يعرض 1 - 20 نتائج من 62 نتيجة بحث عن '"Judith Sebolt-Leopold"', وقت الاستعلام: 0.54s تنقيح النتائج
  1. 1
    Academic Journal
    A Role for K-ras in Conferring Resistance to the MEK Inhibitor, CI-1040

    المؤلفون: Yuli Wangab, Keri Van Becelaere, Ping Jiang, Sally Przybranowski, Charles Omer, Judith Sebolt-Leopold

    المصدر: Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 4, Pp 336-347 (2005)

    مصطلحات موضوعية: MEK, ERK, Ras, CI-1040, C26, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S147655860580065X; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

    URL الوصول: https://doaj.org/article/b2b6a25a37cf43719d13564e012ba8a6

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  2. 2
    Supplementary Figure 4 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b4ca5413ad1dd1119493f5dcf452a3
    https://doi.org/10.1158/1535-7163.22497604.v1

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  3. 3
    Supplementary Table 1 from Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

    المؤلفون: Michael J. Weber, Mark Conaway, Emanuel F. Petricoin, Julia D. Wulfkuhle, Stefan Bekiranov, Judith Sebolt-Leopold, Winfried Wunderlich, Daniel Gioeli

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bda629ec270def6038a48a97f235f8
    https://doi.org/10.1158/1535-7163.22496325.v1

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  4. 4
    Supplementary Figure 2 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3846abdebb37d10ac4b6edb13399ed
    https://doi.org/10.1158/1535-7163.22497610

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  5. 5
    Supplementary Figure 5 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c400f77d459c33e1f7467bef001d3be
    https://doi.org/10.1158/1535-7163.22497598.v1

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  6. 6
    Supplementary Figure 3 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0072a68526c75955735ec102d2965437
    https://doi.org/10.1158/1535-7163.22497607.v1

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  7. 7
    Supplementary Figure 1 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df4c8c4a876d89e13fc7c594368c5c1
    https://doi.org/10.1158/1535-7163.22497613

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  8. 8
    Supplementary Figure and Table Legend from Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

    المؤلفون: Michael J. Weber, Mark Conaway, Emanuel F. Petricoin, Julia D. Wulfkuhle, Stefan Bekiranov, Judith Sebolt-Leopold, Winfried Wunderlich, Daniel Gioeli

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4bfa2f4fa80edc990368e1926cd48a
    https://doi.org/10.1158/1535-7163.22496328.v1

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  9. 9
    Supplementary Figure Legend from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115c5899bb76fc459dfb59b2bb94b548
    https://doi.org/10.1158/1535-7163.22497595

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  10. 10
    Data from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer

    المؤلفون: Judith Sebolt-Leopold, Alnawaz Rehemtulla, Theodore S. Lawrence, Brian D. Ross, Craig J. Galbán, Stefanie Galbán, David Karnak, Ashwin Ram, Paul Keller, Athena R. Flecha, Terence M. Williams

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7662108ee8bc8d7b049f3bb943642e
    https://doi.org/10.1158/1535-7163.c.6535666

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  11. 11
    Data from Compensatory Pathways Induced by MEK Inhibition Are Effective Drug Targets for Combination Therapy against Castration-Resistant Prostate Cancer

    المؤلفون: Michael J. Weber, Mark Conaway, Emanuel F. Petricoin, Julia D. Wulfkuhle, Stefan Bekiranov, Judith Sebolt-Leopold, Winfried Wunderlich, Daniel Gioeli

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b4b86ea4ebd4bf01be9fceb6b6c88e
    https://doi.org/10.1158/1535-7163.c.6535233.v1

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  12. 12
    Systematic analysis uncovers SYK dependency in NF1LoF melanoma cells

    المؤلفون: Cara Abecunas, Christopher Whitehead, Elizabeth Ziemke, Douglas G. Baumann, Christy Frankowski-McGregor, Judith Sebolt-Leopold, Mohammad Fallahi-Sichani

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2b44b7bd40faa8c80a93506b5660c138
    https://doi.org/10.1101/2022.03.06.483170

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  13. 13
    DDDR-25. CO-INHIBITION OF KINASE SIGNALING PATHWAYS AND EPIGENETIC REGULATORS OVERCOMES COMPENSATORY EFFECTS IN PEDIATRIC HIGH-GRADE GLIOMAS

    المؤلفون: Jack Adams, Lea Stitzlein, Melissa Singh, Xiaoping Su, Yue Lu, Cavan Bailey, Michelle Monje, Christopher Whitehead, Judith Sebolt-Leopold, Joya Chandra

    المصدر: Neuro-Oncology. 24:vii104-vii104

    مصطلحات موضوعية: Cancer Research, Oncology, Neurology (clinical)

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7518b1247b781ab8565faea06a81367b
    https://doi.org/10.1093/neuonc/noac209.390

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  14. 14
    Abstract 3329: Efficacy of EGFR/PI3K signaling inhibition is enhanced with LSD1 inhibition in glioblastoma stem cell (GSC) models

    المؤلفون: Lea Stitzlein, Matthew Luetzen, Caitlin McCabe, Maninder Khosla, Melissa Singh, Xiaoping Su, Yue Lu, Joy Gumin, Frederick Lang, Christopher Whitehead, Judith Sebolt-Leopold, Joya Chandra

    المصدر: Cancer Research. 82:3329-3329

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7915ff99ccdcd1f44a4488f9d4645321
    https://doi.org/10.1158/1538-7445.am2022-3329

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  15. 15
    Abstract 3966: Targeting DNA repair and survival signaling in diffuse intrinsic pontine gliomas to prevent tumor recurrence

    المؤلفون: Monika Sharma, Rachel Mumby, Varunkumar Krishnamoorthy, Brian Magnuson, Mats Ljungman, Chris Whitehead, Judith Sebolt-Leopold, Stefanie Galban

    المصدر: Cancer Research. 82:3966-3966

    مصطلحات موضوعية: Cancer Research, Oncology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6a838e2e2df391cba8be8b5370814579
    https://doi.org/10.1158/1538-7445.am2022-3966

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  16. 16
    The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

    المؤلفون: W. Allen Howard, Joseph S. Warmus, Haile Tecle, Smith Yvonne Dorothy, Wilbur R. Leopold, Stephen Douglas Barrett, James H. Fergus, Amy M. Delaney, Dan Marston, Alan R. Saltiel, Alexander James Bridges, Sophie LePage, Annette M. Doherty, Cathlin Marie Flamme, Sally Przybranowski, Judith Sebolt-Leopold, Robert M. Kennedy, Keri Van Becelaere, David T. Dudley, Michael Kaufman

    المصدر: Bioorganic & Medicinal Chemistry Letters. 18:6501-6504

    مصطلحات موضوعية: MAPK/ERK pathway, Chemistry, Pharmaceutical, Clinical Biochemistry, MAP Kinase Kinase Kinase 1, Pharmaceutical Science, Pharmacology, Hydroxamic Acids, Benzoates, Biochemistry, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Anthranilic acid, Animals, ortho-Aminobenzoates, Enzyme Inhibitors, Molecular Biology, Hydroxamic acid, biology, MEK inhibitor, Organic Chemistry, Diphenylamine, In vitro, Solubility, chemistry, Enzyme inhibitor, Drug Design, Benzamides, biology.protein, Molecular Medicine, Neoplasm Transplantation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85ed26d3590855244ac5118ad67f79ca
    https://doi.org/10.1016/j.bmcl.2008.10.054

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  17. 17
    3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition

    المؤلفون: David B. Solit, Elmer Santos, Steven M. Larson, Shangde Cai, Jose Lobo, Ronald G. Blasberg, Maxim A. Moroz, Judith Sebolt-Leopold, Christine A. Pratilas, Neal Rosen

    المصدر: Cancer Research. 67:11463-11469

    مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Cancer Research, Pathology, medicine.medical_specialty, Blotting, Western, Mutant, MAP Kinase Kinase 1, Mice, Nude, Biology, Article, Mice, chemistry.chemical_compound, In vivo, Tumor Cells, Cultured, medicine, Animals, Protein kinase A, Melanoma, Kinase, Diphenylamine, G1 Phase, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Dideoxynucleosides, Oncology, chemistry, Drug Resistance, Neoplasm, Apoptosis, Positron-Emission Tomography, Benzamides, Cancer research, Female, Radiopharmaceuticals, Thymidine, V600E

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed68d510e63d740bf61458661fed19c6
    https://doi.org/10.1158/0008-5472.can-07-2976

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  18. 18
    4-Anilino-5-carboxamido-2-pyridone Derivatives as Noncompetitive Inhibitors of Mitogen-Activated Protein Kinase Kinase

    المؤلفون: Daniel F. Ortwine, Nadia Esmaeil, Haile Tecle, John Quin, Joseph S. Warmus, Michael Kaufman, William A. Denny, Jeffrey F. Ohren, and Alexander G. Pavlovsky, Ronald L. Merriman, Jared B. J. Milbank, Aurash B. Shahripour, Shannon Leigh Black, Judith Sebolt-Leopold, Christopher Whitehead, Julie Ann Spicer, Cathlin Marie Flamme, Heidi S. Camp, Kelley Moore, Richard Gowan, Charles Omer, Mark Stephen Plummer, Sally Pryzbranowski, Gordon W. Rewcastle, Stephen Douglas Barrett

    المصدر: Journal of Medicinal Chemistry. 50:5090-5102

    مصطلحات موضوعية: Male, Models, Molecular, Pyridones, medicine.drug_class, Stereochemistry, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Antineoplastic Agents, Carboxamide, Mitogen-activated protein kinase kinase, Chemical synthesis, Mice, Structure-Activity Relationship, Non-competitive inhibition, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Transferase, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, chemistry.chemical_classification, Aniline Compounds, Amides, In vitro, Rats, Enzyme, chemistry, Biochemistry, Benzamides, Molecular Medicine, Drug Screening Assays, Antitumor, Neoplasm Transplantation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc469624f4d498f355d1441c78d0b65
    https://doi.org/10.1021/jm0704548

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  19. 19
    Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention

    المؤلفون: Roman Herrera, Judith Sebolt-Leopold

    المصدر: Trends in Molecular Medicine. 8:S27-S31

    مصطلحات موضوعية: MAPK/ERK pathway, MAP Kinase Signaling System, Kinase, Drug discovery, Angiogenesis, MAP Kinase Kinase Kinase 1, Antineoplastic Agents, Tumor cells, Protein Serine-Threonine Kinases, Biology, Bioinformatics, Proto-Oncogene Proteins c-raf, Neoplasms, Intervention (counseling), Humans, Molecular Medicine, Enzyme Inhibitors, Signal transduction, Pharmaceutical sciences, Molecular Biology, Signal Transduction

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2329d606bc38ddd8a69b06755745755c
    https://doi.org/10.1016/s1471-4914(02)02307-9

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  20. 20
    Non-Peptidic Prenyltransferase Inhibitors: Diverse Structural Classes and Surprising Anti-Cancer Mechanisms

    المؤلفون: Richard A. Gibbs, Judith Sebolt-Leopold, Todd J. Zahn

    المصدر: Current Medicinal Chemistry. 8:1437-1465

    مصطلحات موضوعية: Peptidomimetic, Farnesyltransferase, Prenyltransferase, Farnesyl pyrophosphate, Antineoplastic Agents, Biology, Biochemistry, chemistry.chemical_compound, Prenylation, Neoplasms, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Pharmacology, Clinical Trials as Topic, Farnesyl-diphosphate farnesyltransferase, Organic Chemistry, Cancer, Dimethylallyltranstransferase, medicine.disease, chemistry, biology.protein, Molecular Medicine, Protein prenylation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88efccd3b7c65c880d8b085c8643ce98
    https://doi.org/10.2174/0929867013372111

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