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1Academic Journal
المؤلفون: Thao T. Ho, Jasmine T. Nguyen, Juping Liu, Pawel Stanczak, Aaron A. Thompson, Yingzhuo G. Yan, Jasmine Chen, Charles K. Allerston, Charles L. Dillard, Hao Xu, Nicholas J. Shoger, Jill S. Cameron, Mark E. Massari, Kathleen Aertgeerts
المصدر: Data in Brief, Vol 12, Iss C, Pp 603-607 (2017)
مصطلحات موضوعية: Galanin Receptor type 3, GPCR recombinant protein expression, Protein engineering, Virus-like particles, GPCR protein stabilization, Membrane protein, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
وصف الملف: electronic resource
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2
المؤلفون: Kathleen, Aertgeerts, Thao T, Ho, Yingzhou G, Yan
المصدر: Methods in molecular biology (Clifton, N.J.). 2507
مصطلحات موضوعية: Biophysics, Gene Expression, Ligands, Chromatography, Affinity, Recombinant Proteins, Receptors, G-Protein-Coupled
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3
المؤلفون: Kathleen Aertgeerts, Thao T. Ho, Yingzhou G. Yan
المصدر: Methods in Molecular Biology ISBN: 9781071623671
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4
المؤلفون: Yingzhuo Yan, Guibao Gu, J. A. Vivian, Adia Zhang, Ali Tabatabaei, Laurent Gomez, Yu-wen Li, J. Guy Breitenbucher, Kathleen Aertgeerts, Hao Xu, Anne Danks, Eben Massari, Andrew Morse, Noelle Warren, Trevor Scott
المصدر: Journal of Pharmacology and Experimental Therapeutics. 370:399-407
مصطلحات موضوعية: Male, 0301 basic medicine, Memory, Long-Term, Phosphodiesterase Inhibitors, medicine.drug_class, Allosteric regulation, Pharmacology, Ligands, 03 medical and health sciences, 0302 clinical medicine, In vivo, medicine, Animals, Receptor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Long-term memory, Brain, Phosphodiesterase, Cooperative binding, Receptor antagonist, Cyclic Nucleotide Phosphodiesterases, Type 2, Rats, 030104 developmental biology, Enzyme, chemistry, Molecular Medicine, 030217 neurology & neurosurgery
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5
المؤلفون: Kiev S. Ly, Laurent Gomez, Mark Eben Massari, Markus Metz, Rui Xu, Tami Jo Marrone, W. Sinko, J.G. Breitenbucher, B. Appleton, R. Truong, B. Selfridge, Kathleen Aertgeerts, William F. Vernier, Yingzhuo Yan, Kristen Sebring
المصدر: Journal of Medicinal Chemistry. 61:7754-7766
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, Binding pocket, Plasma protein binding, Crystallography, X-Ray, Ligands, 010402 general chemistry, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, Protein structure, Additive function, Drug Discovery, Hydrolase, Humans, Structure–activity relationship, Enzyme Inhibitors, Binding site, skin and connective tissue diseases, Binding Sites, Chemistry, fungi, Models, Theoretical, Triazoles, Cyclic Nucleotide Phosphodiesterases, Type 2, 0104 chemical sciences, 030104 developmental biology, Structural change, Quinazolines, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Binding
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6
المؤلفون: Hao Xu, Aaron Thompson, Kathleen Aertgeerts, Charles L. Dillard, Jill S. Cameron, Pawel Stanczak, Jasmine T. Nguyen, Charles K. Allerston, Juping Liu, Yingzhuo G. Yan, Jasmine Chen, Thao T. Ho, Nicholas J. Shoger, Mark Eben Massari
المصدر: Data in Brief
Data in Brief, Vol 12, Iss C, Pp 603-607 (2017)مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, Receptor expression, Sf9, Protein engineering, Biology, Virus-like particles, lcsh:Computer applications to medicine. Medical informatics, 03 medical and health sciences, 030104 developmental biology, GPCR recombinant protein expression, Biochemistry, GPCR protein stabilization, Membrane protein, Galanin Receptor type 3, Enzyme-linked receptor, lcsh:R858-859.7, 5-HT5A receptor, Receptor, lcsh:Science (General), Galanin receptor 3, G protein-coupled receptor, lcsh:Q1-390, Data Article
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7
المؤلفون: Weston Lane, Franz Gruswitz, Yoshihiko Hirozane, Ankita Srivastava, Kathleen Aertgeerts, Kengo Okada, Andrew John Jennings, Jason Yano, Gyorgy Snell, Georgia Kefala, Jasmine T. Nguyen, Anthony Ivetac
المصدر: Nature. 513:124-127
مصطلحات موضوعية: Models, Molecular, Agonist, Surface Properties, medicine.drug_class, Lipid Bilayers, Allosteric regulation, Biology, Crystallography, X-Ray, Ligands, Receptors, G-Protein-Coupled, Allosteric Regulation, Free fatty acid receptor 1, Radioligand, medicine, Humans, Sulfones, Receptor, Protease-activated receptor 2, Benzofurans, G protein-coupled receptor, Binding Sites, Multidisciplinary, Interleukin-13 receptor, Drug Partial Agonism, Diabetes Mellitus, Type 2, Biochemistry, Structural Homology, Protein, Biophysics
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8
المؤلفون: Margaret McCarrick, Richard Barido, Troy Vickers, Ali Tabatabaei, J. Guy Breitenbucher, Mark Eben Massari, Robert Lemus, Laurent Gomez, Marco Peters, Markus Metz, Rui Xu, Xianbo Zhou, David Neul, William F. Vernier, Nicola J. Broadbent, Yingzhou G. Yan, Graeme Freestone, Kathleen Aertgeerts, Zachary W. Yoder, Noelle Warren, Carsten B. Andersen, Kara Schmelzer, Kristen Sebring, Kiev S. Ly, Tami Jo Marrone, Dong Lee
المصدر: Journal of medicinal chemistry. 60(5)
مصطلحات موضوعية: 0301 basic medicine, Exonucleases, Pyrimidine, Stereochemistry, Phosphodiesterase Inhibitors, Proton Magnetic Resonance Spectroscopy, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, Potency, Humans, chemistry.chemical_classification, Memory Disorders, Halogen bond, biology, 010405 organic chemistry, Active site, Combinatorial chemistry, 0104 chemical sciences, 030104 developmental biology, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Phosphodiesterase 2, Chromatography, Liquid
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9
المؤلفون: Nicholas J. Shoger, Charles K. Allerston, Charles L. Dillard, Yingzhuo G. Yan, Jasmine Chen, Juping Liu, Pawel Stanczak, Thao T. Ho, Hao Xu, Mark Eben Massari, Jasmine T. Nguyen, Jill S. Cameron, Aaron Thompson, Kathleen Aertgeerts
المصدر: Protein expression and purification. 133
مصطلحات موضوعية: 0301 basic medicine, 030102 biochemistry & molecular biology, Protein Stability, Ligand binding assay, Recombinant Fusion Proteins, HEK 293 cells, Virion, Gene Expression, Receptor, Galanin, Type 3, Protein engineering, Transfection, Biology, Molecular biology, law.invention, 03 medical and health sciences, 030104 developmental biology, HEK293 Cells, Biochemistry, law, Recombinant DNA, Humans, Surface plasmon resonance, Biosensor, Biotechnology, G protein-coupled receptor
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10
المؤلفون: Oliver S. Smart, Paul Emsley, Cary B. Bauer, David A. Case, John L. Markley, Joseph Marcotrigiano, Jasmine Young, Atsushi Nakagawa, Seth F. Harris, Haruki Nakamura, Wolfram Tempel, Radka Svobodová, T. Krojer, Pamela A. Williams, Robert T. Nolte, Catherine E. Peishoff, Jorg Hendle, Chenghua Shao, Jeff Blaney, Dale E. Tronrud, Paul D. Adams, Randy J. Read, Marc C. Nicklaus, Kirk Clark, Helen M. Berman, Jeffrey A. Bell, Evan E Bolton, Suzanna C. Ward, Stephen K. Burley, Alan E. Mark, Garib N. Murshudov, Victoria A. Feher, Matthew T. Miller, John Spurlino, Sameer Velankar, Steven Sheriff, Tom Darden, Wladek Minor, Talapady N. Bhat, John D. Westbrook, Gerard J. Kleywegt, Terry R. Stouch, Huanwang Yang, Gérard Bricogne, Thomas C. Terwilliger, Anil K. Padyana, Zukang Feng, Colin R. Groom, Andrzej Joachimiak, David G. Brown, Anthony Nicholls, Gaetano T. Montelione, Thomas Holder, Kathleen Aertgeerts, Stephen M. Soisson, Gregory L. Warren, Susan Pieniazek
المساهمون: Read, Randy [0000-0001-8273-0047], Apollo - University of Cambridge Repository
المصدر: Structure (London, England : 1993), vol 24, iss 4
Adams, PD; Aertgeerts, K; Bauer, C; Bell, JA; Berman, HM; Bhat, TN; et al.(2016). Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop. Structure, 24(4), 502-508. doi: 10.1016/j.str.2016.02.017. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/42h5d920مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Protein Conformation, Complex formation, Protein Data Bank (RCSB PDB), Biophysics, Crystallographic data, Guidelines as Topic, 010402 general chemistry, Crystallography, X-Ray, Ligands, 01 natural sciences, Article, 03 medical and health sciences, Structural bioinformatics, Databases, Extant taxon, Structural Biology, Models, Information and Computing Sciences, Databases, Protein, Molecular Biology, Data Curation, Crystallography, Ligand, Chemistry, Protein, Molecular, Proteins, computer.file_format, Collaboratory, Biological Sciences, Protein Data Bank, Data science, 0104 chemical sciences, 030104 developmental biology, Generic Health Relevance, QD431, Chemical Sciences, X-Ray, computer
وصف الملف: application/pdf
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11
المؤلفون: Hidenori Kamiguchi, Akiko Nakayama, Keiji Kamiyama, Satoshi Sogabe, Toshiya Tamura, Hiroshi Banno, Kathleen Aertgeerts, Jason Yano, Noriyuki Habuka, Takahiko Taniguchi, Toshimasa Tanaka, Mami Oorui, Masaki Seto, Youichi Kawakita, Yoshikazu Ohta, Hiroshi Miki, Tomoyasu Ishikawa
المصدر: Journal of Medicinal Chemistry. 54:8030-8050
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Receptor, ErbB-2, Transplantation, Heterologous, Biological Availability, Hydroxybutyrates, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Lapatinib, Mice, Structure-Activity Relationship, Adenosine Triphosphate, Growth factor receptor, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Pyrroles, Growth factor receptor inhibitor, ERBB3, Epidermal growth factor receptor, skin and connective tissue diseases, Receptor, Mice, Inbred BALB C, Binding Sites, biology, Chemistry, Kinase, Bridged Bicyclo Compounds, Heterocyclic, Rats, ErbB Receptors, Transplantation, Pyrimidines, biology.protein, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation, medicine.drug
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12
المؤلفون: Hironobu, Maezaki, Yoshihiro, Banno, Yasufumi, Miyamoto, Yusuke, Moritoh, Yuusuke, Moritou, Tomoko, Asakawa, Osamu, Kataoka, Koji, Takeuchi, Nobuhiro, Suzuki, Koji, Ikedo, Takuo, Kosaka, Masako, Sasaki, Shigetoshi, Tsubotani, Akiyoshi, Tani, Miyuki, Funami, Yoshio, Yamamoto, Michiko, Tawada, Kathleen, Aertgeerts, Jason, Yano, Satoru, Oi
المصدر: Bioorganic & Medicinal Chemistry. 19:4482-4498
مصطلحات موضوعية: Dipeptidyl Peptidase 4, Clinical Biochemistry, Lysine, Pharmaceutical Science, Pharmacology, Biochemistry, Dipeptidyl peptidase, Cell Line, chemistry.chemical_compound, Dogs, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Rats, Wistar, Molecular Biology, Dipeptidyl peptidase-4, Dipeptidyl-Peptidase IV Inhibitors, Chemistry, Organic Chemistry, Quinoline, Rats, Diabetes Mellitus, Type 2, Caco-2, Cell culture, Docking (molecular), Quinolines, Molecular Medicine, Female, Caco-2 Cells, Ex vivo
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13
المؤلفون: Michiko Tawada, Hironobu Maezaki, Satoru Oi, Nobuhiro Suzuki, Tomoko Asakawa, Jason Yano, Osamu Kataoka, Yoshio Yamamoto, Koji Takeuchi, Yasufumi Miyamoto, Mitsuru Sasaki, Kathleen Aertgeerts, Yoshihiro Banno, Koji Ikedo, Shigetoshi Tsubotani, Miyuki Funami, Akiyoshi Tani, Takuo Kosaka
المصدر: Bioorganic & Medicinal Chemistry. 19:4953-4970
مصطلحات موضوعية: Blood Glucose, Stereochemistry, Dipeptidyl Peptidase 4, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Quinolones, Biochemistry, Dipeptidyl peptidase, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Molecular Targeted Therapy, Rats, Wistar, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Molecular Biology, chemistry.chemical_classification, Dipeptidyl-Peptidase IV Inhibitors, Chemistry, Hydrogen bond, Organic Chemistry, Glucose Tolerance Test, Isoquinolines, Rats, Orally active, Enzyme, Diabetes Mellitus, Type 2, Caco-2, Drug Design, Molecular Medicine, Female, Caco-2 Cells, Peptides, Acetamide
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14
المؤلفون: Emily F. Calderwood, Kathleen Aertgeerts, Michael D. Smith, Dylan Bradley England, Roushan Afroze, Ryan Chau, Stepan Vyskocil, Nancy E. Forsyth, Dong Mei Zhang, Ruth Adams, Stephen G. Stroud, O. P. Veiby, Christelle C. Renou, R. Scott Rowland, Erin Paske, Jane X. Liu, Ming Tregay, Michael D. Sintchak, Juliet A Williams, Shih-Chung Huang, Xu Tianlin, Bheemashankar Kulkarni, Sharmila Adhikari, Yuan Tian, Jason Yano, Christopher Blackburn, Paul D. Greenspan, Cheryl A. Farrer, Matthew O. Duffey, Liting Ma, Mi-Sook Kim, Qin Zhang, Sean Harrison, Hirotake Mizutani, Katherine M. Galvin, Alexandra E. Gould, Johnny J. Yang, Steven P. Langston, Dave Janowick, Natalia Iartchouk, Mansoureh Rezaei, Jeffery Gaulin, Khristofer Garcia, Hongbo Zeng, Ribo Guo, Tricia J. Vos, Jouhara Chouitar, Saurabh Menon
المصدر: Journal of Medicinal Chemistry. 54:1836-1846
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, Tetrahydronaphthalenes, Mutant, Melanoma, Experimental, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Pharmacokinetics, Mouse xenograft, In vivo, Drug Discovery, medicine, Animals, chemistry.chemical_classification, Chemistry, Melanoma, Stereoisomerism, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Bioavailability, Enzyme, Drug Design, Mutation, Molecular Medicine
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15
المؤلفون: Keiji Kubo, Takuya Fujimoto, Garret P. Textor, Katsuhiko Hiroe, Kathleen Aertgeerts, Yasuhiro Imaeda, Masaki Kawamura, Noriko Konishi
المصدر: Journal of Medicinal Chemistry. 53:3517-3531
مصطلحات موضوعية: Bleeding Time, medicine.drug_mechanism_of_action, Factor Xa Inhibitor, Administration, Oral, Biological Availability, Pyrimidinones, Pharmacology, Pharmacokinetics, Drug Discovery, Antithrombotic, Hydrolase, medicine, Animals, Humans, Active metabolite, chemistry.chemical_classification, Chemistry, Drug discovery, Anticoagulants, Haplorhini, Enzyme, Biochemistry, Microsomes, Liver, Microsome, Molecular Medicine, Rabbits, Factor Xa Inhibitors
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16
المؤلفون: Kathleen Aertgeerts, Mark T. Hilgers, David J. Hosfield, Yiqin Wu, Gyorgy Snell, Andrew John Jennings, Robert J. Skene
المصدر: Journal of Biological Chemistry. 280:4639-4648
مصطلحات موضوعية: Models, Molecular, Hydrocortisone, Proline, Protein Conformation, Amino Acid Motifs, Dehydrogenase, Crystallography, X-Ray, Endoplasmic Reticulum, Biochemistry, Mass Spectrometry, Tetramer, Oxidoreductase, Escherichia coli, medicine, Humans, Point Mutation, Cysteine, Disulfides, Obesity, Cloning, Molecular, Enzyme Inhibitors, Glucocorticoids, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Active site, Cell Biology, Recombinant Proteins, Enzyme assay, Protein Structure, Tertiary, Cortisone, Oxygen, Kinetics, Enzyme, Diabetes Mellitus, Type 2, Membrane protein, Mutagenesis, biology.protein, 11-beta-Hydroxysteroid Dehydrogenases, Dimerization, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, Protein Binding, medicine.drug
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17
المؤلفون: Mike Tennant, Kathleen Aertgeerts, J. Rogers, David R. Webb, Sheng Ye, Bi-Ching Sang, R.J. Skene, G.S. Prasad, Michelle L. Kraus
المصدر: Protein Science. 13:412-421
مصطلحات موضوعية: Models, Molecular, Insecta, Stereochemistry, Dipeptidyl Peptidase 4, Oligopeptidase, Crystallography, X-Ray, Biochemistry, Article, Dipeptidyl peptidase, Substrate Specificity, Tetrahedral carbonyl addition compound, Catalytic Domain, Hydrolase, Animals, Humans, Neuropeptide Y, Binding site, Molecular Biology, Cells, Cultured, Serine protease, Binding Sites, biology, Chemistry, Active site, Small molecule, Protein Structure, Tertiary, biology.protein, Crystallization, Oligopeptides
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18
المؤلفون: Yoshitaka Inui, Masanori Okaniwa, Takeo Arita, Terufumi Takagi, Tomohiro Kawamoto, Bi-Ching Sang, Noriko Uchiyama, Jason Yano, Kathleen Aertgeerts, Shunichirou Tsutsumi, Sei Yoshida, Masato Yabuki, Masaaki Hirose, Akihiko Sumita, Tomoyasu Ishikawa, Tsuneaki Tottori, Akito Nakamura
المصدر: Journal of medicinal chemistry. 56(16)
مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Models, Molecular, Trifluoromethyl, Drug discovery, Kinase, Stereochemistry, Drug Evaluation, Preclinical, Surface Plasmon Resonance, Crystallography, X-Ray, chemistry.chemical_compound, chemistry, Benzothiazole, Cell culture, Blood-Brain Barrier, Cell Line, Tumor, Drug Discovery, Molecular Medicine, Moiety, Humans, Benzothiazoles, Protein Kinase Inhibitors, Acetamide
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19
المؤلفون: Sei Yoshida, Takeo Arita, Masato Yabuki, Terufumi Takagi, Tomohiro Kawamoto, Shunichirou Tsutsumi, Tomoyasu Ishikawa, Masanori Okaniwa, Akihiko Sumita, Tomohiro Ohashi, Takashi Imada, Tohru Miyazaki, Bi-Ching Sang, Yuta Tanaka, Jason Yano, Masaaki Hirose, Kathleen Aertgeerts
المصدر: Bioorganicmedicinal chemistry. 20(18)
مصطلحات موضوعية: Models, Molecular, Pyrimidine, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Microsomes, Drug Discovery, Human Umbilical Vein Endothelial Cells, Structure–activity relationship, Animals, Humans, Solubility, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Kinase insert domain receptor, Neoplasms, Experimental, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Rats, Inbred F344, Rats, Thiazoles, Drug Design, Molecular Medicine, Amine gas treating, Lead compound, Linker, HT29 Cells
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20
المؤلفون: Shuhei Yao, Hideyuki Oki, Bi-Ching Sang, Shunichirou Tsutsumi, Tsuneaki Tottori, Takashi Imada, Juran Kato, Sei Yoshida, Kazuyo Kakoi, Tomoyasu Ishikawa, Masanori Okaniwa, Akihiko Sumita, Masaaki Hirose, Tohru Miyazaki, Masato Yabuki, Takeo Arita, Jason Yano, Kathleen Aertgeerts, Youko Hayashi, Terufumi Takagi, Tomohiro Ohashi, Tomohiro Kawamoto
المصدر: Journal of medicinal chemistry. 55(7)
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, Stereochemistry, Administration, Oral, Antineoplastic Agents, Crystallography, X-Ray, Cocrystal, Benzoates, Pyridazine, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, Phosphorylation, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Bicyclic molecule, Molecular Structure, Chemistry, Hydrogen bond, Imidazoles, Kinase insert domain receptor, Bridged Bicyclo Compounds, Heterocyclic, Vascular Endothelial Growth Factor Receptor-2, Xenograft Model Antitumor Assays, Rats, Pyridazines, Thiazoles, Drug Design, Benzamides, Molecular Medicine, Derivative (chemistry)
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