المؤلفون: Ismael Rodriguez, Justyna Kocik-Krol, Lukasz Skalniak, Bogdan Musielak, Aneta Wisniewska, Agnieszka Ciesiołkiewicz, Łukasz Berlicki, Jacek Plewka, Przemyslaw Grudnik, Malgorzata Stec, Maciej Siedlar, Tad A. Holak, Katarzyna Magiera-Mularz

المصدر: Molecular Cancer, Vol 22, Iss 1, Pp 1-8 (2023)

مصطلحات موضوعية: PD-1, Programmed death 1, PD-L1, Programmed death ligand 1, CD80, Immune checkpoint blockade, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1476-4598

URL الوصول: https://doaj.org/article/4d89b666a61e477c85c3abb086044bda

المؤلفون: Katarzyna Magiera-Mularz, Justyna Kocik, Bogdan Musielak, Jacek Plewka, Dominik Sala, Monika Machula, Przemyslaw Grudnik, Malgorzata Hajduk, Marcin Czepiel, Maciej Siedlar, Tad A. Holak, Lukasz Skalniak

المصدر: iScience, Vol 24, Iss 1, Pp 101960- (2021)

مصطلحات موضوعية: Therapeutics, Immunology, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004220311573; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/60bd188bec4540759a79eec5931735b6

المؤلفون: Shabnam Shaabani, Louis Gadina, Ewa Surmiak, Zefeng Wang, Bidong Zhang, Roberto Butera, Tryfon Zarganes-Tzitzikas, Ismael Rodriguez, Justyna Kocik-Krol, Katarzyna Magiera-Mularz, Lukasz Skalniak, Alexander Dömling, Tad A. Holak

المصدر: Molecules, Vol 27, Iss 11, p 3454 (2022)

مصطلحات موضوعية: PD-1/PD-L1, small-molecule inhibitors, immune checkpoint blockade, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/11/3454; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/67a2552841844f3d9aa8c069ce56167b

المؤلفون: Bogdan Musielak, Justyna Kocik, Lukasz Skalniak, Katarzyna Magiera-Mularz, Dominik Sala, Miroslawa Czub, Malgorzata Stec, Maciej Siedlar, Tad A. Holak, Jacek Plewka

المصدر: Molecules, Vol 24, Iss 15, p 2804 (2019)

مصطلحات موضوعية: CA-170, PD-1/PD-L1, NMR, HTRF, immune checkpoint, Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/24/15/2804; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/7d516a7031dd4e9d8d1e8fdf4cde5b5c

المؤلفون: Damian Muszak (11189267), Ewa Surmiak (3222531), Jacek Plewka (4518541), Katarzyna Magiera-Mularz (7037945), Justyna Kocik-Krol (11189270), Bogdan Musielak (1528534), Dominik Sala (9409331), Radoslaw Kitel (10720788), Malgorzata Stec (9409340), Kazimierz Weglarczyk (562799), Maciej Siedlar (4524892), Alexander Dömling (1312329), Lukasz Skalniak (4031801), Tad A. Holak (179387)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, terphenyl scaffold, PD-L 1, terphenyl-based scaffolds, antitumor response, rigidified biphenyl-inspired structure, Terphenyl-Based Small-Molecule Inhi., inhibitor, silico docking

Relation: https://figshare.com/articles/journal_contribution/Terphenyl-Based_Small-Molecule_Inhibitors_of_Programmed_Cell_Death-1_Programmed_Death-Ligand_1_Protein_Protein_Interaction/15059780

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00957.s001

المؤلفون: Ewa Surmiak, Katarzyna Magiera-Mularz, Bogdan Musielak, Damian Muszak, Justyna Kocik-Krol, Radoslaw Kitel, Jacek Plewka, Tad A. Holak, Lukasz Skalniak

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 21; Pages: 11797

مصطلحات موضوعية: PD-L1 inhibitor, immune checkpoint blockade, immunotherapy

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Oncology; https://dx.doi.org/10.3390/ijms222111797

الاتاحة: https://doi.org/10.3390/ijms222111797

المؤلفون: Damian Muszak (10123427), Ewa Surmiak (10097260), Jacek Plewka (10190273), Katarzyna Magiera-Mularz (10123433), Justyna Kocik (10123438), Bogdan Musielak (10123439), Dominik Sala (10123489), Radosław Kitel (10123440), Małgorzata Stec (10123442), Maciej Siedlar (10123444), Alexander Domling (8256861), Łukasz Skalniak (10123445), Tad Holak (10123448)

مصطلحات موضوعية: Biochemistry, Cell and Molecular Biology, Drug Discovery and Drug Delivery Systems, immunooncology, PD1-PDL1, Small-Molecule Inhibitors, terphenyl derivatives

Relation: https://figshare.com/articles/preprint/Terphenyl-based_Small-Molecule_Inhibitors_of_Programmed_Cell_Death-1_Programmed_Death-Ligand_1_Protein_Protein_Interaction/13849442

الاتاحة: https://doi.org/10.26434/chemrxiv.13849442.v1

المؤلفون: Ewa Surmiak, Julia Ząber, Jacek Plewka, Grzegorz Wojtanowicz, Justyna Kocik-Krol, Oskar Kruc, Damian Muszak, Ismael Rodríguez, Bogdan Musielak, Lukasz Skalniak, Katarzyna Magiera-Mularz, Tad A. Holak, Justyna Kalinowska-Tłuścik

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f42c65749e6269f9d19dc3dd7e995559
https://doi.org/10.21203/rs.3.rs-2907891/v1

المؤلفون: Justyna Kocik, Monika Machula, Aneta Wisniewska, Ewa Surmiak, Tad A. Holak, Lukasz Skalniak

المصدر: Cancers; Volume 11; Issue 7; Pages: 1014

مصطلحات موضوعية: HDM2 antagonist, MDM2, p53, p21, synergy, combined cancer treatment, targeted therapy, chemotherapy, nutlin, RG7388, idasanutlin

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers11071014

الاتاحة: https://doi.org/10.3390/cancers11071014

المؤلفون: Lukasz Skalniak, Justyna Kocik, Justyna Polak, Anna Skalniak, Monika Rak, Agnieszka Wolnicka-Glubisz, Tad Holak

المصدر: Cancers; Volume 10; Issue 11; Pages: 396

مصطلحات موضوعية: MDM2 antagonists, idasanutlin, RG7388, p53 induction, cancer, secondary drug resistance

وصف الملف: application/pdf

Relation: https://dx.doi.org/10.3390/cancers10110396

الاتاحة: https://doi.org/10.3390/cancers10110396

المؤلفون: Maciej Siedlar, Lukasz Skalniak, Ismael Rodríguez, Dominik Sala, Tad A. Holak, Magdalena Konieczny, Jacek Plewka, Justyna Kocik, Małgorzata Stec, Katarzyna Magiera-Mularz, Miroslawa Czub, Maja Myrcha, Bogdan Musielak

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: medicine.drug_class, medicine.medical_treatment, Proton Magnetic Resonance Spectroscopy, Programmed Cell Death 1 Receptor, Monoclonal antibody, 01 natural sciences, Jurkat cells, Article, B7-H1 Antigen, Small Molecule Libraries, 03 medical and health sciences, Jurkat Cells, Cancer immunotherapy, PD-L1, Drug Discovery, medicine, Humans, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Immunotherapy, Bromine, Small molecule, Immune checkpoint, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cancer research, biology.protein, Molecular Medicine, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032cc6b5402219d3d1dd54b8c4307ac8
http://europepmc.org/articles/PMC7584369

المؤلفون: Lukasz Skalniak, Radoslaw Kitel, Jacek Plewka, Tad A. Holak, Bogdan Musielak, Damian Muszak, Ewa Surmiak, Justyna Kocik-Krol, Katarzyna Magiera-Mularz

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 11797, p 11797 (2021)
International Journal of Molecular Sciences

مصطلحات موضوعية: Peptidomimetic, QH301-705.5, medicine.medical_treatment, Computational biology, CHO Cells, Catalysis, B7-H1 Antigen, Inorganic Chemistry, Jurkat Cells, Cricetulus, Cancer immunotherapy, PD-L1, medicine, Animals, Humans, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, PD-L1 inhibitor, QD1-999, Immune Checkpoint Inhibitors, Spectroscopy, biology, Chemistry, Communication, Organic Chemistry, General Medicine, Immunotherapy, immune checkpoint blockade, Ligand (biochemistry), Immune checkpoint, In vitro, Computer Science Applications, biology.protein, Drug Evaluation, immunotherapy, Peptidomimetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f846fc8bfbfa8eca4fdf24197328b1f
https://pubmed.ncbi.nlm.nih.gov/34769226

المؤلفون: Lukasz Skalniak, Dominik Sala, Alexander Dömling, Justyna Kocik-Krol, Tad A. Holak, Katarzyna Magiera-Mularz, Radoslaw Kitel, Kazimierz Weglarczyk, Jacek Plewka, Damian Muszak, Ewa Surmiak, Małgorzata Stec, Maciej Siedlar, Bogdan Musielak

المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Journal of Medicinal Chemistry, 64(15), 11614-11636. AMER CHEMICAL SOC
Journal of Medicinal Chemistry

مصطلحات موضوعية: Cell Survival, Programmed Cell Death 1 Receptor, CHO Cells, B7-H1 Antigen, Article, Protein–protein interaction, Small Molecule Libraries, chemistry.chemical_compound, Structure-Activity Relationship, Immune system, Molecular level, Cricetulus, Programmed cell death 1, Terphenyl, Drug Discovery, Animals, Humans, Cells, Cultured, biology, Dose-Response Relationship, Drug, Molecular Structure, Biphenyl Compounds, Ligand (biochemistry), Small molecule, chemistry, Biochemistry, biology.protein, Molecular Medicine, Programmed death, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0e35ef9495ca462e48490a926d997d
https://ruj.uj.edu.pl/xmlui/handle/item/277678

المؤلفون: Tad A. Holak, Dominik Sala, Katarzyna Magiera-Mularz, Benedykt Wladyka, Grzegorz Dubin, Jacek Plewka, Justyna Kocik, Kazimierz Weglarczyk, Małgorzata Stec, Lukasz Skalniak, Bogdan Musielak, Przemyslaw Grudnik, Katarzyna Kuska, Maciej Siedlar

مصطلحات موضوعية: Pharmacology, biology, Chemistry, medicine.medical_treatment, Biochemistry (medical), Pharmaceutical Science, Medicine (miscellaneous), Immunotherapy, Immune checkpoint, Macrocyclic peptide, PD-L1, Cancer research, medicine, biology.protein, Pharmacology (medical), Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c76cc20b42efff5f1685b0af242ab16
https://ruj.uj.edu.pl/xmlui/handle/item/267441

المؤلفون: Marcin Czepiel, Malgorzata Hajduk, Justyna Kocik, Monika Machula, Lukasz Skalniak, Przemyslaw Grudnik, Dominik Sala, Jacek Plewka, Maciej Siedlar, Bogdan Musielak, Tad A. Holak, Katarzyna Magiera-Mularz

المصدر: iScience
iScience, Vol 24, Iss 1, Pp 101960-(2021)
'iScience ', vol: 24, pages: 101960-1-101960-13 (2021)

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, Chemistry, In silico, Immunology, Druggability, Sequence (biology), 02 engineering and technology, Computational biology, Therapeutics, 021001 nanoscience & nanotechnology, Jurkat cells, Small molecule, In vitro, Article, 03 medical and health sciences, 030104 developmental biology, In vivo, lcsh:Q, 0210 nano-technology, lcsh:Science, Peptide sequence

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8bab9198c3bc00c2b60b76f31ca2b7
https://pubmed.ncbi.nlm.nih.gov/33437940

المؤلفون: Dominik Sala, Shabnam Shaabani, Tad A. Holak, Grzegorz Dubin, Łukasz Berlicki, Lukasz Skalniak, Justyna Kocik, Krzysztof M. Zak, Alexander Dömling, Bogdan Musielak, Ewa Rudzińska-Szostak, Katarzyna Magiera-Mularz, Tryfon Zarganes-Tzitzikas, Przemyslaw Grudnik

المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)

المصدر: Angewandte Chemie-International Edition, 56(44), 13732-13735. WILEY-V C H VERLAG GMBH

مصطلحات موضوعية: 0301 basic medicine, Macrocyclic Compounds, medicine.drug_class, BLOCKADE, T-Lymphocytes, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Nanotechnology, Monoclonal antibody, Peptides, Cyclic, THERAPY, B7-H1 Antigen, Article, Catalysis, Jurkat Cells, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cancer immunotherapy, FUTURE, PD-L1, Drug Discovery, medicine, Journal Article, Humans, Protein Interaction Maps, biology, Chemistry, General Medicine, General Chemistry, Cell cycle, Small molecule, Immune checkpoint, Cell biology, Molecular Docking Simulation, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, CANCER-IMMUNOTHERAPY, Antibody, MONOCLONAL-ANTIBODIES

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099a3a41894311a5535df0b3b61c42fc
https://doi.org/10.1002/anie.201707707

المؤلفون: Justyna Kocik, Katarzyna Magiera-Mularz, Maciej Siedlar, Jacek Plewka, Lukasz Skalniak, Dominik Sala, Bogdan Musielak, Małgorzata Stec, Tad A. Holak, Miroslawa Czub

المصدر: Molecules, Vol 24, Iss 15, p 2804 (2019)
Molecules
Volume 24
Issue 15

مصطلحات موضوعية: B7 Antigens, Magnetic Resonance Spectroscopy, medicine.drug_class, Pharmaceutical Science, Peptide, Pharmacology, Monoclonal antibody, PD-1/PD-L1, B7-H1 Antigen, Article, Analytical Chemistry, Small Molecule Libraries, lcsh:QD241-441, 03 medical and health sciences, 0302 clinical medicine, lcsh:Organic chemistry, Neoplasms, Drug Discovery, medicine, Humans, Physical and Theoretical Chemistry, immune checkpoint, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Ligand binding assay, Organic Chemistry, Antibodies, Monoclonal, Small molecule, Immune checkpoint, In vitro, NMR, CA-170, chemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Direct binding, Molecular Medicine, Immunotherapy, PD-L1 inhibitor, HTRF, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa2c3302eda70247e8cd867fd1a4d75
https://www.mdpi.com/1420-3049/24/15/2804

المؤلفون: Anna Skalniak, Lukasz Skalniak, Monika Rak, Justyna Polak, Justyna Kocik, Agnieszka Wolnicka-Glubisz, Tad A. Holak

المصدر: Cancers, Vol 10, Iss 11, p 396 (2018)
Cancers
Volume 10
Issue 11

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Cell cycle checkpoint, DNA damage, DNA repair, Chemistry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, In vitro, Article, idasanutlin, p53 induction, MDM2 antagonists, 03 medical and health sciences, 030104 developmental biology, Oncology, Cell culture, Apoptosis, Monoclonal, Cancer cell, Cancer research, cancer, RG7388, secondary drug resistance

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229327ecef79b75fc52241b03eade6b3
https://www.mdpi.com/2072-6694/10/11/396

المؤلفون: Bozena Szelazek, Krzysztof Pyrc, Alexander Dömling, Katarzyna Magiera, Sylwia Krzanik, Tad A. Holak, Bogdan Musielak, Lukasz Skalniak, Grzegorz Dubin, Przemyslaw Grudnik, Magdalena Pachota, Marcin Tomala, Krzysztof M. Zak, Justyna Kocik, Katarzyna Guzik

المساهمون: Drug Design

المصدر: Oncotarget
Oncotarget, 8(42), 72167-72181. Impact Journals LLC

مصطلحات موضوعية: 0301 basic medicine, EXPRESSION, PD-L1, CANCER-THERAPY, BLOCKADE, medicine.medical_treatment, Cell, Biology, Jurkat cells, PATHWAY, 03 medical and health sciences, PROTEIN-PROTEIN INTERACTIONS, 0302 clinical medicine, Immune system, PD-1, medicine, Journal Article, IMMUNOTHERAPY, CRYSTALLOGRAPHY, Immunotherapy, small-molecules, immune checkpoint blockade, Small molecule, Immune checkpoint, 3. Good health, inhibitor, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Immunology, ANTIBODIES, biology.protein, Cancer research, Antibody, DEATH LIGAND 1, Research Paper

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c644be5a65975da6024cd919e6cf509
https://pubmed.ncbi.nlm.nih.gov/29069777

المؤلفون: Tadeusz Holak, Justyna Kocik, Katarzyna Guzik, Grzegorz Dubin, Lukasz Skalniak

المصدر: ESMO Open. 3:A400

مصطلحات موضوعية: Cancer Research, biology, Chemistry, medicine.medical_treatment, In vitro, Immune checkpoint, Immune system, Oncology, Cancer immunotherapy, Atezolizumab, Cancer research, medicine, biology.protein, Immunoglobulin superfamily, Antibody, Nivolumab

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7c8662665c9a626e1f3ed7402f735ff0
https://doi.org/10.1136/esmoopen-2018-eacr25.943