المؤلفون: Eduardo Huarte, Michael T. Peel, Katherine Verbist, Brittany L. Fay, Rachel Bassett, Sabrin Albeituni, Kim E. Nichols, Paul A. Smith

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: hyperinflammatory syndromes, cytokine release syndrome, cytokine storm syndrome, hemophagocytic lymphohistiocytosis, JAK inhibition, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.650295/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/df02de8b70a848108cbd1aee78cceb38

المؤلفون: Takaya Moriyama, Karen R. Rabin, Jeffery M. Klco, Rebekah Baskin-Doerfler, Charles G. Mullighan, Katherine Verbist, Ninad Oak, Jun J. Yang, Kim E. Nichols, Rina Nishii, Keito Hoshitsuki, Mignon L. Loh, Zhenhua Li, Maoxiang Qian, Elizabeth A. Raetz, Allen Eng Juh Yeoh, Mackenzie Bloom, Stephen P. Hunger, Monika L. Metzger, Xujie Zhao, Wentao Yang, Wenjian Yang, Jinghui Zhang, Scott Newman, Julie M. Gastier-Foster, Melissa A. Burns, Gang Wu, Ting-Nien Lin, Ching-Hon Pui

المصدر: Blood. 137:364-373

مصطلحات موضوعية: Childhood leukemia, Immunology, Biology, Biochemistry, Germline, hemic and lymphatic diseases, medicine, Humans, Missense mutation, Genetic Predisposition to Disease, Child, Childhood Acute Lymphoblastic Leukemia, Germ-Line Mutation, Genes, Dominant, Genetics, Proto-Oncogene Proteins c-ets, Genome, Human, Myeloid leukemia, Cell Biology, Hematology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Repressor Proteins, PTPN11, ETV6, Leukemia, Cell Transformation, Neoplastic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a13e78449aecfa40b786a3679941e19
https://doi.org/10.1182/blood.2020006164

المؤلفون: Heather Tillman, Brooks Scull, Katherine Verbist, Carl E. Allen, Lauren K. Meyer, Michelle L. Hermiston, Rachel Bassett, Alexa N. Stroh, Kim E. Nichols, Sabrin Albeituni

المصدر: Blood. 136:657-668

مصطلحات موضوعية: endocrine system, medicine.medical_treatment, T cell, Immunology, Drug Resistance, Apoptosis, CD8-Positive T-Lymphocytes, Lymphocytic Choriomeningitis, Biochemistry, Dexamethasone, Lymphohistiocytosis, Hemophagocytic, Mice, Immune system, hemic and lymphatic diseases, Nitriles, STAT5 Transcription Factor, Animals, Humans, Janus Kinase Inhibitors, Cytotoxic T cell, Medicine, Janus Kinases, Perforin, business.industry, JAK-STAT signaling pathway, Cell Biology, Hematology, medicine.disease, Specific Pathogen-Free Organisms, Mice, Inbred C57BL, Disease Models, Animal, Pyrimidines, Cytokine, medicine.anatomical_structure, Cancer research, Cytokines, Interleukin-2, Pyrazoles, Drug Therapy, Combination, Cytokine Release Syndrome, business, Janus kinase, Cytokine storm, hormones, hormone substitutes, and hormone antagonists, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6344f3823a149439d0c3fff18180c220
https://doi.org/10.1182/blood.2020006075

المؤلفون: Mackenzie Bloom, Rebekah Baskin-Doerfler, Ninad Oak, Ruopeng Feng, Xujie Zhao, Chunliang Li, Patrick Ozark, Katherine Verbist, Alexa Stroh, Sabrin Albeituni, JaQuel Maise, Mitchell J. Weiss, Shannon McKinney-Freeman, Jun J.J. Yang, Kim E. Nichols

المصدر: Blood. 140:2849-2850

مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9810fa7054411923154570b72c15c45d
https://doi.org/10.1182/blood-2022-168076

المؤلفون: Mackenzie Bloom, Rebekah Baskin-Doerfler, Ninad Oak, Ruopeng Feng, Xujie Zhao, Patrick Ozark, Alexa Stroh, sabrin Albeituni, Katherine Verbist, Rina Nishii, Chunliang Li, Mitchell Weiss, Jun Yang, Kim Nichols

المصدر: Experimental Hematology. 111:S62-S63

مصطلحات موضوعية: Cancer Research, Genetics, Cell Biology, Hematology, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::25a1f67337630416c5213f53bd5dbaaf
https://doi.org/10.1016/j.exphem.2022.07.092

المؤلفون: Michael Peel, Rachel Bassett, Katherine Verbist, Kim E. Nichols, Sabrin Albeituni, Eduardo Huarte, Brittany Fay, Paul A. Smith

المصدر: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Ruxolitinib, medicine.medical_treatment, RM1-950, JAK inhibition, Proinflammatory cytokine, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Pharmacology (medical), Pharmacology, Hemophagocytic lymphohistiocytosis, business.industry, Organ dysfunction, cytokine storm syndrome, cytokine release syndrome, Brief Research Report, medicine.disease, Cytokine release syndrome, 030104 developmental biology, Cytokine, hemophagocytic lymphohistiocytosis, 030220 oncology & carcinogenesis, Immunology, Therapeutics. Pharmacology, medicine.symptom, business, Cytokine storm, hyperinflammatory syndromes, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30f487046b78dfa8c538d8847778cf6
https://pubmed.ncbi.nlm.nih.gov/33981229

المؤلفون: Geoffrey Neale, Kelly A. Andrews, Xiaodian Sun, Daniel E. Geraghty, Asha Pillai, Shalini Pereira, Paige Tedrick, Anouk A.J. Hamers, Kim E. Nichols, Katherine Verbist

المصدر: Cytotherapy

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, CD3 Complex, Cell Transplantation, medicine.medical_treatment, Immunology, CD2 Antigens, Apoptosis, Blood Donors, Lymphocyte Activation, Jurkat cells, Article, Antibodies, 03 medical and health sciences, Jurkat Cells, 0302 clinical medicine, Th2 Cells, Cancer immunotherapy, Co-stimulation, CD28 Antigens, medicine, Immunology and Allergy, Cytotoxic T cell, Humans, Genetics (clinical), Cells, Cultured, Cell Proliferation, Transplantation, Chemistry, Gene Expression Profiling, CD28, Cell Biology, Natural killer T cell, Granzyme B, 030104 developmental biology, Oncology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Cytokines, Natural Killer T-Cells, Immunotherapy, K562 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d987de827b6ef67310f6220b2bfab42
https://europepmc.org/articles/PMC7666372/

المؤلفون: Eduardo Huarte (114248), Michael T. Peel (10699236), Katherine Verbist (10699239), Brittany L. Fay (5841065), Rachel Bassett (6429062), Sabrin Albeituni (10699242), Kim E. Nichols (10699245), Paul A. Smith (373104)

مصطلحات موضوعية: Pharmacology, Basic Pharmacology, Clinical Pharmacology and Therapeutics, Clinical Pharmacy and Pharmacy Practice, Pharmaceutical Sciences, Pharmacogenomics, Toxicology (incl. Clinical Toxicology), Pharmacology and Pharmaceutical Sciences not elsewhere classified, hyperinflammatory syndromes, cytokine release syndrome, cytokine storm syndrome, hemophagocytic lymphohistiocytosis, JAK inhibition

Relation: https://figshare.com/articles/figure/image1_Ruxolitinib_a_JAK1_2_Inhibitor_Ameliorates_Cytokine_Storm_in_Experimental_Models_of_Hyperinflammation_Syndrome_jpeg/14482902

الاتاحة: https://doi.org/10.3389/fphar.2021.650295.s001

المؤلفون: Katherine Verbist, Heather Tillman, Jennifer Picarsic, Sabrin Albeituni, Rachel Bassett, Kim E. Nichols, Paige Tedrick

المصدر: Blood

مصطلحات موضوعية: 0301 basic medicine, Ruxolitinib, Immunobiology and Immunotherapy, Neutrophils, T-Lymphocytes, medicine.medical_treatment, Immunology, Inflammation, Lymphocyte Activation, Lymphocytic choriomeningitis, Biochemistry, Lymphohistiocytosis, Hemophagocytic, Proinflammatory cytokine, 03 medical and health sciences, Mice, 0302 clinical medicine, Interferon, Nitriles, Medicine, Animals, Hemophagocytic lymphohistiocytosis, biology, business.industry, Cell Biology, Hematology, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Cytokine, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Pyrazoles, medicine.symptom, Antibody, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bc9b4b87e4d7e8816ccdd30f053bad
https://europepmc.org/articles/PMC6624972/

المؤلفون: Mackenzie Bloom, Rebekah Baskin-Doerfler, Ninad Oak, Patrick Ozark, Katherine Verbist, Alexa Stroh, Chunliang Li, Rina Nishii, Jun Yang, Kim Nichols

المصدر: Experimental Hematology. 100:S66

مصطلحات موضوعية: Cancer Research, Genetics, Cell Biology, Hematology, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::88a7254f1ed69ecd5e2cf122a53a27af
https://doi.org/10.1016/j.exphem.2021.12.268

المؤلفون: Stuart C. Sealfon, Christopher P. Dillon, Swantje Liedmann, Douglas R. Green, Shalini Sharma, Roshan J. Thapa, Justin P. Ingram, Andrew Oberst, Carolina B. López, Peter J. Gough, Rachelle Kosoff, Edward S. Mocarski, Siddharth Balachandran, Boris M. Hartmann, Shoko Nogusa, Paul G. Thomas, William J. Kaiser, Katherine Verbist, Thomas H. Oguin, John Bertin, Oliver E. Sturm, Diego A. Rodriguez

المصدر: Cell Host & Microbe. 20:13-24

مصطلحات موضوعية: 0301 basic medicine, Fas-Associated Death Domain Protein, Necroptosis, Apoptosis, Biology, Microbiology, Article, Cell Line, Mice, Necrosis, 03 medical and health sciences, RIPK1, 0302 clinical medicine, Orthomyxoviridae Infections, Virology, Animals, Humans, FADD, Kinase activity, Mice, Knockout, Innate immune system, Kinase, Signal transducing adaptor protein, Epithelial Cells, Fibroblasts, Protein kinase R, Cell biology, Disease Models, Animal, 030104 developmental biology, Influenza A virus, Receptor-Interacting Protein Serine-Threonine Kinases, biology.protein, Parasitology, Protein Multimerization, Protein Kinases, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5247404d05af9948617bab289c12b081
https://doi.org/10.1016/j.chom.2016.05.011

المؤلفون: Swantje Liedmann, Ruoning Wang, Cliff Guy, Katherine Verbist, Douglas R. Green, Marcin Kamiński, Sandra Milasta

المصدر: Nature

مصطلحات موضوعية: Male, 0301 basic medicine, Amino Acid Transport Systems, Transcription, Genetic, Cell division, T cell, Cellular differentiation, CD8-Positive T-Lymphocytes, Mechanistic Target of Rapamycin Complex 1, Biology, Lymphocyte Activation, Article, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell polarity, medicine, Asymmetric cell division, Animals, Lymphocyte Count, Amino Acids, Mitosis, Multidisciplinary, Cell growth, TOR Serine-Threonine Kinases, Cell Polarity, Cell Differentiation, Cell cycle, Research Highlight, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Multiprotein Complexes, Female, Cell Division, Signal Transduction, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840362466895feff8b8e433f05162771
https://doi.org/10.1038/nature17442

المؤلفون: Ross L. Levine, Edward M. Behrens, Leslee Sprague, Peng Guan, Makoto Kurachi, E. John Wherry, Scott W. Canna, Rupali Das, Qi Angel An, Paige Tedrick, Kim E. Nichols, Katherine Verbist, Cheng Cheng

المصدر: Blood. 127:1666-1675

مصطلحات موضوعية: 0301 basic medicine, Ruxolitinib, medicine.medical_treatment, Immunology, Inflammation, Lymphocyte Activation, Lymphocytic choriomeningitis, Biochemistry, Lymphohistiocytosis, Hemophagocytic, Proinflammatory cytokine, Mice, 03 medical and health sciences, 0302 clinical medicine, Chlorocebus aethiops, Nitriles, medicine, Animals, Vero Cells, Cells, Cultured, Janus Kinases, Mice, Knockout, Hemophagocytic lymphohistiocytosis, biology, Perforin, business.industry, Cell Biology, Hematology, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Pyrimidines, 030104 developmental biology, Cytokine, 030220 oncology & carcinogenesis, biology.protein, Pyrazoles, CpG Islands, medicine.symptom, business, Janus kinase, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1e57ecc59bde7a843b4d6833e15397
https://doi.org/10.1182/blood-2015-12-684399

المؤلفون: Paul Smith, Kim E. Nichols, Brittany Fay, Michael Peel, Eduardo Huarte, Katherine Verbist, Sabrin Albeituni

المصدر: Blood. 136:21-21

مصطلحات موضوعية: Hemophagocytic lymphohistiocytosis, Ruxolitinib, biology, business.industry, Immunology, Cell Biology, Hematology, medicine.disease, Biochemistry, Proinflammatory cytokine, Immune system, Perforin, medicine, biology.protein, Tumor necrosis factor alpha, Immune disorder, business, Cytokine storm, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f82b97286518e2bf5e5075f5b6dd19f3
https://doi.org/10.1182/blood-2020-139539

المؤلفون: Katherine Verbist, Kim E. Nichols

المصدر: Cytokine Storm Syndrome ISBN: 9783030220938

مصطلحات موضوعية: Hemophagocytic lymphohistiocytosis, Mononucleosis, business.industry, medicine.medical_treatment, medicine.disease_cause, medicine.disease, Epstein–Barr virus, Virus, Immune system, Cytokine, Chronic active EBV infection, hemic and lymphatic diseases, Immunology, medicine, Cytokine storm, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::242d1bbac17c7207c6cc1b56a8a3287c
https://doi.org/10.1007/978-3-030-22094-5_15

المؤلفون: Emely Verweyen, Dirk Holzinger, Toni Weinhage, Claas Hinze, Helmut Wittkowski, Peter Pickkers, Sabrin Albeituni, Katherine Verbist, Kim E Nichols, Grant Schulert, Alexei Grom, Dirk Foell, Christoph Kessel

المصدر: American Journal of Respiratory and Critical Care Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::b88af5893d9da5855d77314ed3a7cba3

المؤلفون: Mignon L. Loh, Naomi J. Winick, Shaina N. Porter, Ranran Zhang, Elizabeth A. Raetz, Michelle L. Churchman, Shondra M. Pruett-Miller, Rebekah Baskin, Jennifer L. Peters, Ching-Hon Pui, Maoxiang Qian, William E. Evans, Gang Wu, W. Paul Bowman, Geertruy te Kronnie, Paul L. Martin, Hui Zhang, Paige Tedrick, Kim E. Nichols, Zhaohui Gu, Wenjian Yang, Ian Moore, Stephen P. Hunger, Charles G. Mullighan, Katherine Verbist, Robert S. Fulton, Meenakshi Devidas, Elaine R. Mardis, Eric Larsen, Mary V. Relling, Rupert Handgretinger, Martin Stanulla, Jun J. Yang, Chunxu Qu, Tobia Lana, Hiroki Yoshihara

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Genotype, Somatic cell, Biology, Germline, Article, Mice, 03 medical and health sciences, Ikaros Transcription Factor, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Genetic variation, medicine, Animals, Humans, Genetic Predisposition to Disease, Frameshift Mutation, Child, Gene, Childhood Acute Lymphoblastic Leukemia, Germ-Line Mutation, Immunodeficiency, Genetic Variation, Sequence Analysis, DNA, Cell Biology, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Pedigree, Leukemia, 030104 developmental biology, Germ Cells, Oncology, Cancer research, Female, Tyrosine kinase, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0215e6ad320817a3034cc755c4d78598
https://europepmc.org/articles/PMC5953820/

المؤلفون: Elizabeth A. Raetz, Stephen P. Hunger, Michelle L. Churchman, William E. Evans, Eric Larsen, Rebekah Baskin, Maoxiang Qian, Mary V. Relling, Ching-Hon Pui, Charles G. Mullighan, Katherine Verbist, Meenakshi Devidas, Elaine R. Mardis, Hui Zhang, Martin Stanulla, Jun J. Yang, W. Paul Bowman, Wenjian Yang, Geertruy te Kronnie, Kim E. Nichols, Jennifer L. Peters, Robert S. Fulton, Rupert Handgretinger, Mignon L. Loh, Paige Tedrick, Paul L. Martin, Naomi J. Winick, Tobia Lana, Ranran Zhang

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: Leukemia, Somatic cell, Genetic variation, Cancer research, medicine, Biology, medicine.disease, Gene, Tyrosine kinase, Childhood Acute Lymphoblastic Leukemia, Transcription factor, Germline

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::83dfa9e30df26d85568a1f8dd9f9e344
https://doi.org/10.2139/ssrn.3155671

المؤلفون: Michelle L. Hermiston, Lauren K. Meyer, Kim E. Nichols, Katherine Verbist, Rachel Bassett, Sabrin Albeituni

المصدر: Blood. 134:81-81

مصطلحات موضوعية: endocrine system, biology, business.industry, medicine.medical_treatment, Immunology, JAK-STAT signaling pathway, Inflammation, Cell Biology, Hematology, Systemic inflammation, Biochemistry, Proinflammatory cytokine, Cytokine, Aldesleukin, Cancer research, biology.protein, medicine, medicine.symptom, business, hormones, hormone substitutes, and hormone antagonists, STAT5, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8d63eb9e98d7ad330da25c7a9a0a8734
https://doi.org/10.1182/blood-2019-129112

المؤلفون: Rebekah Baskin-Doerfler, Katherine Verbist, Mackenzie Bloom, Kim E. Nichols, Chunliang Li, Heather Tillman, Gang Wu, Rachel Bassett, Ninad Oak, Wentao Yang, Paige Tedrick, Rina Nishii, Jun J. Yang

المصدر: Experimental Hematology. 76:S58

مصطلحات موضوعية: Cancer Research, medicine.diagnostic_test, Cell Biology, Hematology, Biology, Germline, Flow cytometry, Chromatin, Cell biology, ETV6, Haematopoiesis, medicine.anatomical_structure, Genetics, medicine, Bone marrow, Progenitor cell, Stem cell, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4d6cee9a71dc15da97824f3a500f8007
https://doi.org/10.1016/j.exphem.2019.06.328