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1Academic Journal
المؤلفون: Jason Deng, Svetlana Belyanskaya, Ninad Prabhu, Christopher Arico-Muendel, Hongfeng Deng, Christopher B. Phelps, David I. Israel, Hongfang Yang, Joseph Boyer, G. Joseph Franklin, Jeremy L. Yap, Kenneth E. Lind, Ching-Hsuan Tsai, Christine Donahue, Jennifer D. Summerfield
المصدر: SLAS Discovery, Vol 29, Iss 5, Pp 100171- (2024)
مصطلحات موضوعية: DNA encoded library technology, Affinity selection, Cell profiling, Proteomics, Biomarker, Theranostics, Medicine (General), R5-920, Biotechnology, TP248.13-248.65
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3Academic Journal
المؤلفون: Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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4Academic Journal
المؤلفون: Bing Xia (76986), G. Joseph Franklin (1370352), Xiaojie Lu (1317612), Katie L. Bedard (1463110), LaShadric C. Grady (2216209), Jennifer D. Summerfield (10917160), Eric X. Shi (10917163), Bryan W. King (2177804), Kenneth E. Lind (1370316), Cynthia Chiu (10917166), Eleanor Watts (1774981), Vera Bodmer (10917169), Xiaopeng Bai (2643814), Lisa A. Marcaurelle (1342419)
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Pharmacology, Biotechnology, Cancer, Science Policy, Plant Biology, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, Off-DNA Chemistry DNA-encoded library, RIP, small-molecule mixture, cleavable linker, affinity selection mass spectrometry, acid-labile linker, PCR, tetrahydropyranyl ether, DEL, identification, data analysis, DNA tag, strategy, chemical structure, cleavable linkers, off-DNA resynthesis, receptor-interacting-protein kinase 2, photocleavable linker, AS-MS, affinity selection
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5
المؤلفون: Xiaopeng Bai, Eric X Shi, Kenneth E Lind, Lisa A Marcaurelle, Bing Xia, Vera Q. Bodmer, G Joseph Franklin, Cynthia H. Chiu, LaShadric C. Grady, Eleanor Watts, Jennifer Summerfield, Katie L Sargent Bedard, Xiaojie Lu, Bryan W. King
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Organic Chemistry, Drug Discovery, Active component, Computational biology, Cleavable linker, Biochemistry, Linker, DNA, Bridging (programming)
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6Academic Journal
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.514.94; http://nar.oxfordjournals.org/content/27/10/2189.full.pdf
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7Academic Journal
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.1921; http://nar.oxfordjournals.org/content/26/16/3694.full.pdf
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8
المؤلفون: Alex Shaginian, Graham L. Simpson, Kenneth E Lind, Christopher P. Davie, Zhengrong Zhu, Praew Thansandote, Sandeep Pal, La Shadric C Grady
المصدر: Methods in Molecular Biology ISBN: 9781493995035
مصطلحات موضوعية: 0303 health sciences, 010405 organic chemistry, Computer science, Drug discovery, Computational biology, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, Macrocyclic peptide, ComputingMethodologies_PATTERNRECOGNITION, chemistry, Pharmaceutical sciences, DNA, Selection (genetic algorithm), 030304 developmental biology
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9
المؤلفون: Ghotas Evindar, Zhengrong Zhu, Yun Ding, Kenneth E Lind, Christopher P. Davie, LaShadric C. Grady, Christopher B. Phelps
المصدر: Slas Discovery
مصطلحات موضوعية: 0301 basic medicine, irreversible inhibitors, 01 natural sciences, Biochemistry, Chromatography, Affinity, Analytical Chemistry, 03 medical and health sciences, Viral Proteins, Drug Discovery, Humans, selection of covalent binders, A-DNA, 3c protease, Gene Library, Original Research, 010405 organic chemistry, Drug discovery, Chemistry, affinity selections, DEL, Rupintrivir, 3C Viral Proteases, Combinatorial chemistry, Microspheres, DNA-encoded chemical libraries, 0104 chemical sciences, Cysteine Endopeptidases, 030104 developmental biology, Covalent bond, Molecular Medicine, covalent inhibitors, Selection method, DNA-encoded library technology, Biotechnology
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10
المؤلفون: Michael Thomson, Andrew J. Peat, Hamilton D. Dickson, Zhengrong Zhu, Derek J. Parks, Jianghe Deng, Leah Aquilani, Todd L. Graybill, Kenneth E Lind, Jesse D. Keicher, Christopher C. Arico-Muendel, Frank T. Coppo
المصدر: Antimicrobial Agents and Chemotherapy. 59:3450-3459
مصطلحات موضوعية: Genotype, viruses, Hepacivirus, Hepatitis C virus, Virus Replication, medicine.disease_cause, Antiviral Agents, Cell Line, medicine, Humans, Pharmacology (medical), Replicon, Pharmacology, chemistry.chemical_classification, biology, biology.organism_classification, Molecular biology, Small molecule, In vitro, Amino acid, Infectious Diseases, chemistry, Cell culture
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11
المؤلفون: Patricia A. Elkins, Steven R. Skinner, G Joseph Franklin, Nicholas D. Adams, Joelle Lorraine Burgess, Michael D. Schaber, Kenneth E Lind, Kaushik Raha, Ghotas Evindar, Yun Ding, Hongfang Yang, Paolo A. Centrella, Ruth Lehr, Steven D. Knight, Jennifer L. DeLorey, Kurt R. Auger, Sibongile Mataruse, John W. Cuozzo, Patricia F Medeiros, Schmidt Stanley J, Matthew A. Clark
المصدر: ACS Medicinal Chemistry Letters. 6:531-536
مصطلحات موضوعية: Gene isoform, Chemotype, Organic Chemistry, Mutant, Wild type, Computational biology, Biology, P110α, Biochemistry, Small molecule, Molecular biology, chemistry.chemical_compound, chemistry, Drug Discovery, DNA
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12
المؤلفون: Can Xie, Ching-Hsuan Tsai, Steven R. Skinner, David I. Israel, Koichi Yuki, Kenneth E Lind, John W. Cuozzo, Timothy A. Springer, Ghotas Evindar, Christopher S. Kollmann, Barry A. Morgan, Motomu Shimaoka, Xiaopeng Bai, Hongfang Yang, Zhengrong Zhu
المصدر: Bioorganic & Medicinal Chemistry. 22:2353-2365
مصطلحات موضوعية: Clinical Biochemistry, Intercellular Adhesion Molecule-1, Integrin, Pharmaceutical Science, Ligands, Biochemistry, Small Molecule Libraries, Jurkat Cells, Structure-Activity Relationship, Antigen, Drug Discovery, Cell Adhesion, Humans, Lymphocyte function-associated antigen 1, Cell adhesion, Molecular Biology, ICAM3, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Molecular biology, Small molecule, Lymphocyte Function-Associated Antigen-1, biology.protein, Molecular Medicine, Target protein, Protein Binding
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13
المؤلفون: Ghotas Evindar, Frank T. Coppo, George P. Vlasuk, Eli Schuman, Charles A. Blum, Cheney Mao, Lei Jin, Han Dai, Robert B. Perni, Jianghe Deng, Svetlana L. Belyanskaya, Todd L. Graybill, John W. Cuozzo, Leah Aquilani, Jeremy S. Disch, Cynthia H. Chiu, Siva Lavu, Kenneth E Lind
المصدر: Journal of Medicinal Chemistry. 56:3666-3679
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, medicine.drug_class, Carboxamide, SIRT2, chemistry.chemical_compound, Sirtuin 2, Sirtuin 1, Sirtuin 3, Drug Discovery, medicine, Humans, Sirtuins, biology, Nicotinamide, Drug discovery, Active site, Small molecule, Pyrimidines, chemistry, Biochemistry, Sirtuin, biology.protein, Molecular Medicine, NAD+ kinase
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14
المؤلفون: Todd L. Graybill, John D. Martin, Jason W. Dodson, Hongfeng Deng, Christopher P. Davie, Christopher C. Arico-Muendel, Minghui Wang, Hongwei Qi, Sandy S. Chang, David J. Holmes, Karen A. Ingraham, Kenneth E Lind, Heather O’Keefe, Carl A. Machutta, David Barros-Aguirre, Christine Patricia Donahue, Christina S. Pao, Jeffrey W. Gross, Ghotas Evindar, Jean Zhang, Bing Xia, Juan Wang, Patti McCormick, Xiaorong Liu, Jianzhong Huang, Joël Lelièvre, Quinn Lu, Pan F. Chan, Matt S. Steiginga, Lynn McCloskey, Christopher S. Kollmann, Taylor L. Graham, Xiaopeng Bai, Jing Chai, Yue Li, Walter P. Johnson, Ruth Lehr, Lawrence M. Szewczuk, Jingye Zhou, Lluis Ballell, Genaro S. Scavello, Robert H. Bates, Anthony E. Choudhry, Aaron Coffin, Sharon Sweitzer, Christopher R. Kwiatkowski, Andrew J. Pope, Enoch Gao, Christopher B. Phelps, David T. Fosbenner, Keith Rafferty, Thomas O’Keeffe, Gang Yao, Bryan W. King, Svetlana L. Belyanskaya, May Fern Toh, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Alfonso Mendoza-Losana, Paolo A. Centrella, Flora S. Sundersingh, Jeffrey A. Messer, Yun Ding, Jianghe Deng
المصدر: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)مصطلحات موضوعية: 0301 basic medicine, Acinetobacter baumannii, Staphylococcus aureus, Computer science, Science, Drug Evaluation, Preclinical, General Physics and Astronomy, Computational biology, Bioinformatics, Article, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Molecular Targeted Therapy, Gene Library, Multidisciplinary, Drug discovery, Correction, General Chemistry, Mycobacterium tuberculosis, Anti-Bacterial Agents, 030104 developmental biology, chemistry, Identification (biology), DNA
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15
المؤلفون: Robert P. Davis, Kelly Locke, Rab K. Prinjha, Peter D. Craggs, Gang Yao, Chun-wa Chung, Kenneth E Lind, Oxana Polyakova, Jim E Coote, Daniel J. Slade, Jim Thorpe, John Liddle, David Matthew Wilson, Benjamin D. Bax, Denisa D. Wagner, Kimberly Martinod, Ryan P. Bingham, Yu Hua Chen, Kevin L. Bicker, Claire Maller, Matthew Campbell, Gerard Joberty, Huw D. Lewis, Dirk Eberhard, Martin Rüdiger, Gerard Drewes, Paul R. Thompson, Cecil E Rise, Robert J. Sheppard, Chris Patten, Stephen John Atkinson, Michael David Barker, Pamela Thomas
المساهمون: Biochemistry, Center for Drug Discovery
المصدر: Nature chemical biology
مصطلحات موضوعية: Models, Molecular, Hydrolases, Neutrophils, In Vitro Techniques, Binding, Competitive, Article, Substrate Specificity, Histones, Small Molecule Libraries, Pathogenesis, Mice, chemistry.chemical_compound, Protein-Arginine Deiminase Type 4, Citrulline, Animals, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, HEK 293 cells, Protein-arginine deiminase, Cell Biology, Neutrophil extracellular traps, Cell biology, Histone citrullination, HEK293 Cells, Enzyme, Histone, chemistry, Biochemistry, Protein-Arginine Deiminases, biology.protein, Benzimidazoles, Calcium
وصف الملف: 189 - 191 page(s); application/pdf
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16
المؤلفون: Paolo A. Centrella, Christopher C. Arico-Muendel, Gary M. Olson, Jennifer L Svendsen, Matthew T. Labenski, Steven R. Skinner, Charles D. Thompson, Christopher L. Paradise, Dennis Benjamin, Barbara C. Sluboski, Kenneth E Lind, Brooke D. Contonio, Teresa M Caiazzo, Christopher Self, Gerhard Hannig, Barry A. Morgan, William F. Westlin, Elisabeth Doyle, Charles M. Cook, Kerry White, Lily Lee Searle
المصدر: Journal of Medicinal Chemistry. 52:8047-8056
مصطلحات موضوعية: Models, Molecular, Methionyl aminopeptidase, Cell Growth Processes, Aminopeptidases, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Cyclohexanes, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Fumagillin, Amino Acids, Methionine, biology, Endothelial Cells, Metalloendopeptidases, METAP2, chemistry, Biochemistry, Enzyme inhibitor, Fatty Acids, Unsaturated, biology.protein, Molecular Medicine, Cattle, Carbamates, Sesquiterpenes, Lead compound, medicine.drug
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17
المؤلفون: Malcolm L. Gefter, Alexander L. Satz, Matthew C Oliff, Cecil E Rise, Sibongile Mataruse, Fan Li, Cynthia H. Chiu, John W. Cuozzo, Steven R. Skinner, Matthew A. Clark, Gang Yao, Kurt D Franzen, Paul Myers, Heather O’Keefe, Lujia Tang, Christopher S. Kollmann, Christopher P. Davie, Nils Jakob Vest Hansen, Neil R Carlson, Paolo A. Centrella, Michael Kelley, Patricia F Medeiros, Steven P Hale, Richard W. Wagner, Christopher C. Arico-Muendel, Dennis Benjamin, David I. Israel, Kurt van Vloten, G Joseph Franklin, Svetlana L. Belyanskaya, Jennifer L Svendsen, Kenneth E Lind, Raksha A. Acharya, Barry A. Morgan, Baoguang Zhao, Steffen Phillip Creaser, Malcolm J. Kavarana, Jinwei Jiang, Jeffrey A. Messer, Yun Ding
المصدر: Nature Chemical Biology. 5:647-654
مصطلحات موضوعية: Models, Molecular, Materials science, Phage display, Combinatorial Chemistry Techniques, Oligonucleotide, DNA-encoded chemical library, Drug discovery, Aptamer, Small Molecule Libraries, DNA, Cell Biology, Computational biology, Protein Serine-Threonine Kinases, p38 Mitogen-Activated Protein Kinases, Small molecule, Aurora Kinases, Drug Design, Animals, Protein Kinase Inhibitors, Molecular Biology
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18
المؤلفون: Kenneth E. Lind, Venkatraman Mohan, Muthiah Manoharan, David M. Ferguson, Divi Venkateswarlu
المصدر: Nucleic Acids Research. 27:2189-2195
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Ribose, Implicit solvation, Ribonuclease H, Substituent, Methylation, chemistry.chemical_compound, Drug Stability, Genetics, A-DNA, RNase H, Base Sequence, biology, Nucleic Acid Heteroduplexes, RNA, DNA, DNA Methylation, chemistry, Biochemistry, Nucleic acid, biology.protein, Nucleic Acid Conformation, Thermodynamics, Research Article, Macromolecule
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19
المؤلفون: G Joseph Franklin, Raksha A. Acharya, Thomas Lohr, J. Larkin, Gary K. O’Donovan, Christopher C. Arico-Muendel, Todd W Shearer, Sibongile Mataruse, John W. Cuozzo, Hongfeng Deng, Paolo A. Centrella, Michael Neeb, Rosalie Matico, Katie L Sargent Bedard, Jeffrey W. Gross, Tiffany Carpenter, Kenneth E Lind, Heather O’Keefe, Kurt van Vloten, Matthew A. Clark, Svetlana L. Belyanskaya, Christopher P. Davie, Monique M Thompson, Steven R. Skinner, Barry A. Morgan
المصدر: Journal of medicinal chemistry. 55(16)
مصطلحات موضوعية: Cartilage, Articular, Male, Stereochemistry, Stereoisomerism, In Vitro Techniques, Rats, Sprague-Dawley, Small Molecule Libraries, chemistry.chemical_compound, Epitopes, Structure-Activity Relationship, Drug Discovery, Endopeptidases, Osteoarthritis, Structure–activity relationship, Animals, Humans, Aggrecans, IC50, Glycosaminoglycans, Metalloproteinase, Sulfonamides, Triazines, ADAMTS, Middle Aged, Small molecule, Rats, ADAM Proteins, chemistry, Molecular Medicine, ADAMTS5 Protein, DNA, Databases, Chemical
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20
المؤلفون: Anwer Mujeeb, Thomas L. James, Anton V. Filikov, Kenneth E. Lind
المصدر: Journal of biomolecular structuredynamics. 17
مصطلحات موضوعية: Virtual screening, Chemistry, Drug candidate, Drug discovery, RNA, General Medicine, Genome, Combinatorial chemistry, Lead (geology), Structural Biology, Drug Design, Drug Discovery, Nucleic acid structure, Molecular Biology