المؤلفون: Eric A. Ross, Jean-Nicolas Gallant, Efrat Dotan, Harry S. Cooper, Karen Ruth, Harold A. Harvey, Miriam Kunkel, Arthur Winer, Bora Lim, Kevin P. White, Kenneth R. Korzekwa, Namrata Vijayvergia, Edward W. Wang, Jeffrey Sivik, Steven J. Cohen, Wafik S. El-Deiry, Lanlan Zhou, Igor Astaturov, Crystal S. Denlinger

المصدر: Clinical Colorectal Cancer. 20:e43-e52

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Maximum Tolerated Dose, Colorectal cancer, Gastroenterology, Drug Administration Schedule, Capecitabine, 03 medical and health sciences, 0302 clinical medicine, Refractory, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Clinical endpoint, Humans, Dosing, Aged, business.industry, Middle Aged, medicine.disease, Progression-Free Survival, Regimen, Oncology, Tolerability, Drug Resistance, Neoplasm, Quinacrine, 030220 oncology & carcinogenesis, Cohort, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f987a65b831752ac568337bfd737641e
https://doi.org/10.1016/j.clcc.2020.08.003

المؤلفون: John Gordon, Robert R. Luedtke, Hamed S. Hayatshahi, Armaghan Amani, Jin Liu, Peng Jen Chen, Suzy A. Griffin, Robert H. Mach, Min Ye, Kenneth R. Korzekwa, Michelle Taylor, Benjamin E. Blass

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:2690-2694

مصطلحات موضوعية: Drug, 010405 organic chemistry, Chemistry, Stereochemistry, media_common.quotation_subject, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Pharmacokinetics, Design synthesis, In vivo, Dopamine receptor, Dopamine receptor D3, Drug Discovery, Molecular Medicine, Substance use, Benzamide, Molecular Biology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::62fc22f121446935422ad46d09f3cb6d
https://doi.org/10.1016/j.bmcl.2019.07.020

المؤلفون: Abu J M Sadeque, Michael B Fisher, Kenneth R Korzekwa, Frank J Gonzalez, Allan E Rettie

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://jpet.aspetjournals.org/content/jpet/283/2/698.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1069.6590; http://jpet.aspetjournals.org/content/jpet/283/2/698.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1069.6590
http://jpet.aspetjournals.org/content/jpet/283/2/698.full.pdf

المؤلفون: Magang Shou, Kenneth R. Korzekwa, Ericka N. Brooks, Compounds (endogenous Estrogens, Prolonged Replacement

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://carcin.oxfordjournals.org/content/18/1/207.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.624.5832; http://carcin.oxfordjournals.org/content/18/1/207.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.624.5832
http://carcin.oxfordjournals.org/content/18/1/207.full.pdf

المؤلفون: Kenneth R. Korzekwa

المصدر: Drug-Drug Interactions ISBN: 9780429131967

مصطلحات موضوعية: Drug metabolizing enzymes, Biochemistry, Chemistry, Enzyme kinetics, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3da70b3afe840f183bae61189357c934
https://doi.org/10.1201/9780429131967-2

المؤلفون: Kenneth R. Korzekwa, Swati Nagar, Jaydeep Yadav

المصدر: The FASEB Journal. 32

مصطلحات موضوعية: Pharmacology, Drug, biology, Chemistry, Numerical analysis, media_common.quotation_subject, 010401 analytical chemistry, Pharmaceutical Science, Cytochrome P450, Computational biology, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, Genetics, biology.protein, Pharmacology (medical), Molecular Biology, Biotechnology, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075069eaf82ab4cbb02d03df837df82c
https://doi.org/10.1096/fasebj.2018.32.1_supplement.834.9

المؤلفون: Christiana N. Teijaro, Wayne E. Childers, Srinivas Papaiahgari, Magid Abou-Gharbia, Nicole Lounsbury, Min Ye, George Mateo, Rajash K. Thimmulappa, Kenneth R. Korzekwa, Shyam Biswal, Graham Allaway, Brielle Jones, John Gordon

المصدر: Bioorganic & Medicinal Chemistry. 23:5352-5359

مصطلحات موضوعية: Chalcone, NF-E2-Related Factor 2, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Pharmacology, medicine.disease_cause, Biochemistry, Antioxidants, Cell Line, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Organic Chemistry, KEAP1, In vitro, Bioavailability, Mice, Inbred C57BL, Oxidative Stress, Gene Expression Regulation, Solubility, chemistry, Lipophilicity, Molecular Medicine, Female, Caco-2 Cells, Heme Oxygenase-1, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803033a2b45cc24d7af9187d0d6675fe
https://doi.org/10.1016/j.bmc.2015.07.056

المؤلفون: Kenneth R Korzekwa, William F Trager, Kiyoshi Nagata, AND Andrew Parkinson, James R Gillette

المساهمون: The Pennsylvania State University CiteSeerX Archives

المصدر: http://dmd.aspetjournals.org/content/dmd/18/6/974.full.pdf.

وصف الملف: application/pdf

Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1069.2530; http://dmd.aspetjournals.org/content/dmd/18/6/974.full.pdf

الاتاحة: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1069.2530
http://dmd.aspetjournals.org/content/dmd/18/6/974.full.pdf

المؤلفون: Bora Lim, Jean-Nicolas Gallant, Jeffrey Sivik, Lanlan Zhou, Igor Astsaturov, Crystal S. Denlinger, Efrat Dotan, Edward Wang, Harold A. Harvey, Miriam Kunkel, Karen Ruth, Steven J. Cohen, Arthur Winer, Namrata Vijayvergia, Kenneth R. Korzekwa, Wafik S. El-Deiry, Eric A. Ross

المصدر: Journal of Clinical Oncology. 37:e15020-e15020

مصطلحات موضوعية: Cancer Research, P53 pathway, business.industry, Colorectal cancer, Cell, medicine.disease, Capecitabine, chemistry.chemical_compound, medicine.anatomical_structure, Oncology, Refractory, chemistry, Acridine, Cancer research, Medicine, In patient, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::319d377f53b0d010d70957482d069db8
https://doi.org/10.1200/jco.2019.37.15_suppl.e15020

المؤلفون: Swati Nagar, Masoud Jamei, A Poirier, T Ishikawa, J C Kalvass, Caroline A. Lee, Kenneth R. Korzekwa, Peter W. Swaan, Aleksandra Galetin, Joe Bentz, Maciej J. Zamek-Gliszczynski, Ping Zhao, K S Pang, Mitchell E. Taub, Xiaoyan Chu, Harma Ellens

المصدر: Clinical Pharmacology & Therapeutics. 94:64-79

مصطلحات موضوعية: Biological Availability, Guidelines as Topic, Computational biology, Biology, Pharmacology, Kidney, Models, Biological, Article, Kinetic parameter estimation, Animals, Humans, Drug Interactions, Pharmacokinetics, Tissue Distribution, Pharmacology (medical), Tissue distribution, Brain, Membrane Transport Proteins, Kidney metabolism, Biological Transport, Transporter, Liver metabolism, Liver, Pharmaceutical Preparations, Biological availability

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0c4a60ce7833dac4b3c0a68bc3798d
https://doi.org/10.1038/clpt.2013.45

المؤلفون: Kenneth R. Korzekwa, Priyanka Kulkarni, Swati Nagar

مصطلحات موضوعية: Pharmacology, Drug, Membrane permeability, Liver cytology, media_common.quotation_subject, Atorvastatin, Metabolism, Biology, 030226 pharmacology & pharmacy, Metabolism, Transport, and Pharmacogenomics, Cell membrane, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, medicine, Molecular Medicine, Perfusion, Intracellular, media_common, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3defe001f7ca45a6042627dcf1f5e76
https://europepmc.org/articles/PMC5034709/

المؤلفون: Swati Nagar, Jalia Tucker, Erica A. Weiskircher, Siddhartha Bhoopathy, Kenneth R. Korzekwa, Ismael J. Hidalgo

المصدر: Drug Metabolism and Disposition. 40:865-876

مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Cell Membrane Permeability, Cell, Pharmaceutical Science, ATP-binding cassette transporter, Endogeny, Biology, Models, Biological, Cell Line, Dogs, Predictive Value of Tests, medicine, Animals, ATP Binding Cassette Transporter, Subfamily B, Member 1, Chromatography, High Pressure Liquid, Pharmacology, Cell Membrane, Biological Transport, Transporter, Apical membrane, medicine.anatomical_structure, Membrane, Pharmaceutical Preparations, Biochemistry, Cyclosporine, Biophysics, Efflux, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fbf67f6de4aecbaffbad4a813e0bf2
https://doi.org/10.1124/dmd.111.044289

المؤلفون: Jeffrey P. Jones, Kenneth R. Korzekwa, Rhonda A. Torres, Daniel R. McMasters, Christine M. Fandozzi

المصدر: Journal of Medicinal Chemistry. 50:4642-4647

مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Xanthine Oxidase, Stereochemistry, Metabolite, Quantitative Structure-Activity Relationship, chemistry.chemical_element, Regioselectivity, Stereoisomerism, Aldehyde, Aldehyde Oxidase, chemistry.chemical_compound, Pharmaceutical Preparations, chemistry, Biotransformation, Heterocyclic Compounds, Tetrahedral carbonyl addition compound, Molybdenum, Drug Discovery, Thermodynamics, Molecular Medicine, Xanthine oxidase, Aldehyde oxidase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446368b817195d7f6bdee640cb098aa2
https://doi.org/10.1021/jm0703690

المؤلفون: Matthew J. Walker, Robert P. Sheridan, Rhonda A. Torres, Kenneth R. Korzekwa

المصدر: Journal of Medicinal Chemistry. 50:3173-3184

مصطلحات موضوعية: Quantitative structure–activity relationship, Hydrogen radical, Molecular model, Stereochemistry, Chemistry, Quantitative Structure-Activity Relationship, Regioselectivity, Empirical Research, Article, Drug metabolizing enzymes, Cytochrome P-450 Enzyme System, Models, Chemical, ROC Curve, Computational chemistry, Mechanism (philosophy), Drug Discovery, Humans, Molecular Medicine, Molecule, Hydrogen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d0b9a2456240510a9df85a667029e8
https://doi.org/10.1021/jm0613471

المؤلفون: Rhonda A. Torres, Kenneth R. Korzekwa, Robert B. Nachbar, Deborah L. Dooney, Robert P. Sheridan, Daniel R. McMasters, Susan J. Crathern

المصدر: Journal of Medicinal Chemistry. 50:3205-3213

مصطلحات موضوعية: CYP2D6, Cytochrome, Stereochemistry, Kinetics, Quantitative Structure-Activity Relationship, Isozyme, Article, Fluorescence, law.invention, law, Cytochrome P-450 CYP2D6 Inhibitors, Drug Discovery, Enzyme Inhibitors, Cytochrome P-450 CYP2C9, chemistry.chemical_classification, biology, Chemistry, Cytochrome P450, Recombinant Proteins, Enzyme, Biochemistry, biology.protein, Recombinant DNA, Molecular Medicine, Aryl Hydrocarbon Hydroxylases, Cytochrome P-450 CYP2D6

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654cc363c77b3e4ce9c6e2ef5b370a49
https://doi.org/10.1021/jm0700060

المؤلفون: S.-M. Huang, Robert A. Branch, J. Matthew Hutzler, Kenneth R. Korzekwa, Timothy S. Tracy, Reginald F. Frye

المصدر: European Journal of Pharmaceutical Sciences. 14:47-52

مصطلحات موضوعية: Flurbiprofen, Enzyme Activators, Pharmaceutical Science, Pharmacology, Dapsone, Cytochrome P-450 Enzyme System, Pharmacokinetics, Oral administration, In vivo, Blood plasma, medicine, Antibacterial agent, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Drug interaction, musculoskeletal system, Enzyme Activation, Kinetics, Steroid 16-alpha-Hydroxylase, Area Under Curve, Steroid Hydroxylases, Indicators and Reagents, lipids (amino acids, peptides, and proteins), Aryl Hydrocarbon Hydroxylases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96cfebd9074460dfb94963b28dcde31
https://doi.org/10.1016/s0928-0987(01)00144-0

المؤلفون: Magong Shou, Kenneth R. Korzekwa, LeeAnn Higgins, Streedhara Rao, Jeffrey P. Jones

المصدر: Archives of Biochemistry and Biophysics. 385:220-230

مصطلحات موضوعية: Hydrogen, Biophysics, chemistry.chemical_element, Ether, Anisoles, Photochemistry, Hydrogen atom abstraction, Biochemistry, Gas Chromatography-Mass Spectrometry, Substrate Specificity, Catalysis, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Isotopes, Computational chemistry, Kinetic isotope effect, Tumor Cells, Cultured, Humans, Molecular Biology, Regioselectivity, Kinetics, Models, Chemical, chemistry, Deuterium, Thermodynamics, Software, Methyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4e09dd12ed85800489da754699e6d5
https://doi.org/10.1006/abbi.2000.2147

المؤلفون: Charles A. Laughton, Yeh-Chih Kao, Shiuan Chen, Kenneth R. Korzekwa

المصدر: European Journal of Biochemistry. 268:243-251

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Reaction intermediate, Hydroxylation, Biochemistry, chemistry.chemical_compound, Aromatase, Catalytic Domain, Microsomes, medicine, Humans, Point Mutation, Computer Simulation, Binding site, Site-directed mutagenesis, chemistry.chemical_classification, biology, Aromatase Inhibitors, Substrate (chemistry), Estrogens, Recombinant Proteins, Kinetics, Enzyme, chemistry, Androgens, Mutagenesis, Site-Directed, biology.protein, Vorozole, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f4dfa952d5c070d9259faf79b3b5ce
https://doi.org/10.1046/j.1432-1033.2001.01886.x

المؤلفون: Kenneth E. Thummel, Steven A. Wrighton, Paul B. Watkins, Danny D. Shen, Erin G. Schuetz, Kenneth R. Korzekwa

المصدر: Drug Metabolism Reviews. 32:339-361

مصطلحات موضوعية: Genetics, Binding Sites, Subfamily, biology, CYP3A, Cytochrome P450, Kidney, Mixed Function Oxygenases, Substrate Specificity, Drug metabolizing enzymes, Cytochrome P-450 Enzyme System, Evolutionary biology, Enzyme Induction, Intestine, Small, biology.protein, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c26efda3a0b64569bcc4a98c0f6fd0
https://doi.org/10.1081/dmr-100102338

المؤلفون: Irving W. Wainer, Kenneth R. Korzekwa, Timothy S. Tracy, Frank J. Gonzalez

المصدر: British Journal of Clinical Pharmacology. 47:545-552

مصطلحات موضوعية: Metabolite, Cell Line, Mixed Function Oxygenases, Substrate Specificity, chemistry.chemical_compound, Cytochrome P-450 Enzyme System, Nitriles, Cytochrome P-450 CYP3A, Tumor Cells, Cultured, medicine, Humans, Pharmacology (medical), Pharmacology, Unspecific monooxygenase, biology, Cytochrome P450, Cytochrome P-450 CYP2E1, Stereoisomerism, Norverapamil, Metabolism, Isoenzymes, Kinetics, Cytochrome P-450 CYP2D6, Verapamil, Biochemistry, chemistry, biology.protein, Microsome, Original Article, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240d9771a80c8e2e72bca03cb304c62e
https://doi.org/10.1046/j.1365-2125.1999.00923.x