المؤلفون: Zhulin Tan, Xuan Ju, Hao Wu, Weitong Dong, Joyce C. Leung, Xiaowen Hou, Heewon Lee, Alice Granger, Joshua M. Paolillo, Susan V. DiMeo, Chengsheng Chen, Linglin Wu, Jon C. Lorenz, Max Sarvestani, Frederic Buono, Rogelio Frutos, Thomas G. Tampone, Xiaojun Huang, Gulin Zhang, Yuwen Wang, Earl Spinelli, Zhen Lei, Jinhua J. Song

مصطلحات موضوعية: Biophysics, Biochemistry, Pharmacology, Biotechnology, Ecology, Sociology, Developmental Biology, Hematology, Space Science, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, scalable synthesis toward, scalable asymmetric synthesis, catalyzed epoxide opening, carbon quaternary stereocenter, 1 , requisite ketone, rapid manufacturing, part 2, overall yield, high chemical, heterocyclic core, five steps, final assembly, enantiomeric purities, enabling robust, 300 kg

Relation: https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_2_Asymmetric_Synthesis_via_Shi_Epoxidation/24947434

الاتاحة: https://doi.org/10.1021/acs.oprd.3c00363.s001
https://figshare.com/articles/journal_contribution/Development_of_a_Scalable_Synthesis_toward_a_KRAS_G12C_Inhibitor_Building_Block_Bearing_an_All-Carbon_Quaternary_Stereocenter_Part_2_Asymmetric_Synthesis_via_Shi_Epoxidation/24947434

المؤلفون: Joshua M. Paolillo, Alana D. Duke, Emma S. Gogarnoiu, Dan E. Wise, Marvin Parasram

المصدر: Journal of the American Chemical Society. 145:2794-2799

مصطلحات موضوعية: Colloid and Surface Chemistry, General Chemistry, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::15d486f96297c91c1db3c3d3f7005e16
https://doi.org/10.1021/jacs.2c13502

المؤلفون: Kyle W. Rugg, Regina C. Balk, Joshua M. Paolillo, Dauzhan Yerkozhanov, Thomas G. Tampone, Martin Holan, Frederic G. Buono, Jonathan T. Reeves

المصدر: Journal of Heterocyclic Chemistry. 60:335-340

مصطلحات موضوعية: Organic Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06ac67d14cbe5304b27cf8cce2763d80
https://doi.org/10.1002/jhet.4592

المؤلفون: Dan E. Wise, Emma S. Gogarnoiu, Alana D. Duke, Joshua M. Paolillo, Taylor L. Vacala, Waseem A. Hussain, Marvin Parasram

المصدر: Journal of the American Chemical Society. 144(34)

مصطلحات موضوعية: Oxygen, Colloid and Surface Chemistry, Cycloaddition Reaction, Light, General Chemistry, Anaerobiosis, Alkenes, Biochemistry, Catalysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12213358f39be189b599c2f168ae5e64
https://pubmed.ncbi.nlm.nih.gov/35930615

المؤلفون: Matthew Z. Vaughan, Joshua M. Paolillo, Arturo León Sandoval, Jyoti Nandi, Nicholas E. Leadbeater

المصدر: The Journal of organic chemistry. 85(14)

مصطلحات موضوعية: Tandem, 010405 organic chemistry, Organic Chemistry, Oxidative phosphorylation, Pyrazole, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Amide, lipids (amino acids, peptides, and proteins), Visible spectrum

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6306b99ec121378a0878a082efaf6e1
https://pubmed.ncbi.nlm.nih.gov/32539393

المؤلفون: Vincent A. Pistritto, Nicholas E. Leadbeater, Kathryn A. Bisset, Joshua M. Paolillo

المصدر: Organicbiomolecular chemistry. 16(25)

مصطلحات موضوعية: Trifluoromethyl, Primary (chemistry), 010405 organic chemistry, Organic Chemistry, Photoredox catalysis, 010402 general chemistry, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, chemistry, Alcohol oxidation, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08030e521b16a7d2ce24959cad99ce8
https://pubmed.ncbi.nlm.nih.gov/29900460