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المؤلفون: Nilsson, Åke
المصدر: Journal of Pediatrics. 173:53-59
مصطلحات موضوعية: CRC Colorectal cancer, DSS Dextran sulphate sodium, IBD Inflammatory bowel disease, KO Knockout, MFGM Milk fat globule membrane, NC Neutral ceramidase, NEC Necrotizing enterocolitis, NPP7 Nucleotide phosphodiesterase pyrophosphatase 7, PAF Platelet activating factor, PC Phosphatidylcholine, PL Glycerophospholipids, S1P Sphingosine-1-phosphate, SL Sphingolipids, SM Sphingomyelin, Medicin och hälsovetenskap, Klinisk medicin, Gastroenterologi, Medical and Health Sciences, Clinical Medicine, Gastroenterology and Hepatology
وصف الملف: electronic
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2Academic Journal
المؤلفون: Marcelin, Geneviève, da Cunha, Carla, Gamblin, Camille, Suffee, Nadine, Rouault, Christine, Leclerc, Arnaud, Lacombe, Amélie, Sokolovska, Nataliya, Gautier, Emmanuel, Clément, Karine, Dugail, Isabelle
المساهمون: Nutrition et obésités: approches systémiques (UMR-S 1269) (Nutriomics), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Funding from the French National Agency of Research (ANR) is acknowledged and includes support from RHU collaborative grant CARMMA 15-RHUS-0003 , from the Institute of Cardiometabolism and Nutrition (reference ANR-10-IAHU-05, to AL), ANR-14-CE12-0017-01 LIPOCAMD and ANR CAPTOR (ANR-17-CE14-0009). GM 615 and KC also received funds from AFERO, EFSD-Novo Nordisk, and SFD to support for salaries and consumables., ANR-10-IAHU-0005,ICAN,Institut de Cardiologie-Métabolisme-Nutrition(2010), ANR-14-CE12-0017,LIPOCAMD,LIPA, une nouvelle cible thérapeutique pour le traitement des maladies cardiométaboliques(2014), ANR-17-CE14-0009,CAPTOR,Contrôler la fonction des progéniteurs du tissu adipeux pour améliorer les désordres métaboliques de l'obésité(2017)
المصدر: ISSN: 1554-8627.
مصطلحات موضوعية: ECM: extracellular matrix, EpiAT: epididymal adipose tissue, GTF2IRD1: 25 general transcription factor II I repeat domain-containing 1, HFD: high-fat diet, KO: knockout, OvAT: ovarian adipose tissue, PDGFR: platelet derived growth factor receptor, ScAT: subcutaneous adipose tissue, subcutaneous adipose tissue, obesity, TGF-BMP: transforming growth factor-bone morphogenic protein ARTICLE HISTORY KEYWORDS ATG7, fibrosis, collagen, chloroquine, extracellular matrix, Abbreviations: CQ: chloroquine, MESH: Adipose Tissue, Brown, MESH: Diet, High-Fat, MESH: Extracellular Matrix, MESH: Heart Atria, MESH: Female, MESH: Fibrosis, MESH: Male, MESH: Mice, Inbred C57BL, MESH: MicroRNAs, MESH: Muscle Proteins, MESH: Promoter Regions
Relation: info:eu-repo/semantics/altIdentifier/pmid/31992125; PUBMED: 31992125
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3Academic Journal
المؤلفون: Zhong, Xiaolin, Huang, Menghao, Kim, Hyeong-Geug, Zhang, Yang, Chowdhury, Kushan, Cai, Wenjie, Saxena, Romil, Schwabe, Robert F., Liangpunsakul, Suthat, Dong, X. Charlie
المساهمون: Biochemistry and Molecular Biology, School of Medicine
المصدر: PMC
مصطلحات موضوعية: alanine aminotransferase, chromatin immunoprecipitation, Dulbecco’s modified Eagle medium, green fluorescent protein, hemagglutinin, hepatic stellate cell, KO knockout, Lratlecithin retinol acyl, transferasem, RNA messenger, NAFLD nonalcoholic fatty liver disease, NASH nonalcoholic steatohepatitis, PBS phosphate-buffered saline, PCR polymerase chain reactions, hRNA short hairpin RNA, SIRT6 sirtuin 6, SMAD3 SMAD family member 3, transgenic, transforming growth factor β, Western diet, wild-type
وصف الملف: application/pdf
Relation: Cellular and Molecular Gastroenterology and Hepatology; Zhong, X., Huang, M., Kim, H.-G., Zhang, Y., Chowdhury, K., Cai, W., Saxena, R., Schwabe, R. F., Liangpunsakul, S., & Dong, X. C. (2020). SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. Cellular and Molecular Gastroenterology and Hepatology, 10(2), 341–364. https://doi.org/10.1016/j.jcmgh.2020.04.005; https://hdl.handle.net/1805/24446
الاتاحة: https://hdl.handle.net/1805/24446
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4
المؤلفون: Fei Luo, Eriks Smagris, Sarah A. Martin, Goncalo Vale, Jeffrey G. McDonald, Justin A. Fletcher, Shawn C. Burgess, Helen H. Hobbs, Jonathan C. Cohen
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 879-899 (2022)مصطلحات موضوعية: SDS, sodium dodecyl sulfate, PBS, phosphate-buffered saline, RC799-869, PE, phosphatidylethanolamine, ER, endoplasmic reticulum, PC, phosphatidylcholine, Mice, FLD, fatty liver disease, PCR, polymerase chain reaction, VLDL, very low density lipoprotein, Non-alcoholic Fatty Liver Disease, Animals, mAb, monoclonal antibody, RIPA, radioimmunoprecipitation assay buffer, SER, smooth endoplasmic reticulum, Triglycerides, Original Research, Liver Perfusion, KO, knockout, Hepatology, CE, cholesteryl ester, TG, triglyceride, S2, second supernatant, ACSL5, acyl-CoA synthetase long chain family member 5, Gastroenterology, Membrane Proteins, IP, immunoprecipitation, Diseases of the digestive system. Gastroenterology, LC-MS/MS, liquid chromatography–mass spectrometry, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, WT, wild-type, Rats, Fatty Liver, ERGIC, endoplasmic reticulum–Golgi intermediate compartment, RER, rough endoplasmic reticulum, TM6SF2, transmembrane 6 superfamily 2, Apo, apolipoprotein, PI, protease inhibitor cocktail, UTSW, University of Texas Southwestern Medical Center, PFA, paraformaldehyde, VLDL
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المؤلفون: Mai Tu Dang, Carly I. Misztal, Iakov Efimenko, Matthew Villanueva, Lin Zhang, Kelly M. Dexter, Shiv Krishnaswamy, Malinda Gerard, Fumiaki Yokoi, Patrick Lynch, Yuqing Li
المصدر: IBRO Neuroscience Reports, Vol 11, Iss, Pp 1-7 (2021)
IBRO Neuroscience Reportsمصطلحات موضوعية: medicine.medical_specialty, LTD, long-term depression, ChAT, choline acetyltransferase, Trihexyphenidyl, Dyt1 KI mice, Dyt1 ΔGAG heterozygous knock-in mice, Motor learning, PB, phosphate buffer, PBS, phosphate-buffered saline, ChI, cholinergic interneuron, Neurosciences. Biological psychiatry. Neuropsychiatry, TOR1A, Article, n.s., not significant, PET, positron emission tomography, TrkA, tropomyosin receptor kinase A, THP, trihexyphenidyl, AChE, acetylcholinesterase, Gene knockin, Internal medicine, GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, Medicine, Rotarod, Dystonia, KO, knockout, DAB, 3,3′-diaminobenzidine, ACh, acetylcholine, business.industry, General Neuroscience, Antagonist, DF, degrees of freedom, Muscarinic acetylcholine receptor M1, medicine.disease, WT, wild-type, CI, confidence interval, Endocrinology, TorsinA, Excitatory postsynaptic potential, Cholinergic, BSA, bovine serum albumin, VAChT, vesicular acetylcholine transporter, business, ChT, choline transporter, Cholinergic interneuron, medicine.drug, RC321-571
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المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses
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المؤلفون: Zhengcai Ju, Lin-shan Jiang, Xunjiang Wang, Wendong Huang, Zhengtao Wang, Siming Sun, Eryun Zhang, Lili Ding, Tong Tian, Qiaoling Yang, Li Yang, Yangmeng Wang, Yingbo Yang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1541-1554 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: eWAT, epididymal white adipose tissue, Wt, wild-type, Metabolic disorders, Adipose tissue, Ft1, notoginsenoside Ft1, AUC, area under the curve, iWAT, inguinal white adipose tissue, 0302 clinical medicine, HFD, high fat diet, General Pharmacology, Toxicology and Pharmaceutics, Receptor, ANOVA, analysis of variance, 0303 health sciences, Bile acid, Chemistry, TGR5, GLP-1, glucagon-like peptide-1, Tgr5, membrane-bound G protein-coupled receptor, G protein-coupled bile acid receptor, cAMP, adenosine 3′,5′ cyclic monophosphate, medicine.anatomical_structure, FXR, 030220 oncology & carcinogenesis, GTT, glucose tolerance test, Original Article, Agonist, medicine.medical_specialty, medicine.drug_class, Ileum, RM1-950, 03 medical and health sciences, Insulin resistance, Ucp, uncoupling protein, Internal medicine, Fxr, nuclear farnesoid X receptor, medicine, Lipolysis, Obesity, ITT, insulin tolerance test, 030304 developmental biology, KO, knockout, BAs, bile acids, DIO, diet-induced obesity, medicine.disease, Bile acids, FGF, fibroblast growth factor, BAT, brown adipose tissue, Endocrinology, Therapeutics. Pharmacology, GLP-1, Notoginsenoside Ft1
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المؤلفون: Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, Genetically modified mouse, autophagy, NRCM, neonatal rat cardiomyocytes, mRNA, messenger ribonucleic acid, heart failure, 030204 cardiovascular system & hematology, 03 medical and health sciences, Cellular degradation, RFP, red fluorescent protein, 0302 clinical medicine, In vivo, TG, transgenic, BFA, bafilomycin A1, medicine, FYCO1, GFP, green fluorescent protein, Pressure overload, KO, knockout, business.industry, Autophagy, microRNA, micro–ribonucleic acid, medicine.disease, WT, wild-type, Cell biology, Glucose deprivation, 030104 developmental biology, Heart failure, CSA, cell surface area, Preclinical Research, TAC, transverse aortic constriction, Cardiology and Cardiovascular Medicine, business, MHC, myosin heavy chain
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المؤلفون: Min Xu, Fang Wang, Xiaoni Kong, Junzhe Jiao, Yueqiu Gao, Xuehua Sun, Hailong Wu, Jinyang Gu, Hualian Hang, Dongwei Xu, Jichang Li, Miao Huang
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 567-584 (2021)مصطلحات موضوعية: 0301 basic medicine, Male, DJ-1, Protein Deglycase DJ-1, CQ, chloroquine, MPO, myeloperoxidase, RC799-869, AST, aspartate aminotransferase, Mitochondrion, PARKIN, Parkin, 0302 clinical medicine, Mitophagy, Medicine, Myeloid Cells, GEO, Gene Expression Omnibus, Original Research, Liver injury, Mice, Knockout, TNF, tumor necrosis factor, LDH, lactate dehydrogenase, Protein Stability, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, TEM, transmission electron microscope, Diseases of the digestive system. Gastroenterology, I/R, ischemia-reperfusion, Mitochondria, Protein Transport, Real-time polymerase chain reaction, Liver, Reperfusion Injury, Knockout mouse, 030211 gastroenterology & hepatology, OMM, outer mitochondrial membrane, medicine.medical_specialty, Ubiquitin-Protein Ligases, IHC, immunohistochemical, Down-Regulation, Protective Agents, 03 medical and health sciences, Liver I/R Injury, ΔΨm, mitochondrial membrane potential, Internal medicine, ALT, alanine aminotransferase, H/R, hypoxia/reoxygenation, Autophagy, Animals, PD, Parkinson’s disease, Inflammation, KO, knockout, Hepatology, business.industry, Dj-1-/-, global Dj-1 knockout, medicine.disease, WT, wild-type, IL, interleukin, mtDNA, mitochondrial DNA, 030104 developmental biology, Endocrinology, PINK1, PTEN-induced kinase-1, Hepatocytes, business, Reperfusion injury, 3-MA, 3-methyladenine
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المؤلفون: Chun-Jung Lin, Jer Tsong Hsieh, Andrew Dang, Elizabeth Hernandez
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 169-180 (2021)
Neoplasia (New York, N.Y.)مصطلحات موضوعية: 0301 basic medicine, WT, wild type, Cancer Research, Kinesins, Con, vector control, medicine.disease_cause, Mice, 0302 clinical medicine, Primary cilia, DAB2IP, DAB2 Interacting Protein, C2, protein kinase C conserved region 2 domain, PH, Pleckstrin homology domain, DAPI, 4’, 6-diamidino-2-phenylindole, Tumor suppressor gene, ac-tubulin, acetylated tubulin, STR, short tandem repeat, Kidney, qRT-PCR, Quantitative real-time PCR, Cilium, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Kidney Neoplasms, Renal cell carcinoma, Cell biology, medicine.anatomical_structure, Cell Transformation, Neoplastic, UTSW, University of Texas Southwestern Medical Center, ras GTPase-Activating Proteins, 030220 oncology & carcinogenesis, Kinesin, RCC, renal cell carcinoma, Disease Susceptibility, Protein Binding, Original article, AIG, anchorage independent growth assay, Biology, lcsh:RC254-282, DAB2IP, Cell Line, 03 medical and health sciences, FBS, fetal bovine serum, Microtubule, Ciliogenesis, medicine, Animals, Humans, KIF3A, Cilia, KD, knockdown, KO, knockout, ATCC, American Type Culture Collection, VHL, von Hippel-Lindau, 030104 developmental biology, TCGA, The Cancer Genome Atlas, HIF, hypoxia-inducible factors, KIF3a, kinesin family member 3A, Carcinogenesis, KIF3a, IFT, intraflagellar transport, Protein Processing, Post-Translational, OE, overexpression
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المؤلفون: Shanshan Zhang, Antonio Cigliano, Xianqiong Liu, Xinhua Song, Jie Zhang, Pan Wang, Yong Zeng, Xin Chen, Matthias Evert, Haichuan Wang, Ke Liu, Diego F. Calvisi, Jingxiao Wang, Hong Wu, Jiaoyuan Jia, Silvia Ribback, Li Che
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 4
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1095-1117 (2021)مصطلحات موضوعية: Male, TAZ, 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, YAP, yes-associated protein, Cell Cycle Proteins, law.invention, BrdU, bromodeoxyuridine, Mice, LATS1/2, large tumor-suppressor kinase 1/2, 0302 clinical medicine, law, NEDD4, developmentally down-regulated protein 4, siYT, small interfering RNA targeting yes-associated protein/transcriptional co-activator with PDZ-binding motif, Original Research, Mice, Knockout, siTAZ, small interfering targeting transcriptional co-activator with PDZ-binding motif, TCGA, the cancer genome atlas, ICC, intrahepatic cholangiocarcinoma, pCMV, cytomegalovirus promoter, V12, mutation at position 12 replacing amino acid glycine with valine, Liver Neoplasms, Cell Cycle, Gastroenterology, Hepatitis B, PTX3, pentraxin 3, mRNA, messenger RNA, NRas, Neuroblastoma Ras viral oncogene homolog, Knockout mouse, qPCR, quantitative polymerase chain reaction, Female, 030211 gastroenterology & hepatology, YAP, IHC, immunohistochemistry, TEAD, TEA domain, Hepatitis B virus, Carcinoma, Hepatocellular, TAZ, transcriptional co-activator with PDZ-binding motif, Biology, 03 medical and health sciences, Neuroblastoma, KEGG, Kyoto encyclopedia of genes and genomes, medicine, Animals, Humans, Gene silencing, lcsh:RC799-869, Gene, Protein kinase B, Aged, KO, knockout, Hepatology, myr-Akt-HA, myristoylated-protein kinase B-hemagglutinin tag, p-Erk1/2, phosphorylated extracellular regulated kinase 1/2, YAP-Signaling Proteins, Hepatocellular Carcinoma, HCCS, siSC, scrambled small interfering RNA, medicine.disease, 030104 developmental biology, siYAP, small interfering RNA targeting yes-associated protein, siRNA, small interfering RNA, Ct, cycle threshold, Akt, protein kinase B, Cancer research, Suppressor, lcsh:Diseases of the digestive system. Gastroenterology, HCC, hepatocellular carcinoma, Acyltransferases, MAPK, mitogen-activated protein kinase, Transcription Factors
وصف الملف: application/pdf
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المؤلفون: Nadia Alatrakchi, Tuo Shao, Myung-Ho Kim, Wenyu Lin, Shadi Salloum, Raymond T. Chung, Annie J. Kruger, Andre J Jeyarajan, Kathleen E. Corey, Stuti Shroff, Andrew Kassa, Zhu Zhuo, Sanjoy K. Khan, Mozhdeh Sojoodi, Jacinta A Holmes, Esperance A. Schaefer
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1297-1310 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Liver Cirrhosis, Male, RC799-869, p38 Mitogen-Activated Protein Kinases, PHH, primary human hepatocyte, Mice, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Liver Function Tests, Fibrosis, Non-alcoholic Fatty Liver Disease, Gene expression, Nonalcoholic fatty liver disease, Medicine, L-amino acid defined, high fat diet, Original Research, GFP, green fluorescent protein, YAP1, Fatty Acids, Gastroenterology, Diseases of the digestive system. Gastroenterology, Immunohistochemistry, mRNA, messenger RNA, ECM, extracellular matrix, NT, nontargeting, medicine.anatomical_structure, Hippo signaling, Hepatocyte, JNK, c-Jun N-terminal kinase, shRNA, short hairpin RNA, Disease Progression, 030211 gastroenterology & hepatology, RNAseq, RNA sequencing, Female, CDAHFD, choline-deficient, Disease Susceptibility, YAP, NASH, nonalcoholic steatohepatitis, LD, lipid droplet, Nonalcoholic Fatty Liver Disease, p38 MAPK, Models, Biological, digestive system, α-SMA, α-smooth muscle actin, 03 medical and health sciences, FFA, free fatty acid, Gene silencing, Animals, Humans, KO, knockout, Hepatology, MGH, Massachusetts General Hospital, business.industry, Gene Expression Profiling, pHSC, primary human hepatic stellate cell, Computational Biology, YAP-Signaling Proteins, medicine.disease, WT, wild-type, SS, simple steatosis, digestive system diseases, IL, interleukin, Disease Models, Animal, 030104 developmental biology, Gene Expression Regulation, siRNA, small interfering RNA, Hepatic stellate cell, Cancer research, Hepatocytes, NAFLD, nonalcoholic fatty liver disease, business, HCC, hepatocellular carcinoma, MAPK, mitogen-activated protein kinase, Biomarkers
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المؤلفون: Jie Zan, Bi Wang, Xuya Zhao, Xiya Deng, Hongda Ding, Zijing Wei, Shuai Wang, Zhi Huang, Minyi Lu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 465-487 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, T-Lymphocytes, medicine.medical_treatment, FISH, fluorescence in situ hybridization, RC799-869, IFN-γ, interferon γ, SOCS1, suppressor of cytokine signaling 1, AAV, adeno-associated virus, 0302 clinical medicine, IRF9, interferon regulatory factor 9, Original Research, Receptors, Interferon, Gene knockdown, JAK-STAT, Janus kinase-signal transducer and activator of transcription, Cell Death, Liver Neoplasms, Gastroenterology, qRT-PCR, quantitative real-time polymerase chain reaction, RNA-Binding Proteins, RIP, RNA immunoprecipitation, Diseases of the digestive system. Gastroenterology, lncRNA-NEAT1, long non-coding RNA nuclear enriched abundant transcript 1, Adoptive Transfer, DNA-Binding Proteins, Immunosurveillance, Blot, PD-L1, programmed cell death-ligand 1, Hepatocellular carcinoma, IFNGR1, interferon gamma receptor 1, Paraspeckle, 030211 gastroenterology & hepatology, Immunotherapy, IP, intraperitoneal, NONO, non-POU domain-containing octamer-binding protein, Carcinoma, Hepatocellular, RBP, RNA binding protein, Thr, threonine, PBS, phosphate-buffered saline, Ser, serine, Biology, Interferon-gamma, 03 medical and health sciences, Paraspeckles, Cell Line, Tumor, medicine, Humans, RNA, Messenger, mAb, monoclonal antibody, PSPC1, paraspeckle component 1 protein, neoplasms, PD1, programmed death 1, Immune Evasion, KO, knockout, Hepatology, SFPQ, splicing factor proline- and glutamine-rich protein, Tyr, tyrosine, Hepatocellular Carcinoma, Long Non-coding RNA Nuclear Enriched Abundant Transcript 1, CXLR4, C-X-C motif chemokine receptor 4, medicine.disease, WT, wild-type, digestive system diseases, si, short interfering, RRM, RNA recognition motif, Cytolysis, Non-POU Domain-Containing Octamer-Binding Protein, 030104 developmental biology, NEDD4-1, neuronally expressed developmentally down-regulated 4, Cancer research, Interferon Gamma Receptor 1, ISG, IFN-stimulated gene, HCC, hepatocellular carcinoma, SD, standard deviation
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المؤلفون: Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress
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المؤلفون: Anna E. Goldstein, Victoria G. Weis, Alexander W. Coutts, Milena Saqui-Salces, Evan S. Krystofiak, Anne R. Meyer, Amy C. Engevik, Tamene Melkamu, Izumi Kaji, James R. Goldenring
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 59-80 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, EPEC, enteropathogenic Escherichia coli, RC799-869, DMSO, dimethyl sulfoxide, Occludin, Bulk endocytosis, 0302 clinical medicine, Rab, Ras-related in brain, Apical Bulk Endocytosis, Myosin, P-ERM, phosphorylated ezrin–radixin–moesin, ZO-1, Original Research, Trafficking, biology, Tight junction, Microvilli, Chemistry, Gastroenterology, MYO5B, myosin Vb, Microvillus Inclusion Disease (MVID), Diseases of the digestive system. Gastroenterology, Pals1, proteins associated with Lin-7, Endocytosis, Cell biology, medicine.anatomical_structure, 030211 gastroenterology & hepatology, Patj, Pals1-associated tight junction protein, Cortactin, Intracellular, ERM, ezrin–radixin–moesin, SEM, scanning electron microscope, PBS, phosphate-buffered saline, Myosin Vb, Tight Junctions, 03 medical and health sciences, MVID, microvillus inclusion disease, medicine, aPKC, atypical protein kinase C, KO, knockout, Tight Junction Proteins, Hepatology, Polarity, Cdc42, cell division control protein 42 homolog, Apical membrane, Microvillus, 030104 developmental biology, Inclusions, biology.protein
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المؤلفون: Hui Liu, Sara Maimouni, Sara Coppola, Ye Zhang, Jianliang Shen, Yijun Wang, Shenglan Gao, Ying-Tang Gao, Fengmei Wang, Heineken Queen Daguplo, Wei-Xing Zong, Junrong Yan, Zhi Du, Fang Wang, Yongbo Wang, Peng Wang, Bin Yang, Qin Zhang, Grace L. Guo, Kesong Peng, Wen-Xing Ding, Weiwei Dai, Fei Tang
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 5, Pp 1369-1385 (2021)مصطلحات موضوعية: Male, 0301 basic medicine, PCNA, proliferation cell nuclear antigen, Carcinogenesis, Apoptosis, RC799-869, DMEM, Dulbecco’s modified Eagle’s medium, TRIM21, tripartite motif-containing protein 21, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, Ubiquitin, Tumor Cells, Cultured, Diethylnitrosamine, 8-oxo-dG, 8-oxo-2-deoxyguanosine, Original Research, Mice, Knockout, Kelch-Like ECH-Associated Protein 1, AFP, α-fetoprotein, biology, p62, Liver Neoplasms, Gastroenterology, RNA-Binding Proteins, Diseases of the digestive system. Gastroenterology, PBST, phosphate-buffered saline with 0.02% Tween 20, Prognosis, mRNA, messenger RNA, Ubiquitin ligase, Keap1, Kelch-like ECH-associated protein 1, Gene Expression Regulation, Neoplastic, Survival Rate, Ribonucleoproteins, Knockout mouse, 030211 gastroenterology & hepatology, IHC, immunohistochemistry, Programmed cell death, LD, ligase dead, SDS, sodium dodecyl sulfate, Carcinoma, Hepatocellular, NF-E2-Related Factor 2, PBS, phosphate-buffered saline, Oxidative phosphorylation, Nrf2, α-SMA, α-smooth muscle actin, PI, propidium iodide, cDNA, complementary DNA, 03 medical and health sciences, ROS, reactive oxygen species, Immune system, FBS, fetal bovine serum, Biomarkers, Tumor, Animals, Humans, Carcinogen, Cell Proliferation, KO, knockout, Hepatology, Nrf2, nuclear factor E2-related factor 2, RNA-seq, RNA sequencing, Hepatocellular Carcinoma, WB, western blotting, MEF, mouse embryonic fibroblast, WT, wild-type, KEAP1, Mice, Inbred C57BL, 030104 developmental biology, PB, phenobarbital, biology.protein, Cancer research, TCGA, The Cancer Genome Atlas, HCC, hepatocellular carcinoma, TRIM21, DEN, diethylnitrosamine
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المؤلفون: Stuti Khadka, Kylie N. Peterson, Sara R. Druffner, Lecong Zhou, John A. Cidlowski, Jonathan T. Busada, Deborah J. Stumpo, Robert H. Oakley, Perry J. Blackshear
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1831-1845 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: CTNNB1, β-catenin, Tristetraprolin, Fluorescent Antibody Technique, RC799-869, GSII, Griffonia simplicifolia, Mice, GSEA, gene set enrichment analysis, Metaplasia, hemic and lymphatic diseases, DEG, differentially expressed gene, Original Research, Mice, Knockout, TNF, tumor necrosis factor, SPEM, spasmolytic polypeptide-expressing metaplasia, TTP, tristetraprolin, Stomach, Gastroenterology, Diseases of the digestive system. Gastroenterology, Immunohistochemistry, mRNA, messenger RNA, UTR, untranslated region, medicine.anatomical_structure, RNAseq, RNA sequencing, Tumor necrosis factor alpha, Disease Susceptibility, Gastritis, medicine.symptom, gastric inflammation, adrenalectomy, SPEM, gastric cancer, Inflammation, Proinflammatory cytokine, FPKM, fragments per kilobase of transcript per million mapped reads, MIST1, basic helix-loop-helix family, member a15, medicine, ADX, adrenalectomy, Animals, GO, gene ontology, IPA, Ingenuity Pathway Analysis, ARE, adenylate-uridylate rich element, KO, knockout, Innate immune system, Hepatology, business.industry, WT, wild-type, HDT, high-dose tamoxifen, IL, interleukin, Disease Models, Animal, Tamoxifen, Gene Expression Regulation, Gastric Mucosa, Cancer research, business, Biomarkers
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المؤلفون: Klaudia Theresa Warzecha, Sebastian Huss, Ralf Weiskirchen, Tom Luedde, Matthias Bartneck, Marlene Kohlhepp, Christiane Koppe, Frank Tacke, Christian Trautwein, Viktor Fech
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology : CMGH 11(2), 327-347 (2020). doi:10.1016/j.jcmgh.2020.08.012مصطلحات موضوعية: Liver Cirrhosis, Male, 0301 basic medicine, CCR2, Carcinogenesis, MoMF, monocyte-derived macrophage, PDGF, platelet-derived growth factor, Hepatitis, Mice, Liver disease, Chemokine receptor, 0302 clinical medicine, Fibrosis, Macrophage, BMDM, bone marrow-derived macrophages, Cells, Cultured, Original Research, Mice, Knockout, Liver injury, TNF, tumor necrosis factor, Liver Neoplasms, Intracellular Signaling Peptides and Proteins, CCL, CC motif chemokine, Gastroenterology, HSC, hepatic stellate cell, mRNA, messenger RNA, CCR, CC-chemokine receptor, Liver, Disease Progression, LPS, lipopolysaccharide, 030211 gastroenterology & hepatology, Liver cancer, NASH, nonalcoholic steatohepatitis, NK, natural killer, Liver Cancer, Receptors, CCR5, Receptors, CCR2, Primary Cell Culture, PPAR, Peroxisome proliferator-activated receptor, 03 medical and health sciences, ALT, alanine aminotransferase, TGF-β, transforming growth factor beta, medicine, Animals, Humans, KC, Kupffer cell, KO, knockout, LPC, liver parenchymal cell, Hepatology, SREBP, sterol-regulatory element binding protein, business.industry, Macrophages, Cell Therapy, medicine.disease, WT, wild-type, IL, interleukin, Disease Models, Animal, 030104 developmental biology, CLL, clodronate-loaded liposome, IFNγ, interferon gamma, Hepatocytes, Hepatic stellate cell, Cancer research, NAFLD, nonalcoholic fatty liver disease, business, NEMO, nuclear factor kappa B essential modulator
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المؤلفون: Tetsuo Takehara, Tomohide Tatsumi, Ryotaro Sakamori, Kumiko Shirai, Sadatsugu Sakane, Yuki Makino, Kenji Fukumoto, Takahiro Kodama, Yuta Myojin, Hayato Hikita, Youichi Sasaki, Ryoko Yamada, Yuki Tahata, Naoki Mizutani, Shinnosuke Kudo
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1683-1699 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: eWAT, epididymal white adipose tissue, HFD, high-fat diet, medicine.medical_specialty, Adipose tissue, Nonalcoholic Steatohepatitis, Inflammation, mTOR, mammalian target of rapamycin, RC799-869, White adipose tissue, iWAT, inguinal white adipose tissue, PCR, polymerase chain reaction, Non-alcoholic Fatty Liver Disease, Fibrosis, ALT, alanine aminotransferase, 4-HNE, 4-hydroxynonenal, Internal medicine, Lipid droplet, Nonalcoholic fatty liver disease, Autophagy, medicine, Humans, Original Research, TNF, tumor necrosis factor, KO, knockout, Hepatology, ND, normal diet, business.industry, Intracellular Signaling Peptides and Proteins, Gastroenterology, nutritional and metabolic diseases, Diseases of the digestive system. Gastroenterology, medicine.disease, IL, interleukin, NEFA, nonesterified fatty acid, Endocrinology, Adipose Tissue, NAFLD, nonalcoholic fatty liver disease, FFAs, free fatty acids, medicine.symptom, Steatosis, business, NASH, nonalcoholic steatohepatitis, TUNEL, deoxyuride-5′-triphosphate biotin nick end labeling
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المؤلفون: Sara M. Dann, Zheng Zhou, Suxia Yao, Wenjing Yang, Anthony J. Bilotta, Yu Yu, Xiaojing Zhao, Chunyan Ma, Yingzi Cong, Yanbo Yu
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1023-1044 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, STAT3, signal transducer and activator of transcription 3, Cell, Video microscopy, HDAC, histone deacetylase, DMEM, Dulbecco’s modified Eagle’s medium, IEC, intestinal epithelial cell, Receptors, G-Protein-Coupled, STAT3, Mice, 0302 clinical medicine, HDAC, Propionate, MSIE, mouse small intestinal epithelial cell, OCR, oxygen consumption rate, TGFβ, transforming growth factor beta, IEC, Intestinal Mucosa, ANOVA, analysis of variance, HDACi, histone deacetylase inhibitor, Migration, Original Research, chemistry.chemical_classification, biology, Dextran Sulfate, Gastroenterology, Cell migration, gRNA, guide RNA, Colitis, Cell biology, medicine.anatomical_structure, SCFA, short-chain fatty acid, 030211 gastroenterology & hepatology, STAT3 Transcription Factor, TNFα, tumor necrosis factor alpha, mTOR, mammalian target of rapamycin, Histone Deacetylases, EGF, endothelial growth factor, 03 medical and health sciences, FBS, fetal bovine serum, DSS, dextran sulfate sodium, Intestinal epithelial cell migration, medicine, Animals, MSD, mean-squared displacement, lcsh:RC799-869, ECAR, extracellular acidification rate, KO, knockout, Hepatology, Epithelial Cells, Fatty Acids, Volatile, WT, wild-type, IL, interleukin, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, 030104 developmental biology, chemistry, IFNγ, interferon gamma, Gene Expression Regulation, STAT protein, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, Propionates, Homeostasis, MEK, mitogen-activated protein kinase
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