المؤلفون: Daniel Metzger, Joseph L. Duffy, Weiguo Liu, Jiafang He, Garry Chicchi, Gino Salituro, Ann E. Weber, Margaret Wu, Cai Li, John Wang, Taro E. Akiyama, Andrew D. Howard, Shao Pengcheng Patrick, John Bawiec, Beth Ann Murphy, Gui-Bai Liang, Yun-Ping Zhou, Susan D. Aster, Kwei-Lan Tsao, Jin Shang

المصدر: ACS Medicinal Chemistry Letters. 9:1082-1087

مصطلحات موضوعية: 0301 basic medicine, Chemistry, Insulin, medicine.medical_treatment, Organic Chemistry, Glucose challenge, Antagonist, 030209 endocrinology & metabolism, Glucose excursion, Pharmacology, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Somatostatin, Incretin Hormone, Drug Discovery, medicine, Potency, Dipeptidyl peptidase-4

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f799c113adab203716f4e156f34e4f72
https://doi.org/10.1021/acsmedchemlett.8b00305

المؤلفون: Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann

المصدر: ACS Medicinal Chemistry Letters. 5:748-753

مصطلحات موضوعية: biology, business.industry, Organic Chemistry, hERG, Antagonist, In vitro toxicology, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, QT interval, Somatostatin, Drug Discovery, biology.protein, Medicine, cardiovascular diseases, Receptor, business, Antagonism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced576c72131916fe1527dabb0d36e73
https://doi.org/10.1021/ml500028c

المؤلفون: Janet Kerr, Gary G. Chicchi, Margaret Wu, Cai Li, Shuwen He, Vijay Bhasker G. Reddy, Sharon Tong, William K. Hagmann, Patrick Fitzgerald, Guillermo Fernandez, Andrew D. Howard, Tianying Jian, Zhe Feng, Raman K. Bakshi, Dorina Trusca, Peter H. Dobbelaar, Donald Nelson, Mikhail Reibarkh, Qing Shao, Liangqin Guo, Yun-Ping Zhou, Ravi P. Nargund, Kwei-Lan Tsao, Edward C. Sherer, Stan Mitelman, Pierre Morissette, Maria E. Trujillo, Quang Truong, Zhixiong Ye, James D. Dellureficio, Hongbo Qi, Melissa Lin, Shrenik K. Shah, Sylvia Volksdorf, Jian Liu, Qingmei Hong, Koppara Samuel, Alexander Pasternak, George J. Eiermann, Patricia B. Bunting, Wu Du, Bei B. Zhang

المصدر: Bioorganicmedicinal chemistry letters. 26(6)

مصطلحات موضوعية: QTC PROLONGATION, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, 010402 general chemistry, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, cardiovascular diseases, Receptors, Somatostatin, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Antagonism, Carbolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6412732d83fd31156d7974bed1994494
https://pubmed.ncbi.nlm.nih.gov/26898814

المؤلفون: Kwei-Lan Tsao, Derun Li, Liangqing Guo, Richard G. Ball, Zhicai Wu, David X. Yang, Gary G. Chicchi, William K. Hagmann, Quang Tuang, Dorina Trusca, Yang Yu, Shuwen He, Qingmei Hong, Ravi P. Nargund, Edward C. Sherer, Yun-Ping Zhou, Zhong Lai, Andrew D. Howard

المصدر: Bioorganicmedicinal chemistry letters. 25(17)

مصطلحات موضوعية: Agonist, medicine.drug_class, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Biochemistry, Methylamines, Structure-Activity Relationship, Drug Discovery, medicine, Somatostatin receptor 3, Molecular Medicine, Humans, Receptors, Somatostatin, Antagonism, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e290258042757d2c6805a1afb8166f73
https://pubmed.ncbi.nlm.nih.gov/26199120

المؤلفون: Jason M, Elliott, Robert W, Carling, Gary G, Chicchi, James, Crawforth, Peter H, Hutson, A Brian, Jones, Sarah, Kelly, Rose, Marwood, Georgina, Meneses-Lorente, Elena, Mezzogori, Fraser, Murray, Michael, Rigby, Inmaculada, Royo, Michael G N, Russell, Duncan, Shaw, Bindi, Sohal, Kwei Lan, Tsao, Brian, Williams

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5752-5756

مصطلحات موضوعية: Neurotransmitter Agents, Dose-Response Relationship, Drug, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Receptors, Neurokinin-3, CHO Cells, Fluorine, Biochemistry, Piperazines, Structure-Activity Relationship, Hydrazines, Cricetinae, Drug Discovery, Quinolines, Tumor Cells, Cultured, Animals, Molecular Medicine, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d704e07d074727d41f2d40a900255eb
https://doi.org/10.1016/j.bmcl.2006.08.085

المؤلفون: Gary G. Chicchi, Paul E. Finke, Joseph M. Metzger, Dorothy Levorse, Malcolm MacCoss, Margaret A. Cascieri, D. Euan MacIntyre, Laura C. Meurer, Kwei-Lan Tsao, Sharon Sadowski, Sander G. Mills

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4497-4503

مصطلحات موضوعية: Molecular Structure, Tertiary amine, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Cyclopentanes, Receptors, Neurokinin-1, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, Solubility, chemistry, Morpholine, Drug Discovery, Humans, Molecular Medicine, Molecule, Structure–activity relationship, Cyclopentane, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e221964d3957e25b8e98f1ec2b804da4
https://doi.org/10.1016/j.bmcl.2006.06.035

المؤلفون: Yang Yu, Gary G. Chicchi, Frederick Wong, Janet S. Kerr, Sharon Tong, Zhe Feng, Guillermo Fernandez, Edward C. Sherer, Kwei-Lan Tsao, Qing Shao, Bei B. Zhang, Yun-Ping Zhou, Pierre Morissette, Shuwen He, Shrenik K. Shah, Vijay Bhasker G. Reddy, Liangqin Guo, Ravi P. Nargund, Margaret Wu, Cai Li, Zhixiong Ye, Alexander Pasternak, George J. Eiermann, Patricia R. Bunting, Hongbo Qi, Michele Pachanski, Stan Mitelman, Maria E. Trujillo, Quang Truong, Maria Madiera, Andrew D. Howard, Donald Nelson, Qingmei Hong, Zhong Lai, Yue Feng, Bindhu V. Karanam, Jian Liu, Koppara Samuel, Wu Du, William K. Hagmann, Tianying Jian, Dorina Trusca, Sylvia Volksdorf, Peter H. Dobbelaar

المصدر: ACS medicinal chemistry letters. 6(5)

مصطلحات موضوعية: business.industry, Murine model, Organic Chemistry, Drug Discovery, Antagonist, Qtc interval prolongation, medicine, Type 2 diabetes, Glucose excursion, Pharmacology, medicine.disease, business, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8391d2d13678e95f2d50ddfa654d1520
https://pubmed.ncbi.nlm.nih.gov/26005524

المؤلفون: Gary G. Chicchi, Mark Peter Ridgill, Gregory John Hollingworth, Angela Williams, W. Rycroft, Kwei-Lan Tsao, Christopher John Swain, Kevin Dinnell, Jason Matthew Elliott, Madhumeeta J Dhar, Marc M. Kurtz

المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1237-1240

مصطلحات موضوعية: Indoles, Nitrogen, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Molecular Conformation, Substituent, Pharmaceutical Science, chemistry.chemical_element, Electrons, Carboxamide, CHO Cells, Substance P, Binding, Competitive, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Neurokinin-1 Receptor Antagonists, Cricetinae, Drug Discovery, medicine, Animals, Molecular Biology, Indole test, Behavior, Animal, Bicyclic molecule, Aryl, Organic Chemistry, Recombinant Proteins, chemistry, Molecular Medicine, Gerbillinae, Selectivity, Palladium

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3971536b0f69dcc2942374639fb05eae
https://doi.org/10.1016/s0960-894x(01)00183-4

المؤلفون: Richard G. Ball, Liangqin Guo, Zhicai Wu, Quang Truong, Gary G. Chicchi, Ravi P. Nargund, Dorina Trusca, Kwei-Lan Tsao, Qingmei Hong, Yang Yu, George J. Eiermann, Shuwen He, Yun-Ping Zhou, Bei B. Zhang, William K. Hagmann, Maria E. Trujillo, Michele Pachanski, Hongbo Qi, David X. Yang, Andrew D. Howard, Derun Li, Zhong Lai, Edward C. Sherer

المصدر: ACS medicinal chemistry letters. 5(6)

مصطلحات موضوعية: Agonist, medicine.drug_class, business.industry, Organic Chemistry, Antagonist, Pharmacology, Biochemistry, Partial agonist, HYDIA, Somatostatin, In vivo, Drug Discovery, medicine, Receptor, business, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a64a41cfd844bfc5154bf7fc7e59f92
https://pubmed.ncbi.nlm.nih.gov/24944745

المؤلفون: David S. Waugh, Barbara Debarbieri, Kwei-Lan Tsao, Hanspeter Michel

المصدر: Gene. 169:59-64

مصطلحات موضوعية: Monosaccharide Transport Proteins, Genetic Vectors, Molecular Sequence Data, Protein domain, Biotin, Biology, medicine.disease_cause, Maltose-Binding Proteins, Maltose-binding protein, Affinity chromatography, Escherichia coli, Genetics, medicine, Amino Acid Sequence, Peptide sequence, DNA Primers, Expression vector, Base Sequence, Escherichia coli Proteins, General Medicine, Recombinant Proteins, N-terminus, Biochemistry, Periplasmic Binding Proteins, Sulfurtransferases, Biotinylation, biology.protein, ATP-Binding Cassette Transporters, Carrier Proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f14297c6a579f3f8d706a536fdfaae7
https://doi.org/10.1016/0378-1119(95)00762-8

المؤلفون: S. D. Emerson, J. E. Scheffler, Kwei-Lan Tsao, S. P. Liu, Robert Palermo, David S. Waugh, Vincent S. Madison, David C. Fry, S.E. Kiefer

المصدر: Biochemistry. 34:6911-6918

مصطلحات موضوعية: Binding Sites, Magnetic Resonance Spectroscopy, biology, Protein Conformation, Chemistry, Chemical shift, Nuclear magnetic resonance spectroscopy, Serine threonine protein kinase, Protein Serine-Threonine Kinases, Biochemistry, SH3 domain, Proto-Oncogene Proteins c-raf, Solutions, Crystallography, Protein structure, Proto-Oncogene Proteins, ras Proteins, biology.protein, Humans, Protein G, Binding site, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79085ce8c910b1f15ff4663b489aa17
https://doi.org/10.1021/bi00021a001

المؤلفون: Kathleen Prinzo, Joseph E. LoSardo, B. Wegrzynski, S.E. Kiefer, S. D. Emerson, J. E. Scheffler, Kwei-Lan Tsao, Anthony Neri, Eva Bekesi, David S. Waugh

المصدر: Journal of Biological Chemistry. 269:22340-22346

مصطلحات موضوعية: Germinal vesicle, GTP', biology, GTPase-activating protein, Chemistry, Cell Biology, GTPase, Biochemistry, Fusion protein, Maltose-binding protein, Affinity chromatography, biology.protein, Molecular Biology, Binding domain

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::87f1edc085e5dede0d57155fe12d76b1
https://doi.org/10.1016/s0021-9258(17)31795-7

المؤلفون: Peter H. Dobbelaar, Margaret Wu, Cai Li, Gary G. Chicchi, Lihu Yang, Dorina Trusca, Yue Feng, Scott A. Bradley, Kwei-Lan Tsao, Reynalda K. de Jesus, Ravi P. Nargund, Bei B. Zhang, Zhixiong Ye, Andrew D. Howard, Qing Shao, Yun-Ping Zhou, Shuwen He, Zhe Feng, Sander G. Mills, Alexander Pasternak, George J. Eiermann

المصدر: ACS medicinal chemistry letters. 3(4)

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Organic Chemistry, Antagonist, Type 2 Diabetes Mellitus, Stimulation, Type 2 diabetes, medicine.disease, Biochemistry, Somatostatin, Endocrinology, Internal medicine, Drug Discovery, Knockout mouse, medicine, Antagonism, business, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27f9b6e6b7f778bf3ae34db0993f3b8
https://pubmed.ncbi.nlm.nih.gov/24900466

المؤلفون: Susan Boyce, Kwei-Lan Tsao, Gary G. Chicchi, Karen Townson, Sander G. Mills, Julie A. DeMartino, Neil Collinson, Marc M. Kurtz, Gregori J. Morriello, Robert J. DeVita, Alan Wheeldon, Nadia M.J. Rupniak, Emma J. Carlson, Tricia Johnson, Xinchun Tong, Song Zheng

المصدر: Bioorganicmedicinal chemistry letters. 20(19)

مصطلحات موضوعية: Agonist, animal structures, Pyrrolidines, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Antidepressive Agents, Tricyclic, Biochemistry, Chemical synthesis, Pyrrolidine, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Neurokinin-1 Receptor Antagonists, In vivo, Microsomes, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Receptor, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, Antagonist, Receptors, Neurokinin-1, Macaca mulatta, Rats, embryonic structures, Molecular Medicine, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8e996df1a1b78f6c5cafc9b1d3ed98
https://pubmed.ncbi.nlm.nih.gov/20729082

المؤلفون: Karen Townson, Gregori J. Morriello, Kwei-Lan Tsao, Gary G. Chicchi, Nadia M.J. Rupniak, Sander G. Mills, Mikhail Reibarkh, Philip Davies, Julie A. DeMartino, Neil Collinson, Alan Wheeldon, Marc M. Kurtz, Stephen Moore, Tricia Johnson, F.D. Tattersall, Susan Boyce, Robert J. DeVita, Emma J. Carlson, Song Zheng, Xinchun Tong

المصدر: Bioorganicmedicinal chemistry letters. 20(6)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Substance P, Pharmacology, Gerbil, Biochemistry, chemistry.chemical_compound, Bridged Bicyclo Compounds, Pharmacokinetics, Neurokinin-1 Receptor Antagonists, In vivo, Drug Discovery, Animals, Humans, Pyrroles, Molecular Biology, Bicyclic molecule, Chemistry, Organic Chemistry, Bioavailability, Molecular Medicine, Functional activity, NK1 receptor antagonist

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5f1466795a40ae5e39fb30c2992976
https://pubmed.ncbi.nlm.nih.gov/20153964

المؤلفون: Mariana Spetea, Georg M. Singewald, Gary G. Chicchi, Kwei-Lan Tsao, Francesco Ferraguti, Nicolas Singewald, Helmut Schmidhammer, Karl Ebner, Hari Kishore Sreepathi, Clemens C. Thurner

المصدر: Journal of neurochemistry. 106(6)

مصطلحات موضوعية: Male, medicine.medical_specialty, Microdialysis, medicine.drug_class, Presynaptic Terminals, Substance P, CHO Cells, Neurotransmission, Biology, Ligands, Biochemistry, Synaptic Transmission, Feedback, Rats, Sprague-Dawley, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Cricetulus, Neurokinin-1 Receptor Antagonists, Piperidines, Internal medicine, Cricetinae, medicine, Extracellular, Animals, Receptor, Binding Sites, Antagonist, Receptors, Neurokinin-1, Receptor antagonist, Amygdala, Cell biology, Rats, Endocrinology, chemistry, Synapses, Neurokinin A, Stress, Psychological

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086bc22a688c03ce1375e677c07dc204
https://pubmed.ncbi.nlm.nih.gov/18673452

المؤلفون: Gary G. Chicchi, Mark Stuart Chambers, Michael G. N. Russell, A. Brian Jones, Bindi Sohal, Robert W. Carling, Kwei lan Tsao, Georgina Meneses-Lorente, Inmaculada Royo, Peter H. Hutson, Jason Matthew Elliott, Michael Rigby, Brian John Williams, Elena Mezzogori, Rose Marwood, Fraser Murray, Angus Murray Macleod

المصدر: Bioorganicmedicinal chemistry letters. 16(22)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, CHO Cells, Carbohydrazide, Gerbil, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Cricetinae, Drug Discovery, Tumor Cells, Cultured, Structure–activity relationship, Animals, Receptor, Molecular Biology, Neurotransmitter Agents, Dose-Response Relationship, Drug, Organic Chemistry, Antagonist, Receptors, Neurokinin-3, Hydrazines, chemistry, Quinolines, Molecular Medicine, Lead compound, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d67d6296182f7a7db3242e6f7a3dd6
https://pubmed.ncbi.nlm.nih.gov/16950620

المؤلفون: Laura C. Meurer, Gary G. Chicchi, Karen Owens, Nadia M.J. Rupniak, Angela Williams, Richard G. Ball, Paul E. Finke, Silvi Luell, Nancy N. Tsou, Malcolm MacCoss, Margaret A. Cascieri, Sander G. Mills, Richard Hargreaves, D. Euan MacIntyre, Joseph M. Metzger, Linda A. Egger, Kwei-Lan Tsao, Sharon Sadowski

المصدر: Bioorganicmedicinal chemistry letters. 16(17)

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Context (language use), CHO Cells, Cyclopentanes, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Neurokinin-1 Receptor Antagonists, In vivo, Oral administration, Cricetinae, Drug Discovery, medicine, Animals, Humans, Cyclopentane, Molecular Biology, Aprepitant, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Water, Receptors, Neurokinin-1, In vitro, Solubility, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439fdaa58b1e3898cfa17ee644d1d2ba
https://pubmed.ncbi.nlm.nih.gov/16831551

المؤلفون: Jason Matthew Elliott, Gary G. Chicchi, Ute Gerhard, María Domínguez, Richard Alexander Jelley, Marc M. Kurtz, Alan Wheeldon, Emma J. Carlson, Kwei lan Tsao, Olivier Dirat, A. Brian Jones

المصدر: Bioorganicmedicinal chemistry letters. 16(11)

مصطلحات موضوعية: Lactams, Molecular Structure, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ring (chemistry), Biochemistry, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, chemistry, Neurokinin-1 Receptor Antagonists, In vivo, Drug Discovery, Lactam, Molecular Medicine, Humans, Selectivity, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b72efa2a07077ff37a7612e21d1c3a
https://pubmed.ncbi.nlm.nih.gov/16574413

المؤلفون: Kwei-Lan Tsao, Gregory John Hollingworth, Jason Matthew Elliott, Christopher John Swain, W. Rycroft, Gary G. Chicchi, Jerry Di Salvo, Natalie Clark, Marc M. Kurtz, F. David Tattersall, Laura Catherine Cooper, José L. Castro, Ruth Kilburn, Emma J. Carlson, Olivier Dirat

المصدر: Bioorganicmedicinal chemistry letters. 16(5)

مصطلحات موضوعية: Lactams, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Substance P, Cyclohexylamine, Biochemistry, Chemical synthesis, Methylation, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Tachykinins, Drug Discovery, Animals, Humans, Molecular Biology, Molecular Structure, Organic Chemistry, Antagonist, Receptors, Neurokinin-1, Amides, In vitro, chemistry, Lactam, Molecular Medicine, Antiemetics, Penetrant (biochemical), Gerbillinae

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a1138f7a654eb247e00c990b10bdde
https://pubmed.ncbi.nlm.nih.gov/16384700