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1
المؤلفون: K. B. Nolop, Garson Tsang, Yan Ma, Heidi Carias, D. Fong, Marika Nespi, Peter Hirth, Rafe Shellooe, Elizabeth A. Burton, Paul S. Lin, Jason Walters, Wayne Spevak, Todd Ewing, Ben Powell, Gideon Bollag, Hanna Cho, Womack Patrick, Bernice Matusow, Ying Zhang, Guoxian Wu, Jiazhong Zhang, Hamid Rezaei, Gary Conard Visor, Hoa Nguyen, Laura Sanftner, Brian L. West, Prabha N. Ibrahim, Gaston Habets, Weiru Wang, Jack Lin, Adhirai Marimuthu, James Tsai, Chao Zhang, Songyuan Shi, Emily Light
المصدر: Nature. 526:583-586
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, MAPK/ERK pathway, Cell signaling, Indoles, MAP Kinase Signaling System, Biology, Heterocyclic Compounds, 2-Ring, Models, Biological, Receptor tyrosine kinase, Mice, Cell Line, Tumor, Encorafenib, medicine, Animals, Humans, HRAS, Vemurafenib, Protein kinase A, Protein Kinase Inhibitors, Sulfonamides, Multidisciplinary, Molecular biology, Enzyme Activation, Genes, ras, Mutation, biology.protein, Cancer research, Female, Mitogen-Activated Protein Kinases, medicine.drug
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2
المؤلفون: K. B. Nolop, Keith T. Flaherty, Jeffrey A. Sosman, Paul B. Chapman, Grant A. McArthur, Patrick Hwu, Mark Shackleton, Antoni Ribas, Igor Puzanov, Ravi K. Amaravadi, Kevin B. Kim, Bartosz Chmielowski, Paul S. Lin
المصدر: European journal of cancer (Oxford, England : 1990), vol 51, iss 11
مصطلحات موضوعية: Male, Oncology, Cancer Research, Tumour regression, Skin Neoplasms, Indoles, BRAF inhibitor, 80 and over, Young adult, Vemurafenib, Melanoma, Cancer, Aged, 80 and over, Sulfonamides, Middle Aged, Survival Rate, Disease Progression, Public Health and Health Services, Female, Drug, medicine.drug, Proto-Oncogene Proteins B-raf, Adult, medicine.medical_specialty, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Metastatic melanoma, Article, Disease-Free Survival, Dose-Response Relationship, Young Adult, Clinical Research, Internal medicine, medicine, Humans, Oncology & Carcinogenesis, Survival rate, Aged, Dose-Response Relationship, Drug, business.industry, Disease progression, medicine.disease, Dermatology, Brain Disorders, business, Progressive disease
وصف الملف: application/pdf
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المؤلفون: Fei Su, Matthew J. Klimek, Axel Hauschild, Caroline Robert, Christopher McCormack, Victor G. Prieto, Caroline C. Kim, Olivia Spleiss, Andrew K. Joe, K. B. Nolop, Kerstin Trunzer, James L. Troy, Madeleine Duvic, Joseph F. Grippo, Patricia L. Myskowski, Dirk Schadendorf, B. Nelson, Mario E. Lacouture, Richard J. Lee
المصدر: The Oncologist. 18:314-322
مصطلحات موضوعية: Adult, Male, Cancer Research, medicine.medical_specialty, Keratoacanthoma, Indoles, Skin Neoplasms, Cutaneous squamous cell carcinoma, Adolescent, Treatment outcome, Medizin, Skin Diseases, Young Adult, medicine, Humans, Vemurafenib, Adverse effect, Melanoma, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Clinical Trials as Topic, Sulfonamides, business.industry, Neoplasms, Second Primary, Middle Aged, medicine.disease, Dermatology, Treatment Outcome, Oncology, Female, Melanoma and Cutaneous Malignancies, business, medicine.drug
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4
المؤلفون: Igor Puzanov, Rodney J. Hicks, Ravi K. Amaravadi, K. B. Nolop, Paul B. Chapman, Grant A. McArthur, Antoni Ribas, Jason Callahan, Keith T. Flaherty, Richard J. Lee, Kevin B. Kim, Jeffrey A. Sosman
المصدر: Journal of Clinical Oncology. 30:1628-1634
مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_specialty, Indoles, Skin Neoplasms, Maximum Tolerated Dose, Mutant, Urology, Standardized uptake value, Drug Administration Schedule, Statistics, Nonparametric, Fluorodeoxyglucose F18, Biomarkers, Tumor, Confidence Intervals, medicine, Humans, Neoplasm Invasiveness, Vemurafenib, Melanoma, Survival analysis, Aged, Monitoring, Physiologic, Neoplasm Staging, Advanced melanoma, Aged, 80 and over, Fluorodeoxyglucose, Sulfonamides, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Australia, Middle Aged, medicine.disease, Survival Analysis, Early Diagnosis, Treatment Outcome, Oncology, Positron emission tomography, Positron-Emission Tomography, Mutation, Female, business, Nuclear medicine, Follow-Up Studies, medicine.drug
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5
المؤلفون: Yu Shyr, Andrew K. Joe, Kevin B. Kim, Grant A. McArthur, Richard F. Kefford, Richard J. Lee, Antoni Ribas, Stergios J. Moschos, Thomas E. Hutson, Jiang Li, Jeffrey A. Sosman, Donald P. Lawrence, Ravi K. Amaravadi, H. Jeffrey Lawrence, Rene Gonzalez, Anna C. Pavlick, Karl D. Lewis, Jeffrey S. Weber, Lynn M. Schuchter, Fei Ye, Igor Puzanov, Peter Hersey, Keith T. Flaherty, Bartosz Chmielowski, K. B. Nolop
المصدر: New England Journal of Medicine. 366:707-714
مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Oncology, Keratoacanthoma, medicine.medical_specialty, Indoles, Dacarbazine, Kaplan-Meier Estimate, Article, chemistry.chemical_compound, Internal medicine, medicine, Clinical endpoint, Humans, Neoplasm Metastasis, Vemurafenib, Melanoma, Aged, Cobimetinib, Sulfonamides, business.industry, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Rash, Surgery, Treatment Outcome, chemistry, Mutation, Disease Progression, Female, medicine.symptom, business, medicine.drug
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6
المؤلفون: Holly Hilton, Nicholas Otte, Julie S. Hang, Ion Niculescu-Duvaz, Felipe C. Geyer, Lidia Robert, K. B. Nolop, Jorge S. Reis-Filho, Luc Andries, Alfonso Zambon, Gideon Bollag, Rene Gonzalez, Natasha Preece, Paul B. Chapman, Damien Kee, Min Jung Kim, Kerstin Trunzer, Dan Niculescu-Duvaz, Stephen Mok, Brian Lestini, Roger S. Lo, Gaston Habets, Amaya Viros, James L. Troy, Caroline J. Springer, Mark M. Kockx, Yan Ma, Igor Puzanov, Carla Milagre, Robert Hayward, Elizabeth A. Burton, Antoni Ribas, Xiangju Kong, Chao Zhang, Matthew J. Martin, Maryou B K Lambros, Andrew K. Joe, Richard C. Koya, Jeffrey A. Sosman, Olivia Spleiss, Johannes Noe, Bartosz Chmielowski, Hoa Nguyen, Richard J. Lee, Keith T. Flaherty, Richard Marais, Nathalie Dhomen, Hong Yang, Bernice Wong, Qiongqing Wang, Grant A. McArthur, Fei Su, Thomas E. Hutson
المصدر: ResearcherID
مصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, Neuroblastoma RAS viral oncogene homolog, Indoles, Skin Neoplasms, Gene Expression, medicine.disease_cause, Mice, chemistry.chemical_compound, CDKN2A, Animals, Humans, Medicine, HRAS, Vemurafenib, Protein Kinase Inhibitors, Aged, Aged, 80 and over, Mitogen-Activated Protein Kinase Kinases, Cobimetinib, Sulfonamides, business.industry, Melanoma, General Medicine, Middle Aged, medicine.disease, Gene Expression Regulation, Neoplastic, Genes, ras, chemistry, Mutation, Carcinoma, Squamous Cell, Cancer research, Female, KRAS, business, Carcinogenesis, medicine.drug
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7
المؤلفون: Rachel Langland, Jeanne Tie, Gideon Bollag, Jayesh Desai, Matthew Croxford, Ian T. Jones, K. B. Nolop, Oliver M. Sieber, Daniel McKay, Robert N. Jorissen, Michael Christie, Peter Gibbs, Suzanne Kosmider, Lara Lipton, Antony W. Burgess
المصدر: International Journal of Cancer. 128:2075-2084
مصطلحات موضوعية: Male, Proto-Oncogene Proteins B-raf, Oncology, Cancer Research, medicine.medical_specialty, Pathology, endocrine system diseases, Colorectal cancer, medicine.medical_treatment, Antineoplastic Agents, Kaplan-Meier Estimate, medicine.disease_cause, Targeted therapy, Drug Delivery Systems, Sex Factors, Internal medicine, medicine, Humans, neoplasms, Aged, Neoplasm Staging, Cetuximab, Reverse Transcriptase Polymerase Chain Reaction, business.industry, Age Factors, Cancer, Microsatellite instability, Middle Aged, medicine.disease, Primary tumor, digestive system diseases, Treatment Outcome, Drug Resistance, Neoplasm, Mutation, Female, Microsatellite Instability, KRAS, Colorectal Neoplasms, business, V600E, medicine.drug
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8
المؤلفون: K. B. Nolop, Andrew J. Wagner, Gaston Habets, Igor Puzanov, Hoa Nguyen, Vicki L. Keedy, Stephen P. Anthony, Charles Peterfy, John H. Healey, Zev A. Wainberg, Marie J Kim, Arthur P Staddon, Laura Sanftner, Prabha N. Ibrahim, Brian L. West, Allen Lee Cohn, Matt van de Rijn, Paul Severson, Henry H. Hsu, Elizabeth A. Burton, Garson Tsang, Sandra Tong-Starksen, Glen J. Weiss, Adhirai Marimuthu, Gary Conard Visor, Carolyn Gee, William D. Tap, Arun S. Singh, Ramesh K. Ramanathan, Jiazhong Zhang, Eunice L. Kwak, Geoffrey I. Shapiro, Peter Hirth, Paul S. Lin, Gideon Bollag, Ying Zhang, Daniel D. Von Hoff, Chao Zhang, Rafe Shellooe, Bartosz Chmielowski
المصدر: The New England journal of medicine. 373(5)
مصطلحات موضوعية: Adult, Male, Pexidartinib, Aminopyridines, Receptor, Macrophage Colony-Stimulating Factor, Soft Tissue Neoplasms, In situ hybridization, Pharmacology, Crystallography, X-Ray, Tendons, Pharmacokinetics, Drug Discovery, medicine, Humans, Pyrroles, Receptor, Aged, Dose-Response Relationship, Drug, business.industry, Kinase, Giant Cell Tumors, General Medicine, Middle Aged, Blockade, Tumor Burden, Clinical trial, Mechanism of action, Cancer research, Female, medicine.symptom, business
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المؤلفون: Timothy F. Cloughesy, Joanna J. Phillips, Lakshmi Nayak, Nicholas Butowski, Brian L. West, Arie Perry, Annette M. Molinaro, Henry H. Hsu, Jason T. Huse, Sam Haidar, Michael D. Prados, John de Groot, Antonio Omuro, Adhirai Marimuthu, K. B. Nolop, Keith L. Ligon, Howard Colman, Patrick Y. Wen
المصدر: Neuro-oncology, vol 18, iss 4
مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Phases of clinical research, microglia, Administration, Oral, Aminopyridines, Pharmacology, Cohort Studies, Immunoenzyme Techniques, glioma, Receptors, Tissue Distribution, Cancer, Tumor, Brain Neoplasms, Middle Aged, Prognosis, Tumor Burden, Oncology, Local, Blood-Brain Barrier, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, 6.1 Pharmaceuticals, Administration, Female, Macrophage colony-stimulating factor, Oral, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Cmax, Clinical Investigations, Colony stimulating factor 1 receptor, 03 medical and health sciences, Rare Diseases, Pharmacokinetics, Clinical Research, Glioma, PLX3397, medicine, Biomarkers, Tumor, Humans, Pyrroles, Progression-free survival, Oncology & Carcinogenesis, Neoplasm Staging, Surrogate endpoint, business.industry, glioblastoma, Neurosciences, Granulocyte-Macrophage Colony-Stimulating Factor, Evaluation of treatments and therapeutic interventions, CSF1R, medicine.disease, Brain Disorders, Brain Cancer, 030104 developmental biology, Neoplasm Recurrence, Neurology (clinical), Neoplasm Recurrence, Local, business, Glioblastoma, Biomarkers, Follow-Up Studies
وصف الملف: application/pdf
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المؤلفون: Guoxian Wu, Garson Tsang, Gaston Habets, Chao Zhang, Paul S. Lin, Dean R. Artis, Marika Nespi, Jiazhong Zhang, Elizabeth A. Burton, Hoa Nguyen, Angela Oh, Adhirai Marimuthu, Wayne Spevak, Gideon Bollag, Gregory H Tesch, Rafe Shellooe, Bernice Matusow, Prabha N. Ibrahim, Peter Hirth, Ying Zhang, Brian L. West, Ryan Bremer, Clarence R. Hurt, Kam Y. J. Zhang, Heidi Carias, Ben Powell, K. B. Nolop
مصطلحات موضوعية: Models, Molecular, Indoles, Cell Survival, Protein Conformation, Viral Oncogene, Mutation, Missense, Aminopyridines, Osteoclasts, Inflammation, Biology, Spodoptera, Chromatography, Affinity, Immune system, medicine, Escherichia coli, Human Umbilical Vein Endothelial Cells, Sf9 Cells, Animals, Humans, Pyrroles, Mast Cells, Neoplasm Metastasis, Protein Kinase Inhibitors, Multidisciplinary, Oncogene, Molecular Structure, Oncogene Protein gp140(v-fms), Macrophages, Cancer, Biological Sciences, medicine.disease, Proto-Oncogene Proteins c-kit, Immunology, Cancer cell, Cancer research, medicine.symptom, Crystallization
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11
المؤلفون: Gideon Bollag, Jiazhong Zhang, Peter Hirth, Prabha N. Ibrahim, Chao Zhang, James Tsai, K. B. Nolop
المصدر: Nature reviews. Drug discovery. 11(11)
مصطلحات موضوعية: Drug, Oncology, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Indoles, Skin Neoplasms, Metastatic melanoma, media_common.quotation_subject, Druggability, Antineoplastic Agents, Pharmacology, Internal medicine, Drug Discovery, Drug approval, Medicine, media_common.cataloged_instance, Animals, Humans, European Union, European union, Neoplasm Metastasis, Vemurafenib, neoplasms, Drug Approval, Melanoma, media_common, Sulfonamides, business.industry, Drug discovery, Cancer, General Medicine, medicine.disease, United States, Drug Design, Mutation, business, medicine.drug
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12
المؤلفون: Keith T. Flaherty, Paul S. Lin, Garson Tsang, Paul B. Chapman, Jeffrey A. Sosman, Kevin B. Kim, Joseph Schlessinger, Kurt D'Andrea, Xiaowei Xu, Prabha N. Ibrahim, K. B. Nolop, Brian L. West, Adhirai Marimuthu, Richard J. Lee, Grant A. McArthur, James Tsai, Fei Su, Wayne Spevak, Michael Stumm, Gaston Habets, Jiazhong Zhang, Gideon Bollag, Joseph F. Grippo, Katherine L. Nathanson, Igor Puzanov, Hoa Nguyen, Dean R. Artis, Hanna Cho, Elizabeth A. Burton, Antoni Ribas, Ben Powell, Bernice Wong, Rafe Shellooe, Astrid Koehler, Brian Higgins, Raman Mahadevan Iyer, Chao Zhang, Kam Y. J. Zhang, Peter Hirth, Ying Zhang
المصدر: Nature, vol 467, iss 7315
Natureمصطلحات موضوعية: MAPK/ERK pathway, Models, Molecular, Indoles, Proto-Oncogene Proteins B-raf, Substrate Specificity, oncogene, Models, Encorafenib, Neoplasm Metastasis, Phosphorylation, Vemurafenib, Extracellular Signal-Regulated MAP Kinases, Melanoma, Cancer, Sulfonamides, Multidisciplinary, Kinase, PLX4032, targeted therapy, 5.1 Pharmaceuticals, biomarker, Development of treatments and therapeutic interventions, medicine.drug, MAP Kinase Signaling System, General Science & Technology, Clinical Trials and Supportive Activities, Biology, Serine/Threonine-Protein Kinase B-Raf, Article, BRAF, Dogs, Clinical Research, medicine, melanoma, Animals, Humans, Kinase activity, Alleles, Molecular, medicine.disease, Xenograft Model Antitumor Assays, Rats, Macaca fascicularis, Positron-Emission Tomography, Mutation, Cancer research, Mutant Proteins
وصف الملف: application/pdf
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المؤلفون: Peter J. O'Dwyer, Joseph F. Grippo, Antoni Ribas, Kevin B. Kim, Grant A. McArthur, K. B. Nolop, Igor Puzanov, Paul B. Chapman, Jeffrey A. Sosman, Keith T. Flaherty, Richard J. Lee
مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Oncology, medicine.medical_specialty, Indoles, Drug Resistance, Antineoplastic Agents, Article, Metastasis, Young Adult, Internal medicine, medicine, Humans, Adverse effect, Vemurafenib, Melanoma, Aged, Aged, 80 and over, Sulfonamides, Dose-Response Relationship, Drug, business.industry, Cancer, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Rash, Surgery, Treatment Outcome, Drug Resistance, Neoplasm, Mutation, Female, Commentary - Commissioned, medicine.symptom, business, V600E, medicine.drug
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المؤلفون: Brian L. West, Weiru Wang, D. Erbe, John Cantwell, Ben Powell, J. Arnold, M. Perreault, B.P. England, G. P. Vlasuk, Womack Patrick, Michael V. Milburn, J. Kral, Kam Y. J. Zhang, Prabha N. Ibrahim, K. P. Hirth, Alexander N. Plotnikov, D. Fong, Shenghua Shi, Adhirai Marimuthu, S. Will, K. B. Nolop, Dean R. Artis, H.I. Krupka, Gaston Habets, C. Settachatgull, James Tobin, M. Signaevsky, J. J. Lin, Angela Oh, Hoa Nguyen, Gideon Bollag, U. Mehra, Chao Zhang, D. S. Yan
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 106(1)
مصطلحات موضوعية: Transcriptional Activation, medicine.medical_specialty, Peroxisome Proliferator-Activated Receptors, Peroxisome proliferator-activated receptor, Biology, Partial agonist, PPAR agonist, Cell Line, Diabetes Mellitus, Experimental, chemistry.chemical_compound, Mice, In vivo, Internal medicine, Adipocyte, Drug Discovery, medicine, Adipocytes, Animals, Humans, Hypoglycemic Agents, Obesity, Receptor, chemistry.chemical_classification, Multidisciplinary, Adiponectin, Cell Differentiation, Biological Sciences, Rats, PPAR gamma, Endocrinology, Anti-diabetic Agent, chemistry
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المؤلفون: U. S. Ryan, K. B. Nolop
المصدر: American Journal of Physiology-Lung Cellular and Molecular Physiology. 259:L123-L129
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Endothelium, Cell Survival, Physiology, Cell, Pulmonary Artery, Biology, Cycloheximide, Umbilical vein, Proinflammatory cytokine, chemistry.chemical_compound, Leucine, Physiology (medical), medicine, Animals, Cytotoxic T cell, Cells, Cultured, Tumor Necrosis Factor-alpha, Drug Synergism, Cell Biology, Molecular biology, Chromium Radioisotopes, Recombinant Proteins, Endothelial stem cell, Kinetics, medicine.anatomical_structure, Biochemistry, chemistry, Protein Biosynthesis, Cattle, Tumor necrosis factor alpha, Endothelium, Vascular
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16
المؤلفون: Margo Roberts, Margaret A. Marshall, Omar Pugach, K. B. Nolop, Lily Lu, Steven R. Feldman, Steven A. Rosenberg, James N. Kochenderfer, Marc Better, Adrian Bot, Robert Somerville, Sadik H. Kassim
المصدر: Journal of Clinical Oncology. 32:3079-3079
مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, business.industry, T cell, Anti cd19, Cancer, medicine.disease, Clinical trial, Cell expansion, medicine.anatomical_structure, Internal medicine, Immunology, medicine, In patient, business
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المؤلفون: Adhirai Marimuthu, Howard Colman, K. B. Nolop, Henry H. Hsu, Nicholas Butowski, Michael D. Prados, Arie Perry, Antonio Omuro, Joanna J. Phillips, John de Groot, Lakshmi Nayak, Keith L. Ligon, Brian L. West, Timothy F. Cloughesy
المصدر: Journal of Clinical Oncology. 32:2023-2023
مصطلحات موضوعية: Cancer Research, Microglia, Kinase, business.industry, Recurrent glioblastoma, Phases of clinical research, Tumor cells, Small molecule, medicine.anatomical_structure, Oncology, Immunology, Cancer research, Medicine, In patient, business
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18
المؤلفون: R B, Berkowitz, D I, Bernstein, C, LaForce, A J, Pedinoff, A R, Rooklin, C R, Damaraju, B, Mesarina-Wicki, K B, Nolop
المصدر: Allergy. 54(1)
مصطلحات موضوعية: Adult, Male, Time Factors, Adolescent, Rhinitis, Allergic, Seasonal, Middle Aged, Self Care, Double-Blind Method, Anti-Allergic Agents, Humans, Female, Child, Mometasone Furoate, Pregnadienediols, Administration, Intranasal
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المؤلفون: J E, Ware, J P, Kemp, D A, Buchner, A E, Singer, K B, Nolop, T F, Goss
المصدر: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 7(3)
مصطلحات موضوعية: Adult, Male, Psychometrics, Anti-Inflammatory Agents, Beclomethasone, Discriminant Analysis, Reproducibility of Results, Severity of Illness Index, Asthma, Treatment Outcome, Forced Expiratory Volume, Surveys and Questionnaires, Activities of Daily Living, Health Status Indicators, Humans, Female
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20
المؤلفون: Thomas E. Witzig, R. Gregory Bociek, K. B. Nolop, Brian L. West, Leo I. Gordon, Christian Steidl, Craig H. Moskowitz, Anas Younes, Randy D. Gascoyne, Sven de Vos
المصدر: Blood. 120:1638-1638
مصطلحات موضوعية: medicine.medical_specialty, Leukopenia, business.industry, Immunology, Phases of clinical research, Cell Biology, Hematology, Neutropenia, medicine.disease, Biochemistry, Gastroenterology, Surgery, Lymphoma, Internal medicine, Multicenter trial, medicine, Refractory Hodgkin Lymphoma, Clinical endpoint, medicine.symptom, business, Progressive disease