المؤلفون: G. Leslie Burnett (1530964), Yu C. Yang (14271182), James B. Aggen (1748029), Jennifer Pitzen (1332948), Micah K. Gliedt (14271185), Chris M. Semko (2126905), Abby Marquez (14271188), James W. Evans (1360215), Gang Wang (36685), Walter S. Won (14271191), Aidan C. A. Tomlinson (14271194), Gert Kiss (1345821), Christos Tzitzilonis (275867), Arun P. Thottumkara (2677906), James Cregg (7306595), Kevin T. Mellem (1892248), Jong S. Choi (14271197), Julie C. Lee (2983218), Yongyuan Zhao (14271200), Bianca J. Lee (11216484), Justin G. Meyerowitz (14271203), John E. Knox (2523913), Jingjing Jiang (128923), Zhican Wang (2275534), David Wildes (9434006), Zhengping Wang (1434643), Mallika Singh (202117), Jacqueline A. M. Smith (14271206), Adrian L. Gill (2396434)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Infectious Diseases, Chemical Sciences not elsewhere classified, multiple allosteric inhibitors, also preserving selectivity, also present evidence, allosteric binding sites, steric inhibitors ”, mutant cancer drivers, activated tumors hyperactivation, >< sup ><, orthosteric dual inhibitors, development candidate rmc, g12c , g12c <, steric inhibitor, mutant nsclc, many tumors, >, “ bi, selective bi, preclinical profile, preclinical model

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_RMC-5552_a_Selective_Bi-Steric_Inhibitor_of_mTORC1_for_the_Treatment_of_mTORC1-Activated_Tumors/21741425

الاتاحة: https://doi.org/10.1021/acs.jmedchem.2c01658.s001

المؤلفون: G. Leslie Burnett, Yu C. Yang, James B. Aggen, Jennifer Pitzen, Micah K. Gliedt, Chris M. Semko, Abby Marquez, James W. Evans, Gang Wang, Walter S. Won, Aidan C. A. Tomlinson, Gert Kiss, Christos Tzitzilonis, Arun P. Thottumkara, James Cregg, Kevin T. Mellem, Jong S. Choi, Julie C. Lee, Yongyuan Zhao, Bianca J. Lee, Justin G. Meyerowitz, John E. Knox, Jingjing Jiang, Zhican Wang, David Wildes, Zhengping Wang, Mallika Singh, Jacqueline A. M. Smith, Adrian L. Gill

المصدر: Journal of Medicinal Chemistry. 66:149-169

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cb750ad287b7aa33c649c1e4fa24c0
https://doi.org/10.1021/acs.jmedchem.2c01658

المؤلفون: Ximena Barros-Álvarez, Robert M. Nwokonko, Alexander Vizurraga, Donna Matzov, Feng He, Makaía M. Papasergi-Scott, Michael J. Robertson, Ouliana Panova, Eliane Hadas Yardeni, Alpay B. Seven, Frank E. Kwarcinski, Hongyu Su, Maria Claudia Peroto, Justin G. Meyerowitz, Moran Shalev-Benami, Gregory G. Tall, Georgios Skiniotis

المصدر: Nature

مصطلحات موضوعية: Multidisciplinary

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f964771299933d4cfe203e695aaae90
https://doi.org/10.1038/s41586-022-04575-7

المؤلفون: Justin G. Meyerowitz, Michael J. Robertson, Ximena Barros-Álvarez, Ouliana Panova, Robert M. Nwokonko, Yang Gao, Georgios Skiniotis

المصدر: Nature Structural & Molecular Biology. 29:274-281

مصطلحات موضوعية: Structural Biology, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ed88b0e4db33fb2250abf67e91861a76
https://doi.org/10.1038/s41594-022-00728-4

المؤلفون: Georgios Skiniotis, Justin G. Meyerowitz, Kenneth W. Borrelli, Ouliana Panova, Michael J. Robertson

المصدر: Nature Structural & Molecular Biology. 29:210-217

مصطلحات موضوعية: chemistry.chemical_classification, Drug discovery, Somatostatin receptor, Octreotide, Peptide, Ligand (biochemistry), Ligands, Cell biology, Somatostatin, chemistry, Structural Biology, Extracellular, medicine, Somatostatin receptor 2, Receptors, Somatostatin, Molecular Biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515fde3836e915654635f4d3297bfc77
https://doi.org/10.1038/s41594-022-00727-5

المؤلفون: Michael J, Robertson, Makaía M, Papasergi-Scott, Feng, He, Alpay B, Seven, Justin G, Meyerowitz, Ouliana, Panova, Maria Claudia, Peroto, Tao, Che, Georgios, Skiniotis

المصدر: Nature structuralmolecular biology. 29(12)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::0ac2e9845340037aa2cbff74bbb14ddc
https://pubmed.ncbi.nlm.nih.gov/36396979

المؤلفون: Sabrina N. Rahman, Michael J. Robertson, Alpay B. Seven, Fadil M. Hannan, Jesper Mosolff Mathiesen, Ouliana Panova, Rajesh V. Thakker, Yang Gao, Georgios Skiniotis, Chensong Zhang, Hans Bräuner-Osborne, Justin G. Meyerowitz

المصدر: Nature
Gao, Y, Robertson, M J, Rahman, S N, Seven, A B, Zhang, C, Meyerowitz, J G, Panova, O, Hannan, F M, Thakker, R V, Bräuner-Osborne, H, Mathiesen, J M & Skiniotis, G 2021, ' Asymmetric activation of the calcium-sensing receptor homodimer ', Nature, vol. 595, pp. 455-459 . https://doi.org/10.1038/s41586-021-03691-0

مصطلحات موضوعية: Models, Molecular, Calcimimetic, Protomer, Article, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Heterotrimeric G protein, Humans, Receptor, 030304 developmental biology, G protein-coupled receptor, 0303 health sciences, Multidisciplinary, Chemistry, Cryoelectron Microscopy, Rational design, Calcilytic, Biophysics, Calcium, Calcium-sensing receptor, Protein Multimerization, Peptides, Receptors, Calcium-Sensing, 030217 neurology & neurosurgery, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693269c2b2519871c36c0a6e7ce0ec82
https://ora.ox.ac.uk/objects/uuid:6e7ae25a-1ba1-481e-9597-baf8358fcfc7

المؤلفون: Michael J. Robertson, Makaía Papasergi-Scott, Feng He, Alpay B. Seven, Justin G. Meyerowitz, Ouliana Panova, Maria Claudia Peroto, Tao Che, Georgios Skiniotis

مصطلحات موضوعية: Membrane protein, Structural Biology, Chemistry, Drug discovery, Biophysics, Somatostatin receptor 2, Receptor, Molecular Biology, G protein-coupled receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368a2d97f0e1b5e3872c1feddfc2ed4a
https://doi.org/10.1101/2021.11.02.466983

المؤلفون: Justin G, Meyerowitz, Michael J, Robertson, Ximena, Barros-Álvarez, Ouliana, Panova, Robert M, Nwokonko, Yang, Gao, Georgios, Skiniotis

المصدر: Nature structuralmolecular biology. 29(3)

مصطلحات موضوعية: Receptors, Vasopressin, Pregnancy, Receptors, Oxytocin, Cations, Animals, Female, Magnesium, Oxytocin, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::008ae88b0b70597c6255c64c54d849f5
https://pubmed.ncbi.nlm.nih.gov/35241813

المؤلفون: Georgios Skiniotis, Marine de Lapeyrière, Jean-Philippe Rocher, Alpay B. Seven, Brian K. Kobilka, Justin G. Meyerowitz, Makaía M. Papasergi-Scott, Yang Gao, Ximena Barros-Álvarez, Jesper Mosolff Mathiesen, Robert M Nwokonko, Dominik Schelshorn, Michael J. Robertson, Chensong Zhang

المصدر: Nature
Seven, A B, Barros-Álvarez, X, de Lapeyrière, M, Papasergi-Scott, M M, Robertson, M J, Zhang, C, Nwokonko, R M, Gao, Y, Meyerowitz, J G, Rocher, J P, Schelshorn, D, Kobilka, B K, Mathiesen, J M & Skiniotis, G 2021, ' G-protein activation by a metabotropic glutamate receptor ', Nature, vol. 595, pp. 450-454 . https://doi.org/10.1038/s41586-021-03680-3

مصطلحات موضوعية: Models, Molecular, 0303 health sciences, Multidisciplinary, G protein, Chemistry, Cell Membrane, Protomer, GTP-Binding Protein alpha Subunits, Gi-Go, Receptors, Metabotropic Glutamate, Heterotrimeric GTP-Binding Proteins, Transmembrane protein, Article, 03 medical and health sciences, Transmembrane domain, 0302 clinical medicine, Metabotropic glutamate receptor, Heterotrimeric G protein, Biophysics, Humans, Metabotropic glutamate receptor 2, Protein Multimerization, 030217 neurology & neurosurgery, 030304 developmental biology, G protein-coupled receptor

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b8806cda81f586e7d372c77289eeec
https://europepmc.org/articles/PMC8822903/

المؤلفون: Michael J. Robertson, Justin G. Meyerowitz, Ouliana Panova, Kenneth Borrelli, Georgios Skiniotis

المصدر: Nature Structural & Molecular Biology. 29:841-841

مصطلحات موضوعية: Structural Biology, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9afe45dca65c2f48c3042fb9e91d830b
https://doi.org/10.1038/s41594-022-00813-8

المؤلفون: Kevan M. Shokat, Bryan A. Smith, Robert Baertsch, Jiaoti Huang, John K. Lee, Colleen Mathis, W. Clay Gustafson, Erin McCaffrey, John W. Phillips, Artem Sokolov, Joshua M. Stuart, Tanya Stoyanova, Donghui Cheng, Jung-Wook Park, Owen N. Witte, Justin G. Meyerowitz

المصدر: Cancer Cell. 29:536-547

مصطلحات موضوعية: Male, Oncology, 0301 basic medicine, Cancer Research, Genes, myc, 030232 urology & nephrology, Clone (cell biology), AKT1, Mice, SCID, medicine.disease_cause, Human prostate, Prostate cancer, 0302 clinical medicine, Mice, Inbred NOD, Transduction, Genetic, Prostate, Medicine, Exome, Proto-Oncogene Proteins c-myc, Molecular Targeted Therapy, Neoplasm Metastasis, Aurora Kinase A, Azepines, Phenotype, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Neuroendocrine Tumors, Cell Transformation, Neoplastic, medicine.anatomical_structure, Neoplastic Stem Cells, medicine.medical_specialty, Recombinant Fusion Proteins, Urology, Aurora A kinase, Antineoplastic Agents, Laser Capture Microdissection, Adenocarcinoma, Article, 03 medical and health sciences, Cell Line, Tumor, Internal medicine, Animals, Humans, Neoplasm Invasiveness, Protein Kinase Inhibitors, business.industry, Phenylurea Compounds, Prostatic Neoplasms, Epithelial Cells, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, Enzyme Activation, Pyrimidines, 030104 developmental biology, Cancer research, business, Carcinogenesis, Orchiectomy, Proto-Oncogene Proteins c-akt, N-Myc

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436b9a812a2adb1b7c36a5fff9b76cc0
https://doi.org/10.1016/j.ccell.2016.03.001

المؤلفون: Justin G. Meyerowitz, Xiaodong Yang, Mitchel S. Berger, Nalin Gupta, William A. Weiss, Daphne A. Haas-Kogan, Rintaro Hashizume, Aleksandra Olow, Angela J. Waanders, Claudia Petritsch, C. David James, Lukas J.A. Stalpers, Sabine Mueller, Adam C. Resnick

المساهمون: Other departments, CCA -Cancer Center Amsterdam, Radiotherapy

المصدر: CLINICAL CANCER RESEARCH, vol 22, iss 21
Olow, Aleksandra; Mueller, Sabine; Yang, Xiaodong; Hashizume, Rintaro; Meyerowitz, Justin; Weiss, William; et al.(2016). BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas. CLINICAL CANCER RESEARCH, 22(21), 5312-5321. doi: 10.1158/1078-0432.CCR-15-1101. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1fb9989s
Clinical cancer research, 22(21), 5312-5321. American Association for Cancer Research Inc.

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Proto-Oncogene Proteins B-raf, Cancer Research, Indoles, Cell Survival, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Antineoplastic Agents, Pharmacology, 3T3 cells, Article, Cell Line, S Phase, 03 medical and health sciences, Mice, 0302 clinical medicine, In vivo, Glioma, Cell Line, Tumor, medicine, Animals, Humans, Viability assay, Oncology & Carcinogenesis, PI3K/AKT/mTOR pathway, Sulfonamides, Everolimus, Oncology And Carcinogenesis, business.industry, TOR Serine-Threonine Kinases, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Oncology, Cell culture, 030220 oncology & carcinogenesis, Cancer research, NIH 3T3 Cells, Benzimidazoles, business, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e630e623c10726b3c01334a337a86e9e
https://escholarship.org/uc/item/1fb9989s

المؤلفون: Sabine Mueller, C. David James, Justin G. Meyerowitz, Angela J. Waanders, Aleksandra Olow, Adam C. Resnick, Mitchel S. Berger, Rintaro Hashizume, William A. Weiss, Daphne A. Haas-Kogan, Xiaodong Yang, Nalin Gupta

مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Chemotherapy, Everolimus, medicine.medical_treatment, MEK inhibitor, Context (language use), Pharmacology, Biology, Cell cycle, Oncology, medicine, Cancer research, Neurology (clinical), Viability assay, Abstracts from the 3rd Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research, PI3K/AKT/mTOR pathway, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73b2dca68bff9e98b1c44d585463b29
https://europepmc.org/articles/PMC4482942/

المؤلفون: Jonathan D. Kaunitz, Eli Engel, Tetsu Takeuchi, Misa Mizumori, Claudiu T. Supuran, Paul H. Guth, Shu Lim, Paul W. N. Lee, Justin G. Meyerowitz, Yasutada Akiba

المصدر: The Journal of Physiology. 573:827-842

مصطلحات موضوعية: biology, Physiology, Membrane transport protein, Apical membrane, Molecular biology, Epithelium, Cytosol, medicine.anatomical_structure, Biochemistry, Cytoplasm, biology.protein, Extracellular, medicine, Secretion, Epithelial polarity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::028b69606abd792729a817e737244067
https://doi.org/10.1113/jphysiol.2006.107581

المؤلفون: William A. Weiss, Justin G. Meyerowitz, W. Clay Gustafson

المصدر: Molecular & Cellular Oncology
Molecular & cellular oncology, vol 2, iss 2

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, AURKA, Kinase, Aurora inhibitor, MYC, Biology, Kinase inhibition, kinase inhibition, Aurora kinase A, Enzyme, chemistry, MYCN, Cancer research, Molecular Medicine, Author'S View, cancer, Aurora Kinase A, neoplasms

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ee26632a0609ef036f75098e9d70d
http://europepmc.org/articles/PMC4904880

المؤلفون: Kevan M. Shokat, Elise Charron, Robert C. Seeger, William Clay Gustafson, Erin F. Simonds, Nicholas T. Hertz, Erin A. Nekritz, Justin G. Meyerowitz, Katherine K. Matthay, William A. Weiss, Martin Eilers, Cyril H. Benes, Justin Chen

المصدر: Cancer cell, vol 26, iss 3

مصطلحات موضوعية: Models, Molecular, Cancer Research, Secondary, Nude, Mice, SCID, Crystallography, X-Ray, Protein Structure, Secondary, Mice, Neuroblastoma, Mice, Inbred NOD, Models, Catalytic Domain, Nuclear protein, Phosphorylation, Aurora Kinase A, Cancer, Oncogene Proteins, N-Myc Proto-Oncogene Protein, Tumor, Crystallography, Nuclear Proteins, 3. Good health, Tumor Burden, Oncology, Biochemistry, Area Under Curve, S Phase Cell Cycle Checkpoints, Protein Structure, Cell Survival, Allosteric regulation, Oncology and Carcinogenesis, Aurora A kinase, Aurora inhibitor, Mice, Nude, Antineoplastic Agents, Biology, SCID, Article, Cell Line, Structure-Activity Relationship, Allosteric Regulation, Cell Line, Tumor, Genetics, Animals, Humans, Oncology & Carcinogenesis, neoplasms, Protein Processing, Phenylurea Compounds, Post-Translational, Neurosciences, Molecular, Cell Biology, DNA-binding domain, Xenograft Model Antitumor Assays, Pyrimidines, Proteolysis, X-Ray, Inbred NOD, Protein Processing, Post-Translational, N-Myc

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d511f594507c0954481d51191f786bb8
https://escholarship.org/uc/item/1xz0f97j

المؤلفون: Marion K. Mateos, Belamy B. Cheung, Daniel R. Carter, Justin G. Meyerowitz, Tao Liu, Glenn M. Marshall, William A. Weiss

المصدر: Nature reviews. Cancer. 14(4)

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Carcinogenesis, General Mathematics, Cell of origin, Childhood cancer, Cancer therapy, Early detection, Biology, Genomic Instability, Article, Neuroblastoma, Paediatric cancer, Pregnancy, Internal medicine, medicine, Animals, Humans, Cerebellar Neoplasms, Child, B-Lymphocytes, Cancer prevention, Myeloproliferative Disorders, Applied Mathematics, Cancer, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Embryo, Mammalian, Neural Crest, Immunology, Mutation, Female, Down Syndrome, Medulloblastoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814cf5cb396effa6135fbd2aa48ebaf3
https://pubmed.ncbi.nlm.nih.gov/24599217

المؤلفون: Armen Parsyan, Justin G. Meyerowitz, William A. Weiss

المصدر: Translation and Its Regulation in Cancer Biology and Medicine ISBN: 9789401790772

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6d5a8aadefd112bc371e71492fba2e63
https://doi.org/10.1007/978-94-017-9078-9_24

المؤلفون: William A. Weiss, Martin Eilers, Elise Charron, Erin A. Nekritz, Katherine K. Matthay, W. Clay Gustafson, Nicholas T. Hertz, Justin G. Meyerowitz, Kevan M. Shokat

المصدر: Cancer Research. 74:PR08-PR08

مصطلحات موضوعية: Cancer Research, Kinase, Allosteric regulation, Aurora inhibitor, Biology, medicine.disease, Molecular biology, Pediatric cancer, Aurora kinase, Oncology, Neuroblastoma, medicine, Cancer research, Aurora Kinase A, neoplasms, N-Myc

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f81c942b39696665f780d649edd328b3
https://doi.org/10.1158/1538-7445.pedcan-pr08