المؤلفون: R. Benjamin Free (1316697), Ashley N. Nilson (14312793), Noelia M. Boldizsar (14312796), Trevor B. Doyle (14312799), Ramona M. Rodriguiz (185135), Vladimir M. Pogorelov (133492), Mayako Machino (14312802), Kuo Hao Lee (8436282), Jeremiah W. Bertz (14312805), Jinbin Xu (33400), Herman D. Lim (1655842), Andrés E. Dulcey (1316673), Robert H. Mach (279778), James H. Woods (1290507), J Robert Lane (12503554), Lei Shi (8144), Juan J. Marugan (191299), William C. Wetsel (185139), David R. Sibley (1618657)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Cancer, Science Policy, Mental Health, Infectious Diseases, Chemical Sciences not elsewhere classified, thus indicating exceptional, receptor binding rates, orthosteric binding site, human primates demonstrated, functional profiling screens, dopamine receptor antagonist, 168 different gpcrs, pet imaging studies, kinetic studies revealed, approved d2r antagonists, ml321 exhibits slow, induced locomotor activity, 2 , novel d2r antagonist, vivo <, ppi studies, taken together, selectively antagonize, restored pre, relatively ineffective, rats demonstrate

Relation: https://figshare.com/articles/journal_contribution/Identification_and_Characterization_of_ML321_A_Novel_and_Highly_Selective_D_sub_2_sub_Dopamine_Receptor_Antagonist_with_Efficacy_in_Animal_Models_That_Predict_Atypical_Antipsychotic_Activity/21799104

الاتاحة: https://doi.org/10.1021/acsptsci.2c00202.s001

المؤلفون: Anver Basha Shaik (7500401), Comfort A. Boateng (3617120), Francisco O. Battiti (10830442), Alessandro Bonifazi (1322385), Jianjing Cao (1307898), Li Chen (5749), Rezvan Chitsazi (4751388), Saiprasad Ravi (11551926), Kuo Hao Lee (8436282), Lei Shi (8144), Amy Hauck Newman (1307901)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, sterically bulky groups, require long linkers, molecular models confirmed, structure activity relationships, r bioconjugate tools, >- alkyl groups, position modifications would, 33 , 11 , r binding affinities, pyrrolidine ring system, >- alkylated compounds, 3 nm ), 3 , receptor bitopic ligands, 2 , bitopic ligands, pyrrolidine ring, >- alkylated, n <, improved affinities, crystal structure

Relation: https://figshare.com/articles/journal_contribution/Structure_Activity_Relationships_for_a_Series_of_Eticlopride-Based_Dopamine_D_sub_2_sub_D_sub_3_sub_Receptor_Bitopic_Ligands/16797486

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01353.s001

المؤلفون: R. Benjamin Free (1316697), Ashley N. Nilson (14312793), Noelia M. Boldizsar (14312796), Trevor B. Doyle (14312799), Ramona M. Rodriguiz (185135), Vladimir M. Pogorelov (133492), Mayako Machino (14312802), Kuo Hao Lee (8436282), Jeremiah W. Bertz (14312805), Jinbin Xu (33400), Herman D. Lim (1655842), Andrés E. Dulcey (1316673), Robert H. Mach (279778), James H. Woods (1290507), J Robert Lane (12503554), Lei Shi (8144), Juan J. Marugan (191299), William C. Wetsel (185139), David R. Sibley (1618657)

مصطلحات موضوعية: Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Cancer, Science Policy, Mental Health, Infectious Diseases, Chemical Sciences not elsewhere classified, thus indicating exceptional, receptor binding rates, orthosteric binding site, human primates demonstrated, functional profiling screens, dopamine receptor antagonist, 168 different gpcrs, pet imaging studies, kinetic studies revealed, approved d2r antagonists, ml321 exhibits slow, induced locomotor activity, 2 , novel d2r antagonist, vivo <, ppi studies, taken together, selectively antagonize, restored pre, relatively ineffective, rats demonstrate

Relation: https://figshare.com/articles/media/Identification_and_Characterization_of_ML321_A_Novel_and_Highly_Selective_D_sub_2_sub_Dopamine_Receptor_Antagonist_with_Efficacy_in_Animal_Models_That_Predict_Atypical_Antipsychotic_Activity/21799107

الاتاحة: https://doi.org/10.1021/acsptsci.2c00202.s002

المؤلفون: Anver Basha Shaik (7500401), Comfort A. Boateng (3617120), Francisco O. Battiti (10830442), Alessandro Bonifazi (1322385), Jianjing Cao (1307898), Li Chen (5749), Rezvan Chitsazi (4751388), Saiprasad Ravi (11551926), Kuo Hao Lee (8436282), Lei Shi (8144), Amy Hauck Newman (1307901)

مصطلحات موضوعية: Biophysics, Biochemistry, Molecular Biology, Neuroscience, Pharmacology, Biotechnology, Cancer, Chemical Sciences not elsewhere classified, sterically bulky groups, require long linkers, molecular models confirmed, structure activity relationships, r bioconjugate tools, >- alkyl groups, position modifications would, 33 , 11 , r binding affinities, pyrrolidine ring system, >- alkylated compounds, 3 nm ), 3 , receptor bitopic ligands, 2 , bitopic ligands, pyrrolidine ring, >- alkylated, n <, improved affinities, crystal structure

Relation: https://figshare.com/articles/dataset/Structure_Activity_Relationships_for_a_Series_of_Eticlopride-Based_Dopamine_D_sub_2_sub_D_sub_3_sub_Receptor_Bitopic_Ligands/16797489

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01353.s002