المؤلفون: S. Kaleem Ahmed (1327023), Nicole N. Haese (3826969), Jaden T. Cowan (10578771), Vibha Pathak (172306), Omar Moukha-Chafiq (7271546), Valerie J. Smith (10578774), Kevin J. Rodzinak (2181544), Fahim Ahmad (1467625), Sixue Zhang (1371636), Kiley M. Bonin (10578777), Aaron D. Streblow (10578780), Cassilyn E. Streblow (10516011), Craig N. Kreklywich (7592762), Clayton Morrison (10578783), Sanjay Sarkar (3386969), Nathaniel Moorman (446135), Wes Sander (10578786), Robbie Allen (10578789), Victor DeFilippis (200525), Babu L. Tekwani (1328517), Mousheng Wu (4837155), Alec J. Hirsch (3826948), Jessica L. Smith (834950), Nichole A. Tower (589415), Lynn Rasmussen (589424), Robert Bostwick (9903900), Joseph A. Maddry (10578792), Subramaniam Ananthan (591094), John M Gerdes (10578795), Corinne E. Augelli-Szafran (2651497), Mark J. Suto (2053921), Thomas E. Morrison (7592765), Mark T. Heise (10053165), Daniel N. Streblow (7592771), Ashish K. Pathak (1333083)

مصطلحات موضوعية: Biochemistry, Pharmacology, Biotechnology, Infectious Diseases, Virology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Moderate efficacy, CC 50, Chikungunya virus, EC 90, 10 μ M, Targeting Chikungunya Virus Replication, vivo CHIKV challenge mouse model, fibroblast cells, titer reduction, compound 8 q, 270 nM, 2.5 log, nsP 3 macrodomain, drug-like properties, Benzoannulene Inhibitors, activity EC 90, CHIKV resistance, 169 μ M, VTR, 4.5 log, dihydroorotate dehydrogenase

Relation: https://figshare.com/articles/journal_contribution/Targeting_Chikungunya_Virus_Replication_by_Benzoannulene_Inhibitors/14394846

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c02183.s001

المؤلفون: Mark T. Heise, Thomas E. Morrison, Subramaniam Ananthan, Joseph A. Maddry, Sanjay Sarkar, Jessica L. Smith, Kevin J Rodzinak, Nicole N. Haese, Daniel N. Streblow, Nathaniel J. Moorman, Cassilyn E. Streblow, Ashish K. Pathak, Vibha Pathak, Aaron D Streblow, Lynn Rasmussen, Fahim Ahmad, Corinne E. Augelli-Szafran, S Kaleem Ahmed, Victor R. DeFilippis, Robert Bostwick, Craig N. Kreklywich, Mark J. Suto, Sixue Zhang, Robbie Allen, Alec J. Hirsch, Jaden T Cowan, Babu L. Tekwani, Kiley Bonin, Nichole A. Tower, Wes Sander, Valerie J Smith, Mousheng Wu, John M Gerdes, Clayton R. Morrison, Omar Moukha-Chafiq

المصدر: J Med Chem

مصطلحات موضوعية: Male, Oxidoreductases Acting on CH-CH Group Donors, Cell Survival, Dihydroorotate Dehydrogenase, Virus Replication, Antiviral Agents, 01 natural sciences, Article, Virus, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Benzene Derivatives, medicine, Animals, Humans, Benzamide, Cytotoxicity, 030304 developmental biology, 0303 health sciences, Binding Sites, Chemistry, virus diseases, Virology, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Titer, Mechanism of action, Viral replication, Microsomes, Liver, Dihydroorotate dehydrogenase, Chikungunya Fever, Molecular Medicine, Female, medicine.symptom, Chikungunya virus, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd9fc90c3516c776e90ca2779eb4634
https://doi.org/10.1021/acs.jmedchem.0c02183

المؤلفون: Nathaniel J. Moorman, Nikhil Madadi, Daniel N. Streblow, Nicole N. Haese, Robert Bostwick, Mark T. Heise, Wes Sanders, Theresa H Nguyen, Corinne E. Augelli-Szafran, Nichole A Towers, Omar Moukha-Chafiq, Victor R. DeFilippis, Joseph A. Maddry, Sixue Zhang, Ashish K. Pathak, Mark J. Suto, Subramaniam Ananthan, Sharon Taft-Benz, Lynn Rasmussen, Shuklendu D Karyakarte, Michael Denton, Nicholas A May, Kevin J Rodzinak, Aaron D Streblow, Thomas E. Morrison

المصدر: Antimicrob Agents Chemother

مصطلحات موضوعية: viruses, Alphavirus, Quinolones, medicine.disease_cause, Virus Replication, Antiviral Agents, Virus, Encephalitis Virus, Venezuelan Equine, 03 medical and health sciences, Ross River virus, 0302 clinical medicine, medicine, Animals, Humans, Pharmacology (medical), Chikungunya, Horses, Alphavirus infection, 030304 developmental biology, 030203 arthritis & rheumatology, Pharmacology, 0303 health sciences, biology, virus diseases, biology.organism_classification, medicine.disease, Virology, Human morbidity, Infectious Diseases, Viral replication, Venezuelan equine encephalitis virus, Chikungunya virus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19d1e226b321e833dfc136126ea7547
https://pubmed.ncbi.nlm.nih.gov/34152810

المؤلفون: Michael J. Kelly, Marlene A. Jacobson, Kerry L. Fillgrove, Alexander J. Reif, Ken Arrington, Robert M. Garbaccio, Kevin J. Rodzinak, Cheng Wang, Timothy J. Hartingh, Brian C. Magliaro, Sarah L. Huszar, Yuhsin Kuo, Cuyue Tang, Jason M. Uslaner, Vadim Y. Dudkin, Julie A. O'Brien, Mark E. Layton

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:1260-1264

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Pyridones, Clinical Biochemistry, Allosteric regulation, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Receptors, Metabotropic Glutamate, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Animals, Potency, Structure–activity relationship, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Imidazoles, Glutamate receptor, Rats, Disease Models, Animal, 030104 developmental biology, Metabotropic receptor, Psychotic Disorders, Metabotropic glutamate receptor, Molecular Medicine, Metabotropic glutamate receptor 2, Locomotion, 030217 neurology & neurosurgery, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8abce83ed7482841fbf9df1f25b2368
https://doi.org/10.1016/j.bmcl.2016.01.021

المؤلفون: Nicole Trainor, E V Lis, Anthony G. DiLella, Terrence P. McDonald, Annie Liang, Mark E. Layton, Duane R. Reiss, Michael J. Kelly, Sanderson Philip E, James Yergey, Kevin J. Rodzinak, Steven D. Young, Guy R. Seabrook, Christine Fandozzi, Michael E. Cunningham, Scott D. Mosser, Mark O. Urban, John F. Fay, Hao Wang, Kenneth S. Koblan, Rodney A. Bednar

المصدر: ACS Chemical Neuroscience. 2:352-362

مصطلحات موضوعية: Male, ERG1 Potassium Channel, Physiology, Cognitive Neuroscience, Administration, Oral, Biological Availability, Cyclopentanes, Catalepsy, Pharmacology, Receptors, N-Methyl-D-Aspartate, Biochemistry, Rotarod performance test, Rats, Sprague-Dawley, Dogs, Isomerism, Piperidines, Oral administration, Drug Discovery, medicine, Animals, Benzopyrans, Receptor, Ligation, Oxadiazoles, Chemistry, Antagonist, Parkinson Disease, Cell Biology, General Medicine, medicine.disease, Macaca mulatta, Ether-A-Go-Go Potassium Channels, Rats, Pyrimidines, Spinal Nerves, nervous system, Neuropathic pain, Excitatory Amino Acid Antagonists, Neuralgia, NMDA receptor, Female, Indicators and Reagents, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2684ec1a091b2da7e8fdaae9487129
https://doi.org/10.1021/cn200013d

المؤلفون: Kevin J. Rodzinak, Mark E. Layton, Michael J. Kelly

المصدر: Current Topics in Medicinal Chemistry. 6:697-709

مصطلحات موضوعية: Molecular Structure, Chemistry, Isostere, General Medicine, Pharmacology, Subtype selective, Receptors, N-Methyl-D-Aspartate, nervous system, Drug Discovery, Excitatory Amino Acid Antagonists, Animals, Humans, NMDA receptor, Pharmacophore, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0a6709801a49f4d8b795a2bc5d36d8
https://doi.org/10.2174/156802606776894447