المؤلفون: Karen Stanic, Alonso Quiroz, Carmen G. Lemus, Ignacio A. Wichmann, Alejandro H. Corvalán, Gareth I. Owen, Juan C. Opazo, Miguel L. Concha, Julio D. Amigo

المصدر: Frontiers in Neuroanatomy, Vol 12 (2018)

مصطلحات موضوعية: reprimo, zebrafish (Danio rerio), olfactory systems, opticum tectum, neurogenesis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Human anatomy, QM1-695

وصف الملف: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fnana.2018.00023/full; https://doaj.org/toc/1662-5129

URL الوصول: https://doaj.org/article/1c93528dcb314159bbdab0305f9eadc7

المؤلفون: Julio D. Amigo, Juan C. Opazo, Roddy Jorquera, Ignacio A. Wichmann, Benjamin A. Garcia-Bloj, Maria Alejandra Alarcon, Gareth I. Owen, Alejandro H. Corvalán

المصدر: International Journal of Molecular Sciences; Volume 19; Issue 7; Pages: 1862

مصطلحات موضوعية: gastric cancer, reprimo, tumor suppressive gene properties, development, evolution, biomarker

جغرافية الموضوع: agris

وصف الملف: application/pdf

Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms19071862

الاتاحة: https://doi.org/10.3390/ijms19071862

المؤلفون: Ricardo J Figueroa, Gonzalo Carrasco-Avino, Ignacio A Wichmann, Martin Lange, Gareth I Owen, Arndt F Siekmann, Alejandro H Corvalán, Juan C Opazo, Julio D Amigo

المصدر: PLoS ONE, Vol 12, Iss 5, p e0178274 (2017)

مصطلحات موضوعية: Medicine, Science

Relation: http://europepmc.org/articles/PMC5451059?pdf=render; https://doaj.org/toc/1932-6203; https://doaj.org/article/9cbee38730524667b02d8d6c0c3629a2

الاتاحة: https://doi.org/10.1371/journal.pone.0178274
https://doaj.org/article/9cbee38730524667b02d8d6c0c3629a2

المؤلفون: Elvin V. Leonard, Ricardo J. Figueroa, Jeroen Bussmann, Nathan D. Lawson, Julio D. Amigo, Arndt F. Siekmann

المصدر: Development
Development, 149(7):dev199640

مصطلحات موضوعية: Receptor, Platelet-Derived Growth Factor beta, Myocytes, Smooth Muscle, Animals, Endothelial Cells, Zebrafish Proteins, Pericytes, Stem Cells and Regeneration, Molecular Biology, Zebrafish, Developmental Biology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07622e544ca3bd26092765c969aec47
https://pubmed.ncbi.nlm.nih.gov/35297968

المؤلفون: Arndt F. Siekmann, Julio D. Amigo, Nathan D. Lawson, Jeroen Bussmann, Leonard Ev, Ricardo J. Figueroa

مصطلحات موضوعية: Cell type, biology, Precursor cell, Regeneration (biology), Mesenchymal stem cell, Myosin, cardiovascular system, PDGFRB, biology.organism_classification, Zebrafish, Mural cell, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9d726b79fe97531f8fa13e4a800bcc0b
https://doi.org/10.1101/2021.03.27.437334

المؤلفون: Gareth I. Owen, Tomas de Mayo, Enrique Norero, Franz Villarroel-Espindola, Maria Alejandra Alarcon, Alejandro H. Corvalan, Wilda Olivares, Julio D. Amigo, Gonzalo Carrasco-Avino, Marcelo Garrido, Miguel Cordova-Delgado, Natalia Landeros, Matías Muñoz-Medel, Ignacio A. Wichmann, Arnoldo Riquelme

المصدر: International Journal of Molecular Sciences, Vol 21, Iss 9472, p 9472 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24

مصطلحات موضوعية: 0301 basic medicine, Male, Bisulfite sequencing, Epigenesis, Genetic, lcsh:Chemistry, 0302 clinical medicine, intronless, Genes, Tumor Suppressor, lcsh:QH301-705.5, Spectroscopy, General Medicine, Middle Aged, Immunohistochemistry, Computer Science Applications, Up-Regulation, Gene Expression Regulation, Neoplastic, 030220 oncology & carcinogenesis, DNA methylation, Biomarker (medicine), Female, Cell-Free Nucleic Acids, non-invasive, Down-Regulation, Biology, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Stomach Neoplasms, Cell Line, Tumor, medicine, Biomarkers, Tumor, Gene silencing, Humans, Epigenetics, Gene Silencing, Physical and Theoretical Chemistry, Clonogenic assay, Molecular Biology, plasma, Aged, Cell Proliferation, Retrospective Studies, Reprimo, gastric cancer, Organic Chemistry, Cancer, Membrane Proteins, biomarkers, DNA Methylation, medicine.disease, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Cancer research, methylation

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a98bd640464a799bb9cdd2794e8bd2
https://www.mdpi.com/1422-0067/21/24/9472

المؤلفون: Julio D. Amigo, Gareth I. Owen, German Reig, Karen Stanic, Ignacio A. Wichmann, Juan C. Opazo, Ricardo J. Figueroa, Alejandro H. Corvalan, Miguel L. Concha, Pedro A. Retamal

المصدر: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)

مصطلحات موضوعية: Reprimo, Multidisciplinary, Hemangioblasts, lcsh:R, lcsh:Medicine, Embryonic Development, Membrane Proteins, Cell Cycle Proteins, Computational biology, Biology, Zebrafish Proteins, biology.organism_classification, Embryonic stem cell, Hematopoiesis, Morpholinos, Multigene Family, Gene family, Animals, lcsh:Q, CRISPR-Cas Systems, lcsh:Science, Author Correction, Zebrafish

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee9f75fca2f2cb3b989a5baa4487173
http://europepmc.org/articles/PMC7048797

المؤلفون: Ignacio A. Wichmann, Gareth I. Owen, German Reig, Juan C. Opazo, Julio D. Amigo, Karen Stanic, Miguel L. Concha, Alejandro H. Corvalan, Pedro A. Retamal, Ricardo J. Figueroa

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

مصطلحات موضوعية: 0301 basic medicine, Reprimo, Multidisciplinary, Tumor suppressor gene, Hematopoietic Tissue, lcsh:R, lcsh:Medicine, Biology, biology.organism_classification, Embryonic stem cell, Article, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Haematopoiesis, Genetics research, Hemangioblast, Gene family, lcsh:Q, Leukopoiesis, Progenitor cell, lcsh:Science, Zebrafish, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c9c09894a88e185d6187f538537748
http://europepmc.org/articles/PMC6509255

المؤلفون: Michael W. Vandewege, Gareth I. Owen, Federico G. Hoffmann, Ignacio A. Wichmann, Juan C. Opazo, Kattina Zavala, Julio D. Amigo, Alejandro H. Corvalan

المصدر: Gene
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
GENE

مصطلحات موضوعية: 0301 basic medicine, Most recent common ancestor, Transcription, Genetic, Lineage (evolution), Cell Cycle Proteins, Synteny, Genome, Evolution, Molecular, 03 medical and health sciences, 0302 clinical medicine, Gene Duplication, biology.animal, Genetics, Animals, Humans, Gene family, Genes, Tumor Suppressor, Amino Acid Sequence, Epigenetics, Gene, Phylogeny, Likelihood Functions, Reprimo, biology, Tumor Suppressor Proteins, Vertebrate, General Medicine, 030104 developmental biology, Multigene Family, 030220 oncology & carcinogenesis, Vertebrates, Tumor Suppressor Protein p53, Sequence Alignment

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e8a261779b85ecec1436534bf59bbd
https://doi.org/10.1016/j.gene.2016.07.036

المؤلفون: Miguel Cordova-Delgado, Marcelo Garrido, Alejandro H. Corvalan, Maria J. Maturana, Edmundo Aravena, Wilda Olivares, Matías Muñoz-Medel, Maria Alejandra Alarcon, Robinson G. Gonzalez, Julio D. Amigo, Andres Rodriguez, Franz Villarroel-Espindola, Gonzalo Carrasco-Avino, Tomas de Mayo, Gareth I. Owen, Arnoldo Riquelme, Iva Polakovicova, Carlos Barrientos, Rocío Bustos

المصدر: Cancer Research. 80:2437-2437

مصطلحات موضوعية: Cancer Research, Reprimo, Oncology, medicine, Cancer research, Cancer, Gene family, Biology, medicine.disease, Gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2e4fa20f78f45f078a231d47cd9babe0
https://doi.org/10.1158/1538-7445.am2020-2437

المؤلفون: Arndt F. Siekmann, Ignacio A. Wichmann, Martin Lange, Gareth I. Owen, Julio D. Amigo, Gonzalo Carrasco-Avino, Ricardo J. Figueroa, Juan C. Opazo, Alejandro H. Corvalan

المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0178274 (2017)
Plos One
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

مصطلحات موضوعية: 0301 basic medicine, Evolutionary Genetics, Embryology, lcsh:Medicine, Gene Expression, Cell Cycle Proteins, Conserved sequence, 0302 clinical medicine, Gene duplication, Medicine and Health Sciences, lcsh:Science, Zebrafish, Conserved Sequence, In Situ Hybridization, In Situ Hybridization, Fluorescence, Genetics, Regulation of gene expression, Multidisciplinary, Fishes, Gene Expression Regulation, Developmental, Animal Models, medicine.anatomical_structure, Experimental Organism Systems, Osteichthyes, 030220 oncology & carcinogenesis, Vertebrates, Anatomy, Research Article, Biology, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Extraction techniques, Notochord, medicine, Gene family, Animals, Humans, Amino Acid Sequence, Gene, Glycoproteins, Reprimo, Evolutionary Biology, Sequence Homology, Amino Acid, Evolutionary Developmental Biology, lcsh:R, Embryos, Organisms, Biology and Life Sciences, biology.organism_classification, RNA extraction, Gastrointestinal Tract, 030104 developmental biology, Gene Expression Regulation, lcsh:Q, Digestive System, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b32dfe943e2ee840fd07c06480c8094
https://pubmed.ncbi.nlm.nih.gov/28562620

المؤلفون: Julio D. Amigo, Mark D. Fleming, Caitlin Hall, Michael Krause, Mathew K. Mathew, Meng Tian, Suji Uhm, Barry H. Paw, Anita U. Rao, Abbhirami Rajagopal, Sanjeev K. Upadhyay, Iqbal Hamza

المصدر: Nature. 453:1127-1131

مصطلحات موضوعية: Hemeproteins, Metalloporphyrins, Cellular differentiation, Heme, Article, Cell Line, chemistry.chemical_compound, polycyclic compounds, Animals, Homeostasis, Humans, Erythropoiesis, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Zebrafish, Multidisciplinary, biology, digestive, oral, and skin physiology, Biological Transport, Zebrafish Proteins, biology.organism_classification, Heme transport, Transmembrane protein, Cell biology, chemistry, Biochemistry, Function (biology), Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e87c3c411d0aaaf62bd472137a368b
https://doi.org/10.1038/nature06934

المؤلفون: Kana Suzuki, Nathan D. Lawson, Juerg R. Straubhaar, Julio D. Amigo, Laurence D. Covassin, Viktor I. Teplyuk

المصدر: Developmental Biology. 299:551-562

مصطلحات موضوعية: Cell type, Hematopoietic System, Green Fluorescent Proteins, Cell, Gene Expression, Cell Separation, Biology, Article, Green fluorescent protein, Animals, Genetically Modified, Gene expression, medicine, Animals, Molecular Biology, Zebrafish, Oligonucleotide Array Sequence Analysis, Microarray analysis techniques, fungi, Cell Biology, Zebrafish Proteins, Cell sorting, biology.organism_classification, Molecular biology, Branchial Region, medicine.anatomical_structure, Endothelium, Vascular, Pharyngeal arch, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26109865d2edb3633074c27c7e361dda
https://doi.org/10.1016/j.ydbio.2006.08.020

المؤلفون: Verónica Torres-Estay, Carla Cembrano, Patricia Fuenzalida, Xavier F. Figueroa, Julio D. Amigo, Alejandro Godoy, Viviana P. Montecinos, Néstor Corro, Catalina Ascencio, Juan C. Sáez, Daniela V Carreño, Gareth I. Owen

المصدر: Cancer Research. 77:2969-2969

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Prostate cancer, Paracrine signalling, medicine.anatomical_structure, Endothelium, business.industry, Internal medicine, Medicine, business, medicine.disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::05e19e38a87870a9fa70f463f9f31355
https://doi.org/10.1158/1538-7445.am2017-2969

المؤلفون: Neil C. Chi, Ming Yu, Jerry Kaplan, Mitchell J. Weiss, Jeffrey D. Cooney, Julio D. Amigo, Marie-Bérengère Troadec, Barry H. Paw, Alan B. Cantor, Babette Gwynn, Luanne L. Peters, Amy J. Lambert

المساهمون: Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement (Inserm U781), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génétique et Développement de Rennes ( IGDR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Génétique et épigénétique des maladies métaboliques, neurosensorielles et du développement ( Inserm U781 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

المصدر: Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2011, 31 (7), pp.1344-56. ⟨10.1128/MCB.01010-10⟩
Molecular and Cellular Biology, American Society for Microbiology, 2011, 31 (7), pp.1344-56. 〈10.1128/MCB.01010-10〉
Molecular and Cellular Biology, 2011, 31 (7), pp.1344-56. ⟨10.1128/MCB.01010-10⟩

مصطلحات موضوعية: Chromatin Immunoprecipitation, Transcription, Genetic, Morpholino, [SDV]Life Sciences [q-bio], Green Fluorescent Proteins, Molecular Sequence Data, Mice, 03 medical and health sciences, 0302 clinical medicine, Genes, Reporter, Animals, Erythropoiesis, GATA1 Transcription Factor, Promoter Regions, Genetic, Enhancer, Base Pairing, Cation Transport Proteins, Molecular Biology, Zebrafish, Transcription factor, 030304 developmental biology, Genetics, Regulation of gene expression, 0303 health sciences, Binding Sites, Genome, Base Sequence, biology, [ SDV ] Life Sciences [q-bio], Gene Transfer Techniques, Membrane Transport Proteins, Heart, GATA1, Articles, Cell Biology, Zebrafish Proteins, biology.organism_classification, Cell biology, Enhancer Elements, Genetic, Gene Expression Regulation, Genetic Loci, embryonic structures, Gene chip analysis, Chromatin immunoprecipitation, 030217 neurology & neurosurgery, Protein Binding, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b68e848da610d7ac6f543b5930913d2
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01120680

المؤلفون: Camila O. dos Santos, Wei Tong, Louis C. Dore, Janine D'Souza, Julio D. Amigo, Guowei Zhao, Mitchell J. Weiss, Duonan Yu, John K. Choi, Sherree Friend, Jordan S. Orange, Eugene Khandros, Jing Jiang, Barry H. Paw, Yu Yao, Saghi Ghaffari, Zhe Zhang

المصدر: Genesdevelopment. 24(15)

مصطلحات موضوعية: Active Transport, Cell Nucleus, Small hairpin RNA, Mice, Erythroid Cells, microRNA, Gene expression, Genetics, medicine, Animals, Zebrafish, Transcription factor, Sequence Deletion, Regulation of gene expression, Mice, Knockout, biology, Base Sequence, Forkhead Box Protein O3, Gene Expression Regulation, Developmental, Forkhead Transcription Factors, biology.organism_classification, Catalase, Molecular biology, Cell nucleus, MicroRNAs, Oxidative Stress, medicine.anatomical_structure, 14-3-3 Proteins, Gene Knockdown Techniques, FOXO3, Sequence Alignment, Developmental Biology, Research Paper

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb1d3363530377761eb81e02503ff0d
https://pubmed.ncbi.nlm.nih.gov/20679398

المؤلفون: Karl Hsu, Ebrahim Shafizadeh, Tyler B. Moran, Barry H. Paw, Jeffrey D. Cooney, John P. Kanki, Robert I. Handin, Gabriele E. Ackermann, Nathaniel B. Langer, George C. Shaw, David Traver, Yi Zhou, Bruce A. Barut, Wyatt Horsely, Hui Feng Lin, Dongdong Ma, Nikolaus S. Trede, Dhvanit I. Shah, Sarah A. Wojiski, George Kourkoulis, Alan B. Cantor, Julio D. Amigo, Alan J. Davidson, Ming Yu, John J. Cope

المصدر: Blood. 114(21)

مصطلحات موضوعية: Myeloid, genetic structures, Hematopoiesis and Stem Cells, Immunology, Embryonic Development, Biochemistry, Polymerase Chain Reaction, Gene expression, medicine, Animals, GATA1 Transcription Factor, Regulatory Elements, Transcriptional, Nuclear protein, Enhancer, Zebrafish, Transcription factor, In Situ Hybridization, Oligonucleotide Array Sequence Analysis, Regulation of gene expression, biology, Gene Expression Regulation, Developmental, Nuclear Proteins, Cell Biology, Hematology, Zebrafish Proteins, biology.organism_classification, Molecular biology, Cell biology, Hematopoiesis, medicine.anatomical_structure, embryonic structures, Endoderm

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b939d032343045e0cc0512e175344154
https://pubmed.ncbi.nlm.nih.gov/19729519

المؤلفون: John W. Tobias, Louis C. Dore, Christine M. Dorman, Alyssa M. Klein, Julio D. Amigo, Barry H. Paw, Mitchell J. Weiss, Ross C. Hardison, Zhe Zhang, Duonan Yu, Xiaowu Gai, Weisheng Wu, Camila O. dos Santos

مصطلحات موضوعية: Erythroid Precursor Cells, Multidisciplinary, Microarray analysis techniques, RNA, RNA polymerase II, Biology, Biological Sciences, Microarray Analysis, Molecular biology, Mice, MicroRNAs, Transcription (biology), Cell Line, Tumor, microRNA, biology.protein, Erythropoiesis, Animals, Erythroid-Specific DNA-Binding Factors, GATA1 Transcription Factor, Gene, Transcription factor, In Situ Hybridization, Zebrafish

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87866bb627e61803aa354aecce9f1bf
https://europepmc.org/articles/PMC2265118/

المؤلفون: Alejandra R. Alvarez, Lina Vargas, L. Fernanda Yévenes, Julio D. Amigo, Matias Mosqueira, Gonzalo I. Cancino, Silvana Zanlungo, Francisca C. Bronfman, Andrés D. Klein, Juan Castro

المصدر: FASEB JOURNAL
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
FASEB J.
Faseb J.

مصطلحات موضوعية: Cerebellum, Gene Expression, Apoptosis, Biochemistry, Piperazines, Mice, Purkinje Cells, hemic and lymphatic diseases, Tumor Protein p73, Proto-Oncogene Proteins c-abl, Mice, Knockout, Neurodegeneration, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Niemann-Pick Disease, Type C, DNA-Binding Proteins, medicine.anatomical_structure, Benzamides, Imatinib Mesylate, lipids (amino acids, peptides, and proteins), Niemann–Pick disease, Biotechnology, medicine.drug, medicine.medical_specialty, Cell Survival, Biology, Motor Activity, Cerebellar Cortex, Niemann-Pick C1 Protein, Internal medicine, Genetics, medicine, otorhinolaryngologic diseases, Animals, RNA, Messenger, neoplasms, Molecular Biology, Tumor Suppressor Proteins, nutritional and metabolic diseases, Proteins, Imatinib, medicine.disease, stomatognathic diseases, Disease Models, Animal, Imatinib mesylate, Endocrinology, Pyrimidines, Cancer research, NPC1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac14da41929be1229a8933d4c7915f28

المؤلفون: Jeffrey S. Clark, Seth L. Alper, Christine E. Kurschat, Andrew K. Stewart, Ann Hsu, Boris E. Shmukler, Barry H. Paw, Julio D. Amigo, Yi Zhou, Seong-Kyu Choe, David H. Vandorpe

المصدر: American journal of physiology. Regulatory, integrative and comparative physiology. 294(3)

مصطلحات موضوعية: DNA, Complementary, Embryo, Nonmammalian, Patch-Clamp Techniques, Physiology, SLC4A Proteins, Anion Transport Proteins, Molecular Sequence Data, Danio, Fluorescent Antibody Technique, Genome, Antiporters, Membrane Potentials, AE2 Anion Exchanger, Xenopus laevis, stomatognathic system, Chlorides, Genetic linkage, Physiology (medical), Animals, Amino Acid Sequence, Chloride-Bicarbonate Antiporters, Cloning, Molecular, Zebrafish, Gene, Anion exchanger, Genetics, SLC4A2, biology, biology.organism_classification, stomatognathic diseases, biology.protein, Oocytes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3eec76160d35cadacfbe81f84cd7c0
https://pubmed.ncbi.nlm.nih.gov/18046018