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1A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia
المؤلفون: Rubén Gil-Redondo, Pedro Marset Campos, Juan Agut, Federico Mayor, Cristina Murga, Florenci V. González, Antonio Morreale, Annemieke Kavelaars, Elisa Lucas, Paula Ramos, Hanneke L.D.M. Willemen, Cobi J. Heijnen
المصدر: Biochemical Journal. 459:427-439
مصطلحات موضوعية: Male, MAPK/ERK pathway, Lipopolysaccharide, Drug Evaluation, Preclinical, Mice, Transgenic, Molecular Dynamics Simulation, Pharmacology, Biology, p38 Mitogen-Activated Protein Kinases, Biochemistry, Monocytes, Article, Cell Line, Mice, Random Allocation, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, medicine, Animals, Humans, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Cells, Cultured, Analgesics, Oxadiazoles, Kinase, Macrophages, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, Mice, Inbred C57BL, Molecular Docking Simulation, chemistry, Hyperalgesia, Female, Tumor necrosis factor alpha, Signal transduction, medicine.symptom
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2
المؤلفون: Santiago Rodríguez, Juan Agut, Florenci V. González, Andreu Vidal
المصدر: The Journal of Organic Chemistry. 78:5717-5722
مصطلحات موضوعية: Molecular Structure, Organic Chemistry, Imine, Diastereomer, Enantioselective synthesis, Stereoisomerism, Reductive amination, Kinetics, chemistry.chemical_compound, chemistry, Thermodynamics, Epoxy Compounds, Organic chemistry, Stereoselectivity, Amines, Enantiomer, Oxidation-Reduction, Amination