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1
المؤلفون: Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Chymases, Drug Discovery, Side chain, Humans, Moiety, Protease Inhibitors, Molecular Biology, Indole test, Binding Sites, Organic Chemistry, Chymase, Benzothiophene, Glutathione, Protein Structure, Tertiary, chemistry, Molecular Medicine, Benzimidazoles, Hydrophobic and Hydrophilic Interactions, Oxidation-Reduction, Lead compound, Conjugate
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2
المؤلفون: Eugene R. Hickey, Anthony S. Prokopowicz, George E. Lee, Carol Ann Homon, Scott Jakes, Wang Mao, Jun Li, Charlene Peng, Bennett T. Farmer, Scott F. Leonard, Mohammed A. Kashem, Kevin Chungeng Qian, Charles L. Cywin, Lian Wang, Ronald Magboo, Morgan Welzel, John P. Wolak, Edward Pack, Tina Morwick
المصدر: Journal of Medicinal Chemistry. 52:1814-1827
مصطلحات موضوعية: Models, Molecular, Binding Sites, Phenylpropionates, Kinase, Chemistry, Stereochemistry, High-throughput screening, Stereoisomerism, Azepines, Hit to lead, Crystallography, X-Ray, Homology (biology), Structure-Activity Relationship, Crystallography, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Molecular Medicine, Structure–activity relationship, Transferase, Kinase binding, Binding site, Casein Kinase II
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3
المؤلفون: Derek Cogan, Ming-Hong Hao, Neil Moss, Christopher Pargellis, Tazmeen N. Fadra, E.C. Breinlinger, Rachel R. Kroe, Daniel R. Goldberg, Alan David Swinamer, Ronald A. Aungst, Kevin Chungeng Qian
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3251-3255
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Carboxamide, p38 Mitogen-Activated Protein Kinases, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Transferase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Organic Chemistry, Triazoles, In vitro, Sulfonamide, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Computer-Aided Design, Molecular Medicine
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4
المؤلفون: Tazmeen N. Fadra, Kirrane Thomas M, Carol A. Torcellini, Christopher Pargellis, Neil Moss, Jeffrey B. Madwed, Rachel R. Kroe, John R. Regan, Raj Betageri, Pier F. Cirillo, Eugene R. Hickey, Kevin Chungeng Qian, Richard M. Nelson, Steffen Breitfelder, Alan David Swinamer
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4242-4247
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrazole, p38 Mitogen-Activated Protein Kinases, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Humans, Binding site, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Adenine, Organic Chemistry, B vitamins, Enzyme, chemistry, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Signal transduction
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5
المؤلفون: Michele Tsang, Christopher Pargellis, Alan David Swinamer, Rajiv Sharma, Kirrane Thomas M, Kevin Chungeng Qian, Pier F. Cirillo, Carol A. Torcellini, Matthew R. Netherton, Zhaoming Xiong, Neil Moss, Rachel R. Kroe, Eugene R. Hickey, Usha R. Patel, Steffen Breitfelder, Jeffrey B. Madwed, Faith Corbo Gaenzler, Daniel R. Goldberg, Sanxing Sun, Moriak Monica Helen, Victor Marc Kamhi, Hidenori Takahashi, Tazmeen N. Fadra, Gilmore Thomas A, Raj Betageri
المصدر: Bioorganicmedicinal chemistry letters. 19(9)
مصطلحات موضوعية: Lipopolysaccharides, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Chemistry, Organic, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, p38 Mitogen-Activated Protein Kinases, Inhibitory Concentration 50, Mice, In vivo, 2-Naphthylamine, Drug Discovery, Transferase, Potency, Animals, Urea, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, biology, Molecular Structure, Chemistry, Tumor Necrosis Factor-alpha, Organic Chemistry, In vitro, Sulfonamide, Enzyme, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine
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6
المؤلفون: Nathan K. Yee, Jeffrey B. Madwed, Clare Zimmitti, Angela Berry, Tazmeen N. Fadra, Jinhua J. Song, Donna Skow, Leslie Martin, Alan David Swinamer, Ming-Hong Hao, John Lord, Zhaoming Xiong, Chris Sarko, Zhulin Tan, Ronald L. Magolda, Christopher Pargellis, Neil Moss, Gao Donghong A, Daniel R. Goldberg, Rachel R. Kroe, Alison Kukulka, Kevin Chungeng Qian, Carol A. Torcellini
المصدر: Journal of medicinal chemistry. 50(17)
مصطلحات موضوعية: Drug, Lipopolysaccharides, Male, Models, Molecular, Niacinamide, Molecular model, Stereochemistry, media_common.quotation_subject, Biological Availability, Computational biology, Thiophenes, Crystallography, X-Ray, p38 Mitogen-Activated Protein Kinases, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Computer Simulation, Tumor necrosis factor α, Protein Kinase Inhibitors, media_common, Sulfonamides, Binding Sites, Chemistry, Tumor Necrosis Factor-alpha, Computer aid, Rats, Drug Design, Molecular Medicine
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7
المؤلفون: Christopher Ronald Sarko, Antonio J.M. Jr Barbosa, Kevin Chungeng Qian, Mark Stephen Ralph, Neil Moss, Ming-Hong Hao, Daniel R. Goldberg, Tazmeen N. Fadra, Faith Corbo Gaenzler, Fariba Soleymanzadeh, Rachel R. Kroe, Pingrong Liu, Abdelhakim Hammach
المصدر: Bioorganicmedicinal chemistry letters. 16(24)
مصطلحات موضوعية: Models, Molecular, Molecular model, Protein Conformation, High-throughput screening, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, p38 Mitogen-Activated Protein Kinases, Structure-Activity Relationship, Drug Discovery, Enzyme Inhibitors, Protein kinase A, Molecular Biology, chemistry.chemical_classification, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Enzyme, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Benzimidazoles, Signal transduction
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8Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase
المؤلفون: Andre White, Bennett T. Farmer, Anthony Kronkaitis, Lian Wang, Eugene R. Hickey, Charline Peng, Joey Studts, Jun Li, Kevin Barringer, Sheenah Mische, Kevin Chungeng Qian
المصدر: The Journal of biological chemistry. 280(7)
مصطلحات موضوعية: Models, Molecular, Protein Folding, Protein Conformation, Adenylyl Imidodiphosphate, Biology, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, MAP2K7, Serine, Structure-Activity Relationship, Protein structure, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Catalytic Domain, Proto-Oncogene Proteins, Humans, Amino Acid Sequence, Molecular Biology, Peptide sequence, MAPK14, Serine/threonine-specific protein kinase, Kinase, Cell Biology, Enzyme Activation, Apoproteins, Protein Binding
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9
المؤلفون: Ian Potocki, Shirlynn Chen, Rosemarie Sellati, Patricia L. Reilly, Kei Kishimoto, Emeigh Jonathan Emilian, Gerald Nabozny, Robert Rothlein, Donghong A. Gao, Miao Clara K, Daniel R. Goldberg, Sorcek Ronald J, Daniel Kuzmich, Terence A. Kelly, Drané O'Brien, Deborah D. Jeanfavre, Charline Peng, and Stephen H. Norris, Kevin Chungeng Qian, Elizabeth Mainolfi, Wu Jiang-Ping, Joseph R. Woska, Jocelyn A. Gunn
المصدر: Journal of medicinal chemistry. 47(22)
مصطلحات موضوعية: chemistry.chemical_classification, Sulfonyl, Bicyclic molecule, Chemistry, Stereochemistry, Imidazoles, Hydantoin, Stereoisomerism, Crystallography, X-Ray, Chemical synthesis, Lymphocyte Function-Associated Antigen-1, Sulfonamide, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Potency, Imidazole, Lymphocyte function-associated antigen 1, Protein Binding
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10
المؤلفون: Kevin Barringer, Roger R. LaFrance, Kevin Chungeng Qian, Sheenah Mische, Bennett T. Farmer, Alistair Baptiste, Joey Studts, Lian Wang, Charline Peng, Anthony Kronkaitis
المصدر: Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 1)
مصطلحات موضوعية: Protein Conformation, Restriction Mapping, Biophysics, Biology, medicine.disease_cause, Crystallography, X-Ray, Transfection, Biochemistry, MAP2K7, Serine, Apoenzymes, Proto-Oncogene Proteins c-pim-1, Structural Biology, hemic and lymphatic diseases, Genetics, medicine, Humans, c-Raf, Threonine, Cloning, Molecular, Escherichia coli, DNA Primers, Serine/threonine-specific protein kinase, Base Sequence, Kinase, Condensed Matter Physics, Recombinant Proteins, Crystallography, Crystallization Communications, Signal transduction, Crystallization