المؤلفون: Harvey, Edward P, Shin, Jung-Eun, Skiba, Meredith A, Nemeth, Genevieve R, Hurley, Joseph D, Wellner, Alon, Shaw, Ada Y, Miranda, Victor G, Min, Joseph K, Liu, Chang C, Marks, Debora S, Kruse, Andrew C

المصدر: Nature Communications. 13(1)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Biotechnology, Generic health relevance, Immunoglobulin Fragments

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8dw5h5jr
https://escholarship.org/content/qt8dw5h5jr/qt8dw5h5jr.pdf

المؤلفون: Alon, Assaf, Lyu, Jiankun, Braz, Joao M, Tummino, Tia A, Craik, Veronica, O’Meara, Matthew J, Webb, Chase M, Radchenko, Dmytro S, Moroz, Yurii S, Huang, Xi-Ping, Liu, Yongfeng, Roth, Bryan L, Irwin, John J, Basbaum, Allan I, Shoichet, Brian K, Kruse, Andrew C

المصدر: Nature. 600(7890)

مصطلحات موضوعية: Theory Of Computation, Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Information and Computing Sciences, Neurosciences, Neurodegenerative, Chronic Pain, Pain Research, Peripheral Neuropathy, 5.1 Pharmaceuticals, Animals, Ligands, Mice, Neuralgia, Receptors, sigma, Structure-Activity Relationship, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/9gp7838k

المؤلفون: Wellner, Alon, McMahon, Conor, Gilman, Morgan SA, Clements, Jonathan R, Clark, Sarah, Nguyen, Kianna M, Ho, Ming H, Hu, Vincent J, Shin, Jung-Eun, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Wingler, Laura M, Schmidt, Aaron G, Marks, Debora S, Abraham, Jonathan, Kruse, Andrew C, Liu, Chang C

المصدر: Nature Chemical Biology. 17(10)

مصطلحات موضوعية: Prevention, Biotechnology, Vaccine Related, Immunization, Generic health relevance, Antibodies, Antibody Formation, Antigens, COVID-19, Humans, Peptide Library, Protein Engineering, Recombinant Proteins, SARS-CoV-2, Saccharomyces cerevisiae, Single-Domain Antibodies, Spike Glycoprotein, Coronavirus, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Biochemistry & Molecular Biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4vm82163

المؤلفون: Tummino, Tia A, Rezelj, Veronica V, Fischer, Benoit, Fischer, Audrey, O'Meara, Matthew J, Monel, Blandine, Vallet, Thomas, White, Kris M, Zhang, Ziyang, Alon, Assaf, Schadt, Heiko, O'Donnell, Henry R, Lyu, Jiankun, Rosales, Romel, McGovern, Briana L, Rathnasinghe, Raveen, Jangra, Sonia, Schotsaert, Michael, Galarneau, Jean-René, Krogan, Nevan J, Urban, Laszlo, Shokat, Kevan M, Kruse, Andrew C, García-Sastre, Adolfo, Schwartz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois, Shoichet, Brian K

المصدر: Science. 373(6554)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Infectious Diseases, Orphan Drug, Rare Diseases, Clinical Research, Emerging Infectious Diseases, Clinical Trials and Supportive Activities, Coronaviruses, 5.1 Pharmaceuticals, Good Health and Well Being, A549 Cells, Animals, Antiviral Agents, COVID-19, Cations, Chlorocebus aethiops, Dose-Response Relationship, Drug, Drug Repositioning, Female, Humans, Lipidoses, Mice, Microbial Sensitivity Tests, Phospholipids, SARS-CoV-2, Surface-Active Agents, Vero Cells, Virus Replication, COVID-19 Drug Treatment, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/41h684bv
https://escholarship.org/content/qt41h684bv/qt41h684bv.pdf

المؤلفون: Shin, Jung-Eun, Riesselman, Adam J, Kollasch, Aaron W, McMahon, Conor, Simon, Elana, Sander, Chris, Manglik, Aashish, Kruse, Andrew C, Marks, Debora S

المصدر: Nature communications. 12(1)

مصطلحات موضوعية: Humans, Proteins, Antibodies, Antigens, Protein Engineering, Computational Biology, Amino Acid Sequence, Genotype, Phenotype, Mutation, Algorithms, Neural Networks, Computer, Neural Networks, Computer

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3gt7q4tp

المؤلفون: Page, Julia E., Skiba, Meredith A., Do, Truc, Kruse, Andrew C., Walker, Suzanne

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2022 Jun . 119(26), 1-10.

URL الوصول: https://www.jstor.org/stable/27152847

المؤلفون: Pahil, Karanbir S., Gilman, Morgan S. A., Baidin, Vadim, Clairfeuille, Thomas, Mattei, Patrizio, Bieniossek, Christoph, Dey, Fabian, Muri, Dieter, Baettig, Remo, Lobritz, Michael, Bradley, Kenneth, Kruse, Andrew C., Kahne, Daniel

المصدر: Nature ; volume 631, issue 8022, page E18-E18 ; ISSN 0028-0836 1476-4687

الاتاحة: https://doi.org/10.1038/s41586-024-07645-0
https://www.nature.com/articles/s41586-024-07645-0.pdf
https://www.nature.com/articles/s41586-024-07645-0

المؤلفون: Gao, Yongqiang, Amon, Jeremy D., Brogan, Anna P., Artzi, Lior, Ramírez-Guadiana, Fernando H., Cofsky, Joshua C., Kruse, Andrew C., Rudner, David Z.

مصطلحات موضوعية: Research Papers

وصف الملف: text/html

Relation: http://genesdev.cshlp.org/cgi/content/short/38/1-2/31; http://dx.doi.org/10.1101/gad.351353.123

الاتاحة: http://genesdev.cshlp.org/cgi/content/short/38/1-2/31
https://doi.org/10.1101/gad.351353.123

المؤلفون: Pahil, Karanbir S., Gilman, Morgan S. A., Baidin, Vadim, Clairfeuille, Thomas, Mattei, Patrizio, Bieniossek, Christoph, Dey, Fabian, Muri, Dieter, Baettig, Remo, Lobritz, Michael, Bradley, Kenneth, Kruse, Andrew C., Kahne, Daniel

المصدر: Nature ; volume 625, issue 7995, page 572-577 ; ISSN 0028-0836 1476-4687

الاتاحة: http://dx.doi.org/10.1038/s41586-023-06799-7
https://www.nature.com/articles/s41586-023-06799-7.pdf
https://www.nature.com/articles/s41586-023-06799-7

المؤلفون: Erlandson, Sarah C., Wang, Jialu, Jiang, Haoran, Osei-Owusu, James, Rockman, Howard A., Kruse, Andrew C.

المساهمون: Damon Runyon Cancer Research Foundation, National Heart, Lung, and Blood Institute, Harvard Medical School, National Institute of General Medical Sciences

المصدر: Molecular Pharmaceutics ; volume 21, issue 9, page 4441-4449 ; ISSN 1543-8384 1543-8392

الاتاحة: http://dx.doi.org/10.1021/acs.molpharmaceut.4c00368
https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.4c00368

المؤلفون: Thaiprayoon, Apisitt, Chantarasorn, Yodpong, Oonanant, Worrapoj, Kasorn, Anongnard, Longsompurana, Phoomintara, Tapaneeyakorn, Satita, Riangrungroj, Pinpunya, Loison, Fabien, Kruse, Andrew C., DeLisa, Matthew P., Waraho-Zhmayev, Dujduan

المصدر: Scientific Reports; 1/28/2025, Vol. 15 Issue 1, p1-14, 14p

المؤلفون: Staus, Dean P, Wingler, Laura M, Choi, Minjung, Pani, Biswaranjan, Manglik, Aashish, Kruse, Andrew C, Lefkowitz, Robert J

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 115(15)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Allosteric Regulation, Aminoacyltransferases, Bacterial Proteins, Cysteine Endopeptidases, Humans, Phosphorylation, Receptor, Muscarinic M2, Receptors, Adrenergic, beta-2, Receptors, G-Protein-Coupled, Receptors, Opioid, mu, beta-Arrestin 1, G protein-coupled receptor, beta-arrestin, sortase, allostery, phosphorylation, β-arrestin

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3663568p

المؤلفون: McMahon, Conor, Baier, Alexander S, Pascolutti, Roberta, Wegrecki, Marcin, Zheng, Sanduo, Ong, Janice X, Erlandson, Sarah C, Hilger, Daniel, Rasmussen, Søren GF, Ring, Aaron M, Manglik, Aashish, Kruse, Andrew C

المصدر: Nature Structural & Molecular Biology. 25(3)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Immunization, Biotechnology, Generic health relevance, Antibody Specificity, Antigens, Cell Separation, Cell Surface Display Techniques, Flow Cytometry, Humans, Protein Conformation, Receptors, G-Protein-Coupled, Single-Domain Antibodies, Yeasts, Chemical Sciences, Medical and Health Sciences, Biophysics, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/41j4n2wz
https://escholarship.org/content/qt41j4n2wz/qt41j4n2wz.pdf

المؤلفون: Korczynska, Magdalena, Clark, Mary J, Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R, Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C, Lyda, Brent R, May, Lauren T, Baltos, Jo-Anne, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur, Shoichet, Brian K, Sunahara, Roger K

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 115(10)

مصطلحات موضوعية: Animals, Humans, Rats, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Receptor, Muscarinic M2, Muscarinic Agonists, Ligands, Allosteric Regulation, Allosteric Site, Protein Binding, Phosphorylation, Kinetics, Molecular Docking Simulation, GPCR, PAM antagonist, docking, structure-based ligand discovery, subtype selectivity, Prevention, Neurosciences, 5.1 Pharmaceuticals, 1.1 Normal biological development and functioning, Development of treatments and therapeutic interventions, Underpinning research

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/1d24t5gm

المؤلفون: Shlosman, Irina, Fivenson, Elayne M., Gilman, Morgan S. A., Sisley, Tyler A., Walker, Suzanne, Bernhardt, Thomas G., Kruse, Andrew C., Loparo, Joseph J.

المساهمون: U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases, U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

الاتاحة: http://dx.doi.org/10.1038/s41467-023-39037-9
https://www.nature.com/articles/s41467-023-39037-9.pdf
https://www.nature.com/articles/s41467-023-39037-9

المؤلفون: McMahon, Conor, Staus, Dean P., Wingler, Laura M., Wang, Jialu, Skiba, Meredith A., Elgeti, Matthias, Hubbell, Wayne L., Rockman, Howard A., Kruse, Andrew C., Lefkowitz, Robert J.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2020 Aug . 117(33), 20284-20291.

URL الوصول: https://www.jstor.org/stable/26968626

المؤلفون: Yu, Chunxiao, Wang, Longfei, Rowe, R. Grant, Han, Areum, Ji, Wanying, McMahon, Conor, Baier, Alexander S., Huang, Yu-Chung, Marion, William, Pearson, Daniel S., Kruse, Andrew C., Daley, George Q., Wu, Hao, Sliz, Piotr

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2020 Mar 01. 117(9), 4653-4663.

URL الوصول: https://www.jstor.org/stable/26929159

المؤلفون: Manglik, Aashish, Kruse, Andrew C

المصدر: Biochemistry. 56(42)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, Crystallography, X-Ray, Humans, Receptors, G-Protein-Coupled, Signal Transduction, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3k69x55m

المؤلفون: Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J

المصدر: Nature. 535(7612)

مصطلحات موضوعية: Humans, Isoproterenol, Receptors, Adrenergic, beta-2, Ligands, Crystallography, X-Ray, Nuclear Magnetic Resonance, Biomolecular, Allosteric Regulation, Allosteric Site, Protein Conformation, Models, Molecular, Drug Partial Agonism, Protein Stability, Adrenergic beta-2 Receptor Agonists, Single-Domain Antibodies, Crystallography, X-Ray, Models, Molecular, Nuclear Magnetic Resonance, Biomolecular, Receptors, Adrenergic, beta-2, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4sf4012j

المؤلفون: Schmidt, Hayden R, Zheng, Sanduo, Gurpinar, Esin, Koehl, Antoine, Manglik, Aashish, Kruse, Andrew C

المصدر: Nature. 532(7600)

مصطلحات موضوعية: Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Brain Disorders, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Aetiology, 2.1 Biological and endogenous factors, Generic health relevance, Benzamides, Binding Sites, Crystallography, X-Ray, Endoplasmic Reticulum, Humans, Hydrophobic and Hydrophilic Interactions, Intracellular Membranes, Isoxazoles, Ligands, Models, Molecular, Piperidines, Protein Structure, Tertiary, Pyridines, Receptors, sigma, Substrate Specificity, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3jh9959v