المؤلفون: Klitgaard, Mette, Jacobsen, Jette, Kristensen, Maja Nørgaard, Berthelsen, Ragna, Müllertz, Anette

المساهمون: Lundbeck Foundation, Danmarks Grundforskningsfond, Villum Fonden, Copenhagen University

المصدر: Drug Delivery and Translational Research ; ISSN 2190-393X 2190-3948

الاتاحة: http://dx.doi.org/10.1007/s13346-024-01574-1
https://link.springer.com/content/pdf/10.1007/s13346-024-01574-1.pdf
https://link.springer.com/article/10.1007/s13346-024-01574-1/fulltext.html

المؤلفون: Klitgaard, Mette, Mullertz, Anette, Berthelsen, Ragna

المصدر: Klitgaard , M , Mullertz , A & Berthelsen , R 2021 , ' Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method ' , Pharmaceutics , vol. 13 , no. 4 , 489 . https://doi.org/10.3390/pharmaceutics13040489

مصطلحات موضوعية: in vivo–, in vitro correlation, lipolysis-permeation, lipid-based drug delivery system, PermeaPad, cinnarizine, lipolysis

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/estimating-the-oral-absorption-from-selfnanoemulsifying-drug-delivery-systems-using-an-in-vitro-lipolysispermeation-method(56cda346-04df-4910-9bf0-7c47d7d8cb41).html
https://doi.org/10.3390/pharmaceutics13040489
https://curis.ku.dk/ws/files/263033907/pharmaceutics_13_00489_v2.pdf

المؤلفون: Falavigna, Margherita, Brurok, Sunniva, Klitgaard, Mette, Flaten, Goril Eide

المصدر: Falavigna , M , Brurok , S , Klitgaard , M & Flaten , G E 2021 , ' Simultaneous assessment of in vitro lipolysis and permeation in the mucus-PVPA model to predict oral absorption of a poorly water soluble drug in SNEDDSs ' , International Journal of Pharmaceutics , vol. 596 , 120258 . https://doi.org/10.1016/j.ijpharm.2021.120258

مصطلحات موضوعية: In vivo-in vitro correlation (IVIVC), In vitro permeation, In vitro lipolysis, Lipid-based formulation, Oral drug delivery, Poorly water-soluble drugs

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/simultaneous-assessment-of-in-vitro-lipolysis-and-permeation-in-the-mucuspvpa-model-to-predict-oral-absorption-of-a-poorly-water-soluble-drug-in-sneddss(f17994f1-d514-49bf-9ff3-0540a5af1ff2).html
https://doi.org/10.1016/j.ijpharm.2021.120258
https://curis.ku.dk/ws/files/317091576/392180603.pdf

المؤلفون: Falavigna, Margherita, Klitgaard, Mette, Berthelsen, Ragna, Muellertz, Anette, Flaten, Goril Eide

المصدر: Falavigna , M , Klitgaard , M , Berthelsen , R , Muellertz , A & Flaten , G E 2021 , ' Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model ' , Journal of Pharmaceutical Sciences , vol. 110 , no. 1 , pp. 208-216 . https://doi.org/10.1016/j.xphs.2020.08.026

مصطلحات موضوعية: Gastrointestinal tract, In vitro/in vivo (IVIVC) correlation, In vitro model, Lipid-based formulation, Oral drug delivery, Permeability, Poorly water-soluble drug, Precipitation, Self-emulsifying, VESICLE-BASED BARRIER, WATER-SOLUBLE DRUGS, PERMEATION ASSAY, VIVO PERFORMANCE, FORMULATIONS, TRANSPORT, EFFICIENT

وصف الملف: application/pdf

الاتاحة: https://researchprofiles.ku.dk/da/publications/predicting-oral-absorption-of-fenofibrate-in-lipidbased-drug-delivery-systems-by-combining-in-vitro-lipolysis-with-the-mucuspvpa-permeability-model(a98cb5f1-187b-4cda-9815-b07f626a9380).html
https://doi.org/10.1016/j.xphs.2020.08.026
https://curis.ku.dk/ws/files/313052508/425292933.pdf

المؤلفون: Klitgaard, Mette, Kristensen, Maja Nørgaard, Venkatasubramanian, Ramakrishnan, Guerra, Priscila, Jacobsen, Jette, Berthelsen, Ragna, Rades, Thomas, Müllertz, Anette

المصدر: Klitgaard , M , Kristensen , M N , Venkatasubramanian , R , Guerra , P , Jacobsen , J , Berthelsen , R , Rades , T & Müllertz , A 2023 , ' Assessing acute colitis induced by dextran sulfate sodium in rats and its impact on gastrointestinal fluids ' , Drug Delivery and Translational Research , vol. 13 , pp. 1484–1499 .

مصطلحات الفهرس: Bile salts, Charged aerosol detection, DSS-induced colitis, Lipids, Luminal pH, article

URL: https://curis.ku.dk/portal/da/publications/assessing-acute-colitis-induced-by-dextran-sulfate-sodium-in-rats-and-its-impact-on-gastrointestinal-fluids(f7d45c01-2073-4514-90d9-5702d4859f07).html
https://doi.org/10.1007/s13346-023-01313-y

المؤلفون: Falavigna, Margherita, Klitgaard, Mette, Steene, Erik, Flaten, Gøril Eide

مصطلحات موضوعية: VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728, In vitro model, pH-dependent permeability, pH-dependent solubility, Mucus, FaSSIF/FeSSIF, Simulated intestinal fluids

Relation: Falavigna, M. (2021). The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model. (Doctoral thesis). https://hdl.handle.net/10037/20754 .; European Journal of Pharmaceutical Sciences; Falavigna, M., Klitgaard, M., Steene, E. & Flaten, G.E. (2019). Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model: The impact of pH and simulated intestinal fluids on drug permeability. European Journal of Pharmaceutical Sciences, 132 44-54. https://doi.org/10.1016/j.ejps.2019.02.035; FRIDAID 1682489; https://doi.org/10.1016/j.ejps.2019.02.035; https://hdl.handle.net/10037/14923

الاتاحة: https://hdl.handle.net/10037/14923
https://doi.org/10.1016/j.ejps.2019.02.035

المؤلفون: Falavigna, Margherita, Klitgaard, Mette, Brase, Christina, Ternullo, Selenia, Skalko-Basnet, Natasa, Flaten, Gøril Eide

مصطلحات موضوعية: VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728, VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728, In vitro model, Permeability, Mucosal administration, Mucus, Liposomes, Mucoadhesive, Mucopenetrating

Relation: Falavigna, M. (2021). The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model. (Doctoral thesis). https://hdl.handle.net/10037/20754 .; International Journal of Pharmaceutics; Falavigna, M., Klitgaard, M., Brase, C., Ternullo, S., Škalko-Basnet, N. & Flaten, G.E.F. (2018). Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay): An artificial permeability tool for drug screening and formulation development. International Journal of Pharmaceutics, 537 (1-2), 213-222. https://doi.org/10.1016/j.ijpharm.2017.12.038; FRIDAID 1535820; https://hdl.handle.net/10037/14570

الاتاحة: https://hdl.handle.net/10037/14570
https://doi.org/10.1016/j.ijpharm.2017.12.038

المؤلفون: Klitgaard, Mette, Beilles, Stephane, Sassene, Philip Jonas, Berthelsen, Ragna, Mullertz, Anette

المصدر: Klitgaard , M , Beilles , S , Sassene , P J , Berthelsen , R & Mullertz , A 2020 , ' Adding a Gastric Step to the Intestinal In Vitro Digestion Model Improves the Prediction of Pharmacokinetic Data in Beagle Dogs of Two Lipid-Based Drug Delivery Systems ' , Molecular Pharmaceutics , vol. 17 , no. 9 , pp. 3214-3222 . https://doi.org/10.1021/acs.molpharmaceut.0c00307

مصطلحات موضوعية: gastro-intestinal digestion, in vitro, in vivo, lipid-based drug delivery system, oral biopharmaceutical tools (OrBiTo), WATER-SOLUBLE DRUGS, LIPOLYSIS MODEL, GASTROINTESTINAL LIPOLYSIS, VIVO PERFORMANCE, FORMULATIONS, LIPASES, TESTS, BIOAVAILABILITY, ESTABLISHMENT, DISSOLUTION

الاتاحة: https://curis.ku.dk/portal/da/publications/adding-a-gastric-step-to-the-intestinal-in-vitro-digestion-model-improves-the-prediction-of-pharmacokinetic-data-in-beagle-dogs-of-two-lipidbased-drug-delivery-systems(1046f025-3b1f-421b-a86b-06743fc353d9).html
https://doi.org/10.1021/acs.molpharmaceut.0c00307

المؤلفون: Falavigna, Margherita, Klitgaard, Mette, Berthelsen, Ragna, Mullertz, Anette, Flaten, Gøril Eide

المصدر: Falavigna M, Klitgaard M, Berthelsen R, Mullertz A, Flaten gef. Predicting oral absorption of fenofibrate in lipid-based drug delivery systems by combining in vitro lipolysis with the mucus-PVPA permeability model. Jo

Relation: Falavigna, M. (2021). The development journey of an artificial intestinal model predicting oral drug absorption: the mucus-PVPA model. (Doctoral thesis). https://hdl.handle.net/10037/20754.

الاتاحة: https://hdl.handle.net/10037/20753

المؤلفون: Berthelsen, Ragna, Klitgaard, Mette, Rades, Thomas, Müllertz, Anette

المصدر: Berthelsen , R , Klitgaard , M , Rades , T & Müllertz , A 2019 , ' In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends ' , Advanced Drug Delivery Reviews , vol. 142 , pp. 35-49 . https://doi.org/10.1016/j.addr.2019.06.010

الاتاحة: https://researchprofiles.ku.dk/da/publications/in-vitro-digestion-models-to-evaluate-lipid-based-drug-delivery-systems-present-status-and-current-trends(8234b822-003f-4287-8564-e3bd738acbee).html
https://doi.org/10.1016/j.addr.2019.06.010

المؤلفون: Falavigna, Margherita, Klitgaard, Mette, Steene, Erik, Flaten, Gøril Eide

المصدر: Falavigna , M , Klitgaard , M , Steene , E & Flaten , G E 2019 , ' Mimicking regional and fasted/fed state conditions in the intestine with the mucus-PVPA in vitro model : The impact of pH and simulated intestinal fluids on drug permeability ' , European Journal of Pharmaceutical Sciences , vol. 132 , pp. 44-54 .

مصطلحات الفهرس: article

URL: https://curis.ku.dk/portal/da/publications/mimicking-regional-and-fastedfed-state-conditions-in-the-intestine-with-the-mucuspvpa-in-vitro-model(2c5eaa37-4c9b-4bd2-bb67-3ca324c02cdc).html
https://doi.org/10.1016/j.ejps.2019.02.035
https://curis.ku.dk/ws/files/250486511/Mimicking_regional_and_fasted_fed_state_conditions_in_the_intestine_with_the_mucus_PVPA_in_vitro_model_The_impact_of_pH_and_simulated_intestinal_fluids_on_drug_permeability_version_of_record_.pdf

المؤلفون: Klitgaard, Mette, Sassene, Philip Jonas, Selen, Arzu, Müllertz, Anette, Berthelsen, Ragna

المصدر: Klitgaard , M , Sassene , P J , Selen , A , Müllertz , A & Berthelsen , R 2017 , ' Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants ' , European Journal of Pharmaceutical Sciences , vol. 109 , pp. 191-199 . https://doi.org/10.1016/j.ejps.2017.08.003

مصطلحات موضوعية: Journal Article

الاتاحة: https://researchprofiles.ku.dk/da/publications/studying-furosemide-solubilization-using-an-in-vitro-model-simulating-gastrointestinal-digestion-and-drug-solubilization-in-neonates-and-young-infants(d997dd1b-8c06-4577-85d0-931ec57e1f7b).html
https://doi.org/10.1016/j.ejps.2017.08.003

المؤلفون: Falavigna, Margherita, Klitgaard, Mette, Brase, Christina, Ternullo, Selenia, Škalko-Basnet, Nataša, Flaten, Gøril Eide

المصدر: Falavigna , M , Klitgaard , M , Brase , C , Ternullo , S , Škalko-Basnet , N & Flaten , G E 2018 , ' Mucus-PVPA (mucus Phospholipid Vesicle-based Permeation Assay) : An artificial permeability tool for drug screening and formulation development ' , International Journal of Pharmaceutics , vol. 537 , no. 1-2 , pp. 213-222 .

مصطلحات الفهرس: Animals, Biological Assay/methods, Chemistry, Pharmaceutical/methods, Drug Evaluation, Preclinical/methods, Humans, Liposomes/chemistry, Mucus/chemistry, Permeability, Phospholipids/chemistry, article

URL: https://curis.ku.dk/portal/da/publications/mucuspvpa-mucus-phospholipid-vesiclebased-permeation-assay(bc62a48a-029c-43f5-a76c-17b59ffe2a63).html
https://doi.org/10.1016/j.ijpharm.2017.12.038

المؤلفون: Klitgaard, Mette, Beilles, Stephane, Sassene, Philip Jonas, Berthelsen, Ragna, Müllertz, Anette

المصدر: Molecular Pharmaceutics; September 2020, Vol. 17 Issue: 9 p3214-3222, 9p

المؤلفون: Rosenberg, Jacob, Klitgaard, Mette Lykke, Kitaj, Torben

المصدر: Rosenberg , J , Klitgaard , M L & Kitaj , T 2011 , ' Apps og tags til Ugeskrift for Læger og Danish Medical Journal ' , Ugeskrift for Laeger , bind 173 , nr. 49 , s. 3167 .

الاتاحة: https://researchprofiles.ku.dk/da/publications/apps-og-tags-til-ugeskrift-for-laeger-og-danish-medical-journal(113c5f77-4c1a-43d1-9406-cf64c7e946f5).html

المؤلفون: Rosenberg, Jacob, Klitgaard, Mette Lykke, Kitaj, Torben

المصدر: Ugeskrift for Laeger. 173(49):3167

Additional Titles: Apps and tags for Ugeskrift for Laeger and the Danish Medical Journal

المؤلفون: Rosenberg, Jacob, Klitgaard, Mette Lykke, Kitaj, Torben

المصدر: Rosenberg , J , Klitgaard , M L & Kitaj , T 2011 , ' Apps og tags til Ugeskrift for Læger og Danish Medical Journal ' , Ugeskrift for Laeger , bind 173 , nr. 49 , s. 3167 .

مصطلحات الفهرس: article

URL: https://curis.ku.dk/portal/da/publications/apps-og-tags-til-ugeskrift-for-laeger-og-danish-medical-journal(113c5f77-4c1a-43d1-9406-cf64c7e946f5).html