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1
المؤلفون: Daniel Hammler, Franziska Müller, Stormy J. Chamberlain, Jasmin Jansen, Carissa L. Sirois, Andreas Marx, Florian Stengel, Kathrin H. Götz, Martin Scheffner, Fabian Offensperger
المصدر: Cell chemical biology. 27(12)
مصطلحات موضوعية: Angelman syndrome, E6AP, UBE3A, ubiquitin ligase, fluorescence polarization, high-throughput screen, small-molecule activator, cross-linking coupled to mass spectrometry, XL-MS, Protein Conformation, Ubiquitin-Protein Ligases, Clinical Biochemistry, UBE3A gene, 01 natural sciences, Biochemistry, Small Molecule Libraries, ddc:570, Drug Discovery, Enzyme Stability, medicine, Point Mutation, Molecular Biology, Gene, Pharmacology, Genetics, biology, 010405 organic chemistry, Point mutation, medicine.disease, Small molecule, 0104 chemical sciences, Ubiquitin ligase, Enzyme Activation, Drug Design, biology.protein, Molecular Medicine, Identification (biology), Angelman Syndrome
وصف الملف: application/pdf
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2
المؤلفون: Daniel Mayer, Jan-Niklas Dürig, Kathrin H. Götz, Steffen Stenger, Stephan M. Hacker, Andreas Marx
المصدر: ACS Chemical Biology. 12:2682-2689
مصطلحات موضوعية: 0301 basic medicine, Cell Survival, Biology, 01 natural sciences, Biochemistry, Gene Expression Regulation, Enzymologic, Mycobacterium tuberculosis, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, Glycogen phosphorylase, Humans, Enzyme Inhibitors, chemistry.chemical_classification, 010405 organic chemistry, Gene Expression Regulation, Bacterial, General Medicine, biology.organism_classification, Nucleotidyltransferases, Molecular biology, Small molecule, In vitro, High-Throughput Screening Assays, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine, Signal transduction, Ap4A, Dinucleoside Phosphates, Intracellular, HeLa Cells, Protein Binding
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3
المصدر: Carbohydrate research. 486
مصطلحات موضوعية: Reaction conditions, Glycosylation, Series (mathematics), 010405 organic chemistry, Chemistry, Organic Chemistry, General Medicine, Chemistry Techniques, Synthetic, 010402 general chemistry, Bromine, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, Characterization (materials science), symbols.namesake, Basic research, Computational chemistry, symbols, Glycosides, Systematic synthesis, Fischer glycosidation
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4
المؤلفون: Fabian Offensperger, Kathrin H. Götz, Katrin Stuber, Andreas Marx, Martin Mex, Martin Scheffner
المصدر: Cell chemical biology. 26(11)
مصطلحات موضوعية: Ubiquitin-activating enzyme, Clinical Biochemistry, Adenylate kinase, Ubiquitin-Activating Enzymes, 01 natural sciences, Biochemistry, Mass Spectrometry, Ubiquitin, Drug Discovery, Humans, Molecular Biology, Chromatography, High Pressure Liquid, Pharmacology, Amino acid activation, chemistry.chemical_classification, biology, 010405 organic chemistry, UBA1, Recombinant Proteins, 0104 chemical sciences, Cell biology, Enzyme, chemistry, Mutagenesis, ddc:540, biology.protein, Biocatalysis, Small Ubiquitin-Related Modifier Proteins, Molecular Medicine, diadenosine tetraphosphate, diadenosine triphosphate, ApnA, ubiquitin-activating enzyme, UBA1, ubiquitin-like proteins, alarmone, ATP, Intracellular, Dinucleoside Phosphates, Alarmone
وصف الملف: application/pdf
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5
المصدر: Carbohydrate Research. 425:28-34
مصطلحات موضوعية: Molecular Conformation, Triazole, Oligosaccharides, chemistry.chemical_element, 010402 general chemistry, 01 natural sciences, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, chemistry.chemical_compound, Organic chemistry, Ferrous Compounds, 010405 organic chemistry, Organic Chemistry, General Medicine, Triazoles, Copper, Combinatorial chemistry, Cycloaddition, 0104 chemical sciences, chemistry, Ferrocene, Elemental analysis, Molecular Probes, Click chemistry, Molecular probe
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6Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors
المؤلفون: Andreas Marx, Meng Zheng, Kathrin H. Götz, Martin Mex
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Poly Adenosine Diphosphate Ribose, Chemistry, Drug discovery, Poly ADP ribose polymerase, Organic Chemistry, Poly (ADP-Ribose) Polymerase-1, Disaccharide, Cancer therapy, Chemistry Techniques, Synthetic, Poly(ADP-ribose) Polymerase Inhibitors, Disaccharides, Biochemistry, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Enzyme, Drug Discovery, ddc:540, Humans, Physical and Theoretical Chemistry, Nucleoside
وصف الملف: application/pdf
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7
المؤلفون: Kathrin H. Götz, Martin Grützke, Thomas Huhn, Tiankun Zhao, Tetiana V. Druzhenko
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, Cell Survival, Pyridines, Molecular Conformation, Antineoplastic Agents, Crystallography, X-Ray, Medicinal chemistry, Pyrrolidine, Inorganic Chemistry, chemistry.chemical_compound, Azepane, Coordination Complexes, Humans, Chelation, Picolinic Acids, IC50, Chelating Agents, chemistry.chemical_classification, Titanium, Sulfonamides, Cell growth, Nuclear magnetic resonance spectroscopy, Hep G2 Cells, Sulfonamide, Hep G2, chemistry, ddc:540, HeLa Cells
وصف الملف: application/pdf