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1Academic Journal
المؤلفون: Andrew K. Dilger (2461681), Kumar B. Pabbisetty (1601845), James R. Corte (1705543), Indawati De Lucca (11407452), Tianan Fang (1705540), Wu Yang (414613), Donald J. P. Pinto (8212503), Yufeng Wang (274657), Yeheng Zhu (1870663), Arvind Mathur (144120), Jianqing Li (523126), Xiaoping Hou (3225315), Daniel Smith (6120), Dawn Sun (1565869), Huiping Zhang (135186), Subramaniam Krishnananthan (1402561), Dauh-Rurng Wu (1402558), Joseph E. Myers (2383984), Steven Sheriff (1601854), Karen A. Rossi (1601821), Silvi Chacko (10732002), Joanna J. Zheng (1601842), Michael A. Galella (2065051), Theresa Ziemba (10048686), Elizabeth A. Dierks (2443834), Jeffrey M. Bozarth (1601851), Yiming Wu (295996), Earl Crain (11407455), Pancras C. Wong (1601836), Joseph M. Luettgen (1550428), Ruth R. Wexler (1550446), William R. Ewing (1870717)
مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Hematology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, coagulation cascade thought, amplify thrombin generation, orally bioavailable inhibitor, milvexian , k <, , thromboembolic disorders, superior efficacy, solubility resulted, preclinical models, pk properties, oral administration, limited role, irreversible inhibitors, human genetics, free fraction, factor xia, clinical studies, clinical candidate, antithrombotic agent
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2
المؤلفون: Arunachalam Arumugam, Dietmar A. Seiffert, Arvind Mathur, Joanna J. Zheng, Ruth R. Wexler, Jeon Yoon T, Premsai Rai Neithnadka, Earl J. Crain, Paul J. Gilligan, Patrick Y.S. Lam, Yiming Wu, Mahammed Kaspady, Pancras C. Wong, Tianan Fang, Silvi A. Chacko, William R. Ewing, Pabbisetty Kumar Balashanmuga, Zhen Lou, Steven Sheriff, Joseph M. Luettgen, Joseph E. Myers, Wu Yang, Karen A. Rossi, Richard Rampulla, James R. Corte, Amy Lai, Charles G. Clark, Jeffrey M. Bozarth, Yufeng Wang, Sivashankaran Raju
المصدر: Journal of Medicinal Chemistry. 63:7226-7242
مصطلحات موضوعية: Models, Molecular, Proteases, Macrocyclic Compounds, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Factor XIa, Serine, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Fibrinolytic Agents, Pharmacokinetics, In vivo, Drug Discovery, Antithrombotic, Animals, Humans, Structure–activity relationship, 030304 developmental biology, 0303 health sciences, Chemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Rabbits, Hydrophobic and Hydrophilic Interactions, Linker
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3
المؤلفون: Karen A. Rossi, Ruth R. Wexler, Steven Sheriff, Dawn Sun, Jeffrey M. Bozarth, Jianqing Li, Elizabeth A. Dierks, James R. Corte, Yiming Wu, Donald J. P. Pinto, Silvi A. Chacko, Michael Galella, Joanna J. Zheng, Joseph E. Myers, Dauh-Rurng Wu, Tianan Fang, Joseph M. Luettgen, Pancras C. Wong, Xiaoping Hou, Pabbisetty Kumar Balashanmuga, Daniel Smith, Indawati De Lucca, Huiping Zhang, Wu Yang, Arvind Mathur, Yufeng Wang, Dilger Andrew K, William R. Ewing, Subramaniam Krishnananthan, Yeheng Zhu, Earl J. Crain, Theresa Ziemba
المصدر: Journal of medicinal chemistry. 65(3)
مصطلحات موضوعية: Administration, Oral, Factor XIa, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Pharmacokinetics, Fibrinolytic Agents, Bleeding time, Oral administration, Drug Discovery, Antithrombotic, medicine, Animals, Carotid Artery Thrombosis, medicine.diagnostic_test, Molecular Structure, Chemistry, Triazoles, Bioavailability, Macaca fascicularis, Pyrimidines, Free fraction, Hemostasis, Molecular Medicine, Pyrazoles, Rabbits
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4
المؤلفون: Doree F. Sitkoff, Alice Y. Chen, Hongwei Zhang, Anne Rose, Xue-Qing Chen, Cailan Wang, Leonard P. Adam, Mimi L. Quan, Nathan L. Cheadle, Zilun Hu, Lisa Zhang, David S. Taylor, Ruth R. Wexler, Songmei Xu, John S. Sack, Joseph E. Myers, Victor R. Guarino, James Hennan, Peter W. Glunz, Chunhong Yan, Julia Li
المصدر: Bioorganicmedicinal chemistry letters. 30(21)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Blood Pressure, Crystallography, X-Ray, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Amide, Drug Discovery, Molecule, Potency, Animals, Humans, Kinome, Molecular Biology, Protein Kinase Inhibitors, rho-Associated Kinases, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Rho kinase inhibitor, Molecular Medicine, Pyrazoles, Selectivity
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5
المؤلفون: Karen A. Rossi, Tianan Fang, Wu Yang, Dietmar A. Seiffert, Yiming Wu, Mimi L. Quan, Zhen Lou, Honey Osuna, Joseph E. Myers, Steven Sheriff, William R. Ewing, Ruth R. Wexler, Joseph M. Luettgen, Amy Lai, Joanna J. Zheng, James R. Corte, Patrick Y.S. Lam, Timothy W. Harper, Yufeng Wang, Jeffrey M. Bozarth
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:3833-3839
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Macrocyclic Compounds, Serine Proteinase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Factor XIa, 030204 cardiovascular system & hematology, Crystallography, X-Ray, Biochemistry, Polar surface area, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Drug Discovery, Humans, Potency, Molecular Biology, Alkyl, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Amides, Combinatorial chemistry, Ring size, 030104 developmental biology, chemistry, Molecular Medicine, Linker
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6
المؤلفون: James R. Corte, Donald J. P. Pinto, Tianan Fang, Honey Osuna, Wu Yang, Yufeng Wang, Amy Lai, Charles G. Clark, Jung-Hui Sun, Richard Rampulla, Arvind Mathur, Mahammed Kaspady, Premsai Rai Neithnadka, Yi-Xin Cindy Li, Karen A. Rossi, Joseph E. Myers, Steven Sheriff, Zhen Lou, Timothy W. Harper, Christine Huang, Joanna J. Zheng, Jeffrey M. Bozarth, Yiming Wu, Pancras C. Wong, Earl J. Crain, Dietmar A. Seiffert, Joseph M. Luettgen, Patrick Y. S. Lam, Ruth R. Wexler, William R. Ewing
المصدر: Journal of medicinal chemistry. 63(2)
مصطلحات موضوعية: Models, Molecular, Macrocyclic Compounds, Serine Proteinase Inhibitors, Pyridines, Imidazoles, Biological Availability, Thrombosis, Crystallography, X-Ray, Factor XIa, Structure-Activity Relationship, Fibrinolytic Agents, Drug Design, Drug Discovery, Molecular Medicine, Animals, Humans, Partial Thromboplastin Time, Rabbits, Blood Coagulation
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7Academic Journal
المؤلفون: Cynthia V. Stauffacher, Victor W. Rodwell, Joseph E. Myers, Martin Rosenberg, Daniel Sylvester, Michael N. Gwynn, R. Dwayne Lunsford, Damien Mcdevitt, E. Imogen Wilding, Dong-yul Kim, Er P. Bryant, Hydroxy--methylglutaryl Coenzyme A
المساهمون: The Pennsylvania State University CiteSeerX Archives
وصف الملف: application/pdf
Relation: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.570.1936; http://jb.asm.org/content/182/18/5147.full.pdf
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8
المؤلفون: John S. Sack, Chunhong Yan, Mian Gao, John A. Newitt, Susan E. Kiefer, Joseph E. Myers, Sophie Wu
المصدر: Acta Crystallographica Section F Structural Biology Communications. 72:129-134
مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Protein Conformation, Molecular Sequence Data, Biophysics, Protein Serine-Threonine Kinases, Biology, Crystallography, X-Ray, Biochemistry, Pyrazolopyrimidine, Research Communications, Serine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Structural Biology, Microtubule, Genetics, Humans, Transferase, Amino Acid Sequence, Threonine, Protein Kinase Inhibitors, Kinase, Condensed Matter Physics, Pyrimidines, 030104 developmental biology, chemistry, Pyrazoles, Phosphorylation, Crystallization, 030217 neurology & neurosurgery
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9
المؤلفون: Erin J.D. Austin, James R. Corte, Cailan Wang, Tianan Fang, Ge Zhang, Vidhyashankar Ramamurthy, Mimi L. Quan, Dietmar A. Seiffert, Alan R. Rendina, Joseph E. Myers, Anzhi Wei, Leon M. Smith, Donald J. P. Pinto, Ruth R. Wexler, Karen A. Rossi, Steven Sheriff, Joanne M. Smallheer, Paul E. Morin, Joseph M. Luettgen, Jeffrey M. Bozarth
المصدر: Bioorganic & Medicinal Chemistry Letters. 25(7):1635-1642
مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Factor XIa, Biochemistry, Compound 32, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Serine protease, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Bioavailability, Coagulation factor XIa, Drug Design, biology.protein, Structure based, Molecular Medicine, Selectivity, Linker
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10
المؤلفون: Wei Han, Ruth R. Wexler, Yiming Wu, Cailan Wang, Joseph M. Luettgen, Zilun Hu, Karen A. Rossi, Jeffrey M. Bozarth, Steven Sheriff, Joseph E. Myers, Dietmar A. Seiffert, Mimi L. Quan
المصدر: Bioorganicmedicinal chemistry letters. 28(6)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Serine Proteinase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Factor XIa, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Pyridazine, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Humans, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, 0104 chemical sciences, Bioavailability, Pyridazines, 030104 developmental biology, Coagulation factor XIa, Microsomes, Liver, Molecular Medicine
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11
المؤلفون: Atsu Apedo, Pancras C. Wong, Olafur S. Gudmundsson, Nathalie Toussaint, Yiming Wu, Timothy W. Harper, Silvi A. Chacko, Leon M. Smith, Baomin Xin, Dietmar A. Seiffert, Steven Sheriff, Ruth R. Wexler, William R. Ewing, Jeffrery M. Bozarth, Mimi L. Quan, Zhen Lou, Earl J. Crain, Brad D. Maxwell, Joanna J. Zheng, Arvind Mathur, Paul Stetsko, Joseph E. Myers, Donald J. P. Pinto, Michael J. Orwat, Karen A. Rossi, Patrick Y.S. Lam, Xiaoping Hou, Joseph M. Luettgen, Huiping Zhang
المصدر: Journal of medicinal chemistry. 60(23)
مصطلحات موضوعية: 0301 basic medicine, Male, Factor XIa, 030204 cardiovascular system & hematology, Pharmacology, Crystallography, X-Ray, Normal hemostasis, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Dogs, Antithrombotic, Drug Discovery, medicine, para-Aminobenzoates, Animals, Humans, Thrombus, Blood Coagulation, Chemistry, Drug discovery, Anticoagulants, Thrombosis, medicine.disease, Isoquinolines, Small molecule, Rats, Molecular Docking Simulation, 030104 developmental biology, Coagulation, Coagulation factor XIa, Molecular Medicine, Rabbits
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12
المؤلفون: Jeffrey M. Bozarth, Joseph M. Luettgen, Steven Sheriff, Karen A. Rossi, Yiming Wu, Joseph E. Myers, Mimi L. Quan, James R. Corte, Cailan Wang, Ruth R. Wexler, Dietmar A. Seiffert
المصدر: Bioorganicmedicinal chemistry letters. 27(17)
مصطلحات موضوعية: Proteases, Macrocyclic Compounds, Serine Proteinase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Factor XIa, Crystal structure, 030204 cardiovascular system & hematology, Biochemistry, Serine, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Potency, Humans, Molecular Biology, medicine.diagnostic_test, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Imidazoles, 030220 oncology & carcinogenesis, Molecular Medicine, Selectivity, circulatory and respiratory physiology, Partial thromboplastin time
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13
المؤلفون: Tianan Fang, James R. Corte, Paul J. Gilligan, Yoon Jeon, Honey Osuna, Karen A. Rossi, Joseph E. Myers, Steven Sheriff, Zhen Lou, Joanna J. Zheng, Timothy W. Harper, Jeffrey M. Bozarth, Yiming Wu, Joseph M. Luettgen, Dietmar A. Seiffert, Ruth R. Wexler, Patrick Y.S. Lam
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:126949
مصطلحات موضوعية: Binding Sites, Macrocyclic Compounds, Serine Proteinase Inhibitors, Pyridines, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Molecular Dynamics Simulation, Biochemistry, Factor XIa, Protein Structure, Tertiary, Rats, Structure-Activity Relationship, Drug Design, Drug Discovery, Animals, Molecular Medicine, Amines, Molecular Biology, Half-Life
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14
المؤلفون: Joseph E. Myers, Javed Khan, Daniel Meyers, Ginger Chao, Doree F. Sitkoff, Fred Lo, Katie A. Russo, Hossain Monshizadegan, Tracy S. Mitchell, Mark R. Witmer, Rex A. Parker, Bowman Miao, Mian Gao, Denhez Fabienne M, Gerald J. Duke, Dibella Rose A, Simon Low, Siew Peng Ho
المصدر: Journal of Pharmacology and Experimental Therapeutics. 350:412-424
مصطلحات موضوعية: Transgene, Molecular Sequence Data, Mice, Transgenic, Pharmacology, Biology, Polyethylene Glycols, Mice, chemistry.chemical_compound, Species Specificity, Pharmacokinetics, Animals, Humans, Amino Acid Sequence, Receptor, Cholesterol, Anticholesteremic Agents, PCSK9, Cholesterol, HDL, Serine Endopeptidases, Proteins, Proprotein convertase, Rats, Lipoproteins, LDL, Mice, Inbred C57BL, Macaca fascicularis, Receptors, LDL, chemistry, Biochemistry, Low-density lipoprotein, Molecular Medicine, Female, Proprotein Convertases, Proprotein Convertase 9, Crystallization, Lipoprotein
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15
المؤلفون: Qian Xiang, Dietmar A. Seiffert, Wu Yang, Tianan Fang, Joseph E. Myers, Joanne M. Smallheer, Patrick Y.S. Lam, Jeon Yoon T, Zhen Lou, Joanna Zheng, Joseph M. Luettgen, Jeffrey M. Bozarth, Steven Sheriff, Yufeng Wang, William R. Ewing, Zilun Hu, Indawati De Lucca, Donald J. P. Pinto, Michael J. Orwat, James R. Corte, Charles G. Clark, Karen A. Rossi, Alan R. Rendina, Timothy W. Harper, Ruth R. Wexler, David S. Nirschl, Baomin Xin, Yiming Wu
المصدر: Bioorganic & Medicinal Chemistry Letters. 29:126604
مصطلحات موضوعية: Models, Molecular, Macrocyclic Compounds, Serine Proteinase Inhibitors, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Factor XIa, Ligands, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, Hydrolase, Humans, Moiety, Molecular Biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Ligand (biochemistry), Combinatorial chemistry, Enhanced bioavailability, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Drug Design, Molecular Medicine, Structure based, Linker
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16
المؤلفون: Karen A. Rossi, Yiming Wu, Joseph M. Luettgen, Mimi L. Quan, Zhen Lou, James R. Corte, Carl P. Decicco, Joanna J. Zheng, Steven Sheriff, Tianan Fang, Joseph E. Myers, Donald J. P. Pinto, Dietmar A. Seiffert, Ruth R. Wexler, Honey Osuna, Timothy W. Harper, Jeffrey M. Bozarth
المصدر: Journal of medicinal chemistry. 60(3)
مصطلحات موضوعية: Macrocyclic Compounds, Serine Proteinase Inhibitors, Stereochemistry, 030204 cardiovascular system & hematology, Ligands, 01 natural sciences, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Amide, Drug Discovery, Imidazole, chemistry.chemical_classification, biology, Molecular Structure, 010405 organic chemistry, Hydrogen bond, Active site, Hydrogen Bonding, Ligand (biochemistry), Combinatorial chemistry, Amides, 0104 chemical sciences, Enzyme, chemistry, biology.protein, Molecular Medicine, Selectivity, Linker
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17
المؤلفون: Liu Yi-Tsung, Frank Bennett, Viyyoor M. Girijavallabhan, F. George Njoroge, Lata Ramanathan, John Pichardo, Kevin X. Chen, S. Shane Taremi, Andrew Prongay, Brian M. Beyer, Corey Strickland, Rumin Zhang, Vincent Madison, Edwin Jao, Zhuyan Guo, Zhi Hong, Patricia C. Weber, Anil K. Saksena, Stephane L. Bogen, Srikanth Venkatraman, Rong-Sheng Yang, Nanhua Yao, Joseph E. Myers, Bruce A. Malcolm, Taisa Yarosh-Tomaine, Raymond G. Lovey, Richard N. Ingram, Ashok Arasappan, Thierry O. Fischmann, Mary M. Senior, Winifred W. Prosise
المصدر: Journal of Synchrotron Radiation
مصطلحات موضوعية: HCV protease, Models, Molecular, Nuclear and High Energy Physics, Diffraction Structural Biology, Proline, medicine.medical_treatment, Tripeptide, Hepacivirus, Viral Nonstructural Proteins, hydrophobic binding, Hydrophobic effect, ketoamides, medicine, Potency, Protease Inhibitors, Instrumentation, NS3, Radiation, Protease, Kunitz STI protease inhibitor, biology, Molecular Structure, Chemistry, Active site, structure-based design, NS2-3 protease, Biochemistry, biology.protein, sense organs
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18
المؤلفون: Mimi L. Quan, Ruth R. Wexler, Joseph E. Myers, Joseph M. Luettgen, Donald J. P. Pinto, Dietmar A. Seiffert, Yi-Xin Li, Steven Sheriff, Timothy W. Harper, Rangaraj Narayanan, Michael J. Orwat, Anzhi Wei, James R. Corte, Tianan Fang, Joanna J. Zheng, Karen A. Rossi, Vidhyashankar Ramamurthy, Alan R. Rendina
المصدر: Bioorganicmedicinal chemistry. 24(10)
مصطلحات موضوعية: Models, Molecular, Carbamate, Pyrimidine, Stereochemistry, Pyridines, medicine.medical_treatment, Clinical Biochemistry, Phenylcarbamates, Pharmaceutical Science, Administration, Oral, 030204 cardiovascular system & hematology, Ring (chemistry), Crystallography, X-Ray, 01 natural sciences, Biochemistry, Factor XIa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Drug Discovery, Pyridine, medicine, Imidazole, Moiety, Animals, Humans, Molecular Biology, Blood Coagulation, Indazole, 010405 organic chemistry, Chemistry, Organic Chemistry, Anticoagulants, 0104 chemical sciences, Bioavailability, Pyrimidines, Molecular Medicine
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19
المؤلفون: Nanhua Yao, Lata Ramanathan, Kevin X. Chen, Thierry O. Fischmann, Andrew Prongay, Corey Strickland, Mary M. Senior, Raymond G. Lovey, Richard N. Ingram, Bruce A. Malcolm, Viyyoor M. Girijavallabhan, Frank Bennett, Patricia C. Weber, Taisa Yarosh-Tomaine, John Pichardo, Anil K. Saksena, F. George Njoroge, Rong-Sheng Yang, Zhuyan Guo, Zhi Hong, Stephane L. Bogen, Srikanth Venkatraman, Ashok Arasappan, S. Shane Taremi, Brian M. Beyer, Rumin Zhang, Vincent Madison, Edwin Jao, Winifred W. Prosise, Yi-Tsung Liu, Joseph E. Myers
المصدر: Journal of Medicinal Chemistry. 50:2310-2318
مصطلحات موضوعية: Alanine, chemistry.chemical_classification, NS3, Dipeptide, Protease, Stereochemistry, medicine.drug_class, medicine.medical_treatment, virus diseases, Peptide, Carboxamide, macromolecular substances, digestive system diseases, Protease inhibitor (biology), Serine, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Molecular Medicine, medicine.drug
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20
المؤلفون: Joanna J. Zheng, Joseph M. Luettgen, Mimi L. Quan, Earl J. Crain, Anzi Wei, Pabbisetty Kumar Balashanmuga, Zilun Hu, Karen A. Rossi, Steven Sheriff, Wei Han, Joseph E. Myers, Vidhyashankar Ramamurthy, Paul J. Gilligan, Timothy W. Harper, Jeffrey M. Bozarth, Ruth R. Wexler, Pancras C. Wong, Carol A. Watson, Dietmar A. Seiffert
مصطلحات موضوعية: medicine.diagnostic_test, Chemistry, Stereochemistry, Organic Chemistry, Phenylalanine, Factor XIa, Pharmacology, Biochemistry, Piperazine, chemistry.chemical_compound, Bleeding time, Amide, Drug Discovery, medicine, Moiety, Potency, EC50