المؤلفون: Qin Gong, Kim Robinson, Chenrui Xu, Phuong Thao Huynh, Kelvin Han Chung Chong, Eddie Yong Jun Tan, Jiawen Zhang, Zhao Zhi Boo, Daniel Eng Thiam Teo, Kenneth Lay, Yaming Zhang, John Soon Yew Lim, Wah Ing Goh, Graham Wright, Franklin L. Zhong, Bruno Reversade, Bin Wu

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/fb33e8feb690411b8e3bbd80f9119b57

المؤلفون: Christina Yan Ru Tan, Malgorzata Morenc, Melina Setiawan, Zen Zhi Yan Lim, Ai Ling Soon, John C. Bierman, Laura Vires, Timothy Laughlin, Yvonne M. DeAngelis, Holly Rovito, Bradley B. Jarrold, Thi Quynh Ngoc Nguyen, John Soon Yew Lim, Olivia Kent, Arto Määttä, Adam M. Benham, Timothy J. Hawkins, Xin Er Lee, Matthew C. Ehrman, John E. Oblong, Oliver Dreesen, Sophie Bellanger

المصدر: International Journal of Molecular Sciences, Vol 25, Iss 15, p 8153 (2024)

مصطلحات موضوعية: aging, senescence, inflammation, oxidative stress, para -coumaric acid, para -hydroxycinnamic acid, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/25/15/8153; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/3f51a2a4a8f74c759e9f358a1cbc8283

الاتاحة: https://doi.org/10.3390/ijms25158153
https://doaj.org/article/3f51a2a4a8f74c759e9f358a1cbc8283

المؤلفون: Yaming Zhang, Franklin L. Zhong, Chenrui Xu, Zhao Zhi Boo, Kim S. Robinson, Bruno Reversade, Daniel Eng Thiam Teo, Kenneth Lay, Jiawen Zhang, Graham D. Wright, John Soon Yew Lim, Eddie Yong Jun Tan, Kelvin Han Chung Chong, Wah Ing Goh, Qin Gong, Phuong Thao Huynh, Bin Wu

المساهمون: ACS - Heart failure & arrhythmias, Reversade, Bruno, Gong, Q., Robinson, K., Xu, C., Huynh, P.T., Chong, K.H.C., Tan, E.Y.J., Zhang, J., Boo, Z.Z., Teo, D.E.T., Lay, K., Zhang, Y., Lim, J.S.Y., Goh, W.I., Wright, G., Zhong, F.L., Wu, B., School of Medicine

المصدر: Nature communications, 12(1):188. Nature Publishing Group
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: 0301 basic medicine, Cell biology, Inflammasomes, Biochemistry, Science, General Physics and Astronomy, NLR Proteins, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Article, Inflammasome, Protein filament, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Receptor, Adaptor Proteins, Signal Transducing, Inflammation, Mutation, Multidisciplinary, Chemistry, HEK 293 cells, Caspase 1, Cryoelectron Microscopy, Signal transducing adaptor protein, General Chemistry, Neoplasm Proteins, CARD Signaling Adaptor Proteins, Molecular Docking Simulation, 030104 developmental biology, HEK293 Cells, Cryoelectron microscopy, Signal transduction, Apoptosis Regulatory Proteins, Inflammasome complex, 030217 neurology & neurosurgery, medicine.drug, Signal Transduction

وصف الملف: pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971fea044a57af53224281deaea2a5a9
https://pure.amc.nl/en/publications/structural-basis-for-distinct-inflammasome-complex-assembly-by-human-nlrp1-and-card8(f93492eb-c2e0-49e8-a33d-9316ae5981a5).html

المؤلفون: John Soon Yew Lim, E. Birgitte Lane, Cedric Badowski, Steven S. Leonardi, John E.A. Common, Muhammad Jasrie Firdaus, Tong San Tan

المساهمون: Lee Kong Chian School of Medicine (LKCMedicine), Skin Research Institute of Singapore, A*STAR, Institute of Medical Biology, A*STAR

المصدر: Journal of Cell Science
article-version (VoR) Version of Record

مصطلحات موضوعية: Keratinocytes, Keratin 14, Intermediate Filaments, EBS, Context (language use), macromolecular substances, Keratin mutation, EGFR signalling, Epidermolysis bullosa simplex, Drug Discovery, Keratin, medicine, Humans, Medicine [Science], Epidermal growth factor receptor, Cytoskeleton, chemistry.chemical_classification, EGFR inhibitors, Keratin Filament, Pathway intervention therapy drug screen, integumentary system, biology, Cell Biology, medicine.disease, Cell biology, Keratin 5, medicine.anatomical_structure, chemistry, Epidermolysis Bullosa Simplex, Mutation, biology.protein, Keratins, ERK1/2 signalling, Keratinocyte, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726b85456909374f01d59aeb8a29a6d7
https://hdl.handle.net/10356/153607

المؤلفون: John Soon Yew Lim, Oliver Dreesen, J. Oblong, Sophie Bellanger, Chin Yee Ho, Ai Ling Soon, Holly Ann Rovito, Chye Ling Tan, Malgorzata Morenc, Christina Yan Ru Tan, T.W.K. Chin, Ling Shih Quek

المصدر: The Journal of investigative dermatology. 142(6)

مصطلحات موضوعية: Senescence, Keratinocytes, Niacinamide, animal structures, DNA damage, Ultraviolet Rays, Photoaging, Dermatology, medicine.disease_cause, Biochemistry, medicine, Humans, Molecular Biology, Involucrin, integumentary system, Epidermis (botany), Chemistry, food and beverages, Cell Biology, medicine.disease, Cell biology, Skin Aging, Oxidative Stress, Loricrin, Oxidative stress, Filaggrin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd4dec81e098905518c89af239bf9a2
https://pubmed.ncbi.nlm.nih.gov/34740582

المؤلفون: Kim S. Robinson, John Soon Yew Lim, Franklin L. Zhong, Chenrui Xu, Bin Wu, Bruno Reversade, Daniel Eng Thiam Teo, Jiawen Zhang, Qin Gong, Graham D. Wright, Wah Ing Goh, Yaming Zhang, Zhao Zhi Boo

مصطلحات موضوعية: Protein filament, Programmed cell death, Chemistry, NLRP1, medicine, CARD domain, Inflammasome, Receptor, Inflammasome complex, medicine.drug, NLR Proteins, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4fe4bb4cd9fbbcea40bf985e8835d4e
https://doi.org/10.1101/2020.06.17.156307

المؤلفون: Shuping Lin, Michael R. Hayden, Wah Ing Goh, Yoonjeong Cha, Chris Kay, Tamara Ratovitski, Bryan Tsong-Jye Ng, Rebecca Kusko, Carola I. Radulescu, Bernice Sim, Christopher A. Ross, John Soon Yew Lim, Nur Amirah Binte Mohammad Yusof, Graham D. Wright, Mahmoud A. Pouladi, Xiaohong Xu

المصدر: Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 9, Pp 1-12 (2020)

مصطلحات موضوعية: Cancer Research, Huntingtin, Immunology, Mutant, Cell death in the nervous system, Context (language use), Oxidative phosphorylation, Biology, Neuroprotection, Article, Cellular and Molecular Neuroscience, Mice, Animals, Humans, lcsh:QH573-671, Induced pluripotent stem cell, lcsh:Cytology, Cell Biology, Phenotype, Cell biology, Mitochondria, Disease Models, Animal, Induced pluripotent stem cells, Huntington Disease, Phosphorylation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf06f62bfd554f0d0ec11b35fcc6e11
https://pubmed.ncbi.nlm.nih.gov/32978366

المؤلفون: Jonathan J Keats, John Soon Yew Lim, Veerabhadran Baladandayuthapani, Hua Wang, Wencai Ma, Dongmin Gu, Isere Kuiatse, Jin He, Jing Yang, Zhiqiang Wang, Richard J. Jones, Robert Z. Orlowski, Sean O'Brien, Richard E. Davis, Hans C. Lee, Heather Lin

المصدر: British Journal of Haematology. 177:80-94

مصطلحات موضوعية: 0301 basic medicine, Myeloma protein, Gene Expression, Antineoplastic Agents, Article, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, RNA Polymerase I, Ribosomal protein, Cell Line, Tumor, RNA polymerase, RNA polymerase I, Animals, Humans, Gene silencing, Benzothiazoles, Molecular Targeted Therapy, Naphthyridines, Messenger RNA, Gene Expression Profiling, Translation (biology), Hematology, Xenograft Model Antitumor Assays, Tumor Burden, Disease Models, Animal, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, Tumor Suppressor Protein p53, Growth inhibition, Multiple Myeloma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31461a52ac2f9f98ff245fdfa05ddabc
https://doi.org/10.1111/bjh.14525

المؤلفون: Wei Xie, Brian Burke, John Soon Yew Lim, Thomas Boudier, Alexandre Chojnowski, Sohail Ahmed, Zheng Ser, Colin L. Stewart

المصدر: Current Biology. 26:2651-2658

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Intermediate Filaments, Anatomy, Biology, Lamin Type A, General Biochemistry, Genetics and Molecular Biology, Cell biology, Nuclear Pore Complex Proteins, Protein filament, 03 medical and health sciences, 030104 developmental biology, Prenylation, Proto-Oncogene Proteins, Nuclear Pore, Humans, Inner membrane, Nuclear lamina, Nuclear pore, General Agricultural and Biological Sciences, Intermediate filament, Lamin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a998b73cb94f5fd43e7c2d4e8d173f2
https://doi.org/10.1016/j.cub.2016.07.049

المؤلفون: Ka Man Yu, Yun-Shen Chan, Huck-Hui Ng, John Soon Yew Lim, Lai Ping Yaw, Chaiyaboot Ariyachet, Deniz Demircioğlu, Chwee Tat Koe, Yee Siang Lim, Einsi Lynn Soe, Hongqing Liang, Kevin Andrew Uy Gonzales, Nur Halisah Binte Jumat, Yock Young Dan, Iwona Szczerbinska, Shu Hui Koh, Zhiping Lu, Cheng Peow Tan, Asim Shabbir, Graham D. Wright, Wei-Quan Tng, Muhammad Nadzim Bin Ramli

المصدر: Gastroenterology. 159:1471-1486.e12

مصطلحات موضوعية: 0301 basic medicine, Hepatology, Chemistry, Liver cell, Gastroenterology, Cholangiocyte proliferation, digestive system, Molecular biology, Embryonic stem cell, Cholangiocyte, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Hepatocyte, Organoid, medicine, Alkaline phosphatase, 030211 gastroenterology & hepatology, Induced pluripotent stem cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e6de067795d3217c7cca411f3125bc
https://doi.org/10.1053/j.gastro.2020.06.010

المؤلفون: Srivats Hariharan, Yen Ling Koon, Jaron Zhongliang Liu, Thankiah Sudhaharan, Graham D. Wright, Sohail Ahmed, John Soon Yew Lim, Keng-Hwee Chiam

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)

مصطلحات موضوعية: 0301 basic medicine, Materials science, Structured illumination microscopy, lcsh:Medicine, Nerve Tissue Proteins, macromolecular substances, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Protein Domains, Cell Movement, Neoplasms, Microscopy, BAR domain, Animals, Humans, lcsh:Science, Multidisciplinary, lcsh:R, Cell Membrane, Fluorescence recovery after photobleaching, Superresolution, Actins, Single Molecule Imaging, 030104 developmental biology, Membrane, Domain (ring theory), Biophysics, lcsh:Q, Filopodia, 030217 neurology & neurosurgery, Fluorescence Recovery After Photobleaching, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71caf468f2ff1bcdee3c3f4e0f985d44
http://europepmc.org/articles/PMC6385187

المؤلفون: Brian Burke, Wei Xie, John Soon Yew Lim, Graham D. Wright

المصدر: Methods (San Diego, Calif.). 157

مصطلحات موضوعية: 0303 health sciences, Nuclear Lamina, Super-resolution microscopy, 030302 biochemistry & molecular biology, Cytological Techniques, Centroid, General Biochemistry, Genetics and Molecular Biology, Single Molecule Imaging, Protein filament, 03 medical and health sciences, User-Computer Interface, Microscopy, Fluorescence microscope, Nuclear Pore, Nuclear lamina, Nuclear pore, Biological system, Molecular Biology, Lamin, Algorithms, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c3f74b55d1d9302fb48567706f1e83
https://pubmed.ncbi.nlm.nih.gov/30268406

المؤلفون: Michael Poidinger, John Soon Yew Lim, Francesca Zolezzi, Norman Pavelka, Jaron Liu, Marina Yurieva, Gaowen Liu, Mei Yun Jacy Yong, Giulia Rancati, Kandhadayar G. Srinivasan, Hyungwon Choi, Graham D. Wright

المصدر: Cell. 163(6):1388-1399

مصطلحات موضوعية: Genetics, Genes, Essential, Saccharomyces cerevisiae Proteins, biology, Biochemistry, Genetics and Molecular Biology(all), Mutant, Saccharomyces cerevisiae, Membrane Proteins, Nuclear Proteins, Genomics, Spores, Fungal, biology.organism_classification, Biological Evolution, General Biochemistry, Genetics and Molecular Biology, Evolvability, Nuclear Pore Complex Proteins, Nucleoporin, Ploidy, Gene, Selection (genetic algorithm), Gene Deletion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933828918326de8342d89b76f5943afe

المؤلفون: Thomas L. Dawson, John Soon Yew Lim, Gregory L. Lovelace, John J. Lemasters, Graham D. Wright, Venkat K. Ramshesh, Duane P. Harland

المصدر: Journal of Investigative Dermatology.

مصطلحات موضوعية: 0301 basic medicine, Cell Count, Dermatology, Biology, Mitochondrion, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Keratin, medicine, Animals, Humans, Propidium iodide, Viability assay, Molecular Biology, Cells, Cultured, Cuticle (hair), chemistry.chemical_classification, Membrane Potential, Mitochondrial, integumentary system, Degranulation, Depolarization, Cell Differentiation, Cell Biology, Fibroblasts, Hair follicle, Cell biology, Mitochondria, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, chemistry, Cattle, Reactive Oxygen Species, Hair Follicle

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f757f5e2eaf73f831746e6ba2279b6a4

المؤلفون: Sohail Ahmed, Hwee Kuan Lee, Weimiao Yu, John Soon Yew Lim

المصدر: The Analyst. 139:4758-4768

مصطلحات موضوعية: Microscopy, Confocal, Embryonic Development, Nanotechnology, Biochemistry, Pattern Recognition, Automated, Analytical Chemistry, Microscopy, Fluorescence, Cell Tracking, Light sheet fluorescence microscopy, Image Processing, Computer-Assisted, Electrochemistry, Animals, Environmental Chemistry, Cell tracking, Spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b7100b051e2f7de158be4b00d4875
https://doi.org/10.1039/c4an00624k

المؤلفون: Alan Colman, Esther Sook Miin Wong, Peh Fern Ong, John Soon Yew Lim, Colin L. Stewart, Alexandre Chojnowski, Thomas Boudier, Henry Yang, Yi Y. Liow, Bamaprasad Dutta, Rafidah Mutalif, Oliver Dreesen, Siu Kwan Sze, Graham D. Wright, Raju Navasankari, Brian Burke

المساهمون: School of Biological Sciences

المصدر: eLife
eLife, Vol 4 (2015)

مصطلحات موضوعية: Senescence, congenital, hereditary, and neonatal diseases and abnormalities, Telomerase, senescence, QH301-705.5, Science, Biology, General Biochemistry, Genetics and Molecular Biology, LMNA, medicine, Humans, human, Biology (General), mouse, lamin A, Microscopy, Progeria, integumentary system, General Immunology and Microbiology, General Neuroscience, Membrane Proteins, progeria, nutritional and metabolic diseases, General Medicine, Telomere, Lamin Type A, telomeres, Progerin, medicine.disease, Molecular biology, Cell biology, DNA-Binding Proteins, Genes and Chromosomes, progerin, Medicine, Nuclear lamina, LAP2 alpha, Lamin, Protein Binding, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e564260cb84d1886b7fda98f655848d
https://doi.org/10.7554/elife.07759

المؤلفون: Julian L. Goggi, Thomas J. Carney, Ivo J. H. M. de Vos, John Soon Yew Lim, Barry J. Coull, Norris R. Dunn, Maurice A. M. van Steensel, Sheena Li Ming Ong, Chee Bing Ong

المصدر: Mechanisms of Development. 145:S28

مصطلحات موضوعية: Embryology, biology, medicine, Winchester syndrome, biology.organism_classification, medicine.disease, Neuroscience, Zebrafish, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::952fe4f76f198639c15ad8706d936009
https://doi.org/10.1016/j.mod.2017.04.020

المؤلفون: Sudaharan Thankiah, John Soon Yew Lim, Sohail Ahmed, Kai Pin Sem, Srivats Hariharan, Amy Chou, Graham D. Wright

المصدر: SPIE Proceedings.

مصطلحات موضوعية: EPS8, Physics, Membrane curvature, Biophysics, Nanotechnology, macromolecular substances, GTPase, CDC42, Filopodia, SH3 domain, Actin, Dynamin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0805269499d0a7aa10ea3bdae161af4e
https://doi.org/10.1117/12.2058123

المؤلفون: Sean O'Brien, Lewis R. Roberts, Yu Wang, John Soon Yew Lim, Mitesh J. Borad, Kais Zakharia, Catherine D. Moser, Katsuyuki Miyabe

المصدر: Gastroenterology. 150:S4

مصطلحات موضوعية: Cisplatin, Hepatology, Chemistry, Gastroenterology, medicine, Cancer research, Casein kinase 2, Gemcitabine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dfdf57f69ebe156ecf7f7a5260837db0
https://doi.org/10.1016/s0016-5085(16)30146-9