المؤلفون: Kaleeckal G Harikumar, Peishen Zhao, Brian P Cary, Xiaomeng Xu, Aditya J Desai, Maoqing Dong, Jesse I Mobbs, Chirine Toufaily, Sebastian G B Furness, Arthur Christopoulos, Matthew J Belousoff, Denise Wootten, Patrick M Sexton, Laurence J Miller

المصدر: PLoS Biology, Vol 22, Iss 7, p e3002673 (2024)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

URL الوصول: https://doaj.org/article/897ba52f46f9422aa4eba66be6e9d3a4

المؤلفون: Jesse I Mobbs, Matthew J Belousoff, Kaleeckal G Harikumar, Sarah J Piper, Xiaomeng Xu, Sebastian G B Furness, Hari Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M Thal, Laurence J Miller, Patrick M Sexton

المصدر: PLoS Biology, Vol 19, Iss 6, p e3001295 (2021)

مصطلحات موضوعية: Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

URL الوصول: https://doaj.org/article/74d05cb5885440089e6bbe22f303c143

المؤلفون: Hans K H Ng, Kaleeckal G Harikumar, Laurence J Miller, Billy K C Chow

المصدر: PLoS ONE, Vol 11, Iss 9, p e0163086 (2016)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC5029868?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/7e1496232d1d43f1b1c1591288448d8b

المؤلفون: Jiyuan Ke, Chenghai Zhang, Kaleeckal G Harikumar, Cassandra R Zylstra-Diegel, Liren Wang, Laura E Mowry, Laurence J Miller, Bart O Williams, H Eric Xu

المصدر: PLoS ONE, Vol 7, Iss 3, p e33676 (2012)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3306284?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/0fe5086c4b2f444282ab40f7c69932b8

المؤلفون: Robert Ardecky, Daniela G. Dengler, Kaleeckal G. Harikumar, Mathew M. Abelman, Jiwen Zou, Bryan A. Kramer, Santhi Reddy Ganji, Steve Olson, Alina Ly, Nikhil Puvvula, Chen-Ting Ma, Raghuveer Ramachandra, Eduard A. Sergienko, Laurence J. Miller

المصدر: SLAS Discovery, Vol 29, Iss 6, Pp 100176- (2024)

مصطلحات موضوعية: Secretin receptor, G protein-coupled receptor, Structure-activity relationships, Small molecule agonist, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

Relation: http://www.sciencedirect.com/science/article/pii/S2472555224000388; https://doaj.org/toc/2472-5552; https://doaj.org/article/3eddfc13db42404aa4f87b29244f0ab2

الاتاحة: https://doi.org/10.1016/j.slasd.2024.100176
https://doaj.org/article/3eddfc13db42404aa4f87b29244f0ab2

المؤلفون: Kaleeckal G. Harikumar, Sarah J. Piper, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

مصطلحات موضوعية: Science

Relation: https://doi.org/10.1038/s41467-024-48853-6; https://doaj.org/toc/2041-1723; https://doaj.org/article/03bd6139abd74708a85a68f98f562b73

الاتاحة: https://doi.org/10.1038/s41467-024-48853-6
https://doaj.org/article/03bd6139abd74708a85a68f98f562b73

المؤلفون: Daniela G. Dengler, Qing Sun, Kaleeckal G. Harikumar, Laurence J. Miller, Eduard A. Sergienko

المصدر: SLAS Discovery, Vol 27, Iss 7, Pp 384-394 (2022)

مصطلحات موضوعية: Cholecystokinin receptor, Positive allosteric modulator, Obesity treatment, High-throughput screening, G protein-coupled receptor, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S247255522213683X; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/422a6a6075cb48808eb30e6c246e9ece

المؤلفون: Daniela G. Dengler, Kaleeckal G. Harikumar, Alice Yen, Eduard A. Sergienko, Laurence J. Miller

المصدر: Membranes; Volume 13; Issue 2; Pages: 150

مصطلحات موضوعية: cholecystokinin, cholecystokinin receptor, G protein-coupled receptor, positive allosteric modulator, obesity

وصف الملف: application/pdf

Relation: Biological Membrane Composition and Structures; https://dx.doi.org/10.3390/membranes13020150

الاتاحة: https://doi.org/10.3390/membranes13020150

المؤلفون: Kaleeckal G. Harikumar, Thomas Coudrat, Aditya J. Desai, Maoqing Dong, Daniela G. Dengler, Sebastian G. B. Furness, Arthur Christopoulos, Denise Wootten, Eduard A. Sergienko, Patrick M. Sexton, Laurence J. Miller

المصدر: Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: cholecystokinin, cholecystokinin receptor, allosteric modulation, cholesterol, obesity, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.789957/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/895703c860ab400c964a97eea810e55b

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

Relation: https://figshare.com/articles/journal_contribution/Data_collection_and_refinement_statistics_/14735899

الاتاحة: https://doi.org/10.1371/journal.pbio.3001295.s008

المؤلفون: Jesse I. Mobbs (10925173), Matthew J. Belousoff (2395753), Kaleeckal G. Harikumar (177023), Sarah J. Piper (10925175), Xiaomeng Xu (313387), Sebastian G. B. Furness (6236942), Hari Venugopal (5573870), Arthur Christopoulos (538751), Radostin Danev (8604666), Denise Wootten (2585149), David M. Thal (10925177), Laurence J. Miller (177040), Patrick M. Sexton (538750)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Evolutionary Biology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, CCK 1R core, CCK peptide agonist, G protein binding pocket, GPCR, type 1 receptor, G protein selectivity, heterotrimeric G proteins, CCK 1R, Gq

Relation: https://figshare.com/articles/journal_contribution/Uncropped_Coomassie-stained_SDS-PAGE_gels_used_for_S1F_and_S1H_Fig_/14735931

الاتاحة: https://doi.org/10.1371/journal.pbio.3001295.s018

المؤلفون: Parijat Sarkar, Kaleeckal G. Harikumar, Satinder S. Rawat, Sanjib Das, Tushar K. Chakraborty, Amitabha Chattopadhyay

المصدر: Molecules; Volume 26; Issue 13; Pages: 3848

مصطلحات موضوعية: NBD, serotonin, serotonin 1A receptor, confocal microscopy, spectral imaging, REES

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Medicinal Chemistry; https://dx.doi.org/10.3390/molecules26133848

الاتاحة: https://doi.org/10.3390/molecules26133848

المؤلفون: Laurence J. Miller, Kaleeckal G. Harikumar, Denise Wootten, Patrick M. Sexton

المصدر: Frontiers in Endocrinology, Vol 12 (2021)

مصطلحات موضوعية: cholecystokinin, type 1 cholecystokinin receptor, obesity, appetite regulation, positive allosteric modulator, biased agonist, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2021.684656/full; https://doaj.org/toc/1664-2392; https://doaj.org/article/de858ba8761e49a7b6412a8eb69243fb

الاتاحة: https://doi.org/10.3389/fendo.2021.684656
https://doaj.org/article/de858ba8761e49a7b6412a8eb69243fb

المؤلفون: Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

مصطلحات موضوعية: Science

Relation: https://doi.org/10.1038/s41467-020-17791-4; https://doaj.org/toc/2041-1723; https://doaj.org/article/35d3a9f45d2f49f5b92ff1e2f30c175a

الاتاحة: https://doi.org/10.1038/s41467-020-17791-4
https://doaj.org/article/35d3a9f45d2f49f5b92ff1e2f30c175a

المؤلفون: Michael D. Holsey, Grant T. Gilmore, Adam W. Smith, Jonathan A. Javitch, Avik Kumar Pati, Kaleeckal G. Harikumar, Zhou Zhou, Jozsef Meszaros, Laurence J. Miller, Khuloud Jaqaman, Peter Geggier, Signe Mathiasen, Wesley B. Asher, Megan J. Kaliszewski, Mitchell D. McCauley, Scott C. Blanchard, Daniel S. Terry, Alekhya Govindaraju

المصدر: Nature Methods. 18:397-405

مصطلحات موضوعية: 0303 health sciences, Chemistry, Cell Biology, Single-molecule FRET, Biochemistry, Transmembrane protein, 03 medical and health sciences, Protein structure, Förster resonance energy transfer, Metabotropic glutamate receptor, Biophysics, Receptor, Molecular Biology, Function (biology), 030304 developmental biology, Biotechnology, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5b1d5af5024e5772f7bfbd0e90f26b66
https://doi.org/10.1038/s41592-021-01081-y

المؤلفون: Juliana E. Milburn, Kaleeckal G. Harikumar, Sarah J. Piper, Sweta Raval, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, Laurence J. Miller

المصدر: Molecular pharmacology. 101(6)

مصطلحات موضوعية: Pharmacology, Structure-Activity Relationship, Secretin, Mutagenesis, Molecular Medicine, Amino Acid Sequence, Peptides, Receptors, G-Protein-Coupled, Receptors, Gastrointestinal Hormone

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c80865a9d9e949a9fc516454ceaa2a
https://pubmed.ncbi.nlm.nih.gov/35351821

المؤلفون: Ba D. Nguyen, Kaleeckal G. Harikumar, Laurence J. Miller, Aditya J. Desai, Hassan Siddiki

المصدر: Journal of Nuclear Medicine Technology. 48:40-45

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Gallbladder Emptying, media_common.quotation_subject, Receptors, Cell Surface, Sensitivity and Specificity, digestive system, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Cholelithiasis, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Aged, media_common, Cholecystokinin, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Gallbladder, Body Weight, digestive, oral, and skin physiology, Appetite, Gallbladder Disorder, General Medicine, Gallstones, Middle Aged, medicine.disease, Kinetics, Cholesterol, Endocrinology, Postprandial, medicine.anatomical_structure, Cholescintigraphy, Female, Indicators and Reagents, business, hormones, hormone substitutes, and hormone antagonists, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701ca420d9c61561bff6cf2a3278b731
https://doi.org/10.2967/jnmt.119.233486

المؤلفون: Denise Wootten, Arthur Christopoulos, Radostin Danev, Sebastian G.B. Furness, Patrick M. Sexton, David M. Thal, Xiaomeng Xu, Hari Venugopal, Sarah J. Piper, Matthew J. Belousoff, Kaleeckal G. Harikumar, Laurence J. Miller, Jesse I. Mobbs

المصدر: PLoS Biology, Vol 19, Iss 6, p e3001295 (2021)
PLoS Biology

مصطلحات موضوعية: Proteomics, Models, Molecular, GTP-Binding Protein alpha Subunits, Peptide Hormones, Plasma protein binding, Biochemistry, Physical Chemistry, Intracellular Receptors, Database and Informatics Methods, 0302 clinical medicine, Protein structure, Heterotrimeric G protein, Macromolecular Structure Analysis, GTP-Binding Protein alpha Subunits, Gs, Electron Microscopy, Biology (General), 0303 health sciences, Microscopy, Proteomic Databases, General Neuroscience, Lipids, Chemistry, Cholesterol, Physical Sciences, Signal transduction, General Agricultural and Biological Sciences, Cholecystokinin, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Protein Binding, Protein Structure, Transmembrane Receptors, G protein, QH301-705.5, Discovery Report, Biology, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Humans, Molecular Biology, 030304 developmental biology, G protein-coupled receptor, General Immunology and Microbiology, Chemical Bonding, Biology and Life Sciences, Proteins, Electron Cryo-Microscopy, Hydrogen Bonding, Cell Biology, Hormones, Biological Databases, HEK293 Cells, Membrane protein, Biophysics, GTP-Binding Protein alpha Subunits, Gq-G11, Receptors, Cholecystokinin, G Protein Coupled Receptors, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf92af4edbc08b4569a3818c54ac9419
https://doaj.org/article/74d05cb5885440089e6bbe22f303c143

المؤلفون: Sarah J. Piper, Denise Wootten, Kaleeckal G. Harikumar, Laurence J. Miller, Jesse I. Mobbs, Arthur Christopoulos, Matthew J. Belousoff, Xiaomeng Xu, Hari Venugopal, Patrick M. Sexton, Sebastian G.B. Furness, David M. Thal, Radostin Danev

مصطلحات موضوعية: Agonist, chemistry.chemical_classification, chemistry, medicine.drug_class, G protein, Heterotrimeric G protein, Helix, medicine, Biophysics, Peptide, Receptor, Function (biology), G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::97fe6e8b23b38b91b338a6931f2b8cdf
https://doi.org/10.1101/2021.05.06.442871

المؤلفون: Laurence Miller, Daniela G. Dengler, Eduard Sergienko, Robert Ardecky, Sirkku Pollari, Kaleeckal G. Harikumar, Qing Sun

المصدر: The FASEB Journal. 35

مصطلحات موضوعية: Chemistry, Genetics, Receptor, Molecular Biology, Biochemistry, Small molecule, Biotechnology, Cell biology, Secretin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4372466f733c2f22375af2b2d9b0da98
https://doi.org/10.1096/fasebj.2021.35.s1.03368