المؤلفون: Sen, Chandani, Rickabaugh, Tammy M, Jeyachandran, Arjit Vijey, Yuen, Constance, Ghannam, Maisam, Durra, Abdo, Aziz, Adam, Castillo, Kristen, Garcia, Gustavo, Purkayastha, Arunima, Han, Brandon, Boulton, Felix W, Chekler, Eugene, Garces, Robert, Wolff, Karen C, Riva, Laura, Kirkpatrick, Melanie G, Gebara-Lamb, Amal, McNamara, Case W, Betz, Ulrich AK, Arumugaswami, Vaithilingaraja, Damoiseaux, Robert, Gomperts, Brigitte N

المصدر: Respiratory Research. 26(1)

مصطلحات موضوعية: Medical Microbiology, Biomedical and Clinical Sciences, Lung, Coronaviruses, Emerging Infectious Diseases, Infectious Diseases, Stem Cell Research, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Humans, SARS-CoV-2, Antiviral Agents, High-Throughput Screening Assays, Drug Evaluation, Preclinical, Respiratory Mucosa, COVID-19 Drug Treatment, COVID-19, Cells, Cultured, Human mucociliary epithelium, Respiratory viral infections, High throughput drug screening, Anti-viral screening, Small-molecules, Air-liquid-interface, Heterogeneity, Image quantification, RNA sequencing, Air–liquid-interface, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0q6105cw
https://escholarship.org/content/qt0q6105cw/qt0q6105cw.pdf

المؤلفون: Bakowski, Malina A, Beutler, Nathan, Wolff, Karen C, Kirkpatrick, Melanie G, Chen, Emily, Nguyen, Tu-Trinh H, Riva, Laura, Shaabani, Namir, Parren, Mara, Ricketts, James, Gupta, Anil K, Pan, Kastin, Kuo, Peiting, Fuller, MacKenzie, Garcia, Elijah, Teijaro, John R, Yang, Linlin, Sahoo, Debashis, Chi, Victor, Huang, Edward, Vargas, Natalia, Roberts, Amanda J, Das, Soumita, Ghosh, Pradipta, Woods, Ashley K, Joseph, Sean B, Hull, Mitchell V, Schultz, Peter G, Burton, Dennis R, Chatterjee, Arnab K, McNamara, Case W, Rogers, Thomas F

المصدر: Nature communications. 12(1)

مصطلحات موضوعية: Cell Line, Hela Cells, Animals, Humans, Mesocricetus, Hydroxylamines, Nelfinavir, Cytidine, Antiviral Agents, Drug Evaluation, Preclinical, Virus Replication, Drug Discovery, High-Throughput Screening Assays, Drug Repositioning, Pandemics, Databases, Pharmaceutical, COVID-19, SARS-CoV-2, HeLa Cells

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/77f9r1t7

المؤلفون: Garcia, Gustavo, Sharma, Arun, Ramaiah, Arunachalam, Sen, Chandani, Purkayastha, Arunima, Kohn, Donald B, Parcells, Mark S, Beck, Sebastian, Kim, Heeyoung, Bakowski, Malina A, Kirkpatrick, Melanie G, Riva, Laura, Wolff, Karen C, Han, Brandon, Yuen, Constance, Ulmert, David, Purbey, Prabhat K, Scumpia, Phillip, Beutler, Nathan, Rogers, Thomas F, Chatterjee, Arnab K, Gabriel, Gülsah, Bartenschlager, Ralf, Gomperts, Brigitte, Svendsen, Clive N, Betz, Ulrich AK, Damoiseaux, Robert D, Arumugaswami, Vaithilingaraja

المصدر: Cell Reports. 35(1)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Lung, Biodefense, Infectious Diseases, Orphan Drug, Coronaviruses Therapeutics and Interventions, Rare Diseases, Emerging Infectious Diseases, Cancer, Coronaviruses, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, A549 Cells, Animals, Antiviral Agents, COVID-19, Chlorocebus aethiops, DNA Damage, Drug Evaluation, Preclinical, HEK293 Cells, HeLa Cells, Humans, Isoxazoles, MAP Kinase Signaling System, Middle East Respiratory Syndrome Coronavirus, Pyrazines, SARS-CoV-2, Vero Cells, Virus Replication, COVID-19 Drug Treatment, Hela Cells, ATR kinase, DNA-damage response pathway, berzosertib, high-throughput screen, mTOR-PI3K-AKT pathway, nucleoside analogs, protein kinase inhibitors, Biochemistry and Cell Biology, Medical Physiology, Biological sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3wv4q7vv
https://escholarship.org/content/qt3wv4q7vv/qt3wv4q7vv.pdf

المؤلفون: Dayan Elshan, N. G. R., Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.

المساهمون: Bill and Melinda Gates Foundation

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 4, page 2369-2378 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.3c01938
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01938

المؤلفون: Elshan, N. G. R. Dayan, Wolff, Karen C., Riva, Laura, Woods, Ashley K., Grabovyi, Gennadii, Wilson, Katy, Pedroarena, James, Ghorai, Sourav, Nazarian, Armen, Weiss, Frank, Liu, Yuyin, Mazumdar, Wrickban, Song, Lirui, Okwor, Neechi, Malvin, Jacqueline, Liu, Dongdong, Bakowski, Malina A., Beutler, Nathan, Kirkpatrick, Melanie G., Gebara-Lamb, Amal, Huang, Edward, Nguyen-Tran, Vân T. B., Chi, Victor, Li, Shuangwei, Rogers, Thomas F., McNamara, Case W., Gupta, Anil Kumar, Rahimi, Alireza, Chen, Jian Jeffrey, Joseph, Sean B., Schultz, Peter G., Chatterjee, Arnab K.

المساهمون: Bill and Melinda Gates Foundation

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 12, page 10508-10509 ; ISSN 0022-2623 1520-4804

الاتاحة: http://dx.doi.org/10.1021/acs.jmedchem.4c01269
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01269

المؤلفون: Boras, Britton, Jones, Rhys M, Anson, Brandon J, Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A, Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E, Hoffman, Robert, Kadar, Eugene P, Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G, Lanyon, Lorraine, Lendy, Emma K, Lillis, Jonathan R, Logue, James, Luthra, Suman A, Ma, Chunlong, Mason, Stephen W, McGrath, Marisa E, Noell, Stephen, Obach, R Scott, O' Brien, Matthew N, O'Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R, Rogers, Thomas F, Rosales, Romel, Rossulek, Michelle I, Sathish, Jean G, Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W, Weston, Stuart, Zhu, Yuao, White, Kris M, García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K, Mesecar, Andrew D, Frieman, Matthew B, Anderson, Annaliesa S, Allerton, Charlotte

المصدر: 12 ; 1 ; 6055 ; England

مصطلحات موضوعية: 3CL protease, phosphate prodrug PF-07304814, PF-00835231, COVID-19, Prodrugs--therapeutic use, SARS-CoV-2--drug effects, Viral Protease Inhibitors

Relation: Nature Communications; http://hdl.handle.net/10713/16970

الاتاحة: http://hdl.handle.net/10713/16970
https://doi.org/10.1038/s41467-021-26239-2

المؤلفون: Chen, Yun, Murillo-Solano, Claribel, Kirkpatrick, Melanie G., Antoshchenko, Tetyana, Park, Hee-Won, Pizarro, Juan C.

المصدر: Scientific Reports ; volume 8, issue 1 ; ISSN 2045-2322

الاتاحة: http://dx.doi.org/10.1038/s41598-018-28608-2
https://www.nature.com/articles/s41598-018-28608-2.pdf
https://www.nature.com/articles/s41598-018-28608-2

المؤلفون: Kirkpatrick, Melanie G., diTargiani, Robert C., Sweeney, Richard E., Otto, Tamara C.

المساهمون: Defense Threat Reduction Agency, Oak Ridge Institute for Science and Education, U.S. Department of Energy, U.S. Army Medical Research and Materiel Command

المصدر: Chemico-Biological Interactions ; volume 259, page 182-186 ; ISSN 0009-2797

الاتاحة: http://dx.doi.org/10.1016/j.cbi.2016.03.016
https://api.elsevier.com/content/article/PII:S0009279716300862?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0009279716300862?httpAccept=text/plain

المؤلفون: Bucşan, Allison N, Chatterjee, Ayan, Singh, Dhiraj K, Foreman, Taylor W, Lee, Tae-Hyung, Threeton, Breanna, Kirkpatrick, Melanie G, Ahmed, Mushtaq, Golden, Nadia, Alvarez, Xavier, Hoxie, James A, Mehra, Smriti, Rengarajan, Jyothi, Khader, Shabaana A, Kaushal, Deepak

المصدر: Open Access Publications

وصف الملف: application/pdf

Relation: https://digitalcommons.wustl.edu/open_access_pubs/8624; https://digitalcommons.wustl.edu/context/open_access_pubs/article/9636/viewcontent/MechanismsOfReactivationOfLatentTuberculosisInfectionDueToSIVCoinfection.pdf; https://digitalcommons.wustl.edu/context/open_access_pubs/article/9636/filename/1/type/additional/viewcontent/Supp_Data_JCI125810.pdf

الاتاحة: https://digitalcommons.wustl.edu/open_access_pubs/8624
https://doi.org/10.1172/JCI125810
https://digitalcommons.wustl.edu/context/open_access_pubs/article/9636/viewcontent/MechanismsOfReactivationOfLatentTuberculosisInfectionDueToSIVCoinfection.pdf
https://digitalcommons.wustl.edu/context/open_access_pubs/article/9636/filename/1/type/additional/viewcontent/Supp_Data_JCI125810.pdf

المؤلفون: Cadieux, C. L., Broomfield, Clarence A., Kirkpatrick, Melanie G., Kazanski, Meghan E., Lenz, David E., Cerasoli, Douglas M.

المساهمون: ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

المصدر: DTIC

مصطلحات موضوعية: Biochemistry, Organic Chemistry, Chemical, Biological and Radiological Warfare, NERVE AGENTS, ORGANOPHOSPHATES, ACETYLCHOLINESTERASE, METABOLISM, ENZYMES, PAIN, BLOOD SERUM, INHIBITION, DEATH, IN VIVO ANALYSIS, ESTERASES, RECEPTOR SITES(PHYSIOLOGY), AMINO ACIDS, CHEMICAL WARFARE AGENTS, ATROPINE, GUINEA PIGS, OXIMES, ACETYLCHOLINE, NUCLEOTIDES, CARBOXYL RADICALS, PRIMATES, POISONING, THERAPY, IN VITRO ANALYSIS, MAMMALS, NEUROTRANSMITTERS

وصف الملف: text/html

Relation: http://www.dtic.mil/docs/citations/ADA539573

الاتاحة: http://www.dtic.mil/docs/citations/ADA539573
http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA539573

المؤلفون: Cadieux, C. Linn, Broomfield, Clarence A., Kirkpatrick, Melanie G., Kazanski, Meghan E., Lenz, David E., Cerasoli, Douglas M.

المساهمون: Defense Threat Reduction Agency

المصدر: Chemico-Biological Interactions ; volume 187, issue 1-3, page 229-233 ; ISSN 0009-2797

الاتاحة: http://dx.doi.org/10.1016/j.cbi.2010.04.020
https://api.elsevier.com/content/article/PII:S0009279710003066?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0009279710003066?httpAccept=text/plain

المؤلفون: ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD, Cadieux, C. L., Broomfield, Clarence A., Kirkpatrick, Melanie G., Kazanski, Meghan E., Lenz, David E., Cerasoli, Douglas M.

المصدر: DTIC

مصطلحات الفهرس: Biochemistry, Organic Chemistry, Chemical, Biological and Radiological Warfare, NERVE AGENTS, ORGANOPHOSPHATES, ACETYLCHOLINESTERASE, METABOLISM, ENZYMES, PAIN, BLOOD SERUM, INHIBITION, DEATH, IN VIVO ANALYSIS, ESTERASES, RECEPTOR SITES(PHYSIOLOGY), AMINO ACIDS, CHEMICAL WARFARE AGENTS, ATROPINE, GUINEA PIGS, OXIMES, ACETYLCHOLINE, NUCLEOTIDES, CARBOXYL RADICALS, PRIMATES, POISONING, THERAPY, IN VITRO ANALYSIS, MAMMALS, NEUROTRANSMITTERS, ORGANOPHOSPHORUS POISONING, ORGANOPHOSPHORUS, REACTIVATION, Text

URL: https://apps.dtic.mil/docs/citations/ADA539573