المؤلفون: Lewis D. Turner (4600186), Chi H. Trinh (1316205), Ryan A. Hubball (11709864), Kyle M. Orritt (11709867), Chi-Chuan Lin (11709870), Julie E. Burns (11709873), Margaret A. Knowles (11709876), Colin W. G. Fishwick (7821107)

مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, subsequent iterative rounds, specific morphological differences, fgfr inhibitors currently, biological evaluation led, additional docking studies, guided approach toward, selective inhibitors exist, existing fragment series, exhibited moderate selectivity, de novo design, selective fgfr2 inhibitors, lead inhibitor resulted, selective fgfr2 inhibitor, yield compounds predicted, selective h, subtle changes, nanomolar potency, improve potency, development toward, complete loss, clinical trials

Relation: https://figshare.com/articles/journal_contribution/From_Fragment_to_Lead_De_Novo_Design_and_Development_toward_a_Selective_FGFR2_Inhibitor/17019711

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01163.s001

المؤلفون: Kyle M. Orritt, Lipeng Feng, Juliette F. Newell, Jack N. Sutton, Scott Grossman, Thomas Germe, Lauren R. Abbott, Holly L. Jackson, Benjamin K. L. Bury, Anthony Maxwell, Martin J. McPhillie, Colin W. G. Fishwick

المصدر: RSC Medicinal Chemistry. 13:831-839

مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::519fd7fc93ae6a9798c16c90eec91cb2
https://doi.org/10.1039/d2md00049k

المؤلفون: Martin J. McPhillie, Colin Wg Fishwick, Kyle M. Orritt, Anthony Maxwell

المصدر: Future Medicinal Chemistry. 13:2125-2127

مصطلحات موضوعية: Pharmacology, biology, Topoisomerase Inhibitors, Topoisomerase IV, Chemistry, Allosteric regulation, DNA gyrase, Anti-Bacterial Agents, Antibiotic resistance, Biochemistry, DNA Gyrase, Drug Discovery, biology.protein, Humans, Molecular Medicine, Antibacterial drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a821e05e1a70110c4b7cf2cbbc07e72c
https://doi.org/10.4155/fmc-2021-0266

المؤلفون: Kyle M. Orritt, Lauren Abbott, Thomas Germe, Colin W. G. Fishwick, Anthony Maxwell, Juliette Newell, Holly Jackson, Martin J. McPhillie, Benjamin Bury

مصطلحات موضوعية: Antibiotic resistance, medicine.drug_class, Chemistry, In silico, Allosteric regulation, Antibiotics, medicine, Computational biology, Binding site, Antimicrobial, Type II topoisomerase, DNA gyrase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67370c43bc395e9e07b0a1805633b0e
https://doi.org/10.26434/chemrxiv-2021-290nh-v2

المؤلفون: Margaret A. Knowles, Ryan A. Hubball, Colin W. G. Fishwick, Julie E. Burns, Chi H. Trinh, Kyle M. Orritt, Lewis D. Turner, Chi-Chuan Lin

المصدر: 'Journal of Medicinal Chemistry ', vol: 65, pages: 1481-1504 (2022)

مصطلحات موضوعية: musculoskeletal diseases, Chemistry, Fibroblast growth factor receptor 1, stomatognathic diseases, Structure-Activity Relationship, Docking (dog), Biochemistry, Drug Development, Urinary Bladder Neoplasms, Fibroblast growth factor receptor, Drug Design, Drug Discovery, embryonic structures, Tumor Cells, Cultured, Molecular Medicine, Potency, Humans, Phosphorylation, Receptor, Fibroblast Growth Factor, Type 2, Selectivity, Protein Kinase Inhibitors, Biological evaluation, Cell Proliferation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d840fc205f9b105b00c9fbe760ddc7e3
https://pubmed.ncbi.nlm.nih.gov/34780700

المؤلفون: Chi Trinh, Margaret A. Knowles, Colin W. G. Fishwick, Ryan A. Hubball, Julie E. Burns, Chi-Chuan Lin, Lewis D. Turner, Kyle M. Orritt

مصطلحات موضوعية: Biochemistry, Cell culture, Chemistry, Fibroblast growth factor receptor, Fibroblast growth factor receptor 1, Potency, Hit to lead, Selectivity, Biological evaluation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1b8cd5c06eaacfc999383d5a56b9e9f7
https://doi.org/10.33774/chemrxiv-2021-xmcgr