نتائج البحث - "L2DTL"

Relation: Aaronson, S.A. (1991). Growth factors and cancer. Science 254, 1146-1153. Abou-Elella, A., Gramlich, T., Fritsch, C., and Gansler, T. (1996). c-myc amplification in hepatocellular carcinoma predicts unfavorable prognosis. Mod Pathol 9, 95-98. Akimitsu, N., Adachi, N., Hirai, H., Hossain, M.S., Hamamoto, H., Kobayashi, M., Aratani, Y., Koyama, H., and Sekimizu, K. (2003). Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha. Genes Cells 8, 393-402. Assmann, V., Jenkinson, D., Marshall, J.F., and Hart, I.R. (1999). The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments. J Cell Sci 112 ( Pt 22), 3943-3954. Assy, N., and Minuk, G.Y. (1997). Liver regeneration: methods for monitoring and their applications. Journal of hepatology 26, 945-952. Baldwin, A.S., Jr. (1996). The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14, 649-683. Banks, D., Wu, M., Higa, L.A., Gavrilova, N., Quan, J., Ye, T., Kobayashi, R., Sun, H., and Zhang, H. (2006). L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle 5, 1719-1729. Barthelmes, H.U., Grue, P., Feineis, S., Straub, T., and Boege, F. (2000). Active DNA topoisomerase IIalpha is a component of the salt-stable centrosome core. J Biol Chem 275, 38823-38830. Bassanello, M., Vitale, A., Ciarleglio, F.A., Brolese, A., Zanus, G., D'Amico, F., Carraro, A., Cappuzzo, G., Bridda, A., Senzolo, M., et al. (2003). Adjuvant chemotherapy for transplanted hepatocellular carcinoma patients: impact on survival or HCV recurrence timing. Transplantation proceedings 35, 2991-2994. Basu, J., Bousbaa, H., Logarinho, E., Li, Z., Williams, B.C., Lopes, C., Sunkel, C.E., and Goldberg, M.L. (1999). Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila. J Cell Biol 146, 13-28. Beasley, R.P., Hwang, L.Y., Lin, C.C., and Chien, C.S. (1981). Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan. Lancet 2, 1129-1133. Block, T.M., Mehta, A.S., Fimmel, C.J., and Jordan, R. (2003). Molecular viral oncology of hepatocellular carcinoma. Oncogene 22, 5093-5107. Brash, D.E. (2006). Roles of the transcription factor p53 in keratinocyte carcinomas. The British journal of dermatology 154 Suppl 1, 8-10. Bressac, B., Kew, M., Wands, J., and Ozturk, M. (1991). Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 350, 429-431. Brunt, E.M., and Swanson, P.E. (1992). Immunoreactivity for c-erbB-2 oncopeptide in benign and malignant diseases of the liver. American journal of clinical pathology 97, S53-61. Buetow, K.H., Murray, J.C., Israel, J.L., London, W.T., Smith, M., Kew, M., Blanquet, V., Brechot, C., Redeker, A., and Govindarajah, S. (1989). Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma. Proc Natl Acad Sci U S A 86, 8852-8856. Castro, A., Vigneron, S., Bernis, C., Labbe, J.C., and Lorca, T. (2003). Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway. Mol Cell Biol 23, 4126-4138. Celis, J.E. (1994). Cell biology: A Laboratory Handbook, Vol 1 (San Diego, Academic Press). Cha, C., and Dematteo, R.P. (2005). Molecular mechanisms in hepatocellular carcinoma development. Best practice & research 19, 25-37. Chan, T.A., Hwang, P.M., Hermeking, H., Kinzler, K.W., and Vogelstein, B. (2000). Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev 14, 1584-1588. Chang, M.H., Chen, D.S., Hsu, H.C., Hsu, H.Y., and Lee, C.Y. (1989). Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma. Cancer 64, 2377-2380. Chen, C.H., and Chen, D.S. (1992). [Hepatocellular carcinoma: 30 years' experience in Taiwan]. Journal of the Formosan Medical Association = Taiwan yi zhi 91 Suppl 3, S187-202. Chen, C.H., Chen, Y.Y., Chen, G.H., Yang, S.S., Tang, H.S., Lin, H.H., Lin, D.Y., Lo, S.K., Du, J.M., Chang, T.T., et al. (2004). Hepatitis B virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinoma. Journal of hepatology 40, 653-659. Chen, C.J., You, S.L., Lin, L.H., Hsu, W.L., and Yang, Y.W. (2002a). Cancer epidemiology and control in Taiwan: a brief review. Japanese journal of clinical oncology 32 Suppl, S66-81. Chen, D.S., Sung, J.L., Sheu, J.C., Lai, M.Y., How, S.W., Hsu, H.C., Lee, C.S., and Wei, T.C. (1984). Serum alpha-fetoprotein in the early stage of human hepatocellular carcinoma. Gastroenterology 86, 1404-1409. Chen, F., Zhang, Z., Bower, J., Lu, Y., Leonard, S.S., Ding, M., Castranova, V., Piwnica-Worms, H., and Shi, X. (2002b). Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A 99, 1990-1995. Cheung, W.M., Chu, A.H., Chu, P.W., and Ip, N.Y. (2001). Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. J Biol Chem 276, 17083-17091. Chevaillier, P. (1993). Pest sequences in nuclear proteins. The International journal of biochemistry 25, 479-482. Choi, W.J., Clark, M.W., Chen, J.X., and Jong, A.Y. (1990). The CDC4 gene product is associated with the yeast nuclear skeleton. Biochemical and biophysical research communications 172, 1324-1330. Collier, J.D., Guo, K., Mathew, J., May, F.E., Bennett, M.K., Corbett, I.P., Bassendine, M.F., and Burt, A.D. (1992). c-erbB-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma. Journal of hepatology 14, 377-380. Cortes, F., Pastor, N., Mateos, S., and Dominguez, I. (2003). Roles of DNA topoisomerases in chromosome segregation and mitosis. Mutation research 543, 59-66. Coverley, D., Laman, H., and Laskey, R.A. (2002). Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 4, 523-528. D'Andrilli, G., Kumar, C., Scambia, G., and Giordano, A. (2004). Cell cycle genes in ovarian cancer: steps toward earlier diagnosis and novel therapies. Clin Cancer Res 10, 8132-8141. Dash, B.C., and El-Deiry, W.S. (2004). Cell cycle checkpoint control mechanisms that can be disrupted in cancer. Methods in molecular biology (Clifton, NJ 280, 99-161. Deshpande, A., Sicinski, P., and Hinds, P.W. (2005). Cyclins and cdks in development and cancer: a perspective. Oncogene 24, 2909-2915. Ed Harlow, D.L. (1988). Antibodies: A LABORATORY MANUAL (New York, Cold Spring Harbor Laboratory). El-Serag, H.B. (2002). Hepatocellular carcinoma: an epidemiologic view. Journal of clinical gastroenterology 35, S72-78. Elledge, S.J. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1672. Fausto, N. (2000). Liver regeneration. Journal of hepatology 32, 19-31. Forsburg, S.L. (2004). Eukaryotic MCM proteins: beyond replication initiation. Microbiol Mol Biol Rev 68, 109-131. Fraschini, R., Beretta, A., Sironi, L., Musacchio, A., Lucchini, G., and Piatti, S. (2001). Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores. Embo J 20, 6648-6659. Frouin, I., Toueille, M., Ferrari, E., Shevelev, I., and Hubscher, U. (2005). Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen. Nucleic acids research 33, 5354-5361. Fujimori, M., Tokino, T., Hino, O., Kitagawa, T., Imamura, T., Okamoto, E., Mitsunobu, M., Ishikawa, T., Nakagama, H., Harada, H., et al. (1991). Allelotype study of primary hepatocellular carcinoma. Cancer Res 51, 89-93. Fujita, M. (2006). Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells. Cell division 1, 22. Ganem, D., and Prince, A.M. (2004). Hepatitis B virus infection--natural history and clinical consequences. The New England journal of medicine 350, 1118-1129. Garg, P., and Burgers, P.M. (2005). DNA polymerases that propagate the eukaryotic DNA replication fork. Critical reviews in biochemistry and molecular biology 40, 115-128. Geley, S., Kramer, E., Gieffers, C., Gannon, J., Peters, J.M., and Hunt, T. (2001). Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. J Cell Biol 153, 137-148. Glotzer, M., Murray, A.W., and Kirschner, M.W. (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138. Guan, X.Y., Fang, Y., Sham, J.S., Kwong, D.L., Zhang, Y., Liang, Q., Li, H., Zhou, H., and Trent, J.M. (2000). Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes, chromosomes & cancer 29, 110-116. Hames, R.S., Wattam, S.L., Yamano, H., Bacchieri, R., and Fry, A.M. (2001). APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box. Embo J 20, 7117-7127. Han, S., Park, K., Bae, B.N., Kim, K.H., Kim, H.J., Kim, Y.D., and Kim, H.Y. (2003). Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer. Journal of surgical oncology 83, 241-247. Hartwell, L.H., and Weinert, T.A. (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634. Hermeking, H., Rago, C., Schuhmacher, M., Li, Q., Barrett, J.F., Obaya, A.J., O'Connell, B.C., Mateyak, M.K., Tam, W., Kohlhuber, F., et al. (2000). Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A 97, 2229-2234. Higa, L.A., Banks, D., Wu, M., Kobayashi, R., Sun, H., and Zhang, H. (2006a). L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. Cell Cycle 5, 1675-1680. Higa, L.A., Wu, M., Ye, T., Kobayashi, R., Sun, H., and Zhang, H. (2006b). CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol 8, 1277-1283. Himeno, Y., Fukuda, Y., Hatanaka, M., and Imura, H. (1988). Expression of oncogenes in human liver disease. Liver 8, 208-212. Hsu, H.C., Cheng, W., and Lai, P.L. (1997). Cloning and expression of a developmentally regulated transcript MXR7 in hepatocellular carcinoma: biological significance and temporospatial distribution. Cancer Res 57, 5179-5184. Hsu, H.C., Chiou, T.J., Chen, J.Y., Lee, C.S., Lee, P.H., and Peng, S.Y. (1991). Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. Hepatology 13, 923-928. Hsu, H.C., Huang, A.M., Lai, P.L., Chien, W.M., Peng, S.Y., and Lin, S.W. (1994a). Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma. Hepatology 19, 122-128. Hsu, H.C., Jeng, Y.M., Mao, T.L., Chu, J.S., Lai, P.L., and Peng, S.Y. (2000). Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 157, 763-770. Hsu, H.C., Peng, S.Y., Lai, P.L., Sheu, J.C., Chen, D.S., Lin, L.I., Slagle, B.L., and Butel, J.S. (1994b). Allelotype and loss of heterozygosity of p53 in primary and recurrent hepatocellular carcinomas. A study of 150 patients. Cancer 73, 42-47. Hsu, H.C., Tseng, H.J., Lai, P.L., Lee, P.H., and Peng, S.Y. (1993). Expression of p53 gene in 184 unifocal hepatocellular carcinomas: association with tumor growth and invasiveness. Cancer Res 53, 4691-4694. Hsu, H.C., Wu, M.Z., Chang, M.H., Su, I.J., and Chen, D.S. (1987). Childhood hepatocellular carcinoma develops exclusively in hepatitis B surface antigen carriers in three decades in Taiwan. Report of 51 cases strongly associated with rapid development of liver cirrhosis. Journal of hepatology 5, 260-267. Hsu, H.C., Wu, T.T., Wu, M.Z., Sheu, J.C., Lee, C.S., and Chen, D.S. (1988). Tumor invasiveness and prognosis in resected hepatocellular carcinoma. Clinical and pathogenetic implications. Cancer 61, 2095-2099. Hu, R.H., Lee, P.H., Yu, S.C., Dai, H.C., Sheu, J.C., Lai, M.Y., Hsu, H.C., and Chen, D.S. (1996). Surgical resection for recurrent hepatocellular carcinoma: prognosis and analysis of risk factors. Surgery 120, 23-29. Huang, L.R., and Hsu, H.C. (1995). Cloning and expression of CD24 gene in human hepatocellular carcinoma: a potential early tumor marker gene correlates with p53 mutation and tumor differentiation. Cancer Res 55, 4717-4721. Jallepalli, P.V., Waizenegger, I.C., Bunz, F., Langer, S., Speicher, M.R., Peters, J.M., Kinzler, K.W., Vogelstein, B., and Lengauer, C. (2001). Securin is required for chromosomal stability in human cells. Cell 105, 445-457. Jeng, Y.M., Peng, S.Y., Lin, C.Y., and Hsu, H.C. (2004). Overexpression and amplification of Aurora-A in hepatocellular carcinoma. Clin Cancer Res 10, 2065-2071. Jeong, S.J., Shin, H.J., Kim, S.J., Ha, G.H., Cho, B.I., Baek, K.H., Kim, C.M., and Lee, C.W. (2004). Transcriptional abnormality of the hsMAD2 mitotic checkpoint gene is a potential link to hepatocellular carcinogenesis. Cancer Res 64, 8666-8673. Johnson, A., and O'Donnell, M. (2005). Cellular DNA replicases: components and dynamics at the replication fork. Annual review of biochemistry 74, 283-315. Johnston, J.M., and Carroll, W.L. (1992). c-myc hypermutation in Burkitt's lymphoma. Leukemia & lymphoma 8, 431-439. Kasai, Y., Takeda, S., and Takagi, H. (1996). Pathogenesis of hepatocellular carcinoma: a review from the viewpoint of molecular analysis. Seminars in surgical oncology 12, 155-159. Kawate, S., Fukusato, T., Ohwada, S., Watanuki, A., and Morishita, Y. (1999). Amplification of c-myc in hepatocellular carcinoma: correlation with clinicopathologic features, proliferative activity and p53 overexpression. Oncology 57, 157-163. Ke, P.Y., and Chang, Z.F. (2004). Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway. Mol Cell Biol 24, 514-526. Kelman, Z. (1997). PCNA: structure, functions and interactions. Oncogene 14, 629-640. Ko, L., Cardona, G.R., and Chin, W.W. (2000). Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A 97, 6212-6217. Kobayashi, S., Hayashi, H., Itoh, Y., Asano, T., and Isono, K. (1994). Detection of minus-strand hepatitis C virus RNA in tumor tissues of hepatocellular carcinoma. Cancer 73, 48-52. Kondo, T., Kobayashi, M., Tanaka, J., Yokoyama, A., Suzuki, S., Kato, N., Onozawa, M., Chiba, K., Hashino, S., Imamura, M., et al. (2004). Rapid degradation of Cdt1 upon UV-induced DNA damage is mediated by SCFSkp2 complex. J Biol Chem 279, 27315-27319. Kops, G.J., Kim, Y., Weaver, B.A., Mao, Y., McLeod, I., Yates, J.R., 3rd, Tagaya, M., and Cleveland, D.W. (2005). ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol 169, 49-60. Kraft, C., Vodermaier, H.C., Maurer-Stroh, S., Eisenhaber, F., and Peters, J.M. (2005). The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates. Mol Cell 18, 543-553. Kramer, E.R., Scheuringer, N., Podtelejnikov, A.V., Mann, M., and Peters, J.M. (2000). Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell 11, 1555-1569. Kurzik-Dumke, U., Neubauer, M., and Debes, A. (1996). Identification of a novel Drosophila melanogaster heat-shock gene, lethal(2)denticleless [l(2)dtl], coding for an 83-kDa protein. Gene 171, 163-170. Kusano, N., Shiraishi, K., Kubo, K., Oga, A., Okita, K., and Sasaki, K. (1999). Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology 29, 1858-1862. Lauer, G.M., and Walker, B.D. (2001). Hepatitis C virus infection. The New England journal of medicine 345, 41-52. Laurent-Puig, P., and Zucman-Rossi, J. (2006). Genetics of hepatocellular tumors. Oncogene 25, 3778-3786. Lee, M.H., and Yang, H.Y. (2001). Negative regulators of cyclin-dependent kinases and their roles in cancers. Cell Mol Life Sci 58, 1907-1922. Lee, M.H., and Yang, H.Y. (2003). Regulators of G1 cyclin-dependent kinases and cancers. Cancer Metastasis Rev 22, 435-449. Li, A., and Blow, J.J. (2005). Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus. Embo J 24, 395-404. Li, R., Hannon, G.J., Beach, D., and Stillman, B. (1996). Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr Biol 6, 189-199. Li, X., Zhao, Q., Liao, R., Sun, P., and Wu, X. (2003). The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation. J Biol Chem 278, 30854-30858. Liang, P., and Pardee, A.B. (1992). Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257, 967-971. Liu, C.L., Yu, I.S., Pan, H.W., Lin, S.W., and Hsu, H.C. (2006). L2dtl is essential for cell survival and nuclear division in early mouse embryonic development. J Biol Chem. Liu, S.H., Lin, C.Y., Peng, S.Y., Jeng, Y.M., Pan, H.W., Lai, P.L., Liu, C.L., and Hsu, H.C. (2002). Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation. Am J Pathol 160, 1831-1837. Luo, X., Fang, G., Coldiron, M., Lin, Y., Yu, H., Kirschner, M.W., and Wagner, G. (2000). Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nature structural biology 7, 224-229. Malumbres, M., and Barbacid, M. (2001). To cycle or not to cycle: a critical decision in cancer. Nature reviews 1, 222-231. Masellis-Smith, A., Belch, A.R., Mant, M.J., Turley, E.A., and Pilarski, L.M. (1996). Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44. Blood 87, 1891-1899. Massague, J. (2004). G1 cell-cycle control and cancer. Nature 432, 298-306. Mathewos, T., Ulrich, L., and Hans, K. (2004). Cell cycle and no end. Virchows Archiv V444, 313-323. Maxwell, C.A., Keats, J.J., Crainie, M., Sun, X., Yen, T., Shibuya, E., Hendzel, M., Chan, G., and Pilarski, L.M. (2003). RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol Biol Cell 14, 2262-2276. Mayor, T., Meraldi, P., Stierhof, Y.D., Nigg, E.A., and Fry, A.M. (1999). Protein kinases in control of the centrosome cycle. FEBS Lett 452, 92-95. Meraldi, P., Lukas, J., Fry, A.M., Bartek, J., and Nigg, E.A. (1999). Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol 1, 88-93. Mihaylov, I.S., Kondo, T., Jones, L., Ryzhikov, S., Tanaka, J., Zheng, J., Higa, L.A., Minamino, N., Cooley, L., and Zhang, H. (2002). Control of DNA replication and chromosome ploidy by geminin and cyclin A. Mol Cell Biol 22, 1868-1880. Moriyama, K., Nishida, E., Yonezawa, N., Sakai, H., Matsumoto, S., Iida, K., and Yahara, I. (1990). Destrin, a mammalian actin-depolymerizing protein, is closely related to cofilin. Cloning and expression of porcine brain destrin cDNA. J Biol Chem 265, 5768-5773. Murphy, M., Stinnakre, M.G., Senamaud-Beaufort, C., Winston, N.J., Sweeney, C., Kubelka, M., Carrington, M., Brechot, C., and Sobczak-Thepot, J. (1997). Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nature genetics 15, 83-86. Nagao, K., and Yanagida, M. (2002). Regulating sister chromatid separation by separase phosphorylation. Dev Cell 2, 2-4. Nagasue, N., Uchida, M., Makino, Y., Takemoto, Y., Yamanoi, A., Hayashi, T., Chang, Y.C., Kohno, H., Nakamura, T., and Yukaya, H. (1993). Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma. Gastroenterology 105, 488-494. Nalpas, B., Driss, F., Pol, S., Hamelin, B., Housset, C., Brechot, C., and Berthelot, P. (1991). Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease. Journal of hepatology 12, 70-74. Neer, E.J., Schmidt, C.J., Nambudripad, R., and Smith, T.F. (1994). The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300. Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K.I., Nakayama, K., Fujita, M., et al. (2006). Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. Embo J 25, 1126-1136. Nyberg, K.A., Michelson, R.J., Putnam, C.W., and Weinert, T.A. (2002). Toward maintaining the genome: DNA damage and replication checkpoints. Annual review of genetics 36, 617-656. Ono, S. (2003). Regulation of actin filament dynamics by actin depolymerizing factor/cofilin and actin-interacting protein 1: new blades for twisted filaments. Biochemistry 42, 13363-13370. Pan, H.W., Ou, Y.H., Peng, S.Y., Liu, S.H., Lai, P.L., Lee, P.H., Sheu, J.C., Chen, C.L., and Hsu, H.C. (2003). Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma. Cancer 98, 119-127. Park, M.T., and Lee, S.J. (2003). Cell cycle and cancer. Journal of biochemistry and molecular biology 36, 60-65. Paulovich, A.G., Toczyski, D.P., and Hartwell, L.H. (1997). When checkpoints fail. Cell 88, 315-321. Peng, S.Y., Chen, W.J., Lai, P.L., Jeng, Y.M., Sheu, J.C., and Hsu, H.C. (2004). High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations. Int J Cancer 112, 44-50. Peng, S.Y., Chou, S.P., and Hsu, H.C. (1998). Association of downregulation of cyclin D1 and of overexpression of cyclin E with p53 mutation, high tumor grade and poor prognosis in hepatocellular carcinoma. Journal of hepatology 29, 281-289. Peng, S.Y., Lai, P.L., and Hsu, H.C. (1993). Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance. Journal of the Formosan Medical Association = Taiwan yi zhi 92, 866-870. Peng, S.Y., Ou, Y.H., Chen, W.J., Li, H.Y., Liu, S.H., Pan, H.W., Lai, P.L., Jeng, Y.M., Chen, D.C., and Hsu, H.C. (2005). Aberrant expressions of annexin A10 short isoform, osteopontin and alpha-fetoprotein at chromosome 4q cooperatively contribute to progression and poor prognosis of hepatocellular carcinoma. Int J Oncol 26, 1053-1061. Pfleger, C.M., and Kirschner, M.W. (2000). The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev 14, 655-665. Piao, Z., Kim, H., Jeon, B.K., Lee, W.J., and Park, C. (1997). Relationship between loss of heterozygosity of tumor suppressor genes and histologic differentiation in hepatocellular carcinoma. Cancer 80, 865-872. Pines, J. (1996). Cell cycle: reaching for a role for the Cks proteins. Curr Biol 6, 1399-1402. Polager, S., Kalma, Y., Berkovich, E., and Ginsberg, D. (2002). E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis. Oncogene 21, 437-446. Poon, R.T., Fan, S.T., Lo, C.M., Ng, I.O., Liu, C.L., Lam, C.M., and Wong, J. (2001). Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Annals of surgery 234, 63-70. Poon, R.T., Fan, S.T., Ng, I.O., Lo, C.M., Liu, C.L., and Wong, J. (2000). Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 89, 500-507. Portolani, N., Coniglio, A., Ghidoni, S., Giovanelli, M., Benetti, A., Tiberio, G.A., and Giulini, S.M. (2006). Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications. Annals of surgery 243, 229-235. Powell, J. (1998). Enhanced concatemer cloning-a modification to the SAGE (Serial Analysis of Gene Expression) technique. Nucleic acids research 26, 3445-3446. Qin, L.X., and Tang, Z.Y. (2002). The prognostic significance of clinical and pathological features in hepatocellular carcinoma. World J Gastroenterol 8, 193-199. Raemaekers, T., Ribbeck, K., Beaudouin, J., Annaert, W., Van Camp, M., Stockmans, I., Smets, N., Bouillon, R., Ellenberg, J., and Carmeliet, G. (2003). NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. J Cell Biol 162, 1017-1029. Randell, J.C., Bowers, J.L., Rodriguez, H.K., and Bell, S.P. (2006). Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase. Mol Cell 21, 29-39. Ray, R.B., Lagging, L.M., Meyer, K., and Ray, R. (1996). Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. Journal of virology 70, 4438-4443. Ray, R.B., Lagging, L.M., Meyer, K., Steele, R., and Ray, R. (1995). Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus research 37, 209-220. Ray, R.B., Steele, R., Meyer, K., and Ray, R. (1997). Transcriptional repression of p53 promoter by hepatitis C virus core protein. J Biol Chem 272, 10983-10986. Rechsteiner, M. (1989). PEST regions, proteolysis and cell cycle progression. Revis Biol Celular 20, 235-253. Rechsteiner, M. (1990). PEST sequences are signals for rapid intracellular proteolysis. Seminars in cell biology 1, 433-440. Rechsteiner, M., and Rogers, S.W. (1996). PEST sequences and regulation by proteolysis. Trends Biochem Sci 21, 267-271. Reynolds, S.H., Stowers, S.J., Patterson, R.M., Maronpot, R.R., Aaronson, S.A., and Anderson, M.W. (1987). Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment. Science 237, 1309-1316. Ribbeck, K., Groen, A.C., Santarella, R., Bohnsack, M.T., Raemaekers, T., Kocher, T., Gentzel, M., Gorlich, D., Wilm, M., Carmeliet, G., et al. (2006). NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell 17, 2646-2660. Rocco, J.W., and Sidransky, D. (2001). p16(MTS-1/CDKN2/INK4a) in cancer progression. Experimental cell research 264, 42-55. Rocken, C., and Carl-McGrath, S. (2001). Pathology and pathogenesis of hepatocellular carcinoma. Digestive diseases (Basel, Switzerland) 19, 269-278. Roman-Gomez, J., Castillejo, J.A., Jimenez, A., Gonzalez, M.G., Moreno, F., Rodriguez Mdel, C., Barrios, M., Maldonado, J., and Torres, A. (2002). 5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia. Blood 99, 2291-2296. Sager, R. (1989). Tumor suppressor genes: the puzzle and the promise. Science 246, 1406-1412. Sandal, T. (2002). Molecular aspects of the mammalian cell cycle and cancer. The oncologist 7, 73-81. Sansam, C.L., Shepard, J.L., Lai, K., Ianari, A., Danielian, P.S., Amsterdam, A., Hopkins, N., and Lees, J.A. (2006). DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev 20, 3117-3129. Schena, M., Shalon, D., Davis, R.W., and Brown, P.O. (1995). Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270, 467-470. Schraml, P., Bucher, C., Bissig, H., Nocito, A., Haas, P., Wilber, K., Seelig, S., Kononen, J., Mihatsch, M.J., Dirnhofer, S., et al. (2003). Cyclin E overexpression and amplification in human tumours. J Pathol 200, 375-382. Schwartz, D., and Rotter, V. (1998). p53-dependent cell cycle control: response to genotoxic stress. Semin Cancer Biol 8, 325-336. Scott, M., Bonnefin, P., Vieyra, D., Boisvert, F.M., Young, D., Bazett-Jones, D.P., and Riabowol, K. (2001). UV-induced binding of ING1 to PCNA regulates the induction of apoptosis. J Cell Sci 114, 3455-3462. Scully, R., Xie, A., and Nagaraju, G. (2004). Molecular functions of BRCA1 in the DNA damage response. Cancer biology & therapy 3, 521-527. Shah, S.A., Greig, P.D., Gallinger, S., Cattral, M.S., Dixon, E., Kim, R.D., Taylor, B.R., Grant, D.R., and Vollmer, C.M. (2006). Factors associated with early recurrence after resection for hepatocellular carcinoma and outcomes. Journal of the American College of Surgeons 202, 275-283. Sharp-Baker, H., and Chen, R.H. (2001). Spindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activity. J Cell Biol 153, 1239-1250. Sherman, M. (1995). Hepatocellular carcinoma. The Gastroenterologist 3, 55-66. Simon, D., Knowles, B.B., and Weith, A. (1991a). Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas. Oncogene 6, 765-770. Simon, M.I., Strathmann, M.P., and Gautam, N. (1991b). Diversity of G proteins in signal transduction. Science 252, 802-808. Simon, R., Burger, H., Brinkschmidt, C., Bocker, W., Hertle, L., and Terpe, H.J. (1998). Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol 185, 345-351. Simpson, F., Lammerts, v.B.K., Butterfield, N., Bennetts, J.S., Bowles, J., Adolphe, C., Simms, L.A., Young, J., Walsh, M.D., Leggett, B., et al. (2006). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Exp Cell Res 312, 73-85. Starr, D.A., Saffery, R., Li, Z., Simpson, A.E., Choo, K.H., Yen, T.J., and Goldberg, M.L. (2000). HZwint-1, a novel human kinetochore component that interacts with HZW10. J Cell Sci 113 ( Pt 11), 1939-1950. Steeg, P.S., and Zhou, Q. (1998). Cyclins and breast cancer. Breast cancer research and treatment 52, 17-28. Steer, C.J. (1995). Liver regeneration. Faseb J 9, 1396-1400. Stewart, Z.A., Westfall, M.D., and Pietenpol, J.A. (2003). Cell-cycle dysregulation and anticancer therapy. Trends in pharmacological sciences 24, 139-145. Stier, H., Fahimi, H.D., Van Veldhoven, P.P., Mannaerts, G.P., Volkl, A., and Baumgart, E. (1998). Maturation of peroxisomes in differentiating human hepatoblastoma cells (HepG2): possible involvement of the peroxisome proliferator-activated receptor alpha (PPAR alpha). Differentiation 64, 55-66. Stork, P., Loda, M., Bosari, S., Wiley, B., Poppenhusen, K., and Wolfe, H. (1991). Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction. Oncogene 6, 857-862. Sudo, T., Ota, Y., Kotani, S., Nakao, M., Takami, Y., Takeda, S., and Saya, H. (2001). Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. Embo J 20, 6499-6508. Sung, J.L. (1997). Prevention of hepatitis B and C virus infection for prevention of cirrhosis and hepatocellular carcinoma. Journal of gastroenterology and hepatology 12, S370-376. Takayama, T., Miyanishi, K., Hayashi, T., Sato, Y., and Niitsu, Y. (2006). Colorectal cancer: genetics of development and metastasis. Journal of gastroenterology 41, 185-192. Taketa, K. (1990). Alpha-fetoprotein: reevaluation in hepatology. Hepatology 12, 1420-1432. Taylor, S.S., Scott, M.I., and Holland, A.J. (2004). The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation. Chromosome Res 12, 599-616. Teramoto, T., Satonaka, K., Kitazawa, S., Fujimori, T., Hayashi, K., and Maeda, S. (1994). p53 gene abnormalities are closely related to hepatoviral infections and occur at a late stage of hepatocarcinogenesis. Cancer Res 54, 231-235. Tessema, M., Langer, F., Dingemann, J., Ganser, A., Kreipe, H., and Lehmann, U. (2003). Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML). Leukemia 17, 910-918. Tiniakos, D., Spandidos, D.A., Kakkanas, A., Pintzas, A., Pollice, L., and Tiniakos, G. (1989). Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues. Anticancer research 9, 715-721. Tirkkonen, M., Tanner, M., Karhu, R., Kallioniemi, A., Isola, J., and Kallioniemi, O.P. (1998). Molecular cytogenetics of primary breast cancer by CGH. Genes, chromosomes & cancer 21, 177-184. Togo, S., Makino, H., Kobayashi, T., Morita, T., Shimizu, T., Kubota, T., Ichikawa, Y., Ishikawa, T., Okazaki, Y., Hayashizaki, Y., et al. (2004). Mechanism of liver regeneration after partial hepatectomy using mouse cDNA microarray. Journal of hepatology 40, 464-471. Tsuda, H., Zhang, W.D., Shimosato, Y., Yokota, J., Terada, M., Sugimura, T., Miyamura, T., and Hirohashi, S. (1990). Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A 87, 6791-6794. Turley, E.A. (1992). Hyaluronan and cell locomotion. Cancer Metastasis Rev 11, 21-30. Turley, E.A., Austen, L., Vandeligt, K., and Clary, C. (1991). Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells. J Cell Biol 112, 1041-1047. Tzankov, A., Zimpfer, A., Lugli, A., Krugmann, J., Went, P., Schraml, P., Maurer, R., Ascani, S., Pileri, S., Geley, S., et al. (2003). High-throughput tissue microarray analysis of G1-cyclin alterations in classical Hodgkin's lymphoma indicates overexpression of cyclin E1. J Pathol 199, 201-207. van der Voorn, L., and Ploegh, H.L. (1992). The WD-40 repeat. FEBS Lett 307, 131-134. Velculescu, V.E., Zhang, L., Vogelstein, B., and Kinzler, K.W. (1995). Serial analysis of gene expression. Science 270, 484-487. Vermeulen, K., Van Bockstaele, D.R., and Berneman, Z.N. (2003). The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell proliferation 36, 131-149. Vincent, S., Marty, L., and Fort, P. (1993). S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. Nucleic acids research 21, 1498. Vodermaier, H.C. (2001). Cell cycle: Waiters serving the Destruction machinery. Curr Biol 11, R834-837. Wang, D.S., Shaw, R., Hattori, M., Arai, H., Inoue, K., and Shaw, G. (1995). Binding of pleckstrin homology domains to WD40/beta-transducin repeat containing segments of the protein product of the Lis-1 gene. Biochemical and biophysical research communications 209, 622-629. Wang, H.P., and Rogler, C.E. (1988). Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas. Cytogenetics and cell genetics 48, 72-78. Wasch, R., and Engelbert, D. (2005). Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells. Oncogene 24, 1-10. Watson, J.B., and Margulies, J.E. (1993). Differential cDNA screening strategies to identify novel stage-specific proteins in the developing mammalian brain. Developmental neuroscience 15, 77-86. Whitfield, M.L., Sherlock, G., Saldanha, A.J., Murray, J.I., Ball, C.A., Alexander, K.E., Matese, J.C., Perou, C.M., Hurt, M.M., Brown, P.O., et al. (2002). Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 13, 1977-2000. Wolfel, T., Hauer, M., Schneider, J., Serrano, M., Wolfel, C., Klehmann-Hieb, E., De Plaen, E., Hankeln, T., Meyer zum Buschenfelde, K.H., and Beach, D. (1995). A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269, 1281-1284. Wu, T.C., Tong, M.J., Hwang, B., Lee, S.D., and Hu, M.M. (1987). Primary hepatocellular carcinoma and hepatitis B infection during childhood. Hepatology 7, 46-48. Yam, C.H., Fung, T.K., and Poon, R.Y. (2002). Cyclin A in cell cycle control and cancer. Cell Mol Life Sci 59, 1317-1326. Yanagida, M. (2005). Basic mechanism of eukaryotic chromosome segregation. Philos Trans R Soc Lond B Biol Sci 360, 609-621. Yang, C.H., and Cristofanilli, M. (2006). The role of p53 mutations as a prognostic factor and therapeutic target in inflammatory breast cancer. Future oncology (London, England) 2, 247-255. Yochem, J., and Byers, B. (1987). Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene. J Mol Biol 195, 233-245. Yu, P., Huang, B., Shen, M., Lau, C., Chan, E., Michel, J., Xiong, Y., Payan, D.G., and Luo, Y. (2001). p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues. Oncogene 20, 484-489. Yuan, R.H., Jeng, Y.M., Chen, H.L., Hsieh, F.J., Yang, C.Y., Lee, P.H., and Hsu, H.C. (2005). Opposite roles of human pancreatitis-associated protein and REG1A expression in hepatocellular carcinoma: association of pancreatitis-associated protein expression with low-stage hepatocellular carcinoma, beta-catenin mutation, and favorable prognosis. Clin Cancer Res 11, 2568-2575. Yuan, R.H., Jeng, Y.M., Chen, H.L., Lai, P.L., Pan, H.W., Hsieh, F.J., Lin, C.Y., Lee, P.H., and Hsu, H.C. (2006). Stathmin overexpression cooperates with p53 mutation and osteopontin overexpression, and is associated with tumour progression, early recurrence, and poor prognosis in hepatocellular carcinoma. J Pathol 209, 549-558. Zhang, W.D., Hirohashi, S., Tsuda, H., Shimosato, Y., Yokota, J., Terada, M., and Sugimura, T. (1990). Frequent loss of heterozygosity on chromosomes 16 and 4 in human hepatocellular carcinoma. Jpn J Cancer Res 81, 108-111. Zhou, L., Rui, J.A., Wang, S.B., Chen, S.G., Qu, Q., Chi, T.Y., Wei, X., Han, K., Zhang, N., and Zhao, H.T. (2006). Clinicopathological features, post-surgical survival and prognostic indicators of elderly patients with hepatocellular carcinoma. Eur J Surg Oncol 32, 767-772. Zimonjic, D.B., Keck, C.L., Thorgeirsson, S.S., and Popescu, N.C. (1999). Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization. Hepatology 29, 1208-1214.; en-US; http://ntur.lib.ntu.edu.tw/handle/246246/63588; http://ntur.lib.ntu.edu.tw/bitstream/246246/63588/1/ntu-96-D89444001-1.pdf

الاتاحة: http://ntur.lib.ntu.edu.tw/handle/246246/63588
http://ntur.lib.ntu.edu.tw/bitstream/246246/63588/1/ntu-96-D89444001-1.pdf

View record in BASE

4

Academic Journal

基因轉殖動物模式研究人類L2DTL基因 ; Transgenic Mouse Models for the Study of Human L2DTL Gene

المؤلفون: 劉兆蓮, Liu, Chao-Lien

المساهمون: 許輝吉, 臺灣大學：病理學研究所

مصطلحات موضوعية: 發育, 死亡, 核酸干擾, 細胞分裂, L2dtl, development, lethal, siRNA knockdown, cell division

وصف الملف: 6675548 bytes; application/pdf

Relation: (1992). Abstracts of the United Kingdom Environmental Mutagen Society/DNA Repair Network Joint Meeting. United Kingdom, March 23-27, 1992. Mutagenesis 7, 359-394. Aaronson, S. A. (1991). Growth factors and cancer. Science 254, 1146-1153. Abremski, K., Hoess, R., and Sternberg, N. (1983). Studies on the properties of P1 site-specific recombination: evidence for topologically unlinked products following recombination. Cell 32, 1301-1311. Akagi, K., Sandig, V., Vooijs, M., Van der Valk, M., Giovannini, M., Strauss, M., and Berns, A. (1997). Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res 25, 1766-1773. al-Shawi, R., Burke, J., Wallace, H., Jones, C., Harrison, S., Buxton, D., Maley, S., Chandley, A., and Bishop, J. O. (1991). The herpes simplex virus type 1 thymidine kinase is expressed in the testes of transgenic mice under the control of a cryptic promoter. Mol Cell Biol 11, 4207-4216. Antoch, M. P., Song, E. J., Chang, A. M., Vitaterna, M. H., Zhao, Y., Wilsbacher, L. D., Sangoram, A. M., King, D. P., Pinto, L. H., and Takahashi, J. S. (1997). Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89, 655-667. Araki, K., Araki, M., Miyazaki, J., and Vassalli, P. (1995). Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc Natl Acad Sci U S A 92, 160-164. Archibald, A. L., McClenaghan, M., Hornsey, V., Simons, J. P., and Clark, A. J. (1990). High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice. Proc Natl Acad Sci U S A 87, 5178-5182. Auerbach, A. B. (2004). Production of functional transgenic mice by DNA pronuclear microinjection. Acta Biochim Pol 51, 9-31. Beddington, R. S., Morgernstern, J., Land, H., and Hogan, A. (1989). An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis. Development 106, 37-46. Behringer, R. R., Peschon, J. J., Messing, A., Gartside, C. L., Hauschka, S. D., Palmiter, R. D., and Brinster, R. L. (1988). Heart and bone tumors in transgenic mice. Proc Natl Acad Sci U S A 85, 2648-2652. Berns, A. (1991). Tumorigenesis in transgenic mice: identification and characterization of synergizing oncogenes. J Cell Biochem 47, 130-135. Borrelli, E., Heyman, R. A., Arias, C., Sawchenko, P. E., and Evans, R. M. (1989). Transgenic mice with inducible dwarfism. Nature 339, 538-541. Brinster, R. L., Braun, R. E., Lo, D., Avarbock, M. R., Oram, F., and Palmiter, R. D. (1989). Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs. Proc Natl Acad Sci U S A 86, 7087-7091. Brinster, R. L., Chen, H. Y., Messing, A., van Dyke, T., Levine, A. J., and Palmiter, R. D. (1984). Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 37, 367-379. Burton, J. L., Tsakraklides, V., and Solomon, M. J. (2005). Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box. Mol Cell 18, 533-542. Capelson, M., and Corces, V. G. (2004). Boundary elements and nuclear organization. Biol Cell 96, 617-629. Carlson, J. A., Rogers, B. B., Sifers, R. N., Hawkins, H. K., Finegold, M. J., and Woo, S. L. (1988). Multiple tissues express alpha 1-antitrypsin in transgenic mice and man. J Clin Invest 82, 26-36. Chada, K., Magram, J., Raphael, K., Radice, G., Lacy, E., and Costantini, F. (1985). Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature 314, 377-380. Chen, J. J., and Peck, K. (1996). Non-radioisotopic differential display method to directly visualize and amplify differential bands on nylon membrane. Nucleic Acids Res 24, 793-794. Cheung, W. M., Chu, A. H., Chu, P. W., and Ip, N. Y. (2001). Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. J Biol Chem 276, 17083-17091. Chisari, F. V., Pinkert, C. A., Milich, D. R., Filippi, P., McLachlan, A., Palmiter, R. D., and Brinster, R. L. (1985). A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science 230, 1157-1160. Choi, T., Huang, M., Gorman, C., and Jaenisch, R. (1991). A generic intron increases gene expression in transgenic mice. Mol Cell Biol 11, 3070-3074. Choi, W. J., Clark, M. W., Chen, J. X., and Jong, A. Y. (1990). The CDC4 gene product is associated with the yeast nuclear skeleton. Biochem Biophys Res Commun 172, 1324-1330. Clouet d'Orval, B., Bortolin, M. L., Gaspin, C., and Bachellerie, J. P. (2001). Box C/D RNA guides for the ribose methylation of archaeal tRNAs. The tRNATrp intron guides the formation of two ribose-methylated nucleosides in the mature tRNATrp. Nucleic Acids Res 29, 4518-4529. Colucci-Guyon, E., Portier, M. M., Dunia, I., Paulin, D., Pournin, S., and Babinet, C. (1994). Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell 79, 679-694. Copeland, N. G., Jenkins, N. A., and Court, D. L. (2001). Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet 2, 769-779. Cuthbertson, R. A., and Klintworth, G. K. (1988). Transgenic mice--a gold mine for furthering knowledge in pathobiology. Lab Invest 58, 484-502. Dagli, M. L., Yamasaki, H., Krutovskikh, V., and Omori, Y. (2004). Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver. Carcinogenesis 25, 483-492. Davidson, E. H. (1990). How embryos work: a comparative view of diverse modes of cell fate specification. Development 108, 365-389. DeAngelis, R. A., Markiewski, M. M., Taub, R., and Lambris, J. D. (2005). A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology 42, 1148-1157. Desbarats, J., and Newell, M. K. (2000). Fas engagement accelerates liver regeneration after partial hepatectomy. Nat Med 6, 920-923. Duronio, R. J., Gordon, J. I., and Boguski, M. S. (1992). Comparative analysis of the beta transducin family with identification of several new members including PWP1, a nonessential gene of Saccharomyces cerevisiae that is divergently transcribed from NMT1. Proteins 13, 41-56. Ed Harlow, D. L. (1988). Antibodies: A LABORATORY MANUAL (New York: Cold Spring Harbor Laboratory). Erickson, R. P. (1999). Antisense transgenics in animals. Methods 18, 304-310. Evsikov, A. V., de Vries, W. N., Peaston, A. E., Radford, E. E., Fancher, K. S., Chen, F. H., Blake, J. A., Bult, C. J., Latham, K. E., Solter, D., and Knowles, B. B. (2004). Systems biology of the 2-cell mouse embryo. Cytogenet Genome Res 105, 240-250. Farber, E. (1990). Clonal adaptation during carcinogenesis. Biochem Pharmacol 39, 1837-1846. Fausto, N. (2000). Liver regeneration. J Hepatol 32, 19-31. Geyer, P. K., and Corces, V. G. (1992). DNA position-specific repression of transcription by a Drosophila zinc finger protein. Genes Dev 6, 1865-1873. Goldshmidt, O., Yeikilis, R., Mawasi, N., Paizi, M., Gan, N., Ilan, N., Pappo, O., Vlodavsky, I., and Spira, G. (2004). Heparanase expression during normal liver development and following partial hepatectomy. J Pathol 203, 594-602. Gossen, J. A., de Leeuw, W. J., Tan, C. H., Zwarthoff, E. C., Berends, F., Lohman, P. H., Knook, D. L., and Vijg, J. (1989). Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc Natl Acad Sci U S A 86, 7971-7975. Gratenstein, K., Heggestad, A. D., Fortun, J., Notterpek, L., Pestov, D. G., and Fletcher, B. S. (2005). The WD-repeat protein GRWD1: potential roles in myeloid differentiation and ribosome biogenesis. Genomics 85, 762-773. Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., and Rajewsky, K. (1994). Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265, 103-106. Gu, H., Zou, Y. R., and Rajewsky, K. (1993). Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 73, 1155-1164. Guan, X. Y., Fang, Y., Sham, J. S., Kwong, D. L., Zhang, Y., Liang, Q., Li, H., Zhou, H., and Trent, J. M. (2000). Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 29, 110-116. Guilhot, S., Huang, S. N., Xia, Y. P., La Monica, N., Lai, M. M., and Chisari, F. V. (1994). Expression of the hepatitis delta virus large and small antigens in transgenic mice. J Virol 68, 1052-1058. Hamilton, D. L., and Abremski, K. (1984). Site-specific recombination by the bacteriophage P1 lox-Cre system. Cre-mediated synapsis of two lox sites. J Mol Biol 178, 481-486. Hammer, R. E., Brinster, R. L., Rosenfeld, M. G., Evans, R. M., and Mayo, K. E. (1985). Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315, 413-416. Hammer, R. E., Krumlauf, R., Camper, S. A., Brinster, R. L., and Tilghman, S. M. (1987). Diversity of alpha-fetoprotein gene expression in mice is generated by a combination of separate enhancer elements. Science 235, 53-58. Hanahan, D. (1989). Transgenic mice as probes into complex systems. Science 246, 1265-1275. Hanks, M., Wurst, W., Anson-Cartwright, L., Auerbach, A. B., and Joyner, A. L. (1995). Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2. Science 269, 679-682. Haraguchi, S., Saga, Y., Naito, K., Inoue, H., and Seto, A. (2004). Specific gene silencing in the pre-implantation stage mouse embryo by an siRNA expression vector system. Mol Reprod Dev 68, 17-24. Hogan B, Beddington R, Costantini F, and Lacy E. Manipulating the mouse embryo. 2nd Edition, CSH Laboratory Press, 1994 Higgins GW, Anderson RM. 1931. Experimental pathology of the liver: Restoration of the liver the white rat following partial surgical removal. Arch Pathol 12: 186-202. Heyman, R. A., Borrelli, E., Lesley, J., Anderson, D., Richman, D. D., Baird, S. M., Hyman, R., and Evans, R. M. (1989). Thymidine kinase obliteration: creation of transgenic mice with controlled immune deficiency. Proc Natl Acad Sci U S A 86, 2698-2702. Hirasawa, M., Ohshima, T., Takahashi, S., Longenecker, G., Honjo, Y., Veeranna, Pant, H. C., Mikoshiba, K., Brady, R. O., and Kulkarni, A. B. (2004). Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc Natl Acad Sci U S A 101, 6249-6254. Hook, L. M., Agafonova, Y., Ross, S. R., Turner, S. J., and Golovkina, T. V. (2000). Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of tumor induction to the gag gene. J Virol 74, 8876-8883. Hsu, H. C., Jeng, Y. M., Mao, T. L., Chu, J. S., Lai, P. L., and Peng, S. Y. (2000). Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 157, 763-770. Iizuka, N., Oka, M., Yamada-Okabe, H., Mori, N., Tamesa, T., Okada, T., Takemoto, N., Tangoku, A., Hamada, K., Nakayama, H., et al. (2002). Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res 62, 3939-3944. Jaenisch, R. (1988). Transgenic animals. Science 240, 1468-1474. Jahner, D., and Jaenisch, R. (1985). Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development. Mol Cell Biol 5, 2212-2220. Jallepalli, P. V., Waizenegger, I. C., Bunz, F., Langer, S., Speicher, M. R., Peters, J. M., Kinzler, K. W., Vogelstein, B., and Lengauer, C. (2001). Securin is required for chromosomal stability in human cells. Cell 105, 445-457. Jamison, D. C., Thomas, J. W., and Green, E. D. (2000). ComboScreen facilitates the multiplex hybridization-based screening of high-density clone arrays. Bioinformatics 16, 678-684. Kellum, R., and Schedl, P. (1992). A group of scs elements function as domain boundaries in an enhancer-blocking assay. Mol Cell Biol 12, 2424-2431. Kessel, M., and Gruss, P. (1990). Murine developmental control genes. Science 249, 374-379. Kew, M. C. (2006). Interaction between hepatitis B and C viruses in hepatocellular carcinogenesis. J Viral Hepat 13, 145-149. Kohler, S. W., Provost, G. S., Fieck, A., Kretz, P. L., Bullock, W. O., Sorge, J. A., Putman, D. L., and Short, J. M. (1991). Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. Proc Natl Acad Sci U S A 88, 7958-7962. Krumlauf, R., Hammer, R. E., Tilghman, S. M., and Brinster, R. L. (1985). Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol 5, 1639-1648. Kurzik-Dumke, U., Neubauer, M., and Debes, A. (1996). Identification of a novel Drosophila melanogaster heat-shock gene, lethal(2)denticleless [l(2)dtl], coding for an 83-kDa protein. Gene 171, 163-170. Kusano, N., Shiraishi, K., Kubo, K., Oga, A., Okita, K., and Sasaki, K. (1999). Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features. Hepatology 29, 1858-1862. Lai, E., Birren, B. W., Clark, S. M., Simon, M. I., and Hood, L. (1989). Pulsed field gel electrophoresis. Biotechniques 7, 34-42. Lau, S. H., and Guan, X. Y. (2005). Cytogenetic and molecular genetic alterations in hepatocellular carcinoma. Acta Pharmacol Sin 26, 659-665. Lawitts, J. A., and Biggers, J. D. (1993). Culture of preimplantation embryos. Methods Enzymol 225, 153-164. Lee, E. C., Yu, D., Martinez de Velasco, J., Tessarollo, L., Swing, D. A., Court, D. L., Jenkins, N. A., and Copeland, N. G. (2001). A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73, 56-65. Lewandoski, M. (2001). Conditional control of gene expression in the mouse. Nat Rev Genet 2, 743-755. Li, W., Liang, X., Leu, J. I., Kovalovich, K., Ciliberto, G., and Taub, R. (2001). Global changes in interleukin-6-dependent gene expression patterns in mouse livers after partial hepatectomy. Hepatology 33, 1377-1386. Liang, P., and Pardee, A. B. (1992). Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257, 967-971. Lieu, H. T., Batteux, F., Simon, M. T., Cortes, A., Nicco, C., Zavala, F., Pauloin, A., Tralhao, J. G., Soubrane, O., Weill, B., et al. (2005). HIP/PAP accelerates liver regeneration and protects against acetaminophen injury in mice. Hepatology 42, 618-626. Lievens, S., Goormachtig, S., and Holsters, M. (2001). A critical evaluation of differential display as a tool to identify genes involved in legume nodulation: looking back and looking forward. Nucleic Acids Res 29, 3459-3468. Lin, T. P. (1966). Microinjection of mouse eggs. Science 151, 333-337. Liu, P., Jenkins, N. A., and Copeland, N. G. (2003). A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13, 476-484. Liu, Z., and Hou, J. (2006). Hepatitis B virus (HBV) and hepatitis C virus (HCV) dual infection. Int J Med Sci 3, 57-62. Lo, C. W., Coulling, M., and Kirby, C. (1987). Tracking of mouse cell lineage using microinjected DNA sequences: analyses using genomic Southern blotting and tissue-section in situ hybridizations. Differentiation 35, 37-44. Ludde, T., Kubicka, S., Plumpe, J., Liedtke, C., Manns, M. P., and Trautwein, C. (2001). Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy. Oncogene 20, 5264-5278. Marchio, A., Meddeb, M., Pineau, P., Danglot, G., Tiollais, P., Bernheim, A., and Dejean, A. (1997). Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 18, 59-65. Marra, M. A., Kucaba, T. A., Dietrich, N. L., Green, E. D., Brownstein, B., Wilson, R. K., McDonald, K. M., Hillier, L. W., McPherson, J. D., and Waterston, R. H. (1997). High throughput fingerprint analysis of large-insert clones. Genome Res 7, 1072-1084. McCaffrey, A. P., Meuse, L., Pham, T. T., Conklin, D. S., Hannon, G. J., and Kay, M. A. (2002). RNA interference in adult mice. Nature 418, 38-39. Metsaranta, M., Garofalo, S., Decker, G., Rintala, M., de Crombrugghe, B., and Vuorio, E. (1992). Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain. J Cell Biol 118, 203-212. Miao, C. H., Ohashi, K., Patijn, G. A., Meuse, L., Ye, X., Thompson, A. R., and Kay, M. A. (2000). Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro. Mol Ther 1, 522-532. Morham, S. G., Kluckman, K. D., Voulomanos, N., and Smithies, O. (1996). Targeted disruption of the mouse topoisomerase I gene by camptothecin selection. Mol Cell Biol 16, 6804-6809. Murray, C. J., and Lopez, A. D. (1997). Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349, 1269-1276. Murti, J. R., Bumbulis, M., and Schimenti, J. C. (1992). High-frequency germ line gene conversion in transgenic mice. Mol Cell Biol 12, 2545-2552. Muyrers, J. P., Zhang, Y., Testa, G., and Stewart, A. F. (1999). Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res 27, 1555-1557. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., and Roder, J. C. (1993). Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A 90, 8424-8428. Namciu, S. J., Blochlinger, K. B., and Fournier, R. E. (1998). Human matrix attachment regions insulate transgene expression from chromosomal position effects in Drosophila melanogaster. Mol Cell Biol 18, 2382-2391. Narayanan, K., Williamson, R., Zhang, Y., Stewart, A. F., and Ioannou, P. A. (1999). Efficient and precise engineering of a 200 kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system. Gene Ther 6, 442-447. Neer, E. J., Schmidt, C. J., Nambudripad, R., and Smith, T. F. (1994). The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300. Nielsen, L. B., McCormick, S. P., Pierotti, V., Tam, C., Gunn, M. D., Shizuya, H., and Young, S. G. (1997). Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine. J Biol Chem 272, 29752-29758. Niemann, H., Halter, R., Carnwath, J. W., Herrmann, D., Lemme, E., and Paul, D. (1999). Expression of human blood clotting factor VIII in the mammary gland of transgenic sheep. Transgenic Res 8, 237-247. Osoegawa, K., Tateno, M., Woon, P. Y., Frengen, E., Mammoser, A. G., Catanese, J. J., Hayashizaki, Y., and de Jong, P. J. (2000). Bacterial artificial chromosome libraries for mouse sequencing and functional analysis. Genome Res 10, 116-128. Palmiter, R. D., Behringer, R. R., Quaife, C. J., Maxwell, F., Maxwell, I. H., and Brinster, R. L. (1987). Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 50, 435-443. Palmiter, R. D., and Brinster, R. L. (1986). Germ-line transformation of mice. Annu Rev Genet 20, 465-499. Palmiter, R. D., Brinster, R. L., Hammer, R. E., Trumbauer, M. E., Rosenfeld, M. G., Birnberg, N. C., and Evans, R. M. (1982). Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300, 611-615. Palmiter, R. D., Sandgren, E. P., Avarbock, M. R., Allen, D. D., and Brinster, R. L. (1991). Heterologous introns can enhance expression of transgenes in mice. Proc Natl Acad Sci U S A 88, 478-482. Pan, H. W., Chou, H. Y., Liu, S. H., Peng, S. Y., Liu, C. L., and Hsu, H. C. (2006). Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. Cell Cycle 5, 2676-2687. Patil, M. A., Gutgemann, I., Zhang, J., Ho, C., Cheung, S. T., Ginzinger, D., Li, R., Dykema, K. J., So, S., Fan, S. T., et al. (2005). Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma. Carcinogenesis 26, 2050-2057. Peschon, J. J., Behringer, R. R., Brinster, R. L., and Palmiter, R. D. (1987). Spermatid-specific expression of protamine 1 in transgenic mice. Proc Natl Acad Sci U S A 84, 5316-5319. Peters, K., Werner, S., Liao, X., Wert, S., Whitsett, J., and Williams, L. (1994). Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. Embo J 13, 3296-3301. Peterson, K. R., Clegg, C. H., Li, Q., and Stamatoyannopoulos, G. (1997). Production of transgenic mice with yeast artificial chromosomes. Trends Genet 13, 61-66. Pfleger, C. M., and Kirschner, M. W. (2000). The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev 14, 655-665. Pinkert, C. A., Ornitz, D. M., Brinster, R. L., and Palmiter, R. D. (1987). An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice. Genes Dev 1, 268-276. Pittius, C. W., Hennighausen, L., Lee, E., Westphal, H., Nicols, E., Vitale, J., and Gordon, K. (1988). A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc Natl Acad Sci U S A 85, 5874-5878. Previtali, S. C., Quattrini, A., Fasolini, M., Panzeri, M. C., Villa, A., Filbin, M. T., Li, W., Chiu, S. Y., Messing, A., Wrabetz, L., and Feltri, M. L. (2000). Epitope-tagged P(0) glycoprotein causes Charcot-Marie-Tooth-like neuropathy in transgenic mice. J Cell Biol 151, 1035-1046. Ramirez-Solis, R., Davis, A. C., and Bradley, A. (1993). Gene targeting in embryonic stem cells. Methods Enzymol 225, 855-878. Ramirez-Solis, R., Liu, P., and Bradley, A. (1995). Chromosome engineering in mice. Nature 378, 720-724. Rechsteiner, M., and Rogers, S. W. (1996). PEST sequences and regulation by proteolysis. Trends Biochem Sci 21, 267-271. Rinaudo, P., and Schultz, R. M. (2004). Effects of embryo culture on global pattern of gene expression in preimplantation mouse embryos. Reproduction 128, 301-311. Roers, A., Montesinos-Rongen, M., Hansmann, M. L., Rajewsky, K., and Kuppers, R. (1998). Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal. Eur J Immunol 28, 2424-2431. Rulicke, T., and Hubscher, U. (2000). Germ line transformation of mammals by pronuclear microinjection. Exp Physiol 85, 589-601. Rusconi, S. (1991). Transgenic regulation in laboratory animals. Experientia 47, 866-877. Russo, A. F., Crenshaw, E. B., 3rd, Lira, S. A., Simmons, D. M., Swanson, L. W., and Rosenfeld, M. G. (1988). Neuronal expression of chimeric genes in transgenic mice. Neuron 1, 311-320. Sager, R. (1989). Tumor suppressor genes: the puzzle and the promise. Science 246, 1406-1412. Sato, N., Wang, S., Li, L., Okabe, K., Hashimoto, M., Yaginuma, H., Mikoshiba, K., Uchiyama, Y., Uetsuki, T., Yoshikawa, K., et al. (1998). A novel strategy for introducing exogenous bcl-2 into neuronal cells: the Cre/loxP system-mediated activation of bcl-2 for preventing programmed cell death using recombinant adenoviruses. Mol Cell Neurosci 12, 65-78. Sauer, B. (1998). Inducible gene targeting in mice using the Cre/lox system. Methods 14, 381-392. Schedl, A., Beermann, F., Thies, E., Montoliu, L., Kelsey, G., and Schutz, G. (1992). Transgenic mice generated by pronuclear injection of a yeast artificial chromosome. Nucleic Acids Res 20, 3073-3077. Scherer, E., Van Dijk, W. F., and Emmelot, P. (1976). The effect of antilymphocytic and normal horse serum on growth of precancerous foci and development of tumours induced by diethylnitrosamine in rat liver. Eur J Cancer 12, 25-31. Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., and Singh, H. (1997). PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6, 437-447. Shaw, D. R., Richter, H., Giorda, R., Ohmachi, T., and Ennis, H. L. (1989). Nucleotide sequences of Dictyostelium discoideum developmentally regulated cDNAs rich in (AAC) imply proteins that contain clusters of asparagine, glutamine, or threonine. Mol Gen Genet 218, 453-459. Shi, Y., Son, H. J., Shahan, K., Rodriguez, M., Costantini, F., and Derman, E. (1989). Silent genes in the mouse major urinary protein gene family. Proc Natl Acad Sci U S A 86, 4584-4588. Shiraishi, K., Okita, K., Kusano, N., Harada, T., Kondoh, S., Okita, S., Ryozawa, S., Ohmura, R., Noguchi, T., Iida, Y., et al. (2001). A comparison of DNA copy number changes detected by comparative genomic hybridization in malignancies of the liver, biliary tract and pancreas. Oncology 60, 151-161. Sibon, O. C., Laurencon, A., Hawley, R., and Theurkauf, W. E. (1999). The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition. Curr Biol 9, 302-312. Siegal, M. L., and Hartl, D. L. (1996). Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics 144, 715-726. Silva, F. P., Hamamoto, R., Nakamura, Y., and Furukawa, Y. (2005). WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. Neoplasia 7, 348-355. Simon, M. I., Strathmann, M. P., and Gautam, N. (1991). Diversity of G proteins in signal transduction. Science 252, 802-808. Simon, R., Burger, H., Brinkschmidt, C., Bocker, W., Hertle, L., and Terpe, H. J. (1998). Chromosomal aberrations associated with invasion in papillary superficial bladder cancer. J Pathol 185, 345-351. Skowronski, J., Parks, D., and Mariani, R. (1993). Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. Embo J 12, 703-713. Smith, A. J., De Sousa, M. A., Kwabi-Addo, B., Heppell-Parton, A., Impey, H., and Rabbitts, P. (1995). A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination. Nat Genet 9, 376-385. Sokol, D. L., and Murray, J. D. (1996). Antisense and ribozyme constructs in transgenic animals. Transgenic Res 5, 363-371. Stacey, A., Bateman, J., Choi, T., Mascara, T., Cole, W., and Jaenisch, R. (1988). Perinatal lethal osteogenesis imperfecta in transgenic mice bearing an engineered mutant pro-alpha 1(I) collagen gene. Nature 332, 131-136. Steer, C. J. (1995). Liver regeneration. Faseb J 9, 1396-1400. Sternberg, N. L. (1992). Cloning high molecular weight DNA fragments by the bacteriophage P1 system. Trends Genet 8, 11-16. Stewart, T. A., Pattengale, P. K., and Leder, P. (1984). Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 38, 627-637. Storb, U., O'Brien, R. L., McMullen, M. D., Gollahon, K. A., and Brinster, R. L. (1984). High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes. Nature 310, 238-241. Su, A. I., Guidotti, L. G., Pezacki, J. P., Chisari, F. V., and Schultz, P. G. (2002). Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci U S A 99, 11181-11186. Summers, T. J., Thomas, J. W., Lee-Lin, S. Q., Maduro, V. V., Idol, J. R., and Green, E. D. (2001). Comparative physical mapping of targeted regions of the rat genome. Mamm Genome 12, 508-512. Sun, F. L., and Elgin, S. C. (1999). Putting boundaries on silence. Cell 99, 459-462. Swierczynski, S. L., Siddhanti, S. R., Tuttle, J. S., and Blackshear, P. J. (1996). Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice. Dev Biol 179, 135-147. Tanabe, G., Nuruki, K., Baba, Y., Imamura, Y., Miyazono, N., Ueno, K., Arima, T., Nakajyou, M., and Aikou, T. (1999). A comparison of hepatocellular carcinoma associated with HBV or HCV infection. Hepatogastroenterology 46, 2442-2446. Thomas, J. W., Prasad, A. B., Summers, T. J., Lee-Lin, S. Q., Maduro, V. V., Idol, J. R., Ryan, J. F., Thomas, P. J., McDowell, J. C., and Green, E. D. (2002). Parallel construction of orthologous sequence-ready clone contig maps in multiple species. Genome Res 12, 1277-1285. Thomas, K. R., and Capecchi, M. R. (1987). Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512. Tirkkonen, M., Tanner, M., Karhu, R., Kallioniemi, A., Isola, J., and Kallioniemi, O. P. (1998). Molecular cytogenetics of primary breast cancer by CGH. Genes Chromosomes Cancer 21, 177-184. Torres, R. M., Flaswinkel, H., Reth, M., and Rajewsky, K. (1996). Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272, 1804-1808. Tran, E., Zhang, X., Lackey, L., and Maxwell, E. S. (2005). Conserved spacing between the box C/D and C'/D' RNPs of the archaeal box C/D sRNP complex is required for efficient 2'-O-methylation of target RNAs. Rna 11, 285-293. Tronik, D., Dreyfus, M., Babinet, C., and Rougeon, F. (1987). Regulated expression of the Ren-2 gene in transgenic mice derived from parental strains carrying only the Ren-1 gene. Embo J 6, 983-987. Trudel, M., D'Agati, V., and Costantini, F. (1991). C-myc as an inducer of polycystic kidney disease in transgenic mice. Kidney Int 39, 665-671. van der Voorn, L., and Ploegh, H. L. (1992). The WD-40 repeat. FEBS Lett 307, 131-134. van Nocker, S., and Ludwig, P. (2003). The WD-repeat protein superfamily in Arabidopsis: conservation and divergence in structure and function. BMC Genomics 4, 50. Wianny, F., and Zernicka-Goetz, M. (2000). Specific interference with gene function by double-stranded RNA in early mouse development. Nat Cell Biol 2, 70-75. Wilkie, T. M., Brinster, R. L., and Palmiter, R. D. (1986). Germline and somatic mosaicism in transgenic mice. Dev Biol 118, 9-18. Wirth, J. J., Chen, L., and Fluck, M. M. (2000). Systemic polyomavirus genome increase and dissemination of capsid-defective genomes in mammary gland tumor-bearing mice. J Virol 74, 6975-6983. Wolgemuth, D. J., Behringer, R. R., Mostoller, M. P., Brinster, R. L., and Palmiter, R. D. (1989). Transgenic mice overexpressing the mouse homoeobox-containing gene Hox-1.4 exhibit abnormal gut development. Nature 337, 464-467. Wong, L. F., Wells, S., and Murphy, D. (2000). Gene transfer strategies for the physiologist. Exp Physiol 85, 735-745. Wong, N., Lai, P., Lee, S. W., Fan, S., Pang, E., Liew, C. T., Sheng, Z., Lau, J. W., and Johnson, P. J. (1999). Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis. Am J Pathol 154, 37-43. Woychik, R. P., and Alagramam, K. (1998). Insertional mutagenesis in transgenic mice generated by the pronuclear microinjection procedure. Int J Dev Biol 42, 1009-1017. Xie, P., Cheung, W. M., Ip, F. C., Ip, N. Y., and Leung, M. F. (1997). Induction of TrkA receptor by retinoic acid in leukaemia cell lines. Neuroreport 8, 1067-1070. Yadav, N., Lee, J., Kim, J., Shen, J., Hu, M. C., Aldaz, C. M., and Bedford, M. T. (2003). Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A 100, 6464-6468. Yamada, Y., Kirillova, I., Peschon, J. J., and Fausto, N. (1997). Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci U S A 94, 1441-1446. Yamaguchi, S., Murakami, H., and Okayama, H. (1997). A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2/B-type cyclin complexes. Mol Biol Cell 8, 2475-2486. Yamauchi, H., Uetsuka, K., Okada, T., Nakayama, H., and Doi, K. (2003). Impaired liver regeneration after partial hepatectomy in db/db mice. Exp Toxicol Pathol 54, 281-286. Yang, X. W., Model, P., and Heintz, N. (1997). Homologous recombination based modification in Escherichia coli and germline transmission in transgenic mice of a bacterial artificial chromosome. Nat Biotechnol 15, 859-865. Yochem, J., and Byers, B. (1987). Structural comparison of the yeast cell division cycle gene CDC4 and a related pseudogene. J Mol Biol 195, 233-245. Yu, I. S., Chen, H. J., Lee, Y. S., Huang, P. H., Lin, S. R., Tsai, T. W., and Lin, S. W. (2000). Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability. Thromb Haemost 84, 865-870. Zheng, B., Sage, M., Sheppeard, E. A., Jurecic, V., and Bradley, A. (2000). Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol Cell Biol 20, 648-655. Zou, Y. R., Muller, W., Gu, H., and Rajewsky, K. (1994). Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr Biol 4, 1099-1103.; en-US; http://ntur.lib.ntu.edu.tw/handle/246246/63572; http://ntur.lib.ntu.edu.tw/bitstream/246246/63572/1/ntu-96-D90444001-1.pdf

الاتاحة: http://ntur.lib.ntu.edu.tw/handle/246246/63572
http://ntur.lib.ntu.edu.tw/bitstream/246246/63572/1/ntu-96-D90444001-1.pdf

View record in BASE