المؤلفون: Shilpa Pandit, Doug Wisniewski, Joseph C. Santoro, Sookhee Ha, Vijayalakshmi Ramakrishnan, Rose M. Cubbon, Richard T. Cummings, Samuel D. Wright, Carl P. Sparrow, Ayesha Sitlani, Timothy S. Fisher

المصدر: Journal of Lipid Research, Vol 49, Iss 6, Pp 1333-1343 (2008)

مصطلحات موضوعية: proprotein convertase subtilisin/kexin type 9, LDL, LDL receptor, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520423776; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/596c24147eaa41d09b15a93821963feb

المؤلفون: Brian T. Hopkins (2723545), Eris Bame (7038266), Bekim Bajrami (230244), Cheryl Black (11647791), Tonika Bohnert (2700703), Carrie Boiselle (11647794), Doug Burdette (8379867), Jeremy C. Burns (9903441), Luisette Delva (11647797), Douglas Donaldson (6387041), Richard Grater (11647800), Chungang Gu (1638805), Marc Hoemberger (11647803), Josh Johnson (831725), Sudarshan Kapadnis (3829360), Kris King (11647806), Mukesh Lulla (11647809), Bin Ma (219839), Isaac Marx (11647812), Tom Magee (11647815), Robert Meissner (384997), Claire M. Metrick (9214871), Michael Mingueneau (4182721), Paramasivam Murugan (8042474), Kevin L. Otipoby (9214862), Evelyne Polack (9025907), Urjana Poreci (9214874), Robin Prince (11647818), Allie M. Roach (11647821), Chris Rowbottom (11647824), Joseph C. Santoro (8042477), Patricia Schroeder (647768), Hao Tang (44155), Eric Tien (424500), Fengmei Zhang (836324), Joseph Lyssikatos (1577434)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Genetics, Neuroscience, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, treating autoimmune diseases, tolerability profile suitable, important phosphorylation site, high potency molecule, central nervous system, axonal injury leading, superior safety profiles, inflammation processes leading, selective btk inhibitor, highly selective, reversible inhibitor, unmet need, sequester tyr, primary driver, preclinical characterization, like properties, inactive conformation, good drug, excellent affinity

Relation: https://figshare.com/articles/journal_contribution/Discovery_and_Preclinical_Characterization_of_BIIB091_a_Reversible_Selective_BTK_Inhibitor_for_the_Treatment_of_Multiple_Sclerosis/16930248

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c00926.s001

المؤلفون: J. Howard Jones (2684047), Zhili Xin (1909210), Martin Himmelbauer (1297380), Michael Dechantsreiter (8774891), Istvan Enyedy (2276035), Joseph Hedde (11571227), Terry Fang (10922918), Janaky Coomaraswamy (195660), Kristopher W. King (8681439), Paramasivam Murugan (8042474), Joseph C. Santoro (8042477), Thomas Hesson (8042480), Dirk M. Walther (11571230), Ru Wei (230834), Fengmei Zheng (2706133), Douglas J. Marcotte (8042471), Kerri Spilker (8042483), P. Rajesh Kumar (10744823), Ying Liu (18461), Rab Gilfillan (8042486), Felix Gonzalez-Lopez de Turiso (1692955)

مصطلحات موضوعية: Biochemistry, Microbiology, Cell Biology, Molecular Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Immunology, Cancer, Mental Health, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, transgenic animals treated, thus confirming inhibition, previously reported inhibitor, inflammatory markers (<, human tau transgenic, central nervous system, cellular stress response, uu , u , 50 , regulating kinase 1, 32 , penetrant apoptosis signal, modulate brain inflammation, selective ask1 inhibitor, vivo <

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Potent_Selective_and_Brain-Penetrant_Apoptosis_Signal-Regulating_Kinase_1_ASK1_Inhibitors_that_Modulate_Brain_Inflammation_i_In_Vivo_i_/16821287

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01458.s001

المؤلفون: Bin Ma, Urjana Poreci, Luisette Delva, Fengmei Zhang, Hao Tang, Tonika Bohnert, Patricia Schroeder, Richard Grater, Sudarshan Kapadnis, Kris King, Michael Mingueneau, Marc Hoemberger, Evelyne Polack, Brian T. Hopkins, Prince Robin, Chris Rowbottom, Robert Meissner, Eris Bame, Joseph C Santoro, Paramasivam Murugan, Allie M Roach, Claire M. Metrick, Kevin L. Otipoby, Eric Tien, Josh Johnson, Douglas Donaldson, Joseph P. Lyssikatos, Doug Burdette, Tom Magee, Carrie Boiselle, Chungang Gu, Mukesh Lulla, Bekim Bajrami, Jeremy C. Burns, Cheryl Black, Marx Isaac

المصدر: Journal of medicinal chemistry. 65(2)

مصطلحات موضوعية: Male, Phosphorylation sites, Multiple Sclerosis, Central nervous system, Inflammation, Unmet needs, Rats, Sprague-Dawley, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Tissue Distribution, Protein Kinase Inhibitors, biology, Chemistry, Multiple sclerosis, medicine.disease, Rats, Atp competitive, Macaca fascicularis, medicine.anatomical_structure, Tolerability, Cancer research, biology.protein, Molecular Medicine, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73da50c6f550d3e41002d416b5cebb6
https://pubmed.ncbi.nlm.nih.gov/34734694

المؤلفون: Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins

المصدر: Bioorganicmedicinal chemistry letters. 60

مصطلحات موضوعية: B-Lymphocytes, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Piperazines, Structure-Activity Relationship, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Molecular Medicine, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bd32b8fdba50b6f9d163e6c24a3190
https://pubmed.ncbi.nlm.nih.gov/35728998

المؤلفون: Terry Fang, Rab Gilfillan, Janaky Coomaraswamy, Dirk M. Walther, Martin K Himmelbauer, Zhili Xin, Kerri Spilker, Douglas Marcotte, Joseph C Santoro, Thomas Hesson, Istvan J. Enyedy, Ru Wei, Felix Gonzalez-Lopez de Turiso, J Howard Jones, Michael Dechantsreiter, Zheng Fengmei, Kristopher W King, Ying Liu, Paramasivam Murugan, P Rajesh Kumar, Joseph Hedde

المصدر: Journal of medicinal chemistry. 64(20)

مصطلحات موضوعية: Transgene, Cell, Central nervous system, Inflammation, Mice, Transgenic, Pharmacology, MAP Kinase Kinase Kinase 5, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, ASK1, Protein Kinase Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, Brain, Rats, medicine.anatomical_structure, Apoptosis, Molecular Medicine, Pyrazoles, medicine.symptom

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bdc613fadb1b6767798fc40d289b98
https://pubmed.ncbi.nlm.nih.gov/34653340

المؤلفون: Kerri Spilker, K. Michelsen, E.A. Peterson, P.R. Kumar, I.J. Enyedy, Tricia L. May-Dracka, T. Chen, Claire M. Metrick, Jayanth V. Chodaparambil, Paramasivam Murugan, M. Cullivan, Joseph C Santoro

المصدر: Nature Chemical Biology. 16:391-399

مصطلحات موضوعية: chemistry.chemical_classification, Phospholipase D, Drug discovery, Cell Biology, Phosphatidic acid, Isozyme, Homology (biology), chemistry.chemical_compound, Enzyme, chemistry, Biochemistry, Structure–activity relationship, Molecular Biology, Peptide sequence

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dd624fa65f9f8feb8d5b46db73fcc6af
https://doi.org/10.1038/s41589-019-0458-4

المؤلفون: Bin Ma, Claire M. Metrick, Chungang Gu, Marc Hoemberger, Bekim Bajrami, Eris Bame, Jiansheng Huang, Michael Mingueneau, Paramasivam Murugan, Marta Nevalainen, Joseph C. Santoro, Hao Tang, Ti Wang, Brian T. Hopkins

المصدر: Bioorganic & Medicinal Chemistry Letters. 72:128856

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a2269328ef74fb6f1cdf55f7c5dd90de
https://doi.org/10.1016/j.bmcl.2022.128856

المؤلفون: Jing Zhu, Xiaomei Peng, Alex Pellerin, Brian T. Hopkins, Dipen Sangurdekar, Michael Mingueneau, Urjana Poreci, Eris Bame, Joseph C Santoro, Prince Robin, Katherine Riester, Mike Palte, Allie M Roach, Klaus Michelsen, Bin Ma, Hao Tang, Million Arefayene, Stephen J Rubino, Devangi Mehta, Fergal Casey, Patrick Cullen, Patrick Trapa, Bekim Bajrami, Thomas M. Carlile, Davide Gianni, Marx Isaac, Douglas Donaldson, Baohong Zhang, Jeremy C. Burns, Param Muragan, Alex Coppell, Shibeshih Belachew, Nathalie Franchimont, Matthew Scaramozza

المصدر: Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 6, Pp n/a-n/a (2021)

مصطلحات موضوعية: 0301 basic medicine, Myeloid, Immunology, Antigen presentation, B-cell receptor, Fc receptor, multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, Bruton's tyrosine kinase, General Nursing, B cell, B cells, biology, B‐cell receptor, Chemistry, BTK inhibitor, Germinal center, Original Articles, RC581-607, 030104 developmental biology, medicine.anatomical_structure, myeloid cells, biology.protein, Cancer research, Original Article, Immunologic diseases. Allergy, Tyrosine kinase, 030215 immunology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188cf6754afaaa237193991f00885497
https://doi.org/10.1002/cti2.1295

المؤلفون: Zhili Xin, Douglas Marcotte, Joseph C Santoro, Rab Gilfillan, J Howard Jones, Thomas Hesson, Istvan J. Enyedy, Martin K Himmelbauer, Paramasivam Murugan, Felix Gonzalez-Lopez de Turiso, Kristopher W King

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: 010405 organic chemistry, Kinase, Organic Chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Cns penetration, Cell biology, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Mediator, chemistry, Apoptosis, Cellular stress response, Drug Discovery, ASK1, Penetrant (biochemical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca9a306448f636bdc3b87bc3cb5c746
https://europepmc.org/articles/PMC7153032/

المؤلفون: Thomas Hesson, Istvan J. Enyedy, Kristopher W King, Martin K Himmelbauer, Joseph C. Santoro, Paramasivam Murugan, J. Howard Jones, Joshua L Johnson, Felix Gonzalez-Lopez de Turiso, Kerri Spilker, Douglas Marcotte, Rab Gilfillan, Zhili Xin, Michael Joseph Luzzio

المصدر: Journal of medicinal chemistry. 62(23)

مصطلحات موضوعية: Macrocyclic Compounds, Cell, MAP Kinase Kinase Kinase 5, 01 natural sciences, 03 medical and health sciences, In vivo, Drug Discovery, medicine, Animals, Humans, ASK1, 030304 developmental biology, 0303 health sciences, Molecular Structure, Kinase, Chemistry, Rational design, Brain, 0104 chemical sciences, Cell biology, Rats, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Protein kinase domain, Apoptosis, Drug Design, Microsomes, Liver, Molecular Medicine, Efflux

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150776d7925313644d75434a3c742926
https://pubmed.ncbi.nlm.nih.gov/31710475

المؤلفون: Marco Mattu, Carl P. Sparrow, Matthew J. Bottomley, Joseph C. Santoro, Lionello Ruggeri, Fabio Talamo, Paola Lo Surdo, Jennifer Baysarowich, Richard T. Cummings, Rose M. Cubbon, Raffaele De Francesco, Laura Orsatti, Ayesha Sitlani, Alessandra Calzetta, Andrea Carfi, A. Noto, Timothy S. Fisher, Agostino Cirillo

المصدر: Journal of Biological Chemistry. 284:1313-1323

مصطلحات موضوعية: Models, Molecular, EGF-like domain, Molecular Sequence Data, Mutant, Familial hypercholesterolemia, Crystallography, X-Ray, Biochemistry, Cell Line, Hyperlipoproteinemia Type II, medicine, Humans, Amino Acid Sequence, Protein Structure, Quaternary, Molecular Biology, Chemistry, Hydrogen bond, PCSK9, Serine Endopeptidases, Wild type, Cell Biology, medicine.disease, Molecular biology, Protein Structure, Tertiary, Receptors, LDL, Mutation, LDL receptor, Proprotein Convertases, Salt bridge, Proprotein Convertase 9, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79deb7f15c827e7acb5cff540bbd397
https://doi.org/10.1074/jbc.m808363200

المؤلفون: Timothy S. Fisher, Rose M. Cubbon, Carl P. Sparrow, Joseph C. Santoro, Vijayalakshmi Ramakrishnan, Sookhee Ha, Douglas Wisniewski, Shilpa Pandit, Samuel D. Wright, Richard T. Cummings, Ayesha Sitlani

المصدر: Journal of Lipid Research, Vol 49, Iss 6, Pp 1333-1343 (2008)

مصطلحات موضوعية: PCSK9, Mutant, Mutagenesis (molecular biology technique), LDL receptor, Cell Biology, Familial hypercholesterolemia, QD415-436, Biology, Proprotein convertase, medicine.disease, Biochemistry, In vitro, LDL, Endocrinology, proprotein convertase subtilisin/kexin type 9, medicine, Kexin, lipids (amino acids, peptides, and proteins)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbf3b2a77a614fe54ef7b0cdac3874c
http://www.sciencedirect.com/science/article/pii/S0022227520423776

المؤلفون: Joseph C. Santoro, Marco Mattu, Carl P. Sparrow, Anil Tarachandani, Raffaele De Francesco, Douglas Wisniewski, Samuel D. Wright, Paola Lo Surdo, Rose M. Cubbon, Shilpa Pandit, Timothy S. Fisher, Ayesha Sitlani, Richard T. Cummings, Paul A. Fischer, Andrea Carfi, Alessandra Calzetta

المصدر: Journal of Biological Chemistry. 282:20502-20512

مصطلحات موضوعية: Low-density lipoprotein receptor gene family, Endosome, Hypercholesterolemia, Mutation, Missense, CHO Cells, Biology, Models, Biological, Biochemistry, Cell Line, chemistry.chemical_compound, Cricetulus, Cricetinae, medicine, Animals, Humans, Molecular Biology, Genes, Dominant, PCSK9, Chinese hamster ovary cell, Serine Endopeptidases, Genetic Diseases, Inborn, Cell Biology, medicine.disease, Molecular biology, Lipoproteins, LDL, Hypocholesterolemia, Receptors, LDL, chemistry, Low-density lipoprotein, LDL receptor, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9, Lysosomes, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a911a86c95d8b22fe88b633d55b647
https://doi.org/10.1074/jbc.m701634200

المؤلفون: Christopher F. Thompson, Silvi Luell, Milton L. Hammond, Dennis M. Zaller, James M. Balkovec, Chuanlin Wang, Amjad Ali, Michael J. Forrest, Shilpa Pandit, Nazia Quraishi, Georgianna Harris, Edward A. O'Neill, Lan Ge, Ting-Ting Yamin, Monica Einstein, Ralph T. Mosley, Terri M. Kelly, Douglas K. Miller, Ayesha Sitlani, Joseph C. Santoro, Joanne M. Williamson, Ester Carballo-Jane, James R. Tata, Chris M. Thompson, Paul Mazur

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3354-3361

مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pyrazole, Ligands, Biochemistry, Chemical synthesis, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Glucocorticoids, Molecular Biology, Transrepression, Bicyclic molecule, Organic Chemistry, Models, Chemical, chemistry, Pyrazoles, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db11f5478513867bd52ccaf5fe7eea86
https://doi.org/10.1016/j.bmcl.2007.03.103

المؤلفون: Georgianna Harris, Ayesha Sitlani, Joseph C. Santoro

المصدر: Analytical Biochemistry. 289:18-25

مصطلحات موضوعية: medicine.medical_specialty, Biophysics, Biology, Biochemistry, Catalysis, Dexamethasone, Cell Line, Receptors, Glucocorticoid, Glucocorticoid receptor, Glutamate-Ammonia Ligase, Internal medicine, Glutamine synthetase, medicine, Animals, Potency, Muscle, Skeletal, Molecular Biology, Reproducibility of Results, Skeletal muscle, gamma-Glutamyltransferase, Cell Biology, Mifepristone, Rats, medicine.anatomical_structure, Endocrinology, Prednisolone, Colorimetry, Glucocorticoid, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b636de183f5ad30cb63617a50a7ecb4
https://doi.org/10.1006/abio.2000.4911

المؤلفون: Robert A. Gramzinski, Heather L. Davis, Joel R. Haynes, Michael J. McCluskie, Joseph C. Santoro, James T. Fuller, Robert H. Purcell, Cynthia L. Brazolot Millan, Georg Widera, Harriet L. Robinson

المصدر: Molecular Medicine. 5:287-300

مصطلحات موضوعية: HBsAg, biology, business.industry, Gene gun, DNA vaccination, Route of administration, Titer, Immune system, Immunology, Genetics, biology.protein, Molecular Medicine, Medicine, Nasal administration, Antibody, business, Molecular Biology, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::51b511890a8147d0709a814b9360545c
https://doi.org/10.1007/bf03402065

المؤلفون: Roberto Fernandez-Larsson, Joseph C. Santoro, Maryellen O'connell, Joan F. L. Richmond, Jiayu Weng, Eva Maria Fenyö, Harriet L. Robinson, Shan Lu, Eric A. Johnson, Robert Fredriksson, Farah Mustafa

المصدر: Virology. 229(1):269-278

مصطلحات موضوعية: Male, viruses, Molecular Sequence Data, Human immunodeficiency virus (HIV), HIV Envelope Protein gp120, medicine.disease_cause, Virus Replication, Plasmid, Virology, medicine, Env Glycoproteins, Humans, Amino Acid Sequence, Cloning, Molecular, AIDS Vaccines, Syncytium, biology, Immunogenicity, env Gene Products, Human Immunodeficiency Virus, Gene Products, env, virus diseases, Phenotype, Titer, biology.protein, HIV-1, Antibody, Plasmids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50cdbb130d018fc0a2658216717f3d5

المؤلفون: Robert G. Webster, Ellen F. Fynan, Deborah H. Fuller, Harriet L. Robinson, Joseph C. Santoro, Joel R. Haynes

المصدر: International Journal of Immunopharmacology. 17:79-83

مصطلحات موضوعية: Immunology, Orthomyxoviridae, Hemagglutinins, Viral, Hemagglutinin (influenza), Hemagglutinin Glycoproteins, Influenza Virus, Transfection, Virus, DNA vaccination, Gene gun, Mice, Orthomyxoviridae Infections, Viral Envelope Proteins, Animals, Pharmacology, Vaccines, biology, Vaccination, Genetic transfer, biology.organism_classification, Virology, Retroviridae, Immunization, DNA, Viral, biology.protein, Chickens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab0d8c86893e454f185b5c2cde3940e
https://doi.org/10.1016/0192-0561(94)00090-b

المؤلفون: Joseph C. Santoro, Rajiv Shukla, Omar F Laterza, Florent C. Bender

المصدر: Journal of immunological methods. 390(1-2)

مصطلحات موضوعية: Immunoassay, Inflammation, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Interleukins, Immunology, Reproducibility of Results, Pharmacology, Reference Standards, medicine.disease, Inflammatory bowel disease, Sensitivity and Specificity, Interleukin 22, Cytokine, Psoriasis, Pharmacodynamics, Rheumatoid arthritis, medicine, Immunology and Allergy, Biomarker (medicine), Humans, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3cee0afac41ad8daef020443f943cd
https://pubmed.ncbi.nlm.nih.gov/23313291