المؤلفون: Kumar, Anmol, Mutter, Stefan, Parente, Erika B., Harjutsalo, Valma, Lithovius, Raija, Mathavan, Sinnakaruppan, Lehto, Markku, Hiltunen, Timo P., Kontula, Kimmo K., Groop, Per-Henrik

المساهمون: HUS Abdominal Center, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, Nefrologian yksikkö, Research Programs Unit, HUS Internal Medicine and Rehabilitation, Department of Medicine

مصطلحات موضوعية: Endothelial growth-factor, Smooth-muscle-cells, Diabetic-retinopathy, Secretion, Therapy, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: http://hdl.handle.net/10138/358407; 85152601199; 000970963500025

الاتاحة: http://hdl.handle.net/10138/358407

المؤلفون: McDonough, Caitrin W., Warren, Helen R., Jack, John R., Motsinger-Reif, Alison A., Armstrong, Nicole D., Bis, Joshua C., House, John S., Singh, Sonal, El Rouby, Nihal M., Gong, Yan, Mychaleckyj, Joesyf C., Rotroff, Daniel M., Benavente, Oscar R., Caulfield, Mark J., Doria, Alessandrio, Pepine, Carl J., Psaty, Bruce M., Glorioso, Valeria, Glorioso, Nicola, Hiltunen, Timo P., Kontula, Kimmo K., Arnett, Donna K., Buse, John B., Irvin, Marguerite R., Johnson, Julie A., Munroe, Patricia B., Wagner, Michael J., Cooper-DeHoff, Rhonda M.

المساهمون: HUS Internal Medicine and Rehabilitation, Kimmo Kontula Research Group, Clinicum, Department of Medicine, CAMM - Research Program for Clinical and Molecular Metabolism

مصطلحات موضوعية: CORONARY-ARTERY-DISEASE, BLOOD-PRESSURE, GENE POLYMORPHISMS, ASSOCIATION, RISK, HYPERTENSION, PREVENTION, DESIGN, TRIAL, RATIONALE, Pharmacy

وصف الملف: application/pdf

Relation: C.W. M. is supported by National Institutes of Health (NIH) grant K01 HL141690. ASCOT was funded by the National Institutes for Health Research (NIHR) as part of the portfolio of translational research of the NIHR Barts Biomedical Research Unit and the NIHR Biomedical Research Centre at Imperial College, the International Centre for Circulatory Health Charity, and the Medical Research Council through G952010. ACCORD research was supported by NIH grants R01 HL110380 and R01 HL110400, and intramural funds from the National Institute of Environmental Health Sciences. ACCORD cohort was supported by Contract Nos. N01-HC-95178, N01-HC-95179, N01-HC-95180, N01-HC-95181, N01-HC-95182, N01-HC-95183, N01-HC-95184, IAA #Y1-HC-9035, and IAA #Y1-HC-1010 from the National Heart, Lung, and Blood Institute (NHLBI), with additional support from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Eye Institute (NEI), the National Institute on Aging (NIA), and the Centers for Disease Control and Prevention (CDC). INVEST was supported by the NIH grants R01 HL074730, U01 GM074492, and NIH CTSA grant UL1 RR092890, as well as grants from the University of Florida Opportunity Fund and Abbott Pharmaceuticals. The genome-wide genotyping for INVEST--GENES was provided by RIKEN. SPS3 was supported by NIH grants R01 NS073346, U01 GM074492-05S109, and U01 NS038529. Infrastructure for the CHARGE Consortium and the CHARGE Pharmacogenetics Working Group is supported in part by the NHLBI grants R01 HL105756, R01 HL103612, and R01 HL085251, and CHS contract number 75N92021D00006. Study descriptions and acknowledgements for the participating CHARGE cohorts are available in https://doi.org/10.1371/journal.pone.0140496.Both the PEAR and PEAR-2 studies were supported by NIH grants U01-GM074492 and UL1 TR000064 (University of Florida); UL1 TR000454 (Emory University), and UL1 TR000135 (Mayo Clinic). PEAR was also supported by funds from the Mayo Foundation. LIFE-Fin and GENRES were supported by the Sigrid Juselius Foundation, The Finnish Foundation for Cardiovascular Research, and the Helsinki University Central Hospital. BB-SS studies were supported by the HYPERGENES project (FP7-HEALTHF4-2007-201550), InterOmics (PB05 MIUR--CNR Italian Flagship Project), and the "Associazione per lo sviluppo della ricerca sull'ipertensione arteriosa e sulle malattie cardiovascolari-ONLUS." GenHAT was supported by NIH grants R01 HL123782 and R01 HL063082, and N.A. was also supported by NIH grant T32 HL007457.; McDonough , C W , Warren , H R , Jack , J R , Motsinger-Reif , A A , Armstrong , N D , Bis , J C , House , J S , Singh , S , El Rouby , N M , Gong , Y , Mychaleckyj , J C , Rotroff , D M , Benavente , O R , Caulfield , M J , Doria , A , Pepine , C J , Psaty , B M , Glorioso , V , Glorioso , N , Hiltunen , T P , Kontula , K K , Arnett , D K , Buse , J B , Irvin , M R , Johnson , J A , Munroe , P B , Wagner , M J & Cooper-DeHoff , R M 2021 , ' Adverse Cardiovascular Outcomes and Antihypertensive Treatment : A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies ' , Clinical Pharmacology and Therapeutics , vol. 110 , no. 3 , pp. 723-732 . https://doi.org/10.1002/cpt.2355; ORCID: /0000-0001-7011-0422/work/100975867; http://hdl.handle.net/10138/568320; d3361e4a-c6e4-44c7-9645-be4f6ab33ebb; 000684936700001

الاتاحة: http://hdl.handle.net/10138/568320

المؤلفون: Nuotio, Marja-Liisa, Tähtisalo, Heini Sanez, Lahtinen, Alexandra, Donner, Kati, Fyhrquist, Frej, Perola, Markus, Kontula, Kimmo K., Hiltunen, Timo P.

المساهمون: Quantitative Genetics, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, HUS Internal Medicine and Rehabilitation, Research Program in Systems Oncology, Sampsa Hautaniemi / Principal Investigator, Biosciences, Institute for Molecular Medicine Finland, Clinicum, Kimmo Kontula Research Group, Department of Medicine

مصطلحات موضوعية: Epigenomics, hypertension, pharmacogenetics, precision medicine, BLOOD-PRESSURE RESPONSE, DNA METHYLATION, LOCI, ASSOCIATION, EXPRESSION, LOSARTAN, HYDROCHLOROTHIAZIDE, EPIGENETICS, PREDICTORS, Biochemistry, cell and molecular biology, Genetics, developmental biology, physiology

وصف الملف: application/pdf

Relation: This work was supported by the Sigrid Juselius Foundation (Sigrid Juseliuksen saatio) under Grant Sigrid Juseliuksen Saatio 20032019KK and the Finnish Foundation for Cardiovascular Research (Sydantutkimussaatio) under Grant Sydantutkimussaatio 08042019KK. No other conflicts of interest to declare.; Nuotio , M-L , Tähtisalo , H S , Lahtinen , A , Donner , K , Fyhrquist , F , Perola , M , Kontula , K K & Hiltunen , T P 2022 , ' Pharmacoepigenetics of hypertension : genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design ' , Epigenetics , vol. 17 , no. 11 , 2038418 , pp. 1432-1445 . https://doi.org/10.1080/15592294.2022.2038418; ORCID: /0000-0001-7011-0422/work/122638455; ORCID: /0000-0001-7179-2680/work/122643387; ORCID: /0000-0001-6896-3135/work/122646278; ORCID: /0000-0001-9190-4336/work/155648776; http://hdl.handle.net/10138/350493; e3445784-33cc-43f2-9ff7-10f90047dbe9; 000761728600001

الاتاحة: http://hdl.handle.net/10138/350493

المؤلفون: Fontana, Vanessa, Turner, Richard Myles, Francis, Ben, Yin, Peng, Pütz, Benno, Hiltunen, Timo P., Ruotsalainen, Sanni, Kontula, Kimmo K., Müller-Myhsok, Bertam, Pirmohamed, Munir

المساهمون: HUS Internal Medicine and Rehabilitation, Kimmo Kontula Research Group, Clinicum, Department of Medicine, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism, Institute for Molecular Medicine Finland, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Research Programs Unit

مصطلحات موضوعية: bisoprolol, pharmacokinetics, genome-wide association, PHARMACOGENETICS IMPLEMENTATION CONSORTIUM, CYP2D6 GENOTYPE, RECOMMENDATIONS, APOPTOSIS, CCDC34, CANCER, Pharmacy

وصف الملف: application/pdf

Relation: This work was supported by the UK Medical Research Council (MR/S000933/1); and the UK Academy of Medical Sciences/Newton Fund (NIF001/1001) , We want to thank all patients who participate in the studies, the research nurses for collecting the data and laboratory technicians for processing and storage of biological specimens.; Fontana , V , Turner , R M , Francis , B , Yin , P , Pütz , B , Hiltunen , T P , Ruotsalainen , S , Kontula , K K , Müller-Myhsok , B & Pirmohamed , M 2022 , ' Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol ' , Pharmacogenomics and personalized medicine , vol. 15 , pp. 249-260 . https://doi.org/10.2147/PGPM.S352719; ORCID: /0000-0001-7011-0422/work/111916638; http://hdl.handle.net/10138/342921; 4ded6cba-e3e8-42a6-94c1-767d2d776740; 000777020500001

الاتاحة: http://hdl.handle.net/10138/342921

المؤلفون: Fontana,Vanessa, Turner,Richard Myles, Francis,Ben, Yin,Peng, Pütz,Benno, Hiltunen,Timo P, Ruotsalainen,Sanni, Kontula,Kimmo K, Müller-Myhsok,Bertram, Pirmohamed,Munir

مصطلحات موضوعية: Pharmacogenomics and Personalized Medicine

وصف الملف: text/html

Relation: https://www.dovepress.com/chromosomal-region-11p141-is-associated-with-pharmacokinetics-and-phar-peer-reviewed-fulltext-article-PGPM

الاتاحة: https://www.dovepress.com/chromosomal-region-11p141-is-associated-with-pharmacokinetics-and-phar-peer-reviewed-fulltext-article-PGPM

المؤلفون: Ala-Mutka, Eero M., Rimpelä, Jenni M., Fyhrquist, Frej, Kontula, Kimmo K., Hiltunen, Timo P.

المساهمون: Clinicum, University of Helsinki, Department of Medicine, Kimmo Kontula Research Group, HUS Internal Medicine and Rehabilitation

مصطلحات موضوعية: hydrochlorothiazide, pharmacogenomics, uric acid, GROWTH-FACTOR 23, ANTIHYPERTENSIVE DRUG RESPONSES, CHRONIC KIDNEY-DISEASE, HYPERURICEMIA, LIFE, TRANSPORTER, REDUCTION, MORTALITY, EXCRETION, OUTCOMES, Pharmacy

وصف الملف: application/pdf

Relation: The present study was supported by grants from The Sigrid Juselius Foundation and The Finnish Foundation for Cardiovascular Research. EM Ala-Mutka, JM Rimpela, F Fyhrquist, KK Kontula and TP Hiltunen have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.; Ala-Mutka , E M , Rimpelä , J M , Fyhrquist , F , Kontula , K K & Hiltunen , T P 2018 , ' Effect of hydrochlorothiazide on serum uric acid concentration : a genome-wide association study ' , Pharmacogenomics , vol. 19 , no. 6 , pp. 517-527 . https://doi.org/10.2217/pgs-2017-0184; ORCID: /0000-0001-7011-0422/work/45821494; http://hdl.handle.net/10138/326994; b39136d2-6140-4912-bf7f-4cd630f390d4; 85045435706; 000432942300002

الاتاحة: http://hdl.handle.net/10138/326994

المؤلفون: Sánez Tähtisalo, Heini, Ruotsalainen, Sanni, Mars, Nina, Porthan, Kimmo, Oikarinen, Lasse, Virolainen, Juha, Fyhrquist, Frej, Ripatti, Samuli, Kontula, Kimmo K., Hiltunen, Timo P.

المساهمون: HUS Internal Medicine and Rehabilitation, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, Institute for Molecular Medicine Finland, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Helsinki Institute of Life Science HiLIFE, Kardiologian yksikkö, HUS Heart and Lung Center, Department of Medicine, Doctoral Programme in Social Sciences, Centre of Excellence in Complex Disease Genetics, Department of Public Health, University Management, Biostatistics Helsinki, Clinicum, Department of Biochemistry and Developmental Biology, Kimmo Kontula Research Group

مصطلحات موضوعية: BLOOD-PRESSURE RESPONSE, GENOME-WIDE ASSOCIATION, GENETIC-VARIATION, VARIANTS, LOSARTAN, COMMON, LOCI, Genetics, developmental biology, physiology, Biochemistry, cell and molecular biology, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: This research was funded by Sigrid Juselius Foundation, Grant Number 20032019KK and Finnish Foundation for Cardiovascular Research, Grant Number 08042019KK.; Sánez Tähtisalo , H , Ruotsalainen , S , Mars , N , Porthan , K , Oikarinen , L , Virolainen , J , Fyhrquist , F , Ripatti , S , Kontula , K K & Hiltunen , T P 2020 , ' Human essential hypertension : no significant association of polygenic risk scores with antihypertensive drug responses ' , Scientific Reports , vol. 10 , no. 1 , 11940 . https://doi.org/10.1038/s41598-020-68878-3; ORCID: /0000-0001-7011-0422/work/89114664; ORCID: /0000-0001-6896-3135/work/89117884; ORCID: /0000-0002-7259-5993/work/124843802; http://hdl.handle.net/10138/319116; 8a946497-9e1d-4bfd-b165-0682f0d4dc83; 000553550700010

الاتاحة: http://hdl.handle.net/10138/319116

المؤلفون: Sánez Tähtisalo, Heini, Hiltunen, Timo P., Kenttä, Tuomas, Junttila, Juhani, Oikarinen, Lasse, Virolainen, Juha, Kontula, Kimmo K., Porthan, Kimmo

المساهمون: HUS Internal Medicine and Rehabilitation, Department of Medicine, University of Helsinki, Helsinki University Hospital Area, CAMM - Research Program for Clinical and Molecular Metabolism, Research Programs Unit, Faculty of Medicine, HUS Heart and Lung Center, Kardiologian yksikkö, Clinicum

مصطلحات موضوعية: General medicine, internal medicine and other clinical medicine, LEFT-VENTRICULAR HYPERTROPHY, T-WAVE MORPHOLOGY, QT INTERVAL, INTERLEAD HETEROGENEITY, PREDICTIVE-VALUE, INCREASED RISK, ALL-CAUSE, DEATH, POPULATION, HYPERTENSION

وصف الملف: application/pdf

Relation: Sánez Tähtisalo , H , Hiltunen , T P , Kenttä , T , Junttila , J , Oikarinen , L , Virolainen , J , Kontula , K K & Porthan , K 2020 , ' Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study ' , PLoS One , vol. 15 , no. 3 , 0230655 . https://doi.org/10.1371/journal.pone.0230655; RIS: urn:693135AE45CAF02F2623ECD52E0BAF7E; ORCID: /0000-0001-7011-0422/work/75944627; ORCID: /0000-0001-6896-3135/work/75947200; http://hdl.handle.net/10138/316154; 40c71322-0746-4771-828c-6b112f3d3e06; 000535305100032

الاتاحة: http://hdl.handle.net/10138/316154

المؤلفون: Singh, Sonal, Warren, Helen R., Hiltunen, Timo P., McDonough, Caitrin W., El Rouby, Nihal, Salvi, Erika, Wang, Zhiying, Garofalidou, Tatiana, Fyhrquist, Frej, Kontula, Kimmo K., Glorioso, Valeria, Zaninello, Roberta, Glorioso, Nicola, Pepine, Carl J., Munroe, Patricia B., Turner, Stephan T., Chapman, Arlene B., Boerwinkle, Eric, Johnson, Julie A., Gong, Yan, Cooper‐DeHoff, Rhonda M.

المصدر: Journal of the American Heart Association ; volume 8, issue 16 ; ISSN 2047-9980

الاتاحة: http://dx.doi.org/10.1161/jaha.119.013115
https://www.ahajournals.org/doi/full/10.1161/JAHA.119.013115

المؤلفون: Rimpelä, Jenni M., Pörsti, Ilkka H., Jula, Antti, Lehtimäki, Terho, Niiranen, Teemu J., Oikarinen, Lasse, Porthan, Kimmo, Tikkakoski, Antti, Virolainen, Juha, Kontula, Kimmo K., Hiltunen, Timo P.

المساهمون: Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere

مصطلحات موضوعية: blood pressure dipping, genome-wide, circadian gene, BCL11B, ERAP2, left ventricular hypertrophy, Sisätaudit - Internal medicine

وصف الملف: fulltext

Relation: 110; BMC Medical Genetics; 19; https://trepo.tuni.fi/handle/10024/104233; URN:NBN:fi:uta-201809102503

الاتاحة: https://trepo.tuni.fi/handle/10024/104233

المؤلفون: Rimpelä, Jenni M., Kontula, Kimmo K., Fyhrquist, Frej, Donner, Kati M., Tuiskula, Annukka M., Sarin, Antti-Pekka, Mohney, Rob, Stirdivant, Steven, Hiltunen, Timo P.

المساهمون: Clinicum, Kimmo Kontula Research Group, Department of Medicine, Institute for Molecular Medicine Finland, HUS Internal Medicine and Rehabilitation

مصطلحات موضوعية: Pharmacy

وصف الملف: application/pdf

Relation: Rimpelä , J M , Kontula , K K , Fyhrquist , F , Donner , K M , Tuiskula , A M , Sarin , A-P , Mohney , R , Stirdivant , S & Hiltunen , T P 2017 , ' Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses ' , Pharmacogenomics , vol. 18 , no. 5 , pp. 445-458 . https://doi.org/10.2217/pgs-2016-0204; ORCID: /0000-0001-7011-0422/work/34564515; ORCID: /0000-0001-9190-4336/work/155648767; http://hdl.handle.net/10138/195646; d47b0819-6426-414c-8098-5a9a78156b2c; 85016805715; 000399336200005

الاتاحة: http://hdl.handle.net/10138/195646

المؤلفون: Hiltunen, Timo P., Rimpela, Jenni M., Mohney, Robert P., Stirdivant, Steven M., Kontula, Kimmo K.

المساهمون: Clinicum, Kimmo Kontula Research Group, Department of Medicine, University of Helsinki, HUS Internal Medicine and Rehabilitation

مصطلحات موضوعية: BLOOD-PRESSURE RESPONSE, GENOMIC ASSOCIATION ANALYSIS, CARDIOVASCULAR EVENTS, L-CARNITINE, HYDROCHLOROTHIAZIDE, ACYLCARNITINES, DISEASE, WIDE, PREDICTORS, LOSARTAN, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: The present study was supported by grants from The Sigrid Juselius Foundation and The Finnish Foundation for Cardiovascular Research. These foundations provided support in the form of salary to the study technician (but not to any of the authors) and in the form of full coverage of the metabolomic analyses, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Metabolon Inc. performed the metabolomic analyses on a fully commercial (fee per sample) basis. Metabolon Inc. had no role in the funding or planning of the study, nor did the authors (RPM and SMS) employed by it.; Hiltunen , T P , Rimpela , J M , Mohney , R P , Stirdivant , S M & Kontula , K K 2017 , ' Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension ' , PLoS One , vol. 12 , no. 11 , 0187729 . https://doi.org/10.1371/journal.pone.0187729; ORCID: /0000-0001-7011-0422/work/39238279; http://hdl.handle.net/10138/229016; 0d590d5e-352b-40da-b33d-9bfd7b035814; 85033446088; 000414769900067

الاتاحة: http://hdl.handle.net/10138/229016

المؤلفون: Salvi, Erika, Wang, Zhiying, Rizzi, Federica, Gong, Yan, McDonough, Caitrin W., Padmanabhan, Sandosh, Hiltunen, Timo P., Lanzani, Chiara, Zaninello, Roberta, Chittani, Martina, Bailey, Kent R., Sarin, Antti-Pekka, Barcella, Matteo, Melander, Olle, Chapman, Arlene B., Manunta, Paolo, Kontula, Kimmo K., Glorioso, Nicola, Cusi, Daniele, Dominiczak, Anna F., Johnson, Julie A., Barlassina, Cristina, Boerwinkle, Eric, Cooper-DeHoff, Rhonda M., Turner, Stephen T.

المصدر: Hypertension ; volume 69, issue 1, page 51-59 ; ISSN 0194-911X 1524-4563

الاتاحة: http://dx.doi.org/10.1161/hypertensionaha.116.08267
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.116.08267

المؤلفون: Rimpelä, Jenni M, Kontula, Kimmo K, Fyhrquist, Frej, Donner, Kati M, Tuiskula, Annukka M, Sarin, Antti-Pekka, Mohney, Robert P, Stirdivant, Steven M, Hiltunen, Timo P

المساهمون: The Sigrid Juselius Foundation, The Finnish Foundation for Cardiovascular Research

المصدر: Pharmacogenomics ; volume 18, issue 5, page 445-458 ; ISSN 1462-2416 1744-8042

الاتاحة: http://dx.doi.org/10.2217/pgs-2016-0204
https://www.tandfonline.com/doi/pdf/10.2217/pgs-2016-0204

المؤلفون: Backlund, Michael, Paukku, Kirsi, Kontula, Kimmo K., Lehtonen, Jukka Y. A.

المساهمون: Clinicum, Department of Medicine, Kimmo Kontula Research Group, Kardiologian yksikkö

مصطلحات موضوعية: TYPE-1 RECEPTOR EXPRESSION, ARTERY ENDOTHELIAL-CELLS, ANGIOTENSIN-II RECEPTOR, OXIDATIVE STRESS, MYOCARDIAL-INFARCTION, PROTEIN TRANSLATION, UP-REGULATION, KAPPA-B, GRANULES, TIA-1, Biochemistry, cell and molecular biology, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: Finnish Cultural Foundation; Paavo Nurmi Foundation; Maud Kuistila Memorial Foundation; Ida Montin Foundation (to M.B.); Finnish Foundation for Cardiovascular Research; Sigrid Juselius Foundation (to K.K.); Finnish Medical Foundation; Instrumentarium Research Foundation (to J.L.). Funding for open access charge: Foundation for cardiovascular research.; Backlund , M , Paukku , K , Kontula , K K & Lehtonen , J Y A 2016 , ' Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism ' , Nucleic Acids Research , vol. 44 , no. 7 , pp. 3095-3104 . https://doi.org/10.1093/nar/gkv1368; http://hdl.handle.net/10138/163191; a269d0d0-122e-46d5-b31c-0834f530ef7c; 84965114539; 000375800200021

الاتاحة: http://hdl.handle.net/10138/163191

المؤلفون: Paukku, Kirsi, Backlund, Michael, De Boer, Rudolf A., Kalkkinen, Nisse, Kontula, Kimmo K., Lehtonen, Jukka Y. A.

المساهمون: Research Programs Unit, Research Programme of Molecular Medicine, Institute of Biotechnology, Protein Chemistry, Clinicum, Department of Medicine, Yleissisätautien yksikkö, Kardiologian yksikkö

مصطلحات موضوعية: RECEPTOR GENE-EXPRESSION, SMOOTH-MUSCLE-CELLS, ANGIOTENSIN-ALDOSTERONE-SYSTEM, TYPE-2 DIABETES-MELLITUS, RNA-BINDING-PROTEINS, MESSENGER-RNA, UP-REGULATION, INFLAMMATORY RESPONSE, AT(1) RECEPTOR, PROLIFERATION, Biomedicine, General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

Relation: Paukku , K , Backlund , M , De Boer , R A , Kalkkinen , N , Kontula , K K & Lehtonen , J Y A 2012 , ' Regulation of AT1R expression through HuR by insulin ' , Nucleic Acids Research , vol. 40 , no. 12 , pp. 5250-5261 . https://doi.org/10.1093/nar/gks170; http://hdl.handle.net/10138/162472; c5117c6d-daab-4a72-897b-7f161c9c1279; 84863207113; 000305829000015

الاتاحة: http://hdl.handle.net/10138/162472

المؤلفون: Backlund, Michael, Paukku, Kirsi, Kontula, Kimmo K., Lehtonen, Jukka Y.A.

المصدر: Nucleic Acids Research ; volume 44, issue 7, page 3095-3104 ; ISSN 0305-1048 1362-4962

الاتاحة: http://dx.doi.org/10.1093/nar/gkv1368
http://academic.oup.com/nar/article-pdf/44/7/3095/7475035/gkv1368.pdf

المؤلفون: Hiltunen, Timo P., Donner, Kati M., Sarin, Antti‐Pekka, Saarela, Janna, Ripatti, Samuli, Chapman, Arlene B., Gums, John G., Gong, Yan, Cooper‐DeHoff, Rhonda M., Frau, Francesca, Glorioso, Valeria, Zaninello, Roberta, Salvi, Erika, Glorioso, Nicola, Boerwinkle, Eric, Turner, Stephen T., Johnson, Julie A., Kontula, Kimmo K.

المصدر: Journal of the American Heart Association ; volume 4, issue 1 ; ISSN 2047-9980

الاتاحة: http://dx.doi.org/10.1161/jaha.114.001521
https://www.ahajournals.org/doi/full/10.1161/JAHA.114.001521

المؤلفون: Hickok, Noreen J., Seppänen, Pauli J., Kontula, Kimmo K., Jänne, Pasi A., Bardin, C. Wayne, Jänne, Olli A.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1986 Feb 01. 83(3), 594-598.

URL الوصول: https://www.jstor.org/stable/27387

المؤلفون: Kontula, Kimmo K., Torkkeli, Tuula K., Bardin, C. Wayne, Janne, Olli A.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1984 Feb 01. 81(3), 731-735.

URL الوصول: https://www.jstor.org/stable/23683