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1Academic Journal
المؤلفون: Carolyn D Hurst, Guo Cheng, Fiona M Platt, Olivia Alder, Emma VI Black, Julie E Burns, Joanne Brown, Sunjay Jain, Jo‐An Roulson, Margaret A Knowles
المصدر: The Journal of Pathology: Clinical Research, Vol 8, Iss 3, Pp 279-293 (2022)
مصطلحات موضوعية: muscle‐invasive bladder cancer, squamous cell carcinoma, whole exome, transcriptome, copy number, FAT1, Pathology, RB1-214
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2056-4538
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2Academic Journal
المؤلفون: Lewis D. Turner (4600186), Chi H. Trinh (1316205), Ryan A. Hubball (11709864), Kyle M. Orritt (11709867), Chi-Chuan Lin (11709870), Julie E. Burns (11709873), Margaret A. Knowles (11709876), Colin W. G. Fishwick (7821107)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, subsequent iterative rounds, specific morphological differences, fgfr inhibitors currently, biological evaluation led, additional docking studies, guided approach toward, selective inhibitors exist, existing fragment series, exhibited moderate selectivity, de novo design, selective fgfr2 inhibitors, lead inhibitor resulted, selective fgfr2 inhibitor, yield compounds predicted, selective h, subtle changes, nanomolar potency, improve potency, development toward, complete loss, clinical trials
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المؤلفون: Geoffrey A Pettitt, Carolyn D Hurst, Zubeda Khan, Helen R McPherson, Matthew C Dunning, Olivia Alder, Fiona M Platt, Emma VI Black, Julie E Burns, Margaret A Knowles
المصدر: The Journal of Pathology. 259:220-232
مصطلحات موضوعية: Pathology and Forensic Medicine
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المؤلفون: Margaret A. Knowles, Carolyn D. Hurst, Simon J. Allison, Julie E. Burns, Roger M. Phillips
المصدر: Cancer Science
مصطلحات موضوعية: Cancer Research, Epithelial-Mesenchymal Transition, Lactate dehydrogenase A, medicine.medical_treatment, lactate dehydrogenase A, Apoptosis, Transfection, Cystectomy, non–muscle‐invasive and muscle‐invasive bladder cancers, Cell, Molecular, and Stem Cell Biology, Sirtuin 1, Cell Line, Tumor, Warburg Effect, Oncologic, medicine, Humans, Lactic Acid, Molecular Targeted Therapy, Epithelial–mesenchymal transition, education, Neoplasm Staging, education.field_of_study, epithelial‐mesenchymal transition, Bladder cancer, L-Lactate Dehydrogenase, business.industry, Cancer, Original Articles, General Medicine, medicine.disease, Warburg effect, Isoenzymes, Radiation therapy, Urinary Bladder Neoplasms, Oncology, Anaerobic glycolysis, Gene Knockdown Techniques, intratumoral heterogeneity, Cancer research, Original Article, RNA Interference, Transcriptome, business
وصف الملف: application/pdf
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13
المؤلفون: Helen Sewell, Nick Hornigold, Naveen S. Vasudev, Eamonn R. Maher, Margaret A. Knowles, Mini Menon, Tsutomu Fukuwatari, Yasser Riazalhosseini, Alvis Brazma, Karen R. Dunn, Selina Bhattarai, Rachel A. Craven, Rosamonde E. Banks, Adrian L. Harris, Julie E. Burns, Alexandre Zougman, Peter Selby, Lara Feulner, Ghislaine Scelo, Michael Shires, Sebastian Trainor, Rebecca Shreeve, Joanne Brown, Mark Lathrop
المساهمون: Vasudev, Naveen S [0000-0001-8470-7481], Apollo - University of Cambridge Repository, Vasudev, Naveen S. [0000-0001-8470-7481]
المصدر: British Journal of Cancer
مصطلحات موضوعية: Proteomics, Cancer Research, Kynurenine pathway, 631/67/589/1588/1351, Nicotinamide phosphoribosyltransferase, Chromophobe cell, Biology, 631/67/2327, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Kynurenine 3-Monooxygenase, Downregulation and upregulation, Renal cell carcinoma, Cell Line, Tumor, medicine, Humans, 3-Hydroxyanthranilate 3,4-Dioxygenase, Nicotinamide Phosphoribosyltransferase, Carcinoma, Renal Cell, Kynurenine, 030304 developmental biology, 0303 health sciences, Gene Expression Profiling, medicine.disease, Cancer metabolism, Gene Expression Regulation, Neoplastic, Oncology, chemistry, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Phosphoribosyltransferase, Cytokines, Tumor Escape, Metabolic Networks and Pathways
وصف الملف: application/pdf; text/xml; application/zip
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14
المؤلفون: Carolyn D. Hurst, Guo Cheng, Fiona M. Platt, Mauro A.A. Castro, Nour-al-dain S. Marzouka, Pontus Eriksson, Emma V.I. Black, Olivia Alder, Andrew R.J. Lawson, Sia V. Lindskrog, Julie E. Burns, Sunjay Jain, Jo-An Roulson, Joanne C. Brown, Jan Koster, A. Gordon Robertson, Inigo Martincorena, Lars Dyrskjøt, Mattias Höglund, Margaret A. Knowles
المساهمون: Oncogenomics, CCA - Cancer biology and immunology
المصدر: Cell Reports Medicine
Hurst, C D, Cheng, G, Platt, F M, Castro, M A A, Marzouka, N A D S, Eriksson, P, Black, E V I, Alder, O, Lawson, A R J, Lindskrog, S V, Burns, J E, Jain, S, Roulson, J A, Brown, J C, Koster, J, Robertson, A G, Martincorena, I, Dyrskjøt, L, Höglund, M & Knowles, M A 2021, ' Stage-stratified molecular profiling of non-muscle-invasive bladder cancer enhances biological, clinical, and therapeutic insight ', Cell Reports Medicine, vol. 2, no. 12, 100472 . https://doi.org/10.1016/j.xcrm.2021.100472
Cell Reports Medicine, 2(12):100472. Cell Pressمصطلحات موضوعية: Transcription, Genetic, stage T1, Gene Dosage, clinical outcome, General Biochemistry, Genetics and Molecular Biology, Article, transcriptomics, copy number, genomics, Humans, Neoplasm Invasiveness, Neoplasm Staging, NMIBC, Gene Expression Profiling, Muscles, Mycobacterium bovis, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, PPAR gamma, Urinary Bladder Neoplasms, classification, stage Ta, Mutation, Neoplasm Recurrence, Local, Tumor Suppressor Protein p53, non-muscle-invasive bladder cancer
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المؤلفون: Margaret A. Knowles, Ryan A. Hubball, Colin W. G. Fishwick, Julie E. Burns, Chi H. Trinh, Kyle M. Orritt, Lewis D. Turner, Chi-Chuan Lin
المصدر: 'Journal of Medicinal Chemistry ', vol: 65, pages: 1481-1504 (2022)
مصطلحات موضوعية: musculoskeletal diseases, Chemistry, Fibroblast growth factor receptor 1, stomatognathic diseases, Structure-Activity Relationship, Docking (dog), Biochemistry, Drug Development, Urinary Bladder Neoplasms, Fibroblast growth factor receptor, Drug Design, Drug Discovery, embryonic structures, Tumor Cells, Cultured, Molecular Medicine, Potency, Humans, Phosphorylation, Receptor, Fibroblast Growth Factor, Type 2, Selectivity, Protein Kinase Inhibitors, Biological evaluation, Cell Proliferation
وصف الملف: application/pdf
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المؤلفون: Chi Trinh, Margaret A. Knowles, Colin W. G. Fishwick, Ryan A. Hubball, Julie E. Burns, Chi-Chuan Lin, Lewis D. Turner, Kyle M. Orritt
مصطلحات موضوعية: Biochemistry, Cell culture, Chemistry, Fibroblast growth factor receptor, Fibroblast growth factor receptor 1, Potency, Hit to lead, Selectivity, Biological evaluation
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17Academic Journal
المؤلفون: Stephanie L Swift, Guillermo C Rivera, Vincent Dussupt, Regina M Leadley, Lucy C Hudson, Corrina Ma de Ridder, Robert Kraaij, Julie E Burns, Norman J Maitland, Lindsay J Georgopoulos
المصدر: PLoS ONE, Vol 8, Iss 6, p e65557 (2013)
وصف الملف: electronic resource
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18Academic Journal
المؤلفون: Rebecca L Ross, Julie E Burns, Claire F Taylor, Paul Mellor, Deborah H Anderson, Margaret A Knowles
المصدر: PLoS ONE, Vol 8, Iss 12, p e84411 (2013)
وصف الملف: electronic resource
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19Academic Journal
المؤلفون: Norman J. Maitland, Hannah F. Walker, Stephanie Allen, Alfred A. Antson, Elena E. Hern, Julie E. Burns, Wenke Zhang, Type E, N Terminus, Results Dna, Dimerization Of The Human Papillomavirus
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.597.7562; http://jvi.asm.org/content/82/10/4853.full.pdf
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المؤلفون: Dmitry A. Gordenin, Margaret A. Knowles, Alastair Droop, Claire Taylor, Helen Lindsay, Lucy F. Stead, Julie E. Burns, Carolyn D. Hurst, Anne J. Ridley, Fiona M. Platt, Helen R. Mott, Olivia Alder, Sunjay Jain, George J Burghel, Jo-An Roulson, Helene Thygesen, Angus J.M. Cameron, Leszek J. Klimczak
المساهمون: Mott, Helen [0000-0002-7890-7097], Apollo - University of Cambridge Repository
المصدر: Hurst, C D, Alder, O, Platt, F M, Droop, A, Stead, L F, Burns, J E, Burghel, G J, Jain, S, Klimczak, L J, Lindsay, H, Roulson, J-A, Taylor, C F, Thygesen, H, Cameron, A J, Ridley, A J, Mott, H R, Gordenin, D A & Knowles, M A 2017, ' Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency ', Cancer Cell, vol. 32, no. 5, pp. 701-715.e7 . https://doi.org/10.1016/j.ccell.2017.08.005
مصطلحات موضوعية: 0301 basic medicine, Male, Cancer Research, Mutation rate, RHOB, medicine.disease_cause, 0302 clinical medicine, Mutation Rate, Gene Frequency, gender, KDM6A, Mutation frequency, mTORC1, Histone Demethylases, Mutation, biology, subtypes, Nuclear Proteins, Genomics, 3. Good health, Gene Expression Regulation, Neoplastic, Histone, Oncology, 030220 oncology & carcinogenesis, Metabolome, bladder cancer, Female, DNA repair, Sexism, Article, 03 medical and health sciences, Sex Factors, Cell Line, Tumor, medicine, Journal Article, Humans, Metabolomics, recurrence-free survival, Carcinoma, Transitional Cell, Bladder cancer, Gene Expression Profiling, Cell Biology, medicine.disease, 030104 developmental biology, HEK293 Cells, Urinary Bladder Neoplasms, biology.protein, Cancer research, Demethylase, metabolism
وصف الملف: application/pdf
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