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1
المؤلفون: Pauline A. Girdwood, Susan Freeman, Robert G. Davidson, Geoffrey A. Holdgate, Brown George Robert, Walter H.J. Ward, M.Allan Eakin, Fergus McTaggart, Keith Blakeney Mallion
المصدر: Biochemical Pharmacology. 51:1489-1501
مصطلحات موضوعية: Quinuclidines, Stereochemistry, Kinetics, Farnesyl pyrophosphate, Sensitivity and Specificity, Biochemistry, Squalene, chemistry.chemical_compound, Animals, Humans, Enzyme Inhibitors, Pharmacology, Farnesyl-diphosphate farnesyltransferase, Binding Sites, Dose-Response Relationship, Drug, biology, Chemistry, Substrate (chemistry), Callithrix, Rats, Farnesyl-Diphosphate Farnesyltransferase, Enzyme inhibitor, Microsomes, Liver, Microsome, biology.protein, Quinuclidine
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2
المؤلفون: Keith Blakeney Mallion, M. C. Johnson, Brown George Robert, Alan J. Foubister, D. Griffiths, Susan Freeman, S. Chapman, M. A. Eakin, Harrison Peter John, R. J. Butlin
المصدر: Journal of Medicinal Chemistry. 38:4157-4160
مصطلحات موضوعية: Administration, Oral, Mevalonic Acid, Chemical synthesis, Structure-Activity Relationship, Squalene, chemistry.chemical_compound, Oral administration, Drug Discovery, Animals, Enzyme Inhibitors, chemistry.chemical_classification, Farnesyl-diphosphate farnesyltransferase, Molecular Structure, Propylamines, ATP synthase, biology, Cholesterol, Anticholesteremic Agents, Rats, Farnesyl-Diphosphate Farnesyltransferase, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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3
المؤلفون: R. P. Walker, Alan J. Foubister, Brown George Robert, Graham J. Smith, Susan Freeman, M. A. Eakin, Harrison Peter John, D. Griffiths, M. J. Taylor, P. R. O. Whittamore, Fergus McTaggart, A. C. Reid, Keith Blakeney Mallion, M. C. Johnson, R. J. Butlin, S. Chapman
المصدر: ChemInform. 27
مصطلحات موضوعية: Squalene, chemistry.chemical_compound, ATP synthase, biology, Chemistry, Stereochemistry, biology.protein, Organic chemistry, General Medicine
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4
المؤلفون: Fergus McTaggart, Alan J. Foubister, M. J. Taylor, David S. Clarke, John McCormick, Graham J. Smith, M. C. Johnson, Susan Freeman, Keith Blakeney Mallion, Harrison Peter John, Alan C. Reid, George R. Brown
المصدر: ChemInform. 27
مصطلحات موضوعية: chemistry.chemical_compound, Squalene, In vivo, Chemistry, Stereochemistry, Lipophilicity, Microsome, Substituent, Potency, General Medicine, IC50, Quinuclidine
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5
المؤلفون: David S. Clarke, John McCormick, Alan C. Reid, M. C. Johnson, Alan J. Foubister, George R. Brown, Fergus McTaggart, Graham J. Smith, Susan Freeman, Harrison Peter John, M. J. Taylor, Keith Blakeney Mallion
المصدر: Journal of medicinal chemistry. 39(15)
مصطلحات موضوعية: Quinuclidines, Stereochemistry, Substituent, Mevalonic Acid, Chemical synthesis, chemistry.chemical_compound, Squalene, Structure-Activity Relationship, Drug Discovery, Potency, Animals, Enzyme Inhibitors, Farnesyl-diphosphate farnesyltransferase, Binding Sites, biology, Molecular Structure, Anticholesteremic Agents, Stereoisomerism, Rats, Cholesterol, Farnesyl-Diphosphate Farnesyltransferase, chemistry, Enzyme inhibitor, Lipophilicity, biology.protein, Microsomes, Liver, Molecular Medicine, Quinuclidine
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6
المؤلفون: Fergus McTaggart, Graham J. Smith, Robert G. Davidson, Susan Freeman, Keith Blakeney Mallion, Walter H.J. Ward, Geoffrey A. Holdgate, Donald J. Mirrlees, Brown George Robert
المصدر: Biochemical pharmacology. 51(11)
مصطلحات موضوعية: Quinuclidines, Stereochemistry, Farnesyl pyrophosphate, Mevalonic Acid, Tritium, Biochemistry, Sensitivity and Specificity, chemistry.chemical_compound, Squalene, Dolichol, Animals, Enzyme Inhibitors, Pharmacology, Farnesyl-diphosphate farnesyltransferase, biology, Cholesterol, Rats, Inbred Strains, Farnesol, Rats, Kinetics, Farnesyl-Diphosphate Farnesyltransferase, chemistry, Liver, Enzyme inhibitor, biology.protein, Female, Mevalonate pathway
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7
المؤلفون: R. A. Raphael, Jean Bowler, Keith Blakeney Mallion
المصدر: Synthetic Communications. 4:211-213
مصطلحات موضوعية: chemistry.chemical_classification, Allylic rearrangement, Ketone, Sodium, Organic Chemistry, chemistry.chemical_element, Prostaglandin, Aluminium isopropoxide, Zinc, Borohydride, chemistry.chemical_compound, chemistry, Organic chemistry, Enone
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8ChemInform Abstract: 2-ARYLOXYMETHYL-2,3,4,5-TETRAHYDRO-1,4-OXAZINES, A NEW CLASS OF ANTIDEPRESSANTS
المصدر: Chemischer Informationsdienst. 6
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Organic chemistry, Oxazines, General Medicine
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9
المؤلفون: Keith Blakeney Mallion, B. A. Whittle, D. T. Greenwood, Ralph W. Turner, J. Madinaveitia, J. G. Bainbridge, A. R. Somerville, Alexander Henry Todd
المصدر: Nature. 238(5360)
مصطلحات موضوعية: Central Nervous System, Chemical Phenomena, Hydrochloride, Pharmacology, In Vitro Techniques, Motor Activity, Medicinal chemistry, chemistry.chemical_compound, Mice, Oxazines, Animals, Hypnotics and Sedatives, Alkyl, chemistry.chemical_classification, Multidisciplinary, biology, Chemistry, biology.organism_classification, Antidepressive Agents, Rats, Amphetamine, Tetra, Amine gas treating, Anticonvulsants, Psychotropic Agent, Ethers
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10
المؤلفون: J. G. Bainbridge, Alexander Henry Todd, D. T. Greenwood, J. Madinaveitia, A. R. Somerville, Keith Blakeney Mallion, Ralph W. Turner, B. A. Whittle
المصدر: Chemischer Informationsdienst. 3
مصطلحات موضوعية: Chemistry, General Medicine, Medicinal chemistry