المؤلفون: Josephs, Tracy M, Keller, Andrew N, Khajehali, Elham, DeBono, Aaron, Langmead, Christopher J, Conigrave, Arthur D, Capuano, Ben, Kufareva, Irina, Gregory, Karen J, Leach, Katie

المصدر: British Journal of Pharmacology. 177(8)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Underpinning research, 1.1 Normal biological development and functioning, Allosteric Regulation, Allosteric Site, Binding Sites, HEK293 Cells, Humans, Receptors, Calcium-Sensing, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9kc638dm

المؤلفون: Gregory, Karen J, Kufareva, Irina, Keller, Andrew N, Khajehali, Elham, Mun, Hee-Chang, Goolam, Mahvash A, Mason, Rebecca S, Capuano, Ben, Conigrave, Arthur D, Christopoulos, Arthur, Leach, Katie

المصدر: ACS Pharmacology & Translational Science. 1(2)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Lung, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, calcium-sensing receptor, calhex231, allosteric modulator, Biochemistry and cell biology, Medical biochemistry and metabolomics, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3qt2w798

المؤلفون: Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I., Belousoff, Matthew J., Bhattarai, Apurba, Burger, Wessel A.C., Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T., Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W., Tobin, Andrew, Sexton, Patrick, Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David M.

وصف الملف: application/pdf

Relation: Vuckovic, Ziva et al. “Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.” eLife vol. 12 e83477. 30 May. 2023, doi:10.7554/eLife.83477; https://hdl.handle.net/1808/34328; orcid:0000-0001-9165-8526; orcid:0000-0002-1807-3123; orcid:0000-0003-4442-3294; orcid:0000-0002-0325-2524; PMC10229135

الاتاحة: https://hdl.handle.net/1808/34328
https://doi.org/10.7554/eLife.83477

المؤلفون: Leach, Katie, Gregory, Karen J, Kufareva, Irina, Khajehali, Elham, Cook, Anna E, Abagyan, Ruben, Conigrave, Arthur D, Sexton, Patrick M, Christopoulos, Arthur

المصدر: Cell Research. 26(5)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, 1.1 Normal biological development and functioning, 5.1 Pharmaceuticals, Allosteric Regulation, Amines, Amino Acid Sequence, Amino Acids, Binding Sites, Calcium, HEK293 Cells, Humans, Mutation, Pharmaceutical Preparations, Receptors, Calcium-Sensing, Signal Transduction, Structure-Activity Relationship, allosteric modulation, drug discovery, G protein-coupled receptor, molecular modeling, mutagenesis, structural biology, Clinical Sciences, Developmental Biology, Biochemistry and cell biology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0q05v2mc
https://escholarship.org/content/qt0q05v2mc/qt0q05v2mc.pdf

المؤلفون: Dwomoh, Louis, Rossi, Mario, Scarpa, Miriam, Khajehali, Elham, Molloy, Colin, Herzyk, Pawel, Mistry, Shailesh N., Bottrill, Andrew R., Sexton, Patrick M., Christopoulos, Arthur, Conn, Jeffrey, Lindsley, Craig W., Bradley, Sophie J., Tobin, Andrew B.

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

Relation: https://nottingham-repository.worktribe.com/output/13755301; Science Signaling; Volume 15; Issue 760; Pagination 00

الاتاحة: https://doi.org/10.1126/scisignal.abm3720
https://nottingham-repository.worktribe.com/file/13755301/1/M1%20muscarinic%20receptor%20activation
https://nottingham-repository.worktribe.com/output/13755301

المؤلفون: Jorg, Manuela Therese, van der Westhuizen, Emma T, Khajehali, Elham, Burger, Wessel Alexander Christian, White, Jonathan, Choy, Kwok Ho Christopher, Tobin, Andrew B., Sexton, Patrick Michael, Valant, Celine, Capuano, Benvenuto, Christopoulos, Arthur, Scammells, Peter John

المصدر: Jorg , M T , van der Westhuizen , E T , Khajehali , E , Burger , W A C , White , J , Choy , K H C , Tobin , A B , Sexton , P M , Valant , C , Capuano , B , Christopoulos , A & Scammells , P J 2019 , ' 6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M 1 mAChR : The Determinants of Allosteric Activity ' , ACS Chemical Neuroscience , vol. 10 , no. 3 , pp. 1099-1114 . https://doi.org/10.1021/acschemneuro.8b00613

مصطلحات موضوعية: Alzheimer's disease, BQCA, M muscarinic acetylcholine receptor, positive allosteric modulator, pyrimidinones, schizophrenia

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: https://research.monash.edu/en/publications/bbf4774a-f0cf-4c4a-8c5a-73ee770b48ab

الاتاحة: https://research.monash.edu/en/publications/bbf4774a-f0cf-4c4a-8c5a-73ee770b48ab
https://doi.org/10.1021/acschemneuro.8b00613
https://researchmgt.monash.edu/ws/files/313161685/263229472_oa.docx
http://www.scopus.com/inward/record.url?scp=85063237863&partnerID=8YFLogxK

المؤلفون: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Christopher Choy, K.H., Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.

المصدر: European Journal of Medicinal Chemistry ; volume 258, page 115588 ; ISSN 0223-5234

الاتاحة: http://dx.doi.org/10.1016/j.ejmech.2023.115588
https://api.elsevier.com/content/article/PII:S0223523423005548?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0223523423005548?httpAccept=text/plain

المؤلفون: Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I, Belousoff, Matthew J, Bhattarai, Apurba, Burger, Wessel AC, Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T, Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W, Tobin, Andrew, Sexton, Patrick, Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David M

الاتاحة: http://dx.doi.org/10.7554/elife.83477.sa2

المؤلفون: van der Westhuizen, Emma T., Spathis, Arthur, Khajehali, Elham, Jörg, Manuela, Mistry, Shailesh N., Capuano, Ben, Tobin, Andrew B., Sexton, Patrick M., Scammells, Peter J., Valant, Celine, Christopoulos, Arthur

مصطلحات موضوعية: Acetylcholine receptors, Allosterism, Alzheimer's Disease, Biased agonism, Cholinergic pharmacology, Cognition, Drug discovery, G protein-coupled receptors (GPCRs), Muscarinic cholinergic receptors, Schizophrenia

Relation: https://nottingham-repository.worktribe.com/output/928187; Molecular Pharmacology; https://nottingham-repository.worktribe.com/file/928187/1/Assessment%20of%20the%20molecular%20mechanisms%20of%20action%20of%20novel%204-phenylpyridine-2-one%20%28Mol%20Pharm%20accepted%20190418%29.pdf

الاتاحة: https://doi.org/10.1124/mol.118.111633
https://nottingham-repository.worktribe.com/file/928187/1/Assessment%20of%20the%20molecular%20mechanisms%20of%20action%20of%20novel%204-phenylpyridine-2-one%20%28Mol%20Pharm%20accepted%20190418%29.pdf
https://nottingham-repository.worktribe.com/output/928187

المؤلفون: Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olson, Reid H.J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.

مصطلحات موضوعية: QH301 Biology

وصف الملف: text

Relation: http://eprints.gla.ac.uk/177465/13/177465.pdf; Thompson, K. J. et al. (2018) DREADD agonist 21 is an effective agonist for muscarinic-based DREADDs in vitro and in vivo. ACS Pharmacology and Translational Science , 1(1), pp. 61-72. (doi:10.1021/acsptsci.8b00012 ) (PMID:30868140) (PMCID:PMC6407913)

الاتاحة: http://eprints.gla.ac.uk/177465/
http://eprints.gla.ac.uk/177465/13/177465.pdf

المؤلفون: Khajehali, Elham, Valant, Celine, Jörg, Manuela, Tobin, Andrew B., Conn, P. Jeffrey, Lindsley, Craig W., Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur

وصف الملف: text

Relation: http://eprints.gla.ac.uk/163141/1/163141.pdf; Khajehali, E., Valant, C., Jörg, M., Tobin, A. B. , Conn, P. J., Lindsley, C. W., Sexton, P. M., Scammells, P. J. and Christopoulos, A. (2018) Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor. Biochemical Pharmacology , 154, pp. 243-254. (doi:10.1016/j.bcp.2018.05.009 ) (PMID:29777683) (PMCID:PMC6066355)

الاتاحة: http://eprints.gla.ac.uk/163141/
http://eprints.gla.ac.uk/163141/1/163141.pdf

المؤلفون: Gregory, Karen, Kufareva, Irina, Keller, Andrew N., Khajehali, Elham, Mun, Hee-chang, Goolam, Mahvash Ayesha, Mason, Rebecca S, Capuano, Ben, Conigrave, Arthur, Christopoulos, Arthur, Leach, Katie

المصدر: Gregory , K , Kufareva , I , Keller , A N , Khajehali , E , Mun , H , Goolam , M A , Mason , R S , Capuano , B , Conigrave , A , Christopoulos , A & Leach , K 2018 , ' Dual action calcium-sensing receptor modulator unmasks novel mode-switching mechanism ' , ACS Pharmacology & Translational Science , vol. 1 , no. 2 , pp. 96-109 . https://doi.org/10.1021/acsptsci.8b00021

مصطلحات موضوعية: allosteric modulator, calcium-sensing receptor, calhex231

وصف الملف: application/pdf

Relation: https://research.monash.edu/en/publications/eb783571-e7d7-4bd6-b070-478064271f9a

الاتاحة: https://research.monash.edu/en/publications/eb783571-e7d7-4bd6-b070-478064271f9a
https://doi.org/10.1021/acsptsci.8b00021
https://researchmgt.monash.edu/ws/files/284113425/281780379_oa.pdf
http://www.scopus.com/inward/record.url?scp=85079382642&partnerID=8YFLogxK

المؤلفون: Khajehali, Elham, Valant, Celine, Jörg, Manuela, Tobin, Andrew B., Conn, P. Jeffrey, Lindsley, Craig W., Sexton, Patrick M., Scammells, Peter J., Christopoulos, Arthur

المصدر: Khajehali , E , Valant , C , Jörg , M , Tobin , A B , Conn , P J , Lindsley , C W , Sexton , P M , Scammells , P J & Christopoulos , A 2018 , ' Probing the binding site of novel selective positive allosteric modulators at the M 1 muscarinic acetylcholine receptor ' , Biochemical Pharmacology , vol. 154 , pp. 243-254 . https://doi.org/10.1016/j.bcp.2018.05.009

مصطلحات موضوعية: Allosteric modulation, BQCA, Drug discovery, Muscarinic acetylcholine receptor, Mutagenesis

وصف الملف: application/pdf

الاتاحة: https://research.monash.edu/en/publications/b0a13d42-2026-4871-8940-0fe813b7286c
https://doi.org/10.1016/j.bcp.2018.05.009
https://researchmgt.monash.edu/ws/files/278541028/254102619_oa.pdf
http://www.scopus.com/inward/record.url?scp=85047436690&partnerID=8YFLogxK

المؤلفون: Dallagnol, Juliana C.C., Khajehali, Elham, Van Der Westhuizen, Emma T., Jörg, Manuela, Valant, Celine, Gonçalves, Alan G., Capuano, Ben, Christopoulos, Arthur, Scammells, Peter J.

المصدر: Dallagnol , J C C , Khajehali , E , Van Der Westhuizen , E T , Jörg , M , Valant , C , Gonçalves , A G , Capuano , B , Christopoulos , A & Scammells , P J 2018 , ' Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides : Positive Allosteric Modulators of the M 1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles ' , Journal of Medicinal Chemistry , vol. 61 , no. 7 , pp. 2875-2894 . https://doi.org/10.1021/acs.jmedchem.7b01812

وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: https://research.monash.edu/en/publications/d249293d-423e-4e38-a6dc-05948d2976a6

الاتاحة: https://research.monash.edu/en/publications/d249293d-423e-4e38-a6dc-05948d2976a6
https://doi.org/10.1021/acs.jmedchem.7b01812
https://researchmgt.monash.edu/ws/files/313161791/241140344_oa.docx
http://www.scopus.com/inward/record.url?scp=85045569261&partnerID=8YFLogxK

المؤلفون: Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.

المساهمون: National Institute of Neurological Disorders and Stroke, Medical Research Council, National Institute of Diabetes and Digestive and Kidney Diseases, Wellcome Trust, University of Glasgow, National Institute of Mental Health, Cancer Research UK

المصدر: ACS Pharmacology & Translational Science ; volume 1, issue 1, page 61-72 ; ISSN 2575-9108 2575-9108

الاتاحة: http://dx.doi.org/10.1021/acsptsci.8b00012
http://pubs.acs.org/doi/pdf/10.1021/acsptsci.8b00012
https://pubs.acs.org/doi/pdf/10.1021/acsptsci.8b00012

المؤلفون: Nguyen, Huong T. M., van der Westhuizen, Emma T., Khajehali, Elham, Valant, Celine, Christopoulos, Arthur

المصدر: The FASEB Journal ; volume 36, issue S1 ; ISSN 0892-6638 1530-6860

الاتاحة: http://dx.doi.org/10.1096/fasebj.2022.36.s1.r2328
https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fasebj.2022.36.S1.R2328
https://onlinelibrary.wiley.com/doi/full/10.1096/fasebj.2022.36.S1.R2328

المؤلفون: Mojiri-Forushani, Hoda, Khajehali, Elham, Adelipour, Maryam, Mohammadi, Asma

المصدر: Molecular Biology Reports ; volume 50, issue 3, page 2231-2241 ; ISSN 0301-4851 1573-4978

الاتاحة: http://dx.doi.org/10.1007/s11033-022-08219-x
https://link.springer.com/content/pdf/10.1007/s11033-022-08219-x.pdf
https://link.springer.com/article/10.1007/s11033-022-08219-x/fulltext.html

المؤلفون: Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I., Belousoff, Matthew J., Bhattarai, Apurba, Burger, Wessel A.C., Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T., Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W., Tobin, Andrew, Sexton, Patrick M., Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David

المصدر: SSRN Electronic Journal ; ISSN 1556-5068

الاتاحة: http://dx.doi.org/10.2139/ssrn.4034884

المؤلفون: Mojiri-Forushani, Hoda, Khajehali, Elham, Adelipour, Maryam, Mohammadi, Asma

المصدر: Molecular Biology Reports; Mar2023, Vol. 50 Issue 3, p2231-2241, 11p

المؤلفون: Scammells, Peter J., Jörg, Manuela, Khajehali, Elham, van der Westhuizen, Emma T., Choy, K.H. Christopher, Shackleford, David, Tobin, Andrew B., Sexton, Patrick M., Valant, Celine, Capuano, Ben, Christopoulos, Arthur

وصف الملف: text

Relation: http://eprints.gla.ac.uk/222660/7/222660.pdf; Scammells, P. J. et al. (2021) Development of novel 4‐arylpyridin‐2‐one and 6‐arylpyrimidin‐4‐one positive allosteric modulators of the M1 muscarinic acetylcholine receptor. ChemMedChem , 16(1), pp. 216-233. (doi:10.1002/cmdc.202000540 ) (PMID:32851779)

الاتاحة: http://eprints.gla.ac.uk/222660/
http://eprints.gla.ac.uk/222660/7/222660.pdf