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1Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor
المؤلفون: Liang Zhang, Daniel J. Griffin, Matthew G. Beaver, Laura E. Blue, Christopher J. Borths, Derek B. Brown, Seb Caille, Ying Chen, Alan H. Cherney, Brian M. Cochran, John T. Colyer, Michael T. Corbett, Tiffany L. Correll, Richard D. Crockett, Xi-Jie Dai, Peter K. Dornan, Robert P. Farrell, Simon J. Hedley, Hsiao-Wu Hsieh, Liang Huang, Seth Huggins, Min Liu, Michael A. Lovette, Kyle Quasdorf, William Powazinik, Jonathan Reifman, Jo Anna Robinson, Rahul P. Sangodkar, Sonika Sharma, Srividya Sharvan Kumar, Austin G. Smith, Gabrielle St-Pierre, Jason S. Tedrow, Oliver R. Thiel, Jonathan V. Truong, Shawn D. Walker, Carolyn S. Wei, Ashraf Wilsily, Yong Xie, Ning Yang, Andrew T. Parsons
المصدر: Organic Process Research & Development. 26:3115-3125
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry
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2
المؤلفون: Damith Perera, Neil F. Langille, Simone Spada, Tsang-Lin Hwang, Sheng Cui, Rahul P. Sangodkar, Srividya Sharvan Kumar, Ari Ericson, Kiersten Campbell, Doherty Timothy J, Emiliano Rossi, Jillian W. Sheeran, Gabriella Santoni, John T. Colyer, David D. Ford, Min Liu, Michael A. Lovette, Matthew G. Beaver, Shawn D. Walker, Nancy Jiao, Michal Achmatowicz, Yuan-Qing Fang, Janine K. Tom
المصدر: Organic Process Research & Development. 25:486-499
مصطلحات موضوعية: 010405 organic chemistry, Process (engineering), Process development, Computer science, media_common.quotation_subject, Organic Chemistry, Continuous manufacturing, 010402 general chemistry, 01 natural sciences, Manufacturing engineering, 0104 chemical sciences, Key (cryptography), Quality (business), Physical and Theoretical Chemistry, media_common
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3
المؤلفون: Gilles Gorins, Matthew M. Bio, John T. Colyer, Jason S. Tedrow, Maria Victoria Silva Elipe, Austin G. Smith, Shawn D. Walker, Seb Caille, Jones Sian, Khalid Diker
المصدر: Organic Process Research & Development. 24:1164-1174
مصطلحات موضوعية: Active ingredient, 010405 organic chemistry, Chemistry, Organic Chemistry, chemistry.chemical_element, 010402 general chemistry, Highly selective, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Catalysis, Kinetic resolution, Ruthenium, Physical and Theoretical Chemistry
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4
المؤلفون: Seb Caille, John T. Colyer, Stephen Osgood, Kevin Crossley, Michael D. Bartberger, Kyle Quasdorf, Adam B Birkholz
المصدر: Organic letters. 22(6)
مصطلحات موضوعية: Quantitative Biology::Biomolecules, 010405 organic chemistry, Chemistry, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Quantitative Biology::Quantitative Methods, Enantiopure drug, Computational chemistry, Mechanism (philosophy), Physical and Theoretical Chemistry, Racemization
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5
المؤلفون: Mina Dilmeghani Seran, Jacqueline E. Milne, John T. Colyer, Oliver R. Thiel, Thomas Storz, Robert D. Larsen, Jerry A. Murry
المصدر: The Journal of Organic Chemistry. 76:9519-9524
مصطلحات موضوعية: chemistry.chemical_classification, Molecular Structure, Phenylacetates, Organic Chemistry, Iodide, Iodine Compounds, Stereoisomerism, Phosphorus acid, Iodides, Mandelic acid, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, chemistry, Sodium iodide, Mandelic Acids, Molecule, Acids, Oxidation-Reduction
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6
المؤلفون: Charles Bernard, Simon J. Hedley, Evan DiVirgilio, Tiffany L. Correll, Rich Crockett, Robert D. Larsen, Robert R. Milburn, Jamie L. Zigterman, Kumar Ranganathan, Alan M. Allgeier, Karthik Nagapudi, Oliver R. Thiel, Michal Achmatowicz, John T. Colyer, Xiang Wang
المصدر: Organic Process Research & Development. 15:31-43
مصطلحات موضوعية: biology, Computer science, Block (telecommunications), Mitogen-activated protein kinase, Organic Chemistry, Key (cryptography), biology.protein, Computational biology, Physical and Theoretical Chemistry
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7
المؤلفون: Oliver R. Thiel, Maria Victoria Silva Elipe, Joe Tomaskevitch, John T. Colyer, Jason S. Tedrow, Jack Hu, Robert D. Larsen, Michal Achmatowicz
المصدر: Organic Process Research & Development. 14:1490-1500
مصطلحات موضوعية: Exothermic reaction, In situ, Hydrolysis, Quenching (fluorescence), Chemistry, Metastability, Organic Chemistry, Organic chemistry, Physical and Theoretical Chemistry, Photochemistry, Characterization (materials science)
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8eBook
المؤلفون: Trevor Laird, Jaan A. Pesti, Ahmed F. Abdel-Magid, Daniel Levin, Tony Y. Zhang, Sean P. Lapekas, Thomas Archibald, Stephen M. Stefanick, Ryo Sugiyama, Toru Yamano, Joerg Deerberg, Stefan Abele, Gunther Schmidt, Jacques-Alexis Funel, Mischa Schwaninger, Sven Wagner, Noel A. Hamill, Mark E. Howells, James H. Simpson, Atul S. Kotnis, Rajendra P. Deshpande, David J. Kacsur, Jason Hamm, Gus Kodersha, William Merkl, Daniel Domina, Steve Y. Wang, Nicholas A. Straessler, Louis F. Cannizzo, Michael W. Lesley, Oliver R. Thiel, John R. Huckins, Derek B. Brown, Eric A. Bercot, John T. Colyer, Bobby Riahi, Rob R. Milburn, Steve M. Shaw, Joe Tomaskevitch, David J. Ager, Ayman Allian, Bryan Li, Steven Guinness, L. Mleczko, Dongbo Zhao, Sripathy Venkatraman, Scott Tweedie, Mark McLaws, David Lathbury
Resource Type: eBook.
الموضوعات: Research, Medical laboratories, Chemical industry--Waste disposal, Chemical industry--Safety measures, Risk assessment, Chemical industry--Waste minimization
Categories: SCIENCE / Chemistry / Industrial & Technical, TECHNOLOGY & ENGINEERING / Chemical & Biochemical
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9
المؤلفون: Margaret M. Faul, Troy Soukup, Neil G. Andersen, Jason S. Tedrow, John T. Colyer
المصدر: The Journal of Organic Chemistry. 71:6859-6862
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Molecular Structure, Hydride, Organic Chemistry, Imine, Sulfonium Compounds, Diastereomer, Stereoisomerism, Sulfoxide, Borohydrides, chemistry.chemical_compound, chemistry, Sulfinamide, Yield (chemistry), Organic chemistry, Stereoselectivity, Imines, Selectivity
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10
المؤلفون: John T. Colyer, Michael P. Doyle, John P. Morgan
المصدر: Journal of Organometallic Chemistry. 690:5525-5532
مصطلحات موضوعية: inorganic chemicals, Steric effects, Cyclopropanation, Stereochemistry, Imidazolidinone, organic chemicals, Organic Chemistry, Enantioselective synthesis, Biochemistry, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Materials Chemistry, heterocyclic compounds, Stereoselectivity, Carboxylate, Lewis acids and bases, Physical and Theoretical Chemistry, Carbene
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11
المؤلفون: John T. Colyer, Raymond E. Forslund, Michael P. Doyle, James P. Cain
المصدر: Advanced Synthesis & Catalysis. 347:87-92
مصطلحات موضوعية: Steric effects, chemistry.chemical_compound, Chemistry, Ligand, Glyoxylate cycle, Organic chemistry, Ketene, General Chemistry, Enantiomer, Cycloaddition, Catalysis, Lewis acid catalysis
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12
المؤلفون: Neil E. Jacobsen, Darren Bykowski, Luisa S. Gronenberg, Michael P. Doyle, John T. Colyer, Ming Yan, Wenhao Hu
المصدر: Angewandte Chemie. 116:6881-6884
مصطلحات موضوعية: chemistry.chemical_classification, Magnetic Resonance Spectroscopy, Pyrrolidines, Molecular Structure, Bicyclic molecule, Chemistry, chemistry.chemical_element, Stereoisomerism, General Chemistry, General Medicine, Bridged Bicyclo Compounds, Heterocyclic, Combinatorial chemistry, Catalysis, Rhodium, Ylide, Cascade, Scientific method, Organic chemistry, Stereoselectivity
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13
المؤلفون: Michael P. Doyle, John T. Colyer
المصدر: Tetrahedron: Asymmetry. 14:3601-3604
مصطلحات موضوعية: Inorganic Chemistry, chemistry.chemical_compound, chemistry, Stereochemistry, Yield (chemistry), Organic Chemistry, Carboxylate, Asparagine, Physical and Theoretical Chemistry, Hofmann rearrangement, Catalysis
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14
المؤلفون: John T. Colyer, Michael P. Doyle
المصدر: Journal of Molecular Catalysis A: Chemical. 196:93-100
مصطلحات موضوعية: Steric effects, Cyclopropanation, Chemistry, Process Chemistry and Technology, Enantioselective synthesis, Homogeneous catalysis, Combinatorial chemistry, Catalysis, Organic chemistry, Moiety, Stereoselectivity, Physical and Theoretical Chemistry, Selectivity
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15
المؤلفون: Robert R. Milburn, John R. Huckins, Steve M. Shaw, Joe Tomaskevitch, Bobby Riahi, Oliver R. Thiel, Eric A. Bercot, John T. Colyer, Derek B. Brown
المصدر: ACS Symposium Series ISBN: 9780841230330
ACS Symposium Seriesمصطلحات موضوعية: Transport engineering, Process safety, Risk analysis (engineering), Chemistry, SAFER, medicine, Chloride, medicine.drug
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16
المؤلفون: Mina Dilmeghani Seran, Robert D. Larsen, Jerry A. Murry, Jacqueline E. Milne, Thomas Storz, Oliver R. Thiel, John T. Colyer
المصدر: ChemInform. 43
مصطلحات موضوعية: chemistry.chemical_classification, chemistry, Iodide, Organic chemistry, General Medicine, Catalysis
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17
المؤلفون: Tanya Peterkin, Kaustav Biswas, Neil G. Andersen, Babak Riahi, Jian J. Chen, Gondi N. Kumar, Janan Jona, Kevin Yang, Judy Wang, Derin C. D'amico, Jason Brooks Human, Benny C. Askew, Thomas T. Nguyen, Qingyian Liu, Augustus Kamassah, Margaret M. Faul, Nobuko Nishimura, Christopher H. Fotsch, Wenyuan Qian, Eileen Johnson, Jiawang Zhu, Toshihiro Aya, Nianhe Han, Randall W. Hungate, John T. Colyer
المصدر: Bioorganicmedicinal chemistry letters. 21(11)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Bradykinin, Pain, Receptor, Bradykinin B1, Biochemistry, Chemical synthesis, Piperazines, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Acetamides, Potency, Animals, Receptor, Molecular Biology, G protein-coupled receptor, Sulfonyl, chemistry.chemical_classification, Inflammation, Molecular Structure, Organic Chemistry, Stereoisomerism, Rats, Bradykinin B1 Receptor Antagonists, chemistry, Models, Animal, Lactam, Molecular Medicine, Rabbits, Acetamide
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18
المؤلفون: Kezia E. Endsley, John T. Colyer, William H. Moser
المصدر: ChemInform. 31
مصطلحات موضوعية: chemistry.chemical_compound, Chromium, Nucleophilic addition, chemistry, Silylation, Aryl, chemistry.chemical_element, Moiety, Stereoselectivity, General Medicine, Brook rearrangement, Alkylation, Medicinal chemistry
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19
المؤلفون: H. Bruenner, Daren J. Timmons, A. Duursma, Michael P. Doyle, John T. Colyer, M. M. R. Arndt
المصدر: ChemInform. 33
مصطلحات موضوعية: Chemistry, Organic chemistry, General Medicine, Differential (mathematics), Catalysis
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20
المؤلفون: John T. Colyer, James C. Fettinger, John P. Morgan, Daren J. Timmons, Peter Y. Zavalij, Michael D. Carducci, Michael P. Doyle
المصدر: The Journal of organic chemistry. 70(13)
مصطلحات موضوعية: Models, Molecular, Cyclopropanation, Stereochemistry, Organic Chemistry, Diastereomer, Molecular Conformation, Stereoisomerism, Crystallography, X-Ray, Asymmetric induction, Hydrocarbons, Aromatic, Cycloaddition, Catalysis, Stereocenter, chemistry.chemical_compound, Kinetics, Structure-Activity Relationship, chemistry, Cyclization, Intramolecular force, Organometallic Compounds, Diazo, Rhodium, Selectivity