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1
المؤلفون: Susan E. Morgan-Lappe, Bruce Trela, Nandini Rudra-Ganguly, Xin Lu, Enrico DiGiammarino, Li Zhou, Zhihong Liu, Nan Xu, Vivek C. Abraham, Deborah Widomski, Haichao Zhang, Morey L. Smith, Stephen K. Tahir, John Xue, Yu Xiao, Larry R. Solomon, Dong Cheng, Fritz G. Buchanan, Darren C. Phillips
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2
المؤلفون: Susan E. Morgan-Lappe, Bruce Trela, Nandini Rudra-Ganguly, Xin Lu, Enrico DiGiammarino, Li Zhou, Zhihong Liu, Nan Xu, Vivek C. Abraham, Deborah Widomski, Haichao Zhang, Morey L. Smith, Stephen K. Tahir, John Xue, Yu Xiao, Larry R. Solomon, Dong Cheng, Fritz G. Buchanan, Darren C. Phillips
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3
المؤلفون: Deborah Widomski, Vivek C. Abraham, Darren C. Phillips, Fritz G. Buchanan, Zhihong Liu, Stephen K. Tahir, Haichao Zhang, John Xue, Nandini Rudra-Ganguly, Xin Lu, Dong Cheng, Enrico L. Digiammarino, Morey L. Smith, Yu Xiao, Larry R. Solomon, Susan E. Morgan-Lappe, Bruce Trela, Nan Xu, Li Zhou
المصدر: Cancer Research. 81:3402-3414
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Programmed cell death, Recombinant Fusion Proteins, Cell, Antineoplastic Agents, Apoptosis, Mice, SCID, Factor IX, TNF-Related Apoptosis-Inducing Ligand, Mice, 03 medical and health sciences, 0302 clinical medicine, Mice, Inbred NOD, In vivo, Tumor Cells, Cultured, medicine, Animals, Humans, Receptor, Cell Proliferation, Chemistry, Cancer, Biological activity, medicine.disease, Xenograft Model Antitumor Assays, Fusion protein, Immunoglobulin Fc Fragments, Pancreatic Neoplasms, Receptors, TNF-Related Apoptosis-Inducing Ligand, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, Colorectal Neoplasms
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4
المؤلفون: Paul Nimmer, Erwin R. Boghaert, Robin R. Frey, Phuong N Le, Andrew J. Souers, Peter Kovar, Wenqing Gao, Deepak Sampath, Dolores Diaz, Haichao Zhang, T. Matthew Hansen, Michael J. Mitten, Stephen K. Tahir, Russell A. Judge, Edna F. Choo, Yu Xiao, Shashank Shekhar, Xiaohong Song, George Doherty, Zhi-Fu Tao, Andrew S. Judd, Wayne J. Fairbrother, Michael D. Wendt, Steven W. Elmore, Kunzer Aaron R, Le Wang, Xilu Wang, Darren C. Phillips, Morey L. Smith, John A. Flygare, John Xue, Joel D. Leverson, Milan Bruncko, Chang H. Park, Nathaniel D. Catron
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: Drug, media_common.quotation_subject, A-1331852, Design elements and principles, BCL-2, Bcl-xL, Pharmacology, 01 natural sciences, Biochemistry, BCL-XL, Drug Discovery, media_common, biology, 010405 organic chemistry, Drug discovery, Chemistry, Organic Chemistry, apoptosis, A-1155463, Featured Letter, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Orally active, structure-based drug design (SBDD), Apoptosis, biology.protein, Pharmacophore
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5
المؤلفون: Jennifer R. Devlin, Andrew J. Souers, Morey L. Smith, John Xue, Stephen K. Tahir, Daniel H. Albert, Thomas D. Penning, Rick F. Clark, Ricky W. Johnstone, Jake Shortt, Sha Jin, Marina Konopleva, Yunsong Tong, Joel D. Leverson, Darren C. Phillips, Xiaoxian Zhao, Haichao Zhang, Eric D. Hsi, Jun Chen, Gareth P. Gregory, Qi Zhang
المصدر: Leukemia
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Programmed cell death, Cell Survival, Antineoplastic Agents, Apoptosis, Tumor initiation, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cyclin-dependent kinase, In vivo, Cell Line, Tumor, hemic and lymphatic diseases, Tumor Cells, Cultured, Animals, Humans, Protein Kinase Inhibitors, Sulfonamides, biology, Kinase, Venetoclax, Drug Synergism, Hematology, Bridged Bicyclo Compounds, Heterocyclic, Cyclin-Dependent Kinase 9, Xenograft Model Antitumor Assays, 030104 developmental biology, Cell killing, Oncology, chemistry, Hematologic Neoplasms, 030220 oncology & carcinogenesis, biology.protein, Cancer research
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6
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7
المؤلفون: Russell A. Judge, Sha Jin, Lisa A. Hasvold, Andrew J. Souers, Guillaume Lessene, John Xue, Hans E. Purkey, Jun Chen, Chang H. Park, Sarah G. Hymowitz, Nathaniel D. Catron, Xilu Wang, Le Wang, Wayne J. Fairbrother, Brian J. Smith, Brad E. Sleebs, Erwin R. Boghaert, Kurt Deshayes, Chudi Ndubaku, Yu Xiao, Darren C. Phillips, Stephen K. Tahir, Steven W. Elmore, Michael J. Mitten, Zhi-Fu Tao, Keith G. Watson, Michael F. T. Koehler, Anatol Oleksijew, Saul H. Rosenberg, Peter Kovar, Paul Nimmer, Andrew M. Petros, Chris Tse, Morey L. Smith, Peter M. Colman, Haichao Zhang, Kerry Zobel, Joel D. Leverson, Peter E. Czabotar, John A. Flygare
المصدر: ACS Medicinal Chemistry Letters. 5:1088-1093
مصطلحات موضوعية: Navitoclax, Apoptosis Inhibitor, biology, Organic Chemistry, Cancer, Bcl-xL, Pharmacology, medicine.disease, Multiple dosing, Biochemistry, chemistry.chemical_compound, chemistry, Cell culture, Apoptosis, In vivo, Drug Discovery, biology.protein, medicine
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8ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
المؤلفون: Jackie Lee, Darren C. Phillips, Sha Jin, Morey L. Smith, Yu Xiao, Heather Maecker, Nathaniel D. Catron, Saul H. Rosenberg, David C.S. Huang, Michael J. Mitten, John F. Seymour, Anatol Oleksijew, Stephen K. Tahir, Andrew J. Souers, Peter Kovar, Kylie D. Mason, Gerard M. Sullivan, Lloyd T. Lam, Chang H. Park, Sarah G. Hymowitz, Jun Chen, Scott L. Ackler, Steven W. Elmore, Rod A. Humerickhouse, Brian D. Dayton, Andrew W. Roberts, Cheol-Min Park, Sari H. Enschede, Haichao Zhang, Hong Ding, Wayne J. Fairbrother, John Xue, Kennan C. Marsh, Seong Lin Khaw, Deepak Sampath, Erwin R. Boghaert, Chris Tse, Paul Nimmer, Michael D. Wendt, Joel D. Leverson
المساهمون: School of Physical and Mathematical Sciences
المصدر: Nature Medicine. 19:202-208
مصطلحات موضوعية: Blood Platelets, Cell Survival, Chronic lymphocytic leukemia, bcl-X Protein, Antineoplastic Agents, Apoptosis, Mice, SCID, Pharmacology, Biology, General Biochemistry, Genetics and Molecular Biology, Mice, chemistry.chemical_compound, Dogs, medicine, Animals, Humans, MCL1, Science::Chemistry::Biochemistry [DRNTU], Sulfonamides, Aniline Compounds, Navitoclax, Venetoclax, Cancer, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Xenograft Model Antitumor Assays, Tumor Burden, Proto-Oncogene Proteins c-bcl-2, chemistry, Hematologic Neoplasms, Cancer cell, Female, Refractory Chronic Lymphocytic Leukemia, HeLa Cells
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9Academic Journal
المؤلفون: John Xuefeng Jiang, Maobin Wang
المصدر: China Accounting and Finance Review, Vol 24, Iss 3, Pp 416-424 (2022)
مصطلحات موضوعية: china, leadership, covid-19, local public officials, Accounting. Bookkeeping, HF5601-5689, Finance, HG1-9999
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2307-3055
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10
المؤلفون: Peter Ansell, Evelyn McKeegan, Haiying Zhang, John Xue, Rick Lesniewski, Sevan Brodjian, Don J. Davidson, John E. Harlan
المصدر: European Journal of Cancer. 46:966-973
مصطلحات موضوعية: Cancer Research, Angiogenesis, Angiogenesis Inhibitors, Biology, Pichia, Receptor tyrosine kinase, Kringle domain, medicine, Animals, Humans, Protein kinase B, Angiostatin, Hepatocyte Growth Factor, Plasminogen, Proto-Oncogene Proteins c-met, Molecular biology, Peptide Fragments, Recombinant Proteins, Cell biology, Oncology, biology.protein, Phosphorylation, Hepatocyte growth factor, Rabbits, Signal transduction, Proto-Oncogene Proteins c-akt, medicine.drug
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11
المؤلفون: Lisa A. Hasvold, Wen-Zhen Gu, Magdalena Przytulinska, Saul H. Rosenberg, Le Wang, Thomas J. Sowin, Philip Merta, Zehan Chen, Peter Kovar, Chang Park, Haiying Zhang, John Xue, Nan-Horng Lin, Zhan Xiao
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:2311-2315
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Nitro compound, Pharmaceutical Science, Antineoplastic Agents, Non-specific serine/threonine protein kinase, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Potency, Structure–activity relationship, heterocyclic compounds, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Benzodiazepinones, Organic Chemistry, Enzyme, Models, Chemical, chemistry, Drug Design, Checkpoint Kinase 1, Lactam, Molecular Medicine, Protein Kinases, HeLa Cells, Protein Binding
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12
المؤلفون: Magdalena Przytulinska, Gaoquan Li, Thomas J. Sowin, Wen-Zhen Gu, Lisa A. Hasvold, Philip Merta, Zhan Xiao, Le Wang, John Xue, Reema Thalji, Kent D. Stewart, Zehan Chen, Zhi-Fu Tao, Nan-Horng Lin, Jennifer J. Bouska, Chang Park, Hexamer Laura, Hing L. Sham, Haiying Zhang, Mai-Ha Bui, Gerard M. Sullivan, Saul H. Rosenberg, Peter Kovar
المصدر: Journal of Medicinal Chemistry. 50:4162-4176
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Biological Availability, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Peptide bond, Structure–activity relationship, CHEK1, Cytotoxicity, Protein Kinase Inhibitors, Benzodiazepinones, biology, Chemistry, Drug Synergism, Biological activity, Azepines, Doxorubicin, Enzyme inhibitor, Drug Design, Checkpoint Kinase 1, Lactam, biology.protein, Molecular Medicine, Camptothecin, Protein Kinases, Protein Binding, medicine.drug
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13
المؤلفون: Wayne J. Fairbrother, Deepak Sampath, Xiaoju Max Ma, Le Wang, Haichao Zhang, Paul Nimmer, Kedar S. Vaidya, Yu Xiao, Jacqueline M. Tarrant, Anatol Oleksijew, Saul H. Rosenberg, Peter Kovar, Nghi La, Kym N Lowes, Chris Tse, Darren C. Phillips, Dolores Diaz, Erwin R. Boghaert, Jun Chen, Lisa D. Belmont, Michael J. Mitten, Steven W. Elmore, Stephen K. Tahir, Michael D. Wendt, Andrew J. Souers, John Xue, Zhi-Fu Tao, Daniel H. Albert, Morey L. Smith, Terrance J. Magoc, David C.S. Huang, Joel D. Leverson, Sha Jin
المصدر: Science translational medicine. 7(279)
مصطلحات موضوعية: Neutropenia, Cell Survival, Neutrophils, Chronic lymphocytic leukemia, bcl-X Protein, Administration, Oral, Antineoplastic Agents, Docetaxel, Pharmacology, Biology, Granulopoiesis, chemistry.chemical_compound, Mice, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Benzothiazoles, Sulfonamides, Navitoclax, Aniline Compounds, Venetoclax, Gene Expression Profiling, Cancer, General Medicine, medicine.disease, Bridged Bicyclo Compounds, Heterocyclic, Isoquinolines, Thrombocytopenia, Gene Expression Regulation, Neoplastic, Leukemia, Kinetics, chemistry, Proto-Oncogene Proteins c-bcl-2, Cancer research, Taxoids, Neoplasm Transplantation, medicine.drug, Granulocytes
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14
المؤلفون: John Xue, Thomas J. Sowin, Zhan Xiao, Haiying Zhang
المصدر: Molecular Cancer Therapeutics. 5:1935-1943
مصطلحات موضوعية: Cancer Research, Cell cycle checkpoint, Antineoplastic Agents, Protein Serine-Threonine Kinases, Histones, Neoplasms, Tumor Cells, Cultured, Humans, cdc25 Phosphatases, CHEK1, RNA, Small Interfering, Protein kinase A, Checkpoint Kinase 2, DNA-PKcs, biology, Cell Cycle, Cyclin-dependent kinase 2, Intracellular Signaling Peptides and Proteins, Cyclin-dependent kinase 3, G2-M DNA damage checkpoint, Cell biology, Oncology, Doxorubicin, Checkpoint Kinase 1, biology.protein, Camptothecin, Female, Fluorouracil, biological phenomena, cell phenomena, and immunity, Protein Kinases, DNA Damage, HeLa Cells
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15
المؤلفون: Andrew J. Souers, Lisa A. Hasvold, Elizabeth E. Fry, Xiaohong Song, Chang Park, Russell A. Judge, Steve W. Elmore, Paul Nimmer, Morey L. Smith, Milan Bruncko, Gary J. Jenkins, David Madar, Le Wang, Saul H. Rosenberg, Haichao Zhang, Chaohong Sun, George S. Sheppard, Yu Xiao, Andrew M. Petros, Peter Kovar, Chris Tse, Xilu Wang, John Xue, Joel D. Leverson, Scott A. Erickson, Stephen K. Tahir, Zhi-Fu Tao, Darren C. Phillips, Sha Jin, Steve D. Fidanze
المصدر: Journal of medicinal chemistry. 58(5)
مصطلحات موضوعية: Databases, Factual, Cell Survival, Cell, Antineoplastic Agents, Apoptosis, Plasma protein binding, Crystallography, X-Ray, Structure-Activity Relationship, hemic and lymphatic diseases, Drug Discovery, medicine, Tumor Cells, Cultured, Structure–activity relationship, Humans, G protein-coupled receptor, Molecular Structure, Chemistry, Kinase, medicine.disease, Small molecule, Cell biology, High-Throughput Screening Assays, Molecular Docking Simulation, Pancreatic Neoplasms, Leukemia, medicine.anatomical_structure, Cell culture, Drug Design, Cancer research, Molecular Medicine, Myeloid Cell Leukemia Sequence 1 Protein, Multiple Myeloma, Protein Binding
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16
المؤلفون: Zhan Xiao, Thomas J. Sowin, Zhi-Fu Tao, Nan-Horng Lin, Haiying Zhang, Wen-Zhen Gu, John Xue, Gaoquan Li, Mai Bui
المصدر: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 13(6)
مصطلحات موضوعية: Male, Cell cycle checkpoint, Time Factors, medicine.drug_class, Topoisomerase Inhibitors, Health, Toxicology and Mutagenesis, Clinical Biochemistry, Cyclin B, Mitosis, Apoptosis, Mice, SCID, Transfection, Biochemistry, Histones, Mice, Downregulation and upregulation, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, CHEK1, Cyclin B1, Enzyme Inhibitors, Phosphorylation, RNA, Small Interfering, Mitotic catastrophe, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Genetic Therapy, Cell cycle, Molecular biology, Xenograft Model Antitumor Assays, Checkpoint Kinase 1, biology.protein, Cancer research, Female, RNA Interference, biological phenomena, cell phenomena, and immunity, Protein Kinases, Topoisomerase inhibitor, Biomarkers, DNA Topoisomerases, HeLa Cells
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17Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics
المؤلفون: Yunsong Tong, Gary Wang, Thomas J. Sowin, Mai H. Bui, Zehan Chen, John Xue, Wen-Zhen Gu, Gaoquan Li, Zhi-Fu Tao, Saul H. Rosenberg, Jean Y. J. Wang, Peter Kovar, Haiying Zhang, Zhan Xiao, Nan-Horng Lin, Hing L. Sham
المصدر: International journal of cancer. 119(12)
مصطلحات موضوعية: Cancer Research, CDC25A, Cell cycle checkpoint, Time Factors, DNA repair, medicine.drug_class, DNA damage, Cell Survival, Blotting, Western, Biology, Protein Serine-Threonine Kinases, Antibodies, Cell Line, Tumor, Neoplasms, CDC2 Protein Kinase, medicine, Humans, Urea, cdc25 Phosphatases, Phosphorylation, RNA, Small Interfering, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Cell Cycle, Drug Synergism, Cell cycle, Molecular biology, Oncology, Cell culture, Doxorubicin, Caspases, Cancer cell, Checkpoint Kinase 1, Cancer research, Camptothecin, Tumor Suppressor Protein p53, Protein Kinases, Topoisomerase inhibitor, DNA Damage, HeLa Cells
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18
المؤلفون: Haiying Zhang, Thomas J. Sowin, Saul H. Rosenberg, Dimitri Semizarov, John Xue, Zhan Xiao
المصدر: International journal of cancer. 115(4)
مصطلحات موضوعية: Cancer Research, animal structures, Lung Neoplasms, Paclitaxel, Mitosis, Antineoplastic Agents, Apoptosis, Biology, environment and public health, chemistry.chemical_compound, Downregulation and upregulation, Cell Line, Tumor, Humans, Enzyme Inhibitors, RNA, Small Interfering, Mitotic catastrophe, Oligonucleotide Array Sequence Analysis, Cyclin-dependent kinase 1, Kinase, Cell Cycle, enzymes and coenzymes (carbohydrates), Oncology, Securin, chemistry, embryonic structures, Immunology, Cancer cell, Checkpoint Kinase 1, Colonic Neoplasms, Cancer research, biological phenomena, cell phenomena, and immunity, Protein Kinases, Cell Division, HeLa Cells
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19
المؤلفون: Saul H. Rosenberg, Haiying Zhang, Thomas J. Sowin, John Xue, Zhan Xiao
المصدر: Oncogene. 24(8)
مصطلحات موضوعية: DNA Replication, Cancer Research, CDC25A, Antimetabolites, Antineoplastic, medicine.drug_class, DNA damage, Down-Regulation, Apoptosis, Biology, Genetics, medicine, Humans, CHEK1, Phosphorylation, RNA, Small Interfering, Molecular Biology, Mitotic catastrophe, Cell Nucleus, Caspase 8, Caspase 3, Cell Cycle, DNA, Cell cycle, G2-M DNA damage checkpoint, Drug Resistance, Neoplasm, Caspases, Checkpoint Kinase 1, Cancer research, Fluorouracil, biological phenomena, cell phenomena, and immunity, Poly(ADP-ribose) Polymerases, Protein Kinases, Camptothecin, Topoisomerase inhibitor, medicine.drug, DNA Damage, HeLa Cells
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20
المؤلفون: Jeffrey Eastham-Anderson, George S. Sheppard, Andrew J. Souers, Sarah Gierke, Chihunt Wong, Morey L. Smith, Mary J. C. Ludlam, Daniel Anderson, Chris Tse, Milan Bruncko, Lorna Kategaya, D.C. Phillips, Yu Xiao, Wayne J. Fairbrother, Steven W. Elmore, Paul Nimmer, Stephen K. Tahir, Atsushi Tanaka, Ingrid E. Wertz, Leyu Wang, Joel D. Leverson, Jun Chen, Haichao Zhang, Sha S. Jin, Deepak Sampath, John Xue, Saul H. Rosenberg, Peter Kovar
المصدر: Cell Death & Disease
مصطلحات موضوعية: Cancer Research, Programmed cell death, Navitoclax, Cell growth, Immunology, Intrinsic apoptosis, Cell Biology, Biology, Small molecule, Cell biology, Cellular and Molecular Neuroscience, chemistry.chemical_compound, chemistry, Cell culture, hemic and lymphatic diseases, Cancer cell, Original Article, Stem cell
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