المؤلفون: Kailong Jiang, Minjie Deng, Wenjing Du, Tao Liu, Jia Li, Yubo Zhou

المصدر: Medicine in Drug Discovery, Vol 22, Iss , Pp 100185- (2024)

مصطلحات موضوعية: CHK1 inhibitors, Cancer, Biomarker, Combination regimens, Pharmacy and materia medica, RS1-441

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590098624000101; https://doaj.org/toc/2590-0986

URL الوصول: https://doaj.org/article/e839616e6206470bab5f19704a03c7d3

المؤلفون: Kailong Jiang, Xuemei Li, Chang Wang, Xiaobei Hu, Peipei Wang, Lexian Tong, Yutong Tu, Beijing Chen, Tingting Jin, Tao Wang, Hanlin Wang, Yubing Han, Renzhao Gui, Jianmin Yang, Tao Liu, Jia Li, Yubo Zhou

المصدر: Leukemia.

مصطلحات موضوعية: Cancer Research, Oncology, Hematology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef2cebe193f730dc9498f3c72d32c0
https://pubmed.ncbi.nlm.nih.gov/36526736

المؤلفون: Wen-Biao Wu, Kan Weijuan, Tao Liu, Tingting Jin, Lei Xu, Tao Wang, Liu Jieyu, Kailong Jiang, Yu-qi Xiang, Han‐lin Wang, Ning Song, Jian-Min Yang, Xu Gaoya, Yongzhou Hu, Jia Li, Anhui Gao, Jia-Nan Li, Yubo Zhou, Tong Lexian, Hu Xiaobei, Zhang Mengmeng, Kaixiang Zhang

المصدر: Acta Pharmacol Sin

مصطلحات موضوعية: 0301 basic medicine, Cell, Down-Regulation, Mice, Nude, Mice, SCID, Article, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Mice, Inbred NOD, In vivo, medicine, Animals, Humans, Pharmacology (medical), CHEK1, Protein Kinase Inhibitors, Cells, Cultured, Cell Proliferation, Pharmacology, Gene knockdown, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Cancer, Neoplasms, Experimental, General Medicine, Potentiator, medicine.disease, DNA-Binding Proteins, 030104 developmental biology, medicine.anatomical_structure, Hematologic Neoplasms, 030220 oncology & carcinogenesis, Checkpoint Kinase 1, Cancer research, Female, Drug Screening Assays, Antitumor, Signal transduction, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0667d7e1001524d08241785b04e8bc
https://doi.org/10.1038/s41401-021-00652-1

المؤلفون: Tao Liu, Pinrao Song, Yubo Zhou, Xiubing Long, Jia Li, Xu Gaoya, Kailong Jiang, Tingting Jin, Peipei Wang, Wen-Biao Wu

المصدر: ChemMedChem. 16:1477-1487

مصطلحات موضوعية: DNA Repair, DNA damage, Administration, Oral, Pharmacology, 01 natural sciences, Biochemistry, Rats, Sprague-Dawley, Serine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, Cell Line, Tumor, Drug Discovery, Animals, Humans, CHEK1, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, IC50, Cell Proliferation, Binding Sites, 010405 organic chemistry, Chemistry, Organic Chemistry, Autophosphorylation, Myeloid leukemia, Rats, 0104 chemical sciences, Molecular Docking Simulation, Leukemia, Myeloid, Acute, 010404 medicinal & biomolecular chemistry, Pyrimidines, Diaminopyrimidine, Cell culture, Drug Design, Checkpoint Kinase 1, Molecular Medicine, Drug Screening Assays, Antitumor, biological phenomena, cell phenomena, and immunity, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b77552f3cdb56bbb0c756f83850d0bd
https://doi.org/10.1002/cmdc.202000882

المؤلفون: Xin Xie, Kailong Jiang, Bowen Li, Shenglei Hou, Honglin Tang, Baihao Shao, Yuan Ping, Qiqing Zhang

المصدر: Biomaterials. 286

مصطلحات موضوعية: Biophysics, Bioengineering, Antineoplastic Agents, Breast Neoplasms, Tretinoin, Combined Modality Therapy, Biomaterials, Mice, Mechanics of Materials, Cell Line, Tumor, Ceramics and Composites, Neoplastic Stem Cells, Tumor Microenvironment, Animals, Humans, Nanoparticles, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3d6e270c2f1fa12b6112105a5b47dd
https://pubmed.ncbi.nlm.nih.gov/35660821

المؤلفون: Yifei Sun, Qiangsong Zhao, Wudai Liao, Kailong Jiang, Wenxin Tan

المصدر: 2021 6th International Conference on Robotics and Automation Engineering (ICRAE).

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::daedc4da532e5ef85a9e65fb2200c49f
https://doi.org/10.1109/icrae53653.2021.9657818

المؤلفون: Kailong Jiang, Dong Sheng, Xiaoyan Zhou, Jia Li, Ting Li, Meng-Jiao Li, Xiao-Qiu Li, Weige Wang, Anhui Gao

المصدر: Leukemia & Lymphoma. 61:1364-1371

مصطلحات موضوعية: Fluorodeoxyglucose, Cancer Research, biology, Chemistry, Glucose uptake, breakpoint cluster region, Syk, Standardized uptake value, Hematology, medicine.disease, Lymphoma, 03 medical and health sciences, 0302 clinical medicine, Oncology, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, medicine, Cancer research, biology.protein, GLUT1, Diffuse large B-cell lymphoma, 030215 immunology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::479a06c6b1eb7237e95513032ced78b1
https://doi.org/10.1080/10428194.2020.1713317

المؤلفون: Tao Liu, Sui Fang, Yubo Zhou, Peipei Wang, Tong Lexian, Kailong Jiang, Hu Xiaobei, Tingting Jin, Lei Xu, Yongzhou Hu, Anhui Gao, Jia Li, Pinrao Song

المصدر: European Journal of Medicinal Chemistry. 173:44-62

مصطلحات موضوعية: Stereochemistry, hERG, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Low affinity, Drug Discovery, Humans, Potency, Protein Kinase Inhibitors, IC50, 030304 developmental biology, Pharmacology, 0303 health sciences, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Organic Chemistry, General Medicine, 0104 chemical sciences, chemistry, Cell culture, Hematologic Neoplasms, Checkpoint Kinase 1, biology.protein, Selectivity, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a35afea73d962c65e7b9afd3aa424a4
https://doi.org/10.1016/j.ejmech.2019.03.062

المؤلفون: Yi Yang, Hongan Wang, Jiaqi Zhu, Kailong Jiang, Wandong Shi, Yunkun Wu, Wenli Guo

المصدر: IJCAI

مصطلحات موضوعية: Computer science, business.industry, Biterm topic model, Artificial intelligence, business, computer.software_genre, computer, Word (computer architecture), Natural language processing

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::542836d8ed4e4cb3627771c7984a1e37
https://doi.org/10.24963/ijcai.2020/549

المؤلفون: Kailong Jiang, Jia Li, Hejing Huang, Huanan Liu, Chang-Mei Liu, Xianchao Cao, Fajun Nan, Li-xia Fan, Jian Hou, Kun-Zhi Zhang, Hu Xiaobei, Xinwen Zhang, Anhui Gao, Yubo Zhou

المصدر: Cancer letters. 360(2)

مصطلحات موضوعية: Cancer Research, XBP1, Cell cycle checkpoint, Antineoplastic Agents, Cell Growth Processes, Thiophenes, Biology, Small Molecule Libraries, chemistry.chemical_compound, Mice, Downregulation and upregulation, Neoplasms, Acetamides, Animals, Humans, Endoplasmic Reticulum Chaperone BiP, Tumor microenvironment, Mice, Inbred BALB C, Aniline Compounds, Cell cycle, HCT116 Cells, Molecular biology, Xenograft Model Antitumor Assays, HEK293 Cells, Oncology, chemistry, Cancer cell, Unfolded protein response, Cancer research, Unfolded Protein Response, Female, Growth inhibition, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf3f4aecaf850e077ca58d82437ca6
https://pubmed.ncbi.nlm.nih.gov/25721085

المؤلفون: Jing Cheng, Ziqin Yan, Kailong Jiang, Chen Liu, Dehua Xu, Xilin Lyu, Xiaobei Hu, Shiyan Zhang, Yubo Zhou, Jia Li, Yujun Zhao

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, reported herein structure, induced cell apoptosis, efficiently promoted activation, also promoted degradation, 60 , mdm2 mediated degradation, negatively regulate p53, highly potent spiroindoline, (−)< b, inhibits mdm2, blocking mdm2, type p53, target genes, taken together, study showcases, p53 interactions, p53 interaction

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_JN122_a_Spiroindoline-Containing_Molecule_that_Inhibits_MDM2_p53_Protein_Protein_Interaction_and_Exerts_Robust_In_Vivo_Antitumor_Efficacy/24770769

الاتاحة: https://doi.org/10.1021/acs.jmedchem.3c01815.s001
https://figshare.com/articles/journal_contribution/Discovery_of_JN122_a_Spiroindoline-Containing_Molecule_that_Inhibits_MDM2_p53_Protein_Protein_Interaction_and_Exerts_Robust_In_Vivo_Antitumor_Efficacy/24770769