المؤلفون: Shaji Kumar, Carl Simon, Andreas Guenther, Fang Xiang, Sylvia Zhao, K. Gary Vanasse, Enrique M. Ocio, Yeow Tee Goh, Nicolas Hohmann, Sheeba K. Thomas, Marc S. Raab, Moshe Talpaz

المصدر: Leukemia. 33:2924-2933

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Drug Resistance, Antineoplastic Agents, Drug resistance, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, Pharmacokinetics, Refractory, Recurrence, Internal medicine, medicine, Humans, Adverse effect, Protein Kinase Inhibitors, Multiple myeloma, Aged, Aged, 80 and over, business.industry, Cancer, Hematology, Middle Aged, medicine.disease, Discontinuation, Treatment Outcome, 030104 developmental biology, 030220 oncology & carcinogenesis, Population study, Female, Drug Monitoring, Multiple Myeloma, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fda204c3a0904dce5fef2a52d00811
https://doi.org/10.1038/s41375-019-0482-0

المؤلفون: Hans Bitter, Sandra W. Cowan-Jacob, A. Quamrul Hassan, Silvia Buonamici, Andreas Marzinzik, Wolfgang Jahnke, Sanjeev Thohan, Jerry Donovan, Timothy P. Hughes, Wenjing Zhu, Andrew Wylie, Pascal Furet, Michael Palmer, Lilli Petruzzelli, Xavier Pelle, Susan Branford, Joseph Schoepfer, William R. Sellers, K. Gary Vanasse, Alice Loo, Nicholas Keen, Francesco Hofmann, Franco Lombardo, David M. Ross, Giuliano Berellini, Markus Warmuth, Stephanie Kay Dodd, Varsha Iyer

المساهمون: Wylie, Andrew A, Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W, Branford, Susan, Sellers, William R

المصدر: Nature. 543:733-737

مصطلحات موضوعية: Niacinamide, 0301 basic medicine, Allosteric regulation, Dasatinib, Fusion Proteins, bcr-abl, Drug resistance, Biology, Pharmacology, Mice, 03 medical and health sciences, Allosteric Regulation, Catalytic Domain, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, medicine, molecular responses, pattern of resistance, Animals, Humans, cellular potencies, Cell Proliferation, Multidisciplinary, ABL, Kinase, Imatinib, medicine.disease, Xenograft Model Antitumor Assays, Leukemia, Pyrimidines, 030104 developmental biology, Nilotinib, Drug Resistance, Neoplasm, Mutation, Pyrazoles, Drug Therapy, Combination, Chronic myeloid leukaemia (CML), Allosteric Site, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f07354b900e8232f5f55b603e546d48
https://doi.org/10.1038/nature21702

المؤلفون: Philipp le Coutre, Moshe Talpaz, David T Yeung, Jeroen Janssen, Yosuke Minami, Timothy P. Hughes, David Hynds, Martin S. Tallman, Juan Luis Steegmann, Delphine Rea, Yuyan Duan, Christophe Meille, Michael J. Mauro, Yeow Tee Goh, Michael W. Deininger, Fabian Lang, Massimo Breccia, David M. Ross, K. Gary Vanasse, Florence Hourcade-Potelleret, François Xavier Mahon, Daniel J. DeAngelo, Jorge E. Cortes, Oliver G. Ottmann, Dong-Wook Kim, Jae H. Park, Michael Heinrich, Brian J. Druker, Andreas Hochhaus, Hironobu Minami

المساهمون: Hematology, CCA - Cancer Treatment and quality of life

المصدر: Hughes, T P, Mauro, M J, Cortes, J E, Minami, H, Rea, D, DeAngelo, D J, Breccia, M, Goh, Y-T, Talpaz, M, Hochhaus, A, Coutre, P L, Ottmann, O, Heinrich, M C, Steegmann, J L, Deininger, M W N, Janssen, J J W M, Mahon, F-X, Minami, Y, Yeung, D, Ross, D M, Tallman, M S, Park, J H, Druker, B J, Hynds, D, Duan, Y, Meille, C, Hourcade-Potelleret, F, Vanasse, K G, Lang, F & Kim, D-W 2019, ' Asciminib in chronic myeloid leukemia after Abl kinase inhibitor failure ', New England Journal of Medicine, vol. 381, no. 24, pp. 2315-2326 . https://doi.org/10.1056/NEJMoa1902328
New England Journal of Medicine, 381(24), 2315-2326. Massachussetts Medical Society

مصطلحات موضوعية: ABL, business.industry, Kinase, Allosteric regulation, Myeloid leukemia, General Medicine, 030204 cardiovascular system & hematology, medicine.disease, Fusion protein, 03 medical and health sciences, Myelogenous, Leukemia, 0302 clinical medicine, hemic and lymphatic diseases, Cancer research, Medicine, lipids (amino acids, peptides, and proteins), 030212 general & internal medicine, business, Myristoylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cb1c9f305a2f25b8c15f8aceccaaa1
https://research.vumc.nl/en/publications/6d3f9512-421e-4454-8e94-50eae3eb4a1e

المؤلفون: Alex Aycinena, Yu Ding, Audry Kauffmann, Tatiana Zavorotinskaya, Amy Lambert, John L. Langowski, Julie Chan, Cornelia Bellamacina, Robert Lowell Simmons, Yumin Dai, Min Y. Chen, Christine Fritsch, Gordana Atallah, Elaine Ginn, Victoriano Tamez, Matthew Burger, Kristine Muller, Richard Zang, Paul Feucht, Joseph Castillo, Estelle Pfister, K. Gary Vanasse, Mika Lindvall, Pablo Garcia, Michelle Mathur, Wooseok Han, Gisele Nishiguchi, Jocelyn Holash, Yingyun Wang, Kay Huh, Zhang Yanchen, Steve Basham, Jiong Lan

المصدر: Journal of Medicinal Chemistry. 58:8373-8386

مصطلحات موضوعية: Chemistry, Kinase, Myeloid leukemia, Cancer, medicine.disease, Virology, In vitro, Clinical trial, Leukemia, In vivo, hemic and lymphatic diseases, Drug Discovery, medicine, Cancer research, Molecular Medicine, Multiple myeloma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3fbae38e8687d6cf1c7760d3d1539a2b
https://doi.org/10.1021/acs.jmedchem.5b01275

المؤلفون: Alice S. Mims, Asad Bashey, Koichi Takahashi, Wendy Stock, Farhad Ravandi, Raya Mawad, Chelsea M. Johnson, Thomas Ly, James M. Foran, Hagop M. Kantarjian, M. Wayne Saville, K. Gary Vanasse, Bhavana Bhatnagar, William Blum

المصدر: Blood. 132:763-763

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, business.industry, medicine.medical_treatment, Immunology, Cell Biology, Hematology, Hematopoietic stem cell transplantation, medicine.disease, Biochemistry, Tumor lysis syndrome, Transplantation, 03 medical and health sciences, Regimen, Cytokine release syndrome, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Acute lymphocytic leukemia, Internal medicine, medicine, business, Febrile neutropenia, Dose Modification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a5b9840c008c1e936a8422b7005d4b8
https://doi.org/10.1182/blood-2018-99-119786

المؤلفون: Matthew T, Burger, Gisele, Nishiguchi, Wooseok, Han, Jiong, Lan, Robert, Simmons, Gordana, Atallah, Yu, Ding, Victoriano, Tamez, Yanchen, Zhang, Michelle, Mathur, Kristine, Muller, Cornelia, Bellamacina, Mika K, Lindvall, Richard, Zang, Kay, Huh, Paul, Feucht, Tatiana, Zavorotinskaya, Yumin, Dai, Steve, Basham, Julie, Chan, Elaine, Ginn, Alex, Aycinena, Jocelyn, Holash, Joseph, Castillo, John L, Langowski, Yingyun, Wang, Min Y, Chen, Amy, Lambert, Christine, Fritsch, Audry, Kauffmann, Estelle, Pfister, K Gary, Vanasse, Pablo D, Garcia

المصدر: Journal of medicinal chemistry. 58(21)

مصطلحات موضوعية: Models, Molecular, Leukemia, Myeloid, Acute, Mice, Halogenation, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Proto-Oncogene Proteins, Animals, Humans, Protein Serine-Threonine Kinases, Picolinic Acids, Amides, Protein Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::520e2275f65794da2b12343a31ae7d5e
https://pubmed.ncbi.nlm.nih.gov/26505898

المؤلفون: Marc S Raab, Enrique M Ocio, Sheeba K. Thomas, Andreas Günther, Yeow-Tee Goh, Daniel Lebovic, Andrzej Jakubowiak, Dongweon Song, F Xiang, Apurva Patel, K. Gary Vanasse, Shaji Kumar

المصدر: Blood. 124:301-301

مصطلحات موضوعية: Immunology, Cell Biology, Hematology, Biochemistry, health care economics and organizations

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d2f0bbcad25367b13cf94db846e31f9f
https://doi.org/10.1182/blood.v124.21.301.301

المؤلفون: Bahaa Salem, Sanjeev Thohan, Jerry Donovan, Joseph Schoepfer, Bernhard Erb, Tami Hood, Quamrul Hassan, Wolfgang Jahnke, K. Gary Vanasse, Alice Loo, Andreas Marzinzik, Giuliano Berellini, Giorgio Caravatti, Franco Lombardo, Sandra Jacob, Simona Cotesta, Nicholas Keen, Andrew Wylie, Xavier Pelle, Sreenath V. Sharma, Geeti Gangal, Pascal Furet, Suzanne Zhu, Robert Martin Grotzfeld, Hongbo Cai, William R. Sellers, Paul W. Manley, Stephanie Kay Dodd, Varsha Iyer, Michael Palmer, Lilli Petruzzelli

المصدر: Blood. 124:398-398

مصطلحات موضوعية: ABL, business.industry, Immunology, Imatinib, Cell Biology, Hematology, Pharmacology, Philadelphia chromosome, medicine.disease, Biochemistry, Imatinib mesylate, Nilotinib, hemic and lymphatic diseases, Acute lymphocytic leukemia, Medicine, Kinase activity, business, medicine.drug, Chronic myelogenous leukemia

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9060c496106f1c939db7c4db5b293b6d
https://doi.org/10.1182/blood.v124.21.398.398

المؤلفون: Pablo D Garcia, John L Langowski, Jocelyn Holash, Matthew Burger, Richard Zang, Tatiana Zavorotinskaya, Christie Fanton, Abdel Saci, Joseph Growney, K. Gary Vanasse

المصدر: Blood. 122:1666-1666

مصطلحات موضوعية: business.industry, PIM Kinase Inhibitor LGH447, Kinase, Immunology, PIM1, PIM2, Cell Biology, Hematology, medicine.disease, Biochemistry, Cancer cell, Cancer research, Cytarabine, Medicine, business, PI3K/AKT/mTOR pathway, Multiple myeloma, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::43b6939872b88507a93cde738bd629e3
https://doi.org/10.1182/blood.v122.21.1666.1666

المؤلفون: Z. Alexander Cao, Pablo Garcia, Joseph D. Growney, K. Gary Vanasse, Giordano Caponigro, Maria Pinzon-Ortiz, Margaret Squier, Dannie Wang, Xianhui Rong, Thomas Radimerski, Abdel Saci

المصدر: Blood. 122:4100-4100

مصطلحات موضوعية: MAPK/ERK pathway, Ruxolitinib, biology, business.industry, Immunology, PIM1, Cell Biology, Hematology, Cell cycle, Pharmacology, Biochemistry, stat, Growth factor receptor, STAT protein, medicine, biology.protein, business, STAT5, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69dd94883c0ece2c1e033bfa9f56ecba
https://doi.org/10.1182/blood.v122.21.4100.4100