المؤلفون: FinnGen, Makkonen, Kristiina, Jännäri, Meeri, Crisostomo, Luis, Kuusi, Matilda, Patyra, Konrad, Melnyk, Vladyslav, Linnossuo, Veli, Ojala, Johanna, Ravi, Rowmika, Lof, Christoffer, Mäkelä, Juho-Antti, Miettinen, Päivi, Laakso, Saila, Ojaniemi, Marja, Jääskeläinen, Jarmo, Laakso, Markku, Bossowski, Filip, Sawicka, Beata, Stozek, Karolina, Bossowski, Artur, Kleinau, Gunnar, Scheerer, Patrick, Reeve, Mary Pat, Kero, Jukka

المساهمون: Centre of Excellence in Stem Cell Metabolism, HUS Children and Adolescents, Clinicum, Timo Pyry Juhani Otonkoski / Principal Investigator, Children's Hospital, Faculty Common Matters (Faculty of Medicine), Institute for Molecular Medicine Finland, Complex Disease Genetics

مصطلحات موضوعية: Thyroid-stimulating hormone, Tsh-receptor, Somatic mutations, In-vivo, Identification, Polymorphism, Activation, Resistance, Domain, Specificity, Biomedicine, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: We thank the organizations supporting the study with the grants from the Finnish Pediatric (grant no. 190001) and Medical Foundations, grant from Turku University Hospital (no. 13527) , Academy of Finland (no. 355967) , Sigrid Juselius Foundation (no. 115-1956-26) , Novo Nordisk Foundation (no. 0078329) (JK) , and Turku Doctoral Programme for Molecular Medicine and Biocenter Finland (KP) . KM was supported by the Finnish Medical Foundation. GK and PS are supported by the Deutsche Forschungsgemeinschaft (DFG) (German Research Foundation) through SFB1423, Project -ID 421152132, subprojects A01/A05; through SFB1365, Project -ID 394046635, subproject A03; through Germany s Excellence Strategy - EXC 2008 - 390540038 - UniSysCat (Research Unit E); and by the European Union's Horizon 2020 MSCA Program under grant agreement 956314 [ALLODD] . We thank the personnel of the Institute of Biomedicine and Histology Core Facility for skillful technical assistance in various stages of this study, and we thank Meri Davidsson for cAMP, TSH, and T4 measurements and other excellent laboratory work. We also thank Ilpo Huhtaniemi and Maria Alevizaki for commenting on the manuscript. TSHR M453T mice were generated in Montoliu's laboratory (Madrid, Spain) with INFRAFRONTIER2020 support. The model line has been stored in the European Mouse Mutant Archive (EMMA) INFRAFRONTIER reposit. We thank the personnel in these organizations.; FinnGen , Makkonen , K , Jännäri , M , Crisostomo , L , Kuusi , M , Patyra , K , Melnyk , V , Linnossuo , V , Ojala , J , Ravi , R , Lof , C , Mäkelä , J-A , Miettinen , P , Laakso , S , Ojaniemi , M , Jääskeläinen , J , Laakso , M , Bossowski , F , Sawicka , B , Stozek , K , Bossowski , A , Kleinau , G , Scheerer , P , Reeve , M P & Kero , J 2024 , ' Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model ' , JCI INSIGHT , vol. 9 , no. 4 , e167092 . https://doi.org/10.1172/jci.insight.167092; ORCID: /0000-0002-5184-9616/work/156158029; http://hdl.handle.net/10138/573373; e8e6818b-0bb3-4d37-a64b-50b261d6ed56; 001174950800001

الاتاحة: http://hdl.handle.net/10138/573373

المؤلفون: Kuusi, Matilda

المساهمون: Lääketieteellinen tiedekunta, Faculty of Medicine, Kliiniset neurotieteet, Clinical Neurosciences, Kliininen laitos, Department of Clinical Medicine

مصطلحات موضوعية: Post-COVID-19 condition, TSPO-PET, microglial activation, PET/MR, NfL, GFAP

Relation: https://www.utupub.fi/handle/10024/177685; URN:NBN:fi-fe2024052033322

الاتاحة: https://www.utupub.fi/handle/10024/177685