-
1Academic Journal
المؤلفون: David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
-
2
المؤلفون: Matthew A. Powell, Tim Hui-Ming Huang, Pearlly S. Yan, David G. Mutch, Mary Ann Mallon, Ken C. Walls, Amy P. Schmidt, Paul J. Goodfellow, Israel Zighelboim
-
3
المؤلفون: Alessandra C. Martini, Kristine Minh Tran, Kelly Do Huynh, Cristina Nuñez-Diaz, Franklin Garcia, Celia da Cunha, Kim N. Green, Andrea J. Tenner, Rahasson R. Ager, Stefania Forner, David Baglietto-Vargas, Dina P. Matheos, Marcelo A. Wood, Carlos J. Rodriguez-Ortiz, Laura Trujillo-Estrada, Frank M. LaFerla, Enikö A. Kramár, Jimmy Phan, Xinyi Ma, Claudio Soto, Ines Moreno-Gonzalez, Grant R. MacGregor, Vivek Swarup, Juan Antonio García-León, Lena Cai, Masashi Kitazawa, Dominic I. Javonillo, Mohammad Shahnawaz, Jessica E. Childs, Antonia Gutierrez, Ali Mortazavi, Shan Jiang, Marie Minh Thu Nguyen, Gabriela Balderrama-Gutierrez, Ken C. Walls
المساهمون: [Baglietto-Vargas,D, Forner,S, Cai,L, Martini,AC, Trujillo-Estrada,L, Swarup,V, Nguyen,MMT, Do Huynh,K, Javonillo,DI, Tran,KM, Phan,J, Kramár,EA, Garcia,F, Childs,J, Rodriguez-Ortiz,CJ, Kitazawa,M, Matheos,DP, Da Cunha,C, Walls,KC, Ager,RR, Tenner,AJ, Wood,M, Green,KM, LaFerla,FM] Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. [Baglietto-Vargas,D, LaFerla,FM] Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. [Baglietto-Vargas,D, Nuñez-Diaz,C, Garcia-Leon,JA, Gutierrez,A, Moreno-Gonzalez,I] Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain. [Jiang,S, Balderrama-Gutierrez,G, Ma,X, Mortazavi,A, MacGregor,GR] Department of Developmental and Cell Biology, University of California, Irvine, CA, USA. [Rodriguez-Ortiz,CJ, Kitazawa,M] Division of Occupational and Environmental Medicine, Department of Medicine. Center for Occupational and Environmental Health (COEH), University of California, Irvine, CA, USA. [Shahnawaz,M, Soto,C, Moreno-Gonzale,I] The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA. [Tenner,AJ] Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA., This study was initiated by the generosity of Harry Bubb through Cure Alzheimer’s Fund CAF-50997 (F.M.L.). Additional support was from Alzheimer’s Association NIRG-15-363477 (D.B.V.), AARF-16-440760 (S.F.) and NIRG-394284 (I.M.G.), The Larry Hillblom Foundation 2013-A-016-FEL (D.B.V.) and 2016-A-016-FEL (A.C.M.), the National Institute of Health (NIH) NIH/NIA/NINDS AG027544 (F.M.L.), AG00538 (F.M.L.), AG54884 (F.M.L.), OD010420 (F.M.L.), U54 AG054349 (F.M.L., A.J.T.), AG049562 (C.S.) NS083801 (K.N.G.) and AG056768 (K.N.G.), BrightFocus Foundation grant A2015535S (F.M.L.), by Minister of Science and Innovation grant PID2019-108911RA-100 (D.B.V.), Beatriz Galindo program BAGAL18/00052 (D.B.V.) and Institute of Health Carlos III (ISCiii) grant PI18/01557 (A.G.) co-financed by FEDER funds from European Union, by American federation of aging research-AFAR young investigator award and UC Irvine startup funds (V.S.) and UCI MIND pilot project (D.B.V.). The UCI-ADRC is funded by NIH/NIA Grant P50 AG16573 (F.M.L.). Genetically modified hAβ-KI mice were generated by the UCI Transgenic Mouse Facility, a shared resource funded in part by the Chao Family Comprehensive Cancer Center Support Grant (P30CA062203) from the National Cancer Institute. We thank Drs. Malcolm Leissring and Rodrigo Medeiros for critically reading the manuscript.
المصدر: Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)مصطلحات موضوعية: 0301 basic medicine, Male, Aging, Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genetic Research::Gene Ontology [Medical Subject Headings], Information Science::Information Science::Computing Methodologies::Software::Mobile Applications [Medical Subject Headings], General Physics and Astronomy, Neurodegenerative, medicine.disease_cause, Inbred C57BL, Alzheimer's Disease, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Exons [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression [Medical Subject Headings], Transgenic, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Exon, Mice, Amyloid beta-Protein Precursor, Cognition, 0302 clinical medicine, Enfermedad de Alzheimer, Gene expression, Organisms::Eukaryota::Animals [Medical Subject Headings], 2.1 Biological and endogenous factors, Gene Regulatory Networks, Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic [Medical Subject Headings], Aetiology, Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Neuronal Plasticity [Medical Subject Headings], Mutation, Multidisciplinary, Neuronal Plasticity, Reacción del ácido peryódico de Schiff, Brain, Alzheimer's disease, Cell biology, Chemicals and Drugs::Inorganic Chemicals::Acids::Acids, Noncarboxylic::Periodic Acid [Medical Subject Headings], Neurological, Female, Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Periodic acid-schiff, Science, Transgene, Check Tags::Male [Medical Subject Headings], Cre recombinase, Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::Regulatory Sequences, Nucleic Acid::Gene Regulatory Networks [Medical Subject Headings], Locus (genetics), Mice, Transgenic, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling [Medical Subject Headings], Biology, Molecular neuroscience, Exones, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Alzheimer Disease, medicine, Acquired Cognitive Impairment, Genetics, Animals, Humans, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Amino Acids [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Cognición, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings], Amyloid beta-Peptides, Mutación, Animal, Gene Expression Profiling, Wild type, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Amyloid beta-Peptides [Medical Subject Headings], Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings], General Chemistry, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Amyloid::Amyloidogenic Proteins::Amyloid beta-Protein Precursor [Medical Subject Headings], Diseases::Animal Diseases::Disease Models, Animal [Medical Subject Headings], Brain Disorders, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Gene Ontology, Check Tags::Female [Medical Subject Headings], Synaptic plasticity, Disease Models, Dementia, Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL [Medical Subject Headings], 030217 neurology & neurosurgery, Expresión génica
وصف الملف: application/pdf
-
4
المؤلفون: Kathleen C. Baysac, Krikor Dikranian, Ken C. Walls, Heather M. Christensen, John W. Olney, Kevin A. Roth, David A. Harris, Aimin Li
المصدر: The American Journal of Pathology. 176:2695-2706
مصطلحات موضوعية: Programmed cell death, Cerebellum, Prions, Apoptosis, Mice, Transgenic, Biology, Caspase 8, Pathology and Forensic Medicine, Mice, Mice, Neurologic Mutants, Autophagy, medicine, Animals, PrPC Proteins, Cell Shape, Neurons, Cell Death, Caspase 3, Nuclear matrix, Chromatin, Cell biology, Enzyme Activation, medicine.anatomical_structure, Mice, Inbred CBA, biology.protein, Protein A, Biomarkers, Regular Articles
-
5
المؤلفون: Ken C. Walls, Kevin A. Roth, Arindam P. Ghosh, John J. Shacka, Barbara J. Klocke, Jianhua Zhang, Mary E. Ballestas, Aimee V. Franklin
المصدر: Journal of Biological Chemistry. 285:10497-10507
مصطلحات موضوعية: Programmed cell death, Antifungal Agents, Blotting, Western, Fluorescent Antibody Technique, Apoptosis, Vacuole, Biology, Autophagy-Related Protein 7, Biochemistry, Antimalarials, Mice, Cerebellum, Lysosome, Autophagy, medicine, Animals, RNA, Messenger, RNA, Small Interfering, Molecular Biology, bcl-2-Associated X Protein, Mice, Knockout, Neurons, Gene knockdown, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, Neurodegeneration, Chloroquine, Cell Biology, medicine.disease, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Caspases, Fibroblast Growth Factor 2, Macrolides, Tumor Suppressor Protein p53, Lysosomes, Microtubule-Associated Proteins, Signal Transduction
-
6
المؤلفون: Ying Geng, Rizwan S. Akhtar, Arindam P. Ghosh, Ken C. Walls, Barbara J. Klocke, Kevin A. Roth
المصدر: Journal of Histochemistry & Cytochemistry. 58:265-275
مصطلحات موضوعية: Cytoplasm, Histology, Transcription, Genetic, Apoptosis, Mitochondrion, Article, Cell Line, Mice, Bcl-2-associated X protein, Cerebellum, Puma, Precursor cell, medicine, Animals, Staurosporine, bcl-2-Associated X Protein, Mice, Knockout, Neurons, biology, Caspase 3, Kinase, Stem Cells, Nuclear Proteins, Colocalization, biology.organism_classification, Molecular biology, Mitochondria, Cell biology, Enzyme Activation, Animals, Newborn, biology.protein, Tumor Suppressor Protein p53, Anatomy, Nucleophosmin, medicine.drug
-
7
المؤلفون: Barbara J. Klocke, Kevin A. Roth, Andreas Strasser, Arindam P. Ghosh, Rune Toms, Ken C. Walls
المصدر: Journal of Neuropathology & Experimental Neurology. 68:747-756
مصطلحات موضوعية: Programmed cell death, Time Factors, Blotting, Western, Apoptosis, Caspase 3, Article, Pathology and Forensic Medicine, Mice, Cellular and Molecular Neuroscience, Bcl-2-associated X protein, Proto-Oncogene Proteins, Puma, medicine, Animals, BCL-2 Gene Family, bcl-2-Associated X Protein, Mice, Knockout, Neurons, Bcl-2-Like Protein 11, Ethanol, biology, Tumor Suppressor Proteins, Neuropeptides, Bcl-2 family, Neurodegeneration, Membrane Proteins, General Medicine, biology.organism_classification, medicine.disease, Immunohistochemistry, Cell biology, Mice, Inbred C57BL, Proto-Oncogene Proteins c-bcl-2, Neurology, biology.protein, Neurology (clinical), Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins
-
8
المؤلفون: Amy P. Schmidt, Ken C. Walls, David G. Mutch, Israel Zighelboim, Matthew A. Powell, Mary Ann Mallon, Pearlly S. Yan, Tim H M Huang, Paul J. Goodfellow
المصدر: Clinical Cancer Research. 13:2882-2889
مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Survival, Restriction Mapping, Thyroid Nuclear Factor 1, Bisulfite sequencing, Biology, MLH1, Combined bisulfite restriction analysis, Biomarkers, Tumor, medicine, Humans, neoplasms, Heat-Shock Proteins, Oligonucleotide Array Sequence Analysis, Endometrial cancer, Nuclear Proteins, Cancer, Methylation, DNA Methylation, Prognosis, medicine.disease, Endometrial Neoplasms, Oncology, CpG site, DNA methylation, Cancer research, CpG Islands, Female, Carcinoma, Endometrioid, Transcription Factors
-
9
المؤلفون: Paul J. Goodfellow, Ming Yu Fan, Katherine Y. Look, Elizabeth M. Swisher, Randall K. Gibb, Thomas J. Herzog, David G. Mutch, Barbara M. Buttin, Ken C. Walls, Janet S. Rader
المصدر: Proceedings of the National Academy of Sciences. 100:5908-5913
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Base Pair Mismatch, Colorectal cancer, Molecular Sequence Data, Population, Biology, MLH1, Frameshift mutation, Endometrium, Reference Values, medicine, Humans, Amino Acid Sequence, Codon, Frameshift Mutation, education, neoplasms, Polymorphism, Single-Stranded Conformational, Sequence Deletion, education.field_of_study, Multidisciplinary, Endometrial cancer, Age Factors, Genetic Variation, nutritional and metabolic diseases, Microsatellite instability, Exons, DNA Methylation, Middle Aged, Biological Sciences, medicine.disease, digestive system diseases, Endometrial Neoplasms, DNA-Binding Proteins, MSH6, Mutagenesis, Insertional, Mutation, Codon, Terminator, DNA Transposable Elements, Cancer research, Female, DNA mismatch repair
-
10
المؤلفون: Dave Cheng, Frank M. LaFerla, Rodrigo Medeiros, Vitaly Vasilevko, Rahasson R. Ager, Ken C. Walls
مصطلحات موضوعية: Neurofibrillary tangles, Aging, Tau pathology, medicine.medical_treatment, Hippocampus, Mice, Transgenic, tau Proteins, Disease, Beta-amyloid, Neurodegenerative, Alzheimer's Disease, Transgenic, Epitope, Article, Antibodies, Vaccine Related, Mice, Amyloid beta-Protein Precursor, Epitopes, Alzheimer Disease, mental disorders, Acquired Cognitive Impairment, medicine, Psychology, Animals, Phosphorylation, Pathological, biology, Phosphorylated tau, business.industry, General Neuroscience, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Immunotherapy, Brain Disorders, Neurological, Immunology, biology.protein, Immunization, Dementia, Cognitive Sciences, Tau, Antibody, business
وصف الملف: application/pdf
-
11
المؤلفون: Frank M. LaFerla, Anet Minassian, George D. Dickinson, Kim N. Green, Kara M. Neely Kayala, Ken C. Walls
المصدر: Brain research. 1489
مصطلحات موضوعية: Green Fluorescent Proteins, chemistry.chemical_element, Gene Expression, Biology, Calcium, Presenilin, Article, Mice, Lysosome, mental disorders, Presenilin-2, medicine, Autophagy, Presenilin-1, Animals, Molecular Biology, Cells, Cultured, Calcium metabolism, Mice, Knockout, Voltage-dependent calcium channel, Ryanodine receptor, General Neuroscience, Calcium channel, Fibroblasts, Cell biology, Two-pore channel, medicine.anatomical_structure, chemistry, Neurology (clinical), Calcium Channels, Lysosomes, Developmental Biology
-
12
المؤلفون: Nineli Zadourian, Suhail Rasool, Mathew Blurton-Jones, Frank M. LaFerla, Pinar Coskun, Kristine K. Freude, Kim N. Green, Ken C. Walls, Jose Luis Gallegos-Perez
المصدر: The Journal of biological chemistry. 287(36)
مصطلحات موضوعية: Amyloid, Nicastrin, Mice, Transgenic, Mitochondrion, Biochemistry, Cell Line, Mitochondrial Proteins, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, mental disorders, Amyloid precursor protein, Animals, Humans, Molecular Biology, biology, P3 peptide, Brain, Molecular Bases of Disease, Cell Biology, Chaperonin 60, Molecular biology, Biochemistry of Alzheimer's disease, Cell biology, Mitochondria, Disease Models, Animal, Protein Transport, Alpha secretase, biology.protein, HSP60, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase
-
13
المؤلفون: Kevin A. Roth, Ken C. Walls
المصدر: Neural Development and Stem Cells ISBN: 9781461438007
مصطلحات موضوعية: Nervous system, Programmed cell death, medicine.anatomical_structure, biology, DNA damage, Apoptosis, Autophagy, medicine, biology.protein, Cytotoxic T cell, Neuroscience, Neural stem cell, Caspase
-
14
المصدر: Journal of neuropathology and experimental neurology. 68(12)
مصطلحات موضوعية: Programmed cell death, Blotting, Western, Caspase 3, Apoptosis, Article, Pathology and Forensic Medicine, Mitochondrial Proteins, Cellular and Molecular Neuroscience, Mice, Precursor cell, Animals, Enzyme Inhibitors, Caspase, Neurons, Microscopy, Confocal, biology, Reverse Transcriptase Polymerase Chain Reaction, Stem Cells, Membrane Proteins, General Medicine, Molecular biology, Immunohistochemistry, Neural stem cell, Cell Hypoxia, Cell biology, Enzyme Activation, Mice, Inbred C57BL, Neurology, Hypoxia-inducible factors, biology.protein, RNA Interference, Neurology (clinical), Neuron death, Signal Transduction
-
15
المؤلفون: Kevin A. Roth, Lisa D Speake, Talene A. Yacoubian, Yasuo Uchiyama, Takeshi Iwatsubo, Scott M. Wilson, Stephen L. Crimmins, David G. Standaert, Jianhua Zhang, Ken C. Walls, John J. Shacka, Qiuli Liang, Zuo-Lei Xie, Liyan Qiao, Lisheng Peng, YouMing Lu, Rachael Parks, Donna M. Crabtree, Shusei Hamamichi, Kim A. Caldwell, Yi Zhou, Guy A. Caldwell, Lonnie Schneider
المصدر: Scopus-Elsevier
Molecular Brain
Molecular Brain, Vol 1, Iss 1, p 17 (2008)مصطلحات موضوعية: Proteasome Endopeptidase Complex, Programmed cell death, animal diseases, Cathepsin D, Biology, Neuroprotection, lcsh:RC346-429, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Phagosomes, medicine, Animals, Humans, Point Mutation, heterocyclic compounds, RNA, Messenger, Caenorhabditis elegans, Protein Structure, Quaternary, Molecular Biology, lcsh:Neurology. Diseases of the nervous system, 030304 developmental biology, Neurons, Alpha-synuclein, 0303 health sciences, Lewy body, Caspase 3, Research, Neurodegeneration, Autophagy, medicine.disease, Molecular biology, Up-Regulation, nervous system diseases, Mice, Inbred C57BL, Neuroprotective Agents, nervous system, chemistry, alpha-Synuclein, Neuronal ceroid lipofuscinosis, Lysosomes, 030217 neurology & neurosurgery
-
16
المؤلفون: Ying Geng, Ken C. Walls, Kevin A. Roth, Jianhua Zhang
المصدر: The FASEB Journal. 22
مصطلحات موضوعية: Stress (mechanics), business.industry, Autophagy, Genetics, Medicine, business, Molecular Biology, Biochemistry, Biotechnology, Cell biology
-
17
المؤلفون: Ken C. Walls, Kevin A. Roth, Ying Geng
المصدر: The FASEB Journal. 21
مصطلحات موضوعية: Genetics, Biology, Molecular Biology, Biochemistry, Neuroscience, Neural stem cell, Biotechnology
-
18
المؤلفون: Paul Saftig, Yasuo Uchiyama, John J. Shacka, Kevin A. Roth, Barbara J. Klocke, Ken C. Walls, Masahiro Shibata
المصدر: Autophagy. 3(3)
مصطلحات موضوعية: Autophagosome, Batten disease, Cathepsin D, Apoptosis, Biology, Glycogen Synthase Kinase 3, Mice, Phosphatidylinositol 3-Kinases, Phagosomes, medicine, Autophagy, Animals, Phosphorylation, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Neurons, Glycogen Synthase Kinase 3 beta, TOR Serine-Threonine Kinases, Brain, Proteins, Cell Biology, medicine.disease, Cell biology, Mice, Inbred C57BL, Phosphatidylinositol 3-kinase signaling, Beclin-1, Signal transduction, Apoptosis Regulatory Proteins, Protein Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction
Full Text Finder