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1Academic Journal
المؤلفون: Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2
المؤلفون: Sven Wernersson, Romel Bobby, Liz Flavell, Alexander G. Milbradt, Geoffrey A. Holdgate, Kevin J. Embrey, Mikael Akke
المصدر: Biochemistry. 61:2303-2318
مصطلحات موضوعية: Histones, Binding Sites, Nuclear Proteins, Cell Cycle Proteins, Peptides, Biochemistry, Transcription Factors
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3
المؤلفون: Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista
المصدر: Journal of Medicinal Chemistry. 64:14498-14512
مصطلحات موضوعية: chemistry.chemical_compound, PARP1, Chemistry, In vivo, Poly ADP ribose polymerase, Drug Discovery, Mutant, Cancer research, Molecular Medicine, Progenitor cell, Homologous recombination, DNA, In vitro
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4
المؤلفون: Simon C. C. Lucas, Ulf Börjesson, Mark J. Bostock, John Cuff, Fredrik Edfeldt, Kevin J. Embrey, Per-Olof Eriksson, Andrea Gohlke, Anders Gunnarson, Michael Lainchbury, Alexander G. Milbradt, Rachel Moore, Philip B. Rawlins, Ian Sinclair, Christopher Stubbs, R. Ian Storer
المصدر: RSC Med Chem
مصطلحات موضوعية: Pharmacology, Chemistry, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Biochemistry
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5
المؤلفون: Marie-France Langelier, Michael McCauley, Elizabeth Underwood, Laura E. Easton, Ji-Chun Yang, David Neuhaus, Kevin J. Embrey, Philip B. Rawlins, John M. Pascal, Marianne Schimpl, Tom E. H. Ogden
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Models, Molecular, AcademicSubjects/SCI00010, DNA repair, DNA damage, Poly ADP ribose polymerase, Allosteric regulation, Mutant, Poly (ADP-Ribose) Polymerase-1, Poly(ADP-ribose) Polymerase Inhibitors, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Allosteric Regulation, Protein Domains, Structural Biology, Catalytic Domain, Genetics, 030304 developmental biology, 0303 health sciences, Substrate Interaction, biology, Active site, Amides, 0104 chemical sciences, 3. Good health, Enzyme Activation, chemistry, 030220 oncology & carcinogenesis, Mutation, Biophysics, biology.protein, DNA, DNA Damage
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6
المؤلفون: Iacovos N Michaelides, Christopher D. Stubbs, Puneet Khurana, Kun Song, Kevin J. Embrey, R. Ian Storer, Christopher R. Phillips, Gavin W. Collie, Ian L. Dale, Arjan Snijder, Louise Barlind, Ulf Börjesson
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: C-Met, kinase, Chemistry, Kinase, Stereochemistry, Organic Chemistry, small molecule inhibitor, Biochemical Activity, Note, Chemical basis, P-loop, Biochemistry, Cell activity, chemistry.chemical_compound, Drug Discovery, c-MET, X-ray crystallography
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7Academic Journal
المؤلفون: Uybach Vo, Navratna Vajpai, Kevin J. Embrey, Golovanov, Alexander
المصدر: Uybach Vo , Navratna Vajpai , Kevin J. Embrey , & Golovanov , A 2016 , ' Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution ' , Scientific Reports , vol. 6 , 29706 . https://doi.org/10.1038/srep29706
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8Academic Journal
المؤلفون: Felix P Williams, Alexander G Milbradt, Kevin J Embrey, Romel Bobby
المصدر: PLoS ONE, Vol 11, Iss 4, p e0154607 (2016)
Relation: http://europepmc.org/articles/PMC4851411?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/5198e09a8a974c5a846add027c32cf95
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9
المصدر: ADMET and DMPK
Volume 7
Issue 4
ADMET and DMPK, Vol 7, Iss 4, Pp 222-241 (2019)مصطلحات موضوعية: Affinity selection mass spectrometry, surface plasmon resonance, nuclear magnetic resonance, differential scanning fluorimetry, isothermal titration calorimetry, microscale thermophoresis, 0301 basic medicine, Drug discovery, Computer science, lcsh:RM1-950, affinity selection mass spectrometry, Medicine (miscellaneous), Isothermal titration calorimetry, Computational biology, 03 medical and health sciences, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, 0302 clinical medicine, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Surface plasmon resonance, Primary screening
وصف الملف: application/pdf
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10
المؤلفون: Pavel Macek, Jonathan P. Waltho, J. Willem M. Nissink, Matthew J. Cliff, Kevin J. Embrey, Rick Davies, Martin Blackledge, Stanislava Panova, Malene Ringkjøbing Jensen
المساهمون: Manchester Institute of Biotechnology - Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM), University of Manchester, Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Oncology, IMED Biotech Unit, AstraZeneca [Cambridge, UK], Discovery Sciences, IMED Biotech Unit, AstraZeneca, Institut de biologie structurale (IBS - UMR 5075 ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
المصدر: Structure
Structure, Elsevier (Cell Press), 2019, 27 (10), pp.1537-1546.e4. ⟨10.1016/j.str.2019.07.006⟩
Panova, S, Cliff, M, Macek, P, Blackledge, M, Jensen, M R, Nissink, J W M, Embrey, K J, Davies, R & Waltho, J 2019, ' Mapping hidden residual structure within the Myc bHLH-LZ domain using chemical denaturant titration ', Structure . https://doi.org/10.1016/j.str.2019.07.006
Structure, 2019, 27 (10), pp.1537-1546.e4. ⟨10.1016/j.str.2019.07.006⟩مصطلحات موضوعية: Guanidinium chloride, Models, Molecular, Protein Denaturation, MESH: Protein Structure, Secondary, MESH: Thiazoles, Myc, Residual, Intrinsically disordered proteins, Protein Structure, Secondary, Proto-Oncogene Proteins c-myc, molten globule, 03 medical and health sciences, chemistry.chemical_compound, MESH: Protein Structure, Tertiary, Structural Biology, Manchester Institute of Biotechnology, MESH: Nuclear Magnetic Resonance, Biomolecular, MESH: Proto-Oncogene Proteins c-myc, Humans, guanidinium chloride, Molecular Biology, Protein secondary structure, Conformational isomerism, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, solution NMR, Solution NMR, 0303 health sciences, Binding Sites, MESH: Humans, paramagnetic relaxation enhancement, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], 030302 biochemistry & molecular biology, Helix-Loop-Helix Motifs, ResearchInstitutes_Networks_Beacons/manchester_institute_of_biotechnology, Molten globule, Protein Structure, Tertiary, Thiazoles, chemistry, MESH: Binding Sites, Biophysics, Titration, MESH: Protein Denaturation, intrinsically disordered proteins, Biological regulation, MESH: Helix-Loop-Helix Motifs, MESH: Models, Molecular
وصف الملف: application/pdf
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11
المؤلفون: Mark J. O'Connor, Philip B. Rawlins, Kevin J. Embrey, Anders Gunnarsson, Sudhir M. Hande, Anna Staniszewska, Fiona Pachl, Andrew X. Zhang, Jonathan P. Orme, Giuditta Illuzzi, Lisa McWilliams, Sonja J. Gill, Jeffrey W. Johannes, J. Lane, Sébastien L. Degorce, Amber Balazs, Martin J. Packer, Andrew Madin, Marianne Schimpl, Andrew Pike, Elisabetta Leo, Xiaolan Zheng, Avipsa Ghosh, C. Larner
المصدر: Cancer Research. 81:296-296
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Nicotinamide, biology, Poly ADP ribose polymerase, hERG, Olaparib, chemistry.chemical_compound, Enzyme, PARP1, Oncology, chemistry, PARP inhibitor, Cancer research, biology.protein, Binding site
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12
المؤلفون: J. Willem M. Nissink, Pavel Macek, Rick Davies, Jonathan P. Waltho, Stanislava Panova, Geoffrey A. Holdgate, Matthew J. Cliff, Kevin J. Embrey
المصدر: The Journal of biological chemistry. 293(24)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, alpha-Helical, Leucine zipper, Protein Conformation, Cellular homeostasis, Biochemistry, Proto-Oncogene Mas, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Transactivation, Humans, Protein phosphorylation, Neoplastic transformation, Amino Acid Sequence, Protein Interaction Maps, Phosphorylation, Molecular Biology, Transcription factor, Basic helix-loop-helix, Chemistry, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Protein Stability, Cell Biology, DNA, Cell biology, 030104 developmental biology, Protein Structure and Folding, Protein Binding
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13
المؤلفون: Kevin J. Embrey, Alexander L. Breeze, Uybach Vo, Liz Flavell, Romel Bobby, Navratna Vajpai, Alexander P. Golovanov
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Son of Sevenless Protein, Drosophila, Magnetic Resonance Spectroscopy, GTP', nuclear magnetic resonance (NMR), genetic processes, Allosteric regulation, Son of Sevenless, Guanosine Diphosphate, Biochemistry, Fluorescence, Proto-Oncogene Proteins p21(ras), protein-protein interaction, Nucleotide exchange factor, 03 medical and health sciences, chemistry.chemical_compound, Catalytic Domain, Humans, Small GTPase, Sos protein, Molecular Biology, biology, Chemistry, Cell Biology, biochemical phenomena, metabolism, and nutrition, allosteric regulation, enzymes and coenzymes (carbohydrates), 030104 developmental biology, small GTPase, Guanosine diphosphate, biology.protein, Biophysics, bacteria, Guanosine Triphosphate, Guanine nucleotide exchange factor, Ras protein, Allosteric Site, Protein Binding
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14
المؤلفون: Haris Jahic, Kerry E. Murphy-Benenato, P. Ann Boriack-Sjodin, Dan Carcanague, Jenna Harang, Tina Howard, Claire Brassington, Madhusudhan Reddy Gowravaram, Charles J. Eyermann, Lakshmaiah Gingipalli, Herbert Oguto, Sahil Patel, Robert A. Giacobbe, Ludovic Otterbein, Amy Kutschke, James T. Loch, Georgine Ioannidis, Valerie A. Laganas, Michael R. Hale, Adam B. Shapiro, Kevin J. Embrey, Matthew D. Miller
المصدر: Tetrahedron Letters. 56:3108-3112
مصطلحات موضوعية: chemistry.chemical_classification, DNA ligase, biology, Organic Chemistry, biology.organism_classification, Biochemistry, Adenosine, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, medicine, NAD+ kinase, Binding site, LIGA, DNA, Bacteria, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4fe2683d6839ef615d9bfebf560d10c8
https://doi.org/10.1016/j .tetlet.2014.12.067 -
15
المؤلفون: Rajesh Kalkhambkar, Bheemarao G. Ugarkar, Jon Read, Martin Vogtherr, Beena Paul, Swati Prasad, Adrian Liam Gill, Shantika Bhat, Helen H.J. McMiken, Maruti Naik, Jyothi Bhat, Julie A. Tucker, Kevin J. Embrey, Begur Vasanthkumar Varun, Balachandra Bandodkar, Rani Menon, Syeed Hussein, Janani Venkatraman, Kannan Murugan, Harini Iyer, Anandkumar Raichurkar, Manoranjan Panda
المصدر: Journal of Medicinal Chemistry. 58:753-766
مصطلحات موضوعية: chemistry.chemical_classification, Binding Sites, Magnetic Resonance Spectroscopy, Ligand efficiency, Tuberculosis, DNA synthesis, Chemistry, Stereochemistry, Mycobacterium tuberculosis, Thymidylate Synthase, Hit to lead, medicine.disease, Thymidylate kinase, In vitro, High-Throughput Screening Assays, Structure-Activity Relationship, Enzyme, Biochemistry, Drug Discovery, medicine, Humans, Molecular Medicine, Transferase, Enzyme Inhibitors
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16
المصدر: Biomolecular NMR Assignments. 7:215-219
مصطلحات موضوعية: chemistry.chemical_classification, GTPase-activating protein, GTP', Effector, GTPase, Biology, Biochemistry, Proto-Oncogene Proteins p21(ras), chemistry.chemical_compound, chemistry, Structural Biology, Guanosine diphosphate, Nucleotide, Guanine nucleotide exchange factor
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17
المؤلفون: Kevin J. Embrey, Julie Demeritt, Joanna Bryant, Beth Andrews, George B. Mullen, Ning Gao, Lawrence Macpherson, James T. Loch, Ken Hull, Bryan Prince, Brian Sherer, Alok Singh, P. Ann Boriack-Sjodin, Sheila Irene Hauck, Oluyinka Green, Ann E. Eakin, Haihong Ni, Ruth Illingworth, Dave Timms, Maria Uria-Nickelsen, Grant K. Walkup, Neil James Hales, Alexander L. Breeze, April E. Blodgett, Shanta Bist
المصدر: Antimicrobial Agents and Chemotherapy. 56:1240-1246
مصطلحات موضوعية: Models, Molecular, Staphylococcus aureus, Magnetic Resonance Spectroscopy, Mutant, Microbial Sensitivity Tests, Biology, Crystallography, X-Ray, medicine.disease_cause, DNA gyrase, DNA sequencing, Inhibitory Concentration 50, Mice, Nuclear magnetic resonance, Drug Resistance, Bacterial, medicine, Animals, Humans, Topoisomerase II Inhibitors, Pyrroles, Experimental Therapeutics, Pharmacology (medical), Enzyme Inhibitors, Binding site, Pharmacology, chemistry.chemical_classification, Mutation, Binding Sites, DNA synthesis, Staphylococcal Infections, Amides, Molecular biology, Anti-Bacterial Agents, Streptococcus pneumoniae, Infectious Diseases, Enzyme, chemistry, Biochemistry, DNA Gyrase, Antibacterial activity, Protein Binding
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18
المؤلفون: Dorothy A. Sims, Richard D. May, Tomas Mustelin, Joanne Woods, David C. Lowe, Denice T. Y. Chan, Laura Rapley, Benjamin Kemp, Matthew A. Sleeman, Nicholas J. Bond, Christel Séguy Veyssier, Liz Flavell, Katherine A. Vousden, Tristan J. Vaughan, Sara Carmen, Kevin J. Embrey, Overed-Sayer Catherine L, Catherine E. Huntington, Christopher E. Brightling, Michael R. Snaith, Bojana Popovic, D. Gareth Rees, Strain Martin D, Ian C. Scott, E. Suzanne Cohen, Jianqing Xu, Dominic J. Corkill, Jayesh B. Majithiya, Daniel R. Higazi, Elizabeth England, Robin Butler
المصدر: Nature Communications
مصطلحات موضوعية: Male, Interleukin-1 Receptor-Like 1 Protein, General Physics and Astronomy, Receptors, Cell Surface, Inflammation, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Mice, Extracellular, medicine, Animals, Humans, Receptor, Mice, Inbred BALB C, Multidisciplinary, Interleukin, Biological activity, Receptors, Interleukin, General Chemistry, Interleukin-33, Asthma, Cell biology, Interleukin 33, Respiratory epithelium, medicine.symptom, Oxidation-Reduction
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19
المؤلفون: Stefan Gerhardt, Richard A. Pauptit, Jason Breed, Kevin J. Embrey, Jon Read, David Timms, Wendy S. VanScyoc, Geoffrey A. Holdgate, Alun Bermingham, Douglas Campbell, Alexander L. Breeze, Richard A. Norman, Walter H.J. Ward, Jane E. Sullivan
المصدر: Biochemistry. 44:16475-16490
مصطلحات موضوعية: Models, Molecular, Purine, biology, Protein Conformation, Stereochemistry, p38 mitogen-activated protein kinases, MAP Kinase Kinase 6, p38 Mitogen-Activated Protein Kinases, Biochemistry, Recombinant Proteins, Enzyme Activation, chemistry.chemical_compound, A-site, chemistry, Mitogen-activated protein kinase, biology.protein, Humans, Transferase, Moiety, Phosphorylation, Enzyme Inhibitors, Selectivity, Nuclear Magnetic Resonance, Biomolecular, Protein Binding
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20
المؤلفون: Thomas Gero, Andrew David Morley, Julie A. Tucker, Peter W. Kenny, Kevin J. Embrey, Jason Breed, Linda Godfrey, Dorin Toader, Robert Garcia, Claire A. Minshull, Alexander L. Breeze, Emma Black, Andrew Pannifer, Daniel John Russell, Jon Read, Amanda Rees
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:2503-2507
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Molecular model, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Protein tyrosine phosphatase, Crystallography, X-Ray, Ligands, Biochemistry, Structure-Activity Relationship, Drug Discovery, Hydrolase, Structure–activity relationship, Enzyme Inhibitors, Binding site, Tyrosine, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Thiadiazines, biology, Chemistry, Organic Chemistry, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases
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