المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Reducing_i_EGFRAP_i_levels_in_Ras_sup_V12_sup_wing_discs_increases_the_ability_of_tumor_cells_to_migrate_into_surrounding_wild-type_tissue_/15450588

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s003

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Downregulation_of_i_EGFRAP_i_in_Ras_sup_V12_sup_tumor_cells_does_not_alter_the_distribution_of_polarity_markers_such_as_Dlg_and_aPKC_/15450594

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s004

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Reducing_i_EGFRAP_i_levels_in_a_narrow_region_of_the_wing_disc_increases_Ras_sup_V12_sup_-dependent_tissue_hyperplasia_/15450558

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s001

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/_i_EGFRAP_i_sup_L_sup_and_i_EGFRAP_i_sup_SH2_sup_behave_as_i_EGFRAP_i_sup_L_S_sup_in_their_ability_to_synergize_with_i_Ras_i_sup_i_V12_i_sup_to_drive_hyperplasia_in_wing_imaginal_discs_/15450606

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s005

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_2K_/15450651

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s010

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_2L_/15450654

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s011

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/_i_EGFRAP_i_Knock_down_enhances_top-associated_tissue_hyperplasia_in_i_Drosophila_i_wing_imaginal_discs_/15450630

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s008

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Expression_and_requirement_of_EGFRAP_in_i_Drosophila_i_eye_imaginal_discs_/15450621

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s007

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_2J_/15450648

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s009

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_3D_/15450663

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s012

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_7D_/15450705

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s016

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/_i_EGFRAP_i_Knock_down_enhances_Ras_sup_V12_sup_-dependent_tissue_hyperplasia_in_i_Drosophila_i_wing_imaginal_discs_/15450744

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.g001

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_3H_/15450678

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s013

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_Fig_6J_/15450699

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s015

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_S2D_Fig_/15450726

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s018

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Expression_of_EGFRAP_in_i_Drosophila_i_wing_discs_/15450789

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.g006

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_S1D_Fig_/15450714

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s017

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/_i_EGFRAP_i_knockdown_increases_Ras_sup_V12_sup_-dependent_cell_shape_changes_and_growth_in_i_Drosophila_i_wing_imaginal_discs_/15450759

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.g002

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Numerical_Data_underlying_graph_S3E_Fig_/15450735

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.s019

المؤلفون: Jennifer Soler Beatty (11302584), Cristina Molnar (227523), Carlos M. Luque (6828491), Jose F. de Celis (11302587), María D. Martín-Bermudo (8917574)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Cancer, Science Policy, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, wing imaginal disc, presumptive wing margin, new negative regulator, feedback loop leading, driving tumoral growth, driven tissue hyperplasia, div >< p, affect overall organogenesis, egrap levels depend, driven tissue morphogenesis, ras signaling occurs, ortholog pvrap results, novel egfr inhibitor, increased egfr function, potentiates activated ras, activated ras alone, egfrap interacts physically, oncogenic cells results, ras pathway activity

Relation: https://figshare.com/articles/figure/Generation_of_i_EGFRAP_i_mutant_alleles_supports_its_role_as_modulator_of_Ras_sup_V12_sup_-mediated_tissue_hyperplasia_/15450777

الاتاحة: https://doi.org/10.1371/journal.pgen.1009738.g004