المؤلفون: Sameer Urgaonkar (1266348), Kamil Nosol (11857962), Ahmed M. Said (11857965), Nader N. Nasief (1828309), Yahao Bu (2973327), Kaspar P. Locher (1975069), Johnson Y. N. Lau (10319473), Michael P. Smolinski (10319467)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Mental Health, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, remained poorly absorbed, structure guided us, improve oral bioavailability, minimally absorbed p, >, dual p, 3a , vivo <, oral absorption, em structure, dual potency, dual inhibitors, human p, starting point, several analogues, prudently decorate, promising approach, pan inhibitions, em analysis, common substrates

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Characterization_of_Potent_Dual_P_Glycoprotein_and_CYP3A4_Inhibitors_Design_Synthesis_Cryo-EM_Analysis_and_Biological_Evaluations/17297457

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01272.s001

المؤلفون: Sameer Urgaonkar (1266348), Kamil Nosol (11857962), Ahmed M. Said (11857965), Nader N. Nasief (1828309), Yahao Bu (2973327), Kaspar P. Locher (1975069), Johnson Y. N. Lau (10319473), Michael P. Smolinski (10319467)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Biotechnology, Mental Health, Hematology, Infectious Diseases, Chemical Sciences not elsewhere classified, remained poorly absorbed, structure guided us, improve oral bioavailability, minimally absorbed p, >, dual p, 3a , vivo <, oral absorption, em structure, dual potency, dual inhibitors, human p, starting point, several analogues, prudently decorate, promising approach, pan inhibitions, em analysis, common substrates

Relation: https://figshare.com/articles/dataset/Discovery_and_Characterization_of_Potent_Dual_P_Glycoprotein_and_CYP3A4_Inhibitors_Design_Synthesis_Cryo-EM_Analysis_and_Biological_Evaluations/17297460

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01272.s002