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1Academic Journal
المؤلفون: Kathleen M Gillooly, Claudine Pulicicchio, Mark A Pattoli, Lihong Cheng, Stacey Skala, Elizabeth M Heimrich, Kim W McIntyre, Tracy L Taylor, Daniel W Kukral, Shailesh Dudhgaonkar, Jignesh Nagar, Dana Banas, Scott H Watterson, Joseph A Tino, Aberra Fura, James R Burke
المصدر: PLoS ONE, Vol 12, Iss 7, p e0181782 (2017)
وصف الملف: electronic resource
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المؤلفون: Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng
المصدر: Journal of Medicinal Chemistry. 65:4291-4317
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Mian Gao, David J. Shuster, Hai-Yun Xiao, Christine B. Goldstine, Jing Chen, Zhonghui Lu, Victor R. Guarino, Khehyong Ngu, Lisa M. Kopcho, Deepa Calambur, Kurt R. Gregor, Andrew J. Tebben, Jingwu Duan, Luisa Salter-Cid, Hao Lu, Joseph A. Tino, Ning Li, John Hynes, James R. Burke, Joseph Yanchunas, John E. Macor, Steven Sheriff, Dauh-Rurng Wu, Bin Jiang, Patrick J. Shaw, ChiehYing Y. Chang, Jenny Xie, Vojkan Susulic, T. G. Murali Dhar
المصدر: Journal of Medicinal Chemistry. 63:15050-15071
مصطلحات موضوعية: Arthritis, Trimer, Proof of Concept Study, 01 natural sciences, Arthritis, Rheumatoid, Structure-Activity Relationship, 03 medical and health sciences, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Naphthyridines, 030304 developmental biology, 0303 health sciences, Molecular Structure, Tumor Necrosis Factor-alpha, Chemistry, medicine.disease, Arthritis, Experimental, Small molecule, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Drug Design, Microsomes, Liver, Quinolines, Biophysics, Molecular Medicine, Female, Tumor necrosis factor alpha
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4
المؤلفون: Tara Sherry, John E. Macor, Jinhong Wang, Georgia Cornelius, Shiuhang Yip, Luisa Salter-Cid, Qingjie Liu, Purnima Khandelwal, Carolyn A. Weigelt, Max Ruzanov, John S. Sack, Kevin Stefanski, Jenny Xie, T. G. Murali Dhar, Sha Li, Melissa Yarde, Joseph A. Tino, Qihong Zhao, Dauh-Rurng Wu, Mary T. Obermeier, David J. Shuster, Aberra Fura, Douglas G. Batt, Rex Denton
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: chemistry.chemical_classification, Virtual screening, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Prodrug, Cyclohexanecarboxylic acid, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, RAR-related orphan receptor gamma, Drug Discovery, Moiety, Inverse agonist, Solubility, Tricyclic
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المؤلفون: Dauh-Rurng Wu, Joseph Pawluczyk, Robert J. Cherney, Joseph A. Tino, Shiuhang Yip, T. G. Murali Dhar, James Kempson, Jianqing Li, Darpandeep Aulakh, Amy A. Sarjeant, Daniel Smith, Arvind Mathur, Cornelius Lyndon A M, Subramaniam Krishnananthan
المصدر: The Journal of Organic Chemistry. 85:10988-10993
مصطلحات موضوعية: Tert butyl, 010405 organic chemistry, Chemistry, Organic Chemistry, Synthon, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, Enol, 0104 chemical sciences, chemistry.chemical_compound, Inverse agonist, Stereoselectivity, Methylcyclohexane, Trifluoromethanesulfonate, Derivative (chemistry)
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المؤلفون: Carolyn A. Weigelt, Sha Li, David Marcoux, Georgia Cornelius, Qihong Zhao, Mary Ellen Cvijic, John E. Macor, Jingwu Duan, Melissa Yarde, Muthalagu Vetrichelvan, David J. Shuster, Qingjie Liu, Richard Rampulla, Kim W. McIntyre, Mary T. Obermeier, Shiuhang Yip, Purnima Khandelwal, Sureshbabu Vishwakrishnan, Anuradha Gupta, Virna Borowski, Peng Li, Kevin Stefanski, Sridharan Ramlingam, Myra Beaudoin-Bertrand, Nageswara Maddala, Sridhar Vanteru, Percy H. Carter, Arvind Mathur, Aberra Fura, Max Ruzanov, John Hynes, Dauh-Rurng Wu, Jinhong Wang, Luisa Salter-Cid, John S. Sack, Cornelius Lyndon A M, Anurag S. Srivastava, Robert J. Cherney, Kumaravel Selvakumar, Mushkin Basha, Arun Kumar Gupta, Douglas G. Batt, Rex Denton, Sukhen Karmakar, Qing Shi, Ananta Karmakar, Naveen Manjunath, Javed Khan, Jenny Xie, Joseph A. Tino, T. G. Murali Dhar
المصدر: Journal of Medicinal Chemistry. 62:9931-9946
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Drug Inverse Agonism, Protein Conformation, Pharmacology, 01 natural sciences, Jurkat Cells, Mice, Structure-Activity Relationship, 03 medical and health sciences, Psoriatic arthritis, RAR-related orphan receptor gamma, In vivo, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Structure–activity relationship, Tissue Distribution, 030304 developmental biology, 0303 health sciences, Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, medicine.disease, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Nuclear receptor, Drug Design, Molecular Medicine
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المؤلفون: Scott H. Watterson, Joseph A. Tino
المصدر: 2020 Medicinal Chemistry Reviews ISBN: 9781734427400
2020 Medicinal Chemistry Reviewsمصطلحات موضوعية: Biochemistry, Covalent bond, Btk inhibitors, Chemistry, Non covalent
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المؤلفون: Lyndon A M, Cornelius, Jianqing, Li, Daniel, Smith, Subramaniam, Krishnananthan, Shiuhang, Yip, Dauh-Rurng, Wu, Joseph, Pawluczyk, Darpandeep, Aulakh, Amy A, Sarjeant, James, Kempson, Joseph A, Tino, Arvind, Mathur, T G, Murali Dhar, Robert J, Cherney
المصدر: The Journal of organic chemistry. 85(16)
مصطلحات موضوعية: Cyclohexanes, Carboxylic Acids, Esters, Stereoisomerism
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المؤلفون: Soo S. Ko, James Kempson, Yingru Zhang, Tracy L. Taylor, Kim W. McIntyre, James R. Burke, Luisa Salter-Cid, Shiuhang Yip, Celia D’Arienzo, Aberra Fura, Stacey Skala, Joseph A. Tino, Jun Dai, Chunlei Wang, Joel C. Barrish, Michael Galella, Kathleen M. Gillooly, Bei Wang, Dauh-Rurng Wu, Lorell Discenza, Xiaoping Hou, Arvind Mathur, Richard Rampulla, Dawn Sun, Scott H. Watterson, Mary T. Obermeier, Percy H. Carter, Mark A. Pattoli, Anurag S. Srivastava, Lihong Cheng, Rulin Zhao, Peng Li, Claudine Pulicicchio, Joseph Pawluczyk, Rodney Vickery
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Autoimmune disease, Atropisomer, biology, Stereochemistry, Carbazole, Organic Chemistry, medicine.disease, Biochemistry, Small molecule, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, biology.protein, Bruton's tyrosine kinase, Kinase activity, Chirality (chemistry), Tyrosine kinase
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المؤلفون: Peng Li, Shiuhang Henry Yip, Dawn Sun, Rulin Zhao, Scott H. Watterson, Arvind Mathur, Dauh-Rurng Wu, Joseph A. Tino
المصدر: Journal of Chromatography A. 1586:106-115
مصطلحات موضوعية: Stereochemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Humans, Bruton's tyrosine kinase, Protein Kinase Inhibitors, Clinical treatment, Atropisomer, Chromatography, biology, Chemistry, Carbazole, 010401 analytical chemistry, Organic Chemistry, Chromatography, Supercritical Fluid, Stereoisomerism, General Medicine, 0104 chemical sciences, biology.protein, Supercritical fluid chromatography, Separation method, Tyrosine kinase, Bruton's tyrosine kinase inhibitor
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المؤلفون: John Hynes, Joseph A. Tino, Qihong Zhao, Hyunsoo Park, David Marcoux, Jinhong Wang, Sha Li, Melissa Yarde, Michael Galella, Dauh-Rurng Wu, Shiuhang Yip, T. G. Murali Dhar, Myra Beaudoin Bertrand, Mary Ellen Cvijic, Carolyn A. Weigelt
المصدر: Bioorganicmedicinal chemistry letters. 30(19)
مصطلحات موضوعية: Annulation, Drug Inverse Agonism, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hydrocarbons, Cyclic, 01 natural sciences, Biochemistry, Pyrrolidine, chemistry.chemical_compound, Mice, Structure-Activity Relationship, RAR-related orphan receptor gamma, Drug Discovery, Inverse agonist, Animals, Humans, Sulfones, Molecular Biology, chemistry.chemical_classification, Orphan receptor, Chemotype, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, Amides, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Retinoic acid receptor, chemistry, Cyclization, Microsomes, Liver, Molecular Medicine, Tricyclic
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المؤلفون: Qingjie Liu, Mary T. Obermeier, John S. Sack, Carolyn A. Weigelt, Georgia Cornelius, Percy H. Carter, David J. Shuster, Luisa Salter-Cid, Aberra Fura, Virna Borowski, Jingwu Duan, Purnima Khandelwal, Qing Shi, Robert J. Cherney, Cornelius Lyndon A M, Jinhong Wang, Jenny Xie, Max Ruzanov, Kevin Stefanski, Rex Denton, T. G. Murali Dhar, David Marcoux, Shiuhang Yip, Melissa Yarde, Douglas G. Batt, Javed Khan, Joseph A. Tino, Qihong Zhao, Anurag S. Srivastava, Arvind Mathur, Mary Ellen Cvijic, John E. Macor, Sha Li, Dauh-Rurng Wu
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, Inflammation, Acanthosis, Pharmacology, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Pharmacokinetics, Pharmacodynamics, Drug Discovery, medicine, Inverse agonist, medicine.symptom, Whole blood, Tricyclic
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المؤلفون: James R. Burke, Matthew B. Robers, James D Vasta, H. Ribeiro, B. Arey, G. Locke, Jonathan Lippy, Charu Chaudhry, Joseph A. Tino, Mark A. Pattoli, Stacey Skala, Andrew J. Tebben, Lixia Zhang, L. L. Ong, Scott H. Watterson, L. Monereau, Poncho Meisenheimer
المصدر: SLAS discovery : advancing life sciences RD. 25(2)
مصطلحات موضوعية: 0301 basic medicine, Cell signaling, 01 natural sciences, Biochemistry, Analytical Chemistry, 03 medical and health sciences, Agammaglobulinaemia Tyrosine Kinase, Fluorescence Resonance Energy Transfer, Bruton's tyrosine kinase, Structure–activity relationship, Humans, Kinase activity, Phosphorylation, Protein Kinase Inhibitors, biology, 010405 organic chemistry, Chemistry, Kinase, Phenotype, 0104 chemical sciences, Cell biology, High-Throughput Screening Assays, Kinetics, 030104 developmental biology, biology.protein, Molecular Medicine, Tyrosine kinase, Intracellular, Biotechnology
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المؤلفون: Richard Rampulla, Stacey Skala, Charu Chaudhry, Percy H. Carter, Alban Allentoff, Tracy L. Taylor, Ling Li, Andrew J. Tebben, Luisa Salter-Cid, Aberra Fura, Rulin Zhao, Ian M. Catlett, Richard A. Westhouse, Myra Beaudoin Bertrand, John E. Macor, Robin Moore, Celia D’Arienzo, Matt Pokross, Douglas G. Batt, Scott H. Watterson, Mary T. Obermeier, Qingjie Liu, Daniel Smith, Lorell Discenza, Michael Galella, Jun Dai, Arvind Mathur, Kathleen M. Gillooly, Elizabeth M. Heimrich, Jianqing Li, Zheng Yang, Michael Wallace, Kim W. McIntyre, James R. Burke, Mark A. Pattoli, Joseph A. Tino, Lihong Cheng, Naiyu Zheng, Rodney Vickery, Claudine Pulicicchio, Yifan Zhang, Qian Ruan, Paul A. Elzinga
المصدر: Journal of medicinal chemistry. 62(7)
مصطلحات موضوعية: Indoles, B-cell receptor, 01 natural sciences, Arthritis, Rheumatoid, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Piperidines, immune system diseases, In vivo, hemic and lymphatic diseases, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Lupus Erythematosus, Systemic, Receptor, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, biology, Dose-Response Relationship, Drug, Kinase, Drug discovery, Chemistry, breakpoint cluster region, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Cancer research, biology.protein, Molecular Medicine, Tyrosine kinase
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المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Stacey Skala, Paul Davies, Jenny Xie, John S. Sack, T. G. Murali Dhar, Melissa Yarde-Chinn, James Neels, Michael A. Poss, Stefan Ruepp, Robert J. Cherney, Christine Goldstein, Joseph A. Tino, Luisa Salter-Cid, Kevin Stefanski, Vojkan Susulic, Rajeev S. Bhide, Xiaoxia Yang, Anurag S. Srivastava, Zheming Ruan, Lan-Ying Qin, Cornelius Lyndon A M, Ruth Bosnius
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:855-861
مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Piperazines, Autoimmune Diseases, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, In vivo, Drug Discovery, Animals, Humans, Protein Isoforms, Amines, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Amine derivatives, Binding Sites, Triazines, Organic Chemistry, Alternative treatment, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Lead compound
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المؤلفون: Jun Dai, Arvind Mathur, Lihong Cheng, Kim W. McIntyre, Dawn Sun, Joseph A. Tino, Shiuhang Yip, Douglas G. Batt, Jodi K. Muckelbauer, James R. Burke, Joel C. Barrish, Rodney Vickery, Celia D’Arienzo, Luisa Salter-Cid, Qingjie Liu, Tracy L. Taylor, Hua Gong, Mark A. Pattoli, Elizabeth M. Heimrich, Yingru Zhang, Andy J. Tebben, Myra Beaudoin Bertrand, Kathleen M. Gillooly, Chiehying Chang, Percy H. Carter, Scott H. Watterson, Mary T. Obermeier, Claudine Pulicicchio, Aberra Fura, Chunlei Wang, Michael Galella, Charles M. Langevine, Sarah C. Traeger, Lorell Discenza, Peng Li, Yifan Zhang, Qing Shi, Stacey Skala, Dauh-Rurng Wu, Richard Rampulla, George V. De Lucca
المصدر: Journal of Medicinal Chemistry. 59:9173-9200
مصطلحات موضوعية: 0301 basic medicine, Atropisomer, biology, 010405 organic chemistry, medicine.drug_class, Kinase, Chemistry, Stereochemistry, B-cell receptor, Carboxamide, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, immune system diseases, hemic and lymphatic diseases, Drug Discovery, medicine, biology.protein, Molecular Medicine, Structure–activity relationship, Bruton's tyrosine kinase, Transferase, Tyrosine kinase
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المؤلفون: Georgia Cornelius, Carolyn A. Weigelt, Sha Li, Dauh-Rurng Wu, David Marcoux, Luisa Salter-Cid, Aberra Fura, Melissa Yarde, Shiuhang Yip, Peng Li, John Hynes, Tara Sherry, Max Ruzanov, Rex Denton, Robert J. Cherney, Yue-Zhong Shu, Jinhong Wang, Mary Ellen Cvijic, Zili Xiao, David J. Shuster, Jenny Xie, Purnima Khandelwal, Kevin Stefanski, T. G. Murali Dhar, Qing Shi, Yang Michael G, Mary T. Obermeier, Silvi A. Chacko, Javed Khan, John S. Sack, Joseph A. Tino, Qihong Zhao
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127521
مصطلحات موضوعية: Male, Drug Inverse Agonism, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Melanosis, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, Animals, Inverse agonist, Sulfones, Molecular Biology, chemistry.chemical_classification, Mice, Inbred BALB C, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Interleukin-18, Late stage, Regioselectivity, Nuclear Receptor Subfamily 1, Group F, Member 3, Combinatorial chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female, Heterocyclic Compounds, 3-Ring, Protein Binding, Tricyclic
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المؤلفون: Jonathan Lippy, Joseph A. Tino, Qingjie Liu, Mark A. Pattoli, Songmei Xu, James R. Burke, Charu Chaudhry, Percy H. Carter, Douglas G. Batt, Neha Surti
المصدر: Bioorganicmedicinal chemistry letters. 28(18)
مصطلحات موضوعية: Models, Molecular, Indoles, medicine.drug_class, Clinical Biochemistry, Carbazoles, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Humans, Molecular Biology, Protein Kinase Inhibitors, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Carbazole, Btk inhibitors, Organic Chemistry, Combinatorial chemistry, 0104 chemical sciences, chemistry, 030220 oncology & carcinogenesis, Lipophilicity, Electrophile, biology.protein, Molecular Medicine, Selectivity
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المؤلفون: Matt Pokross, Jonathan Lippy, Qingjie Liu, Yongmi An, Chiehying Chang, Joseph A. Tino, James R. Burke, Andrew J. Tebben, Zheng Yang, Lin Chen, Douglas G. Batt, Jodi K. Muckelbauer, Percy H. Carter, Neha Surti, Haiqing Wang
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:4265-4269
مصطلحات موضوعية: Clinical Biochemistry, Carbazoles, Pharmaceutical Science, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Protein-Tyrosine Kinases, Humans, Structure–activity relationship, Bruton's tyrosine kinase, Protein Kinase Inhibitors, Molecular Biology, Janus kinase 2, Dose-Response Relationship, Drug, Molecular Structure, biology, Carbazole, Organic Chemistry, Janus Kinase 2, Amides, chemistry, Drug Design, biology.protein, Molecular Medicine, Tyrosine kinase
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المؤلفون: Joseph A. Tino, Dana Banas, Jignesh Nagar, Claudine Pulicicchio, Kathleen M. Gillooly, Aberra Fura, Daniel W. Kukral, Mark A. Pattoli, Kim W. McIntyre, Scott H. Watterson, James R. Burke, Lihong Cheng, Tracy L. Taylor, Shailesh Dudhgaonkar, Stacey Skala, Elizabeth M. Heimrich
المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181782 (2017)مصطلحات موضوعية: 0301 basic medicine, B Cells, Physiology, medicine.medical_treatment, Arthritis, lcsh:Medicine, Osteoclasts, medicine.disease_cause, Biochemistry, Autoimmunity, Etanercept, White Blood Cells, 0302 clinical medicine, Animal Cells, Immune Physiology, Medicine and Health Sciences, Agammaglobulinaemia Tyrosine Kinase, Enzyme-Linked Immunoassays, lcsh:Science, Innate Immune System, B-Lymphocytes, Mice, Inbred BALB C, Multidisciplinary, Immune System Proteins, biology, Animal Models, Protein-Tyrosine Kinases, Body Fluids, Cytokine, Blood, Experimental Organism Systems, Rheumatoid arthritis, Cytokines, Female, Bone Remodeling, Cellular Types, Anatomy, Tyrosine kinase, medicine.drug, Research Article, Immune Cells, Immunology, Mouse Models, Rheumatoid Arthritis, Research and Analysis Methods, Antibodies, Autoimmune Diseases, 03 medical and health sciences, Model Organisms, Rheumatology, medicine, Bruton's tyrosine kinase, Animals, Humans, Bone Resorption, Antibody-Producing Cells, Immunoassays, Protein Kinase Inhibitors, 030203 arthritis & rheumatology, Blood Cells, business.industry, lcsh:R, RANK Ligand, Biology and Life Sciences, Proteins, Cell Biology, Molecular Development, medicine.disease, Arthritis, Experimental, 030104 developmental biology, Immune System, Antibody Formation, biology.protein, Cancer research, Immunologic Techniques, Leukocytes, Mononuclear, Methotrexate, lcsh:Q, Clinical Immunology, Clinical Medicine, business, Physiological Processes, Developmental Biology