction, PI3K, phosphoinositide 3-kinase, Signal Transduction, autophagy, Programmed cell death, IP3, inositol 1,4,5-trisphosphate, TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator, LAMP, lysosome-associated membrane protein, PINK1, JNK1, c-Jun N-terminal kinase 1, Biology, ER, endoplasmic reticulum, RNS, reactive nitrogen species, ROS, reactive oxygen species, mETC, mitochondrial electron-transport chain, SOD, superoxide dismutase, BNIP3L, BNIP3-like, medicine, Animals, 030304 developmental biology, EM, electron microscopy, Autophagy, Cell Biology, NBR1, neighbour of BRCA1 (breast cancer early-onset 1), GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein, LC3, light chain 3, mtDNA, mitochondrial DNA, PI3P, phosphatidylinositol 3-phosphate, Lysosomes, Oxidative stress
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17
المؤلفون: Ming‑Xu Hu, Li Liu, Rui‑Hong Zhang, Ping Zhang, Ke‑Li Yun, Hong‑Cai Zhang, Li Sui
المصدر: Bioscience Reports, Vol 35, Iss 2, p e00186 (2015)
Bioscience Reportsمصطلحات موضوعية: Programmed cell death, autophagy, Biophysics, lcsh:Life, lcsh:QR1-502, endoplasmic reticulum (ER) stress, Metal toxicity, mTOR, mammalian target of rapamycin, mTORC1, Mechanistic Target of Rapamycin Complex 1, Pharmacology, Biology, Biochemistry, lcsh:Microbiology, ER, endoplasmic reticulum, Mice, ROS, reactive oxygen species, UPR, unfolded protein response, mammalian target of rapamycin (mTOR) pathway, S6K1, S6 kinase 1, Animals, Humans, Molecular Biology, Cells, Cultured, DMEM, Dulbecco's Modified Essential Medium, Original Paper, Myocardium, TOR Serine-Threonine Kinases, Endoplasmic reticulum, Autophagy, mTORC1, mammalian target of rapamycin complex 1, Cell Biology, Fibroblasts, lead toxicity, LC3, light chain 3, Cell biology, lcsh:QH501-531, Lead, Apoptosis, Multiprotein Complexes, Toxicity, Unfolded protein response, 3-MA, 3-methyladenine, cardiofibroblasts
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18
المؤلفون: Irina Madorsky, Lee Sooyeon, Jordan T. Schmidt, Jessica Nicks, Lucia Notterpek, Vinita G. Chittoor, Sunitha Rangaraju, Diana C. Narvaez
المصدر: ASN Neuro, Vol 5 (2013)
ASN NEUROمصطلحات موضوعية: Wt, wild-type, Chaperonins, LAMP1, lysosomal membrane-associated protein 1, pUb, polyubiquitinated, CathD, Cathepsin D, Hsp, heat-shock protein, Mice, Myelin, 0302 clinical medicine, Egr2, early growth response 2, Charcot-Marie-Tooth Disease, Peripheral myelin protein 22, chaperone, TFEB, transcription factor EB, PNGaseF, N-glycosidase F, 0303 health sciences, CD11b Antigen, biology, General Neuroscience, Age Factors, HRP, horseradish peroxidase, CMT1A, Charcot–Marie–Tooth disease type 1A, Sciatic Nerve, 3. Good health, Cell biology, myelin, medicine.anatomical_structure, Neutrophil Infiltration, Disease Progression, Myelin Proteins, Research Article, Proteasome Endopeptidase Complex, autophagy, UPS, ubiquitin–proteasome system, Transgene, MCP-1, monocyte chemoattractant protein 1, Schwann cell, Mice, Transgenic, S3, endoH, endoglycosidase H, protein aggregation, MS, multiple sclerosis, lcsh:RC321-571, ER, endoplasmic reticulum, 03 medical and health sciences, Oct6, octamer-binding transcription factor 6, Lysosome, ubiquitin, medicine, Animals, Humans, HSP70 Heat-Shock Proteins, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, AMC, amino-methyl coumarin, Macrophages, Autophagy, PMP22, peripheral myelin protein 22, Proteins, HSF1, heat-shock factor 1, di-8-ANEPPS, 4-[2-(6-dibutylamino)-2-naphthalenyl)ethenyl]-1-(3-sulfopropyl) hydroxide, LC3, light chain 3, Mice, Inbred C57BL, Disease Models, Animal, Gene Expression Regulation, Proteasome, Chaperone (protein), Immunology, biology.protein, Schwann Cells, Neurology (clinical), IgG, immunoglobulin, 030217 neurology & neurosurgery
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19
المؤلفون: Wenjiao Li, Fei Yue, Leyuan Liu, Jing Zou, Xianhan Jiang, Jinglin Yi
المصدر: Biochemical Journal
مصطلحات موضوعية: LSFC, Leigh syndrome, French-Canadian type, Mitochondrial Degradation, eIF4E, eukaryotic initiation factor 4E, Mitochondrion, Biochemistry, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, mitochondrion, Membrane Potential, Mitochondrial, 0303 health sciences, Protein Stability, Mitophagy, HRP, horseradish peroxidase, p27, PI3KCIII, class III PI3K, Beclin 1, Tom20, translocase of the mitochondrial outer membrane 20, Cell biology, Neoplasm Proteins, Proto-Oncogene Proteins c-bcl-2, 030220 oncology & carcinogenesis, Beclin-1, ATG5, Microtubule-Associated Proteins, PI3K, phosphoinositide 3-kinase, Protein Binding, Research Article, class III phosphoinositide 3-kinase (PI3KCIII), autophagy, Microtubule-associated protein, ATG8, LAMP, lysosome-associated membrane protein, Vps, vacuolar protein sorting, mTOR, mammalian target of rapamycin, Biology, MAP1, microtubule-associated protein 1, 03 medical and health sciences, HEK, human embryonic kidney, Humans, LRPPRC, leucine-rich pentatricopeptide repeat-containing, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, 030304 developmental biology, Autophagy, MAP1S, MAP1 small form, Membrane Proteins, Cell Biology, LC3, light chain 3, microtubule-associated protein 1 small form (MAP1S), AMPK, AMP-activated protein kinase, HEK293 Cells, leucine-rich pentatricopeptide repeat-containing (LRPPRC), Apoptosis Regulatory Proteins, Biogenesis, HeLa Cells
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20
المؤلفون: Jonathan D. Geiger, Liang Hui, Xuesong Chen, Norman J. Haughey
المصدر: ASN Neuro, Vol 4 (2012)
ASN NEUROمصطلحات موضوعية: CXCR4, CXC chemokine receptor type 4, Time Factors, Cell, Vesicular Transport Proteins, MAP, microtubule-associated protein, Hippocampus, 0302 clinical medicine, LDL, low-density lipoprotein, Cells, Cultured, Neurons, 0303 health sciences, Microscopy, Confocal, Cell Death, pH, Endolysosome membrane, General Neuroscience, virus diseases, Hydrogen-Ion Concentration, 3. Good health, Cell biology, medicine.anatomical_structure, lysosome, tat Gene Products, Human Immunodeficiency Virus, Research Article, autophagy, Programmed cell death, Biology, S3, Endocytosis, lcsh:RC321-571, Tat, transactivator of transcription, 03 medical and health sciences, Lysosomal-Associated Membrane Protein 1, Lysosome, medicine, Animals, HIV-1 Tat, endosome, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, Analysis of Variance, neuronal cell death, Cell Membrane, Autophagy, Neurotoxicity, LAMP1, lysosome-associated membrane protein 1, Embryo, Mammalian, medicine.disease, Endolysosome, Rats, LC3, light chain 3, Gene Expression Regulation, AM, acetoxymethyl ester, Atg5, autophagy-related gene-5, EEA1, early endosome antigen 1, Neurology (clinical), Lysosomes, 030217 neurology & neurosurgery, HAND, HIV-1 associated neurocognitive disorder