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1Academic Journal
المؤلفون: Chan Gao, Michael Quigley, Dandan Zhao, Jennifer Koenitzer, Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Yali Chen, Stephanie Briceno, Elizabeth Duperret, Johnni Gullo-Brown, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John T Hunt, Luisa Salter-Cid, Emma Lees, Jinqi Liu
المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
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2Academic Journal
المؤلفون: Jinqi Liu, Joshua Curtin, Dan You, Stephen Hillerman, Bifang Li-Wang, Rukiye Eraslan, Jenny Xie, Jesse Swanson, Ching-Ping Ho, Simone Oppenheimer, Bethanne M Warrack, Colleen A McNaney, David M Nelson, Jordan Blum, Taeg Kim, Mark Fereshteh, Michael Reily, Petia Shipkova, Anwar Murtaza, Miguel Sanjuan, John T Hunt, Luisa Salter-Cid
المصدر: PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1932-6203
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3Academic Journal
المؤلفون: Ashvinikumar V. Gavai (1601491), Derek Norris (1601482), George Delucca (11458610), David Tortolani (2415046), John S. Tokarski (1551424), Dharmpal Dodd (11458613), Daniel O’Malley (6065432), Yufen Zhao (144572), Claude Quesnelle (1601461), Patrice Gill (1601452), Wayne Vaccaro (2093245), Tram Huynh (2093239), Vijay Ahuja (7445426), Wen-Ching Han (1601476), Christopher Mussari (11458616), Lalgudi Harikrishnan (11458619), Muthoni Kamau (3023733), Michael Poss (1711957), Steven Sheriff (1601854), Chunhong Yan (577096), Frank Marsilio (1955395), Krista Menard (1601497), Mei-Li Wen (1601464), Richard Rampulla (1601455), Dauh-Rurng Wu (1402558), Jianqing Li (523126), Huiping Zhang (135186), Peng Li (69518), Dawn Sun (1565869), Henry Yip (11458622), Sarah C. Traeger (1622287), Yingru Zhang (1565884), Arvind Mathur (144120), Haiying Zhang (123360), Christine Huang (743871), Zheng Yang (264955), Asoka Ranasinghe (1601449), Gerry Everlof (1601494), Nirmala Raghavan (2102536), Ching Kim Tye (11458625), Susan Wee (7445438), John T. Hunt (1601446), Gregory Vite (2853350), Richard Westhouse (11458628), Francis Y. Lee (325304)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Cancer, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, targeting transcriptional regulation, solid tumor models, inhibitor using scaffold, differently oriented carbazole, additional lipophilic pocket, functional group optimization, 9 b, 18 b, favorable pk profile, functional assays, vivo activity, shelf conserved, screening hit, properties culminated, preclinical pharmacology, optimize pharmacokinetic, key oncogenes, favorable binding, excellent potency, clinical evaluation
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4Academic Journal
المؤلفون: Emily C. Cherney (8904614), Liping Zhang (177396), Weiwei Guo (117411), Audris Huang (1436374), David Williams (229939), Steven Seitz (10980140), Weifang Shan (1371309), Xiao Zhu (257280), Johnni Gullo-Brown (2387257), Derrick Maley (10048683), Tai-an Lin (10218930), John T. Hunt (1601446), Christine Huang (743871), Zheng Yang (264955), Celia J. D’Arienzo (1429867), Lorell N. Discenza (9406835), Asoka Ranasinghe (1601449), Mary F. Grubb (4230607), Sarah C. Traeger (1622287), Xin Li (51274), Kathy A. Johnston (1372455), Lisa Kopcho (5941772), Mark Fereshteh (6508499), Kimberly A. Foster (2649784), Kevin Stefanski (1551436), Diane Delpy (10048689), Gopal Dhar (8394876), Aravind Anandam (8394879), Sandeep Mahankali (10218936), Shweta Padmanabhan (4067707), Prabhakar Rajanna (8779820), Venkata Murali (10218939), T. Thanga Mariappan (8958191), Shabeerali Pattasseri (10980143), Roshan Y. Nimje (2222026), Zhenqiu Hong (1745164), James Kempson (1665415), Richard Rampulla (1601455), Arvind Mathur (144120), Anuradha Gupta (1551397), Robert Borzilleri (2102530), Gregory Vite (2853350), Aaron Balog (1371318)
مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Chemical Sciences not elsewhere classified, Conformational-Analysis-Guided Disc., metastatic melanoma, mouse xenograft model, cell carcinoma, novel heme-displacing IDO 1 inhibitors, IDO 1 inhibitor, molecules linrodostat, pharmacodynamic activity, oxidative metabolism, fluorine incorporation, compound 29, BMS -986242, quinoline
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5Academic Journal
المؤلفون: Liping Zhang (177396), Emily C. Cherney (8904614), Xiao Zhu (257280), Tai-an Lin (10218930), Johnni Gullo-Brown (2387257), Derrick Maley (10048683), Kathy Johnston-Allegretto (10218933), Lisa Kopcho (5941772), Mark Fereshteh (6508499), Christine Huang (743871), Xin Li (51274), Sarah C. Traeger (1622287), Gopal Dhar (8394876), Aravind Anandam (8394879), Sandeep Mahankali (10218936), Shweta Padmanabhan (4067707), Prabhakar Rajanna (8779820), Venkata Murali (10218939), Thanga Mariappan (10218942), Robert Borzilleri (2102530), Gregory Vite (2853350), John T. Hunt (1601446), Aaron Balog (1371318)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Pharmacology, Biotechnology, Developmental Biology, Cancer, Hematology, Virology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, phase III, metastatic melanoma, Potent Inhibitors, cell carcinoma, variety, BMS, imidazopyridine-containing IDO 1 in., IDO 1 inhibitors, IDO 1 inhibitor, small-molecule immunotherapy, heterocyclic isosteres, Indoleamine, IDO 1-selective inhibitor
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6Academic Journal
المؤلفون: Emily C. Cherney (8904614), Liping Zhang (177396), Susheel Nara (10048680), Xiao Zhu (257280), Johnni Gullo-Brown (2387257), Derrick Maley (10048683), Tai-An Lin (55125), John T. Hunt (1601446), Christine Huang (743871), Zheng Yang (264955), Celia Darienzo (2419681), Lorell Discenza (2332528), Asoka Ranasinghe (1601449), Mary Grubb (2383363), Theresa Ziemba (10048686), Sarah C. Traeger (1622287), Xin Li (51274), Kathy Johnston (2698231), Lisa Kopcho (5941772), Mark Fereshteh (6508499), Kimberly Foster (4230604), Kevin Stefanski (1551436), Joseph Fargnoli (1355358), Jesse Swanson (5877005), Jennifer Brown (102405), Diane Delpy (10048689), Steven P. Seitz (2701921), Robert Borzilleri (2102530), Gregory Vite (2853350), Aaron Balog (1371318)
مصطلحات موضوعية: Biochemistry, Medicine, Genetics, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, novel IDO 1 inhibitor, metastatic melanoma, vivo pharmacodynamic effect, Indoleamine, cell carcinoma, candidate, Preclinical Evaluation, heme-containing dioxygenase enzyme, mouse xenograft model, Selective Inhibitor, BMS -986242, account details, cancer immunotherapy
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7
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8
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9
المؤلفون: Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
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10
المؤلفون: Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
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11
المؤلفون: Chiang Yu, Gregory Vite, Simone Oppenheimer, Derek Norris, Harold Malone, Anne Lewin, Daniel Kukral, Bala Krishnan, John T. Hunt, Christine Hilt, Benjamin Henley, Amy Hammell, Ashvinikumar Gavai, Brian Fink, Joseph Fargnoli, Craig Fairchild, Stuart Emanuel, Francis Y. Lee, Tai W. Wong
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12
المؤلفون: Jay A. Markwalder, Aaron J. Balog, David K. Williams, Susheel J. Nara, Ratnakar Reddy, Saumya Roy, Yadagiri Kanyaboina, Xin Li, Kathy Johnston, Yi Fan, Hal Lewis, Frank Marsilio, Chunhong Yan, David Critton, John A. Newitt, Sarah C. Traeger, Dauh-Rurng Wu, Maria N. Jure-Kunkel, Lata Jayaraman, Tai-An Lin, Michael W. Sinz, John T. Hunt, Steven P. Seitz
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
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13
المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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14
المؤلفون: Mark Fereshteh, Xiao Zhu, Tai-An Lin, Prabhakar Rajanna, Cherney Emily Charlotte, Aravind Anandam, Xin Li, Derrick Maley, Liping Zhang, Gopal Dhar, Aaron Balog, Robert M. Borzilleri, Johnni Gullo-Brown, T. Thanga Mariappan, Kathy Johnston-Allegretto, Christine Huang, Venkata Murali, John T. Hunt, Sandeep Mahankali, Gregory D. Vite, Lisa M. Kopcho, Shweta Padmanabhan, Sarah C. Traeger
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Metastatic melanoma, 010405 organic chemistry, business.industry, medicine.medical_treatment, Organic Chemistry, Phases of clinical research, Immunotherapy, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cancer immunotherapy, Renal cell carcinoma, Drug Discovery, medicine, Cancer research, business, Indoleamine 2,3-dioxygenase
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15
المؤلفون: Lisa M. Kopcho, Johnni Gullo-Brown, Shweta Padmanabhan, Pattasseri Shabeerali, Arvind Mathur, Prabhakar Rajanna, Lorell Discenza, Liping Zhang, Zhenqiu Hong, Sarah C. Traeger, Zheng Yang, Cherney Emily Charlotte, Richard Rampulla, David K. Williams, Gopal Dhar, Kimberly A. Foster, James Kempson, Derrick Maley, Mary F. Grubb, Xiao Zhu, Xin Li, Weifang Shan, Robert M. Borzilleri, Diane Delpy, Kevin Stefanski, T. Thanga Mariappan, Gregory D. Vite, Kathy A. Johnston, Audris Huang, Asoka Ranasinghe, Mark Fereshteh, Aravind Anandam, Steven P. Seitz, John T. Hunt, Aaron Balog, Celia D’Arienzo, Anuradha Gupta, Tai-An Lin, Roshan Y. Nimje, Weiwei Guo, Christine Huang, Venkata Murali, Sandeep Mahankali
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: chemistry.chemical_compound, Oxidative metabolism, chemistry, Metastatic melanoma, Mouse xenograft, Organic Chemistry, Drug Discovery, Pyridine, Quinoline, Biochemistry, Combinatorial chemistry
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16
المؤلفون: Steven P. Seitz, Gregory D. Vite, John T. Hunt, Mark Fereshteh, Cherney Emily Charlotte, Joseph Fargnoli, Lorell Discenza, Liping Zhang, Jennifer Brown, Xin Li, Kevin Stefanski, Christine Huang, Asoka Ranasinghe, Lisa M. Kopcho, Xiao Zhu, Aaron Balog, Diane Delpy, Sarah C. Traeger, Jesse Swanson, Mary F. Grubb, Zheng Yang, Theresa Ziemba, Kathy A. Johnston, Kimberly A. Foster, Johnni Gullo-Brown, Celia D’Arienzo, Susheel Jethanand Nara, Robert M. Borzilleri, Derrick Maley, Tai-An Lin
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, business.industry, medicine.medical_treatment, Organic Chemistry, Cancer, medicine.disease, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Immune system, Cancer immunotherapy, In vivo, Renal cell carcinoma, Dioxygenase, Drug Discovery, medicine, Cancer research, Indoleamine 2,3-dioxygenase, business
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17
المؤلفون: Chunhong Yan, Hal A. Lewis, Micah T. Nelp, John A. Newitt, Steven P. Seitz, Lynn M. Abell, John T. Hunt, Patrick A. Kates, Derrick Maley, Xiao Zhu, Zeyu Lin, Robert M. Borzilleri, Alban Allentoff, John T. Groves, Aaron Balog
المصدر: Proceedings of the National Academy of Sciences of the United States of America
مصطلحات موضوعية: 0301 basic medicine, T cell, Heme, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, 03 medical and health sciences, chemistry.chemical_compound, IDO1, Immune system, Oxidoreductase, medicine, cancer, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Post-translational regulation, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, chemistry.chemical_classification, Multidisciplinary, Dose-Response Relationship, Drug, Myoglobin, Chemistry, Biological Sciences, kynurenine, 3. Good health, Cell biology, 030104 developmental biology, Enzyme, medicine.anatomical_structure, Physical Sciences, Apoproteins, Kynurenine, HeLa Cells
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18
المؤلفون: M. Jure-Kunkel, Jay A. Markwalder, Weifang Shan, Bin Chen, Steven P. Seitz, Andrew Nation, John T. Hunt, Lauren Haque, Gregory D. Vite, Jennifer Donnell, David K. Williams, Kelly L. Covello, Aaron Balog, Hart Amy C, Sunil Kumar Mandal, Libing Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:732-736
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Pharmaceutical Science, Phenylenediamines, Biochemistry, HeLa, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, o-Phenylenediamine, Drug Discovery, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Potency, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Molecular Biology, chemistry.chemical_classification, Tumor microenvironment, biology, Organic Chemistry, biology.organism_classification, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Cancer research, Molecular Medicine, Kynurenine, HeLa Cells
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19
المؤلفون: Steven P. Seitz, John T. Hunt, Kelly L. Covello, Lisa Elkin, Gregory D. Vite, Yuval Blat, Jay A. Markwalder, Jonathan G. Pabalan, Maria Jure-Kunkel
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:582-585
مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Discovery, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Urea, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Tryptophan, Metabolic stability, High-Throughput Screening Assays, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Intracellular, Kynurenine, HeLa Cells
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20
المؤلفون: Joshua C. Curtin, Stephen Hillerman, Rukiye Eraslan, Jinqi Liu, Dan You, Bifang Li-Wang, Taeg Kim, Anwar Murtaza, John T. Hunt, David M. Nelson, Jesse Swanson, Jordan Blum, Mark Fereshteh, Michael D. Reily, Petia Shipkova, Jenny Xie, Bethanne M. Warrack, Luisa Salter-Cid, Colleen A. McNaney, Simone Oppenheimer, Miguel Sanjuan, Ching-Ping Ho
المصدر: PLoS ONE, Vol 14, Iss 3, p e0212670 (2019)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Adenosine, Physiology, medicine.medical_treatment, Glycobiology, Pathology and Laboratory Medicine, Biochemistry, Mice, White Blood Cells, 0302 clinical medicine, Animal Cells, Immune Physiology, Tumor Microenvironment, Medicine and Health Sciences, Cytotoxic T cell, Lymphocytes, Immunologic Surveillance, Immune Response, Immunity, Cellular, Innate Immune System, Multidisciplinary, Kinase, T Cells, Nucleosides, Regulatory T cells, Glycosylamines, 030220 oncology & carcinogenesis, Cytokines, Medicine, Cellular Types, Research Article, Immune Cells, Science, Immunology, Cytotoxic T cells, Biology, Protein Serine-Threonine Kinases, Immune Suppression, 03 medical and health sciences, Immune system, Signs and Symptoms, Diagnostic Medicine, Cell Line, Tumor, medicine, Animals, Point Mutation, Kinase activity, Tumor microenvironment, Blood Cells, Biology and Life Sciences, Immunotherapy, Neoplasms, Experimental, Cell Biology, Molecular Development, Mice, Mutant Strains, 030104 developmental biology, Protein kinase domain, Immune System, Cancer research, CD8, Developmental Biology