المؤلفون: Emily C. Cherney (8904614), Liping Zhang (177396), Julian Lo (12035908), Tram Huynh (2093239), Donna Wei (2387248), Vijay Ahuja (7445426), Claude Quesnelle (1601461), Gary L. Schieven (2459572), Alan Futran (9387879), Gregory A. Locke (5941769), Zeyu Lin (2618836), Laura Monereau (12035911), Charu Chaudhry (1655965), Jordan Blum (5347976), Sha Li (145229), Mark Fereshteh (6508499), Bifang Li-Wang (85432), Sanjeev Gangwar (2853356), Chin Pan (2853359), Colin Chong (9368675), Xiao Zhu (257280), Shana L. Posy (1355322), John S. Sack (2375029), Ping Zhang (86495), Max Ruzanov (5877002), Mary Harner (12035914), Fahad Akhtar (12035917), Gretchen M. Schroeder (1551364), Gregory Vite (2853350), Brian Fink (7445429)

مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Science Policy, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, syngeneic mouse model, intense research due, demonstrate antitumor activity, molecule sting agonists, via <, unique class, tumor immunogenicity, sting agonists, solid tumors, oncology therapy, nucleotide small, interferon genes, currently limited, chemotype hybridization, cdns )

Relation: https://figshare.com/articles/journal_contribution/Discovery_of_Non-Nucleotide_Small-Molecule_STING_Agonists_i_via_i_Chemotype_Hybridization/19111489

الاتاحة: https://doi.org/10.1021/acs.jmedchem.1c01986.s002

المؤلفون: Michael G. Yang (2123170), Myra Beaudoin-Bertrand (4067701), Zili Xiao (2123182), David Marcoux (2182586), Carolyn A. Weigelt (2276455), Shiuhang Yip (1402564), Dauh-Rurng Wu (1402558), Max Ruzanov (5877002), John S. Sack (2375029), Jinhong Wang (34550), Melissa Yarde (1745002), Sha Li (145229), David J. Shuster (2459569), Jenny H. Xie (3385667), Tara Sherry (9610086), Mary T. Obermeier (1436389), Aberra Fura (1436362), Kevin Stefanski (1551436), Georgia Cornelius (1429912), Purnima Khandelwal (4724169), Ananta Karmakar (2236600), Mushkin Basha (7597451), Venkatesh Babu (10151570), Arun Kumar Gupta (7597448), Arvind Mathur (144120), Luisa Salter-Cid (1429873), Rex Denton (2012920), Qihong Zhao (517396), T. G. Murali Dhar (7542971)

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Immunology, Cancer, Infectious Diseases, Computational Biology, X-ray co-crystal structure, ROR γt, vivo PK profiles, efficacy, BMS -986313 SAR efforts, IL -23-induced acanthosis model, ligand binding domain

Relation: https://figshare.com/articles/journal_contribution/Tricyclic-Carbocyclic_ROR_t_Inverse_Agonists_Discovery_of_BMS-986313/14043458

الاتاحة: https://doi.org/10.1021/acs.jmedchem.0c01992.s002

المؤلفون: Emily C. Cherney, Liping Zhang, Julian Lo, Tram Huynh, Donna Wei, Vijay Ahuja, Claude Quesnelle, Gary L. Schieven, Alan Futran, Gregory A. Locke, Zeyu Lin, Laura Monereau, Charu Chaudhry, Jordan Blum, Sha Li, Mark Fereshteh, Bifang Li-Wang, Sanjeev Gangwar, Chin Pan, Colin Chong, Xiao Zhu, Shana L. Posy, John S. Sack, Ping Zhang, Max Ruzanov, Mary Harner, Fahad Akhtar, Gretchen M. Schroeder, Gregory Vite, Brian Fink

المصدر: Journal of Medicinal Chemistry. 65:3518-3538

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::143c186739969ad25a3e8322819f4602
https://doi.org/10.1021/acs.jmedchem.1c01986

المؤلفون: Chunhong, Yan, John S, Sack

المصدر: Acta Crystallogr F Struct Biol Commun

مصطلحات موضوعية: Models, Molecular, Myocardium, Recombinant Fusion Proteins, Troponin I, Biophysics, macromolecular substances, Crystallography, X-Ray, musculoskeletal system, Condensed Matter Physics, Biochemistry, Research Communications, Structural Biology, cardiovascular system, Genetics, Humans, Calcium, Troponin C, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ca196f93ac15db50df3a0e934bfa3e
https://doi.org/10.1107/s2053230x21012395

المؤلفون: Aberra Fura, Shiuhang Yip, Georgia Cornelius, Hai-Yun Xiao, Qingjie Liu, Sha Li, Ning Li, Nicholas A. Meanwell, Shailesh Dudhgaonkar, Max Ruzanov, Jenny Xie, Zili Xiao, Purnima Khandelwal, Carolyn A. Weigelt, David J. Shuster, Dauh-Rurng Wu, T. G. Murali Dhar, Tara Sherry, Yang Michael G, Kevin Stefanski, Jignesh Nagar, Rex Denton, Qihong Zhao, Peng Li, Silvi A. Chacko, Arun Govindarajan, Robert M. Borzilleri, John S. Sack, Yeheng Zhu, Yunling Song, Dawn Sun, Anjuman Rudra, Mary T. Obermeier, Jinhong Wang, Douglas G. Batt, Venkata Murali

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Membrane permeability, 010405 organic chemistry, Chemistry, Organic Chemistry, Pharmacology, medicine.disease, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, In vivo, RAR-related orphan receptor gamma, Psoriasis, Rheumatoid arthritis, Drug Discovery, medicine, Potency, Inverse agonist

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3296d470de82e26da82050921646783
https://doi.org/10.1021/acsmedchemlett.1c00112

المؤلفون: Tara Sherry, John E. Macor, Jinhong Wang, Georgia Cornelius, Shiuhang Yip, Luisa Salter-Cid, Qingjie Liu, Purnima Khandelwal, Carolyn A. Weigelt, Max Ruzanov, John S. Sack, Kevin Stefanski, Jenny Xie, T. G. Murali Dhar, Sha Li, Melissa Yarde, Joseph A. Tino, Qihong Zhao, Dauh-Rurng Wu, Mary T. Obermeier, David J. Shuster, Aberra Fura, Douglas G. Batt, Rex Denton

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: chemistry.chemical_classification, Virtual screening, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Prodrug, Cyclohexanecarboxylic acid, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, RAR-related orphan receptor gamma, Drug Discovery, Moiety, Inverse agonist, Solubility, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cac25cddf4e8f7e9938641eae9eba1
https://doi.org/10.1021/acsmedchemlett.0c00496

المؤلفون: Joel C. Barrish, John Hynes, Ajay Saxena, Natesan Murugesan, Dianlin Xie, Anjaneya Chimalakonda, Stefan Ruepp, Mitalee Das, Richard Rampulla, Durgarao Kantheti, Chunhong Yan, Julie Carman, Jignesh Nagar, Siva Subramani, Qian Ruan, William J. Pitts, Rajeev S. Bhide, Paul A. Elzinga, Venkatram Reddy Paidi, John S. Sack, Mark Fereshteh, Thangavel Soodamani, Amrita Jha Mukherjee, T. Thanga Mariappan, Ramesh Kumar Sistla, Kaushik Ghosh, Debarati Mazumder, Kamalavenkatesh Palanisamy, Deborah A. Holloway, Susan E. Kiefer, John A. Newitt, Satheesh Kesavan Nair, Polimera Subba Rao, Shailesh Dudhgoankar, Percy H. Carter, Xin Li, Srinivas Maddi, S. Pon Saravanakumar, Sreekantha Ratna Kumar, Sucharita Bose

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Nicotinamide, Organic Chemistry, TLR7, Pharmacology, IRAK4, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Pharmacokinetics, Pharmacodynamics, Psoriasis, Drug Discovery, medicine, Potency, Kinome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bbdf7e3f4256a866250ac0c4fba45e
https://doi.org/10.1021/acsmedchemlett.0c00082

المؤلفون: Carolyn A. Weigelt, Sha Li, David Marcoux, Georgia Cornelius, Qihong Zhao, Mary Ellen Cvijic, John E. Macor, Jingwu Duan, Melissa Yarde, Muthalagu Vetrichelvan, David J. Shuster, Qingjie Liu, Richard Rampulla, Kim W. McIntyre, Mary T. Obermeier, Shiuhang Yip, Purnima Khandelwal, Sureshbabu Vishwakrishnan, Anuradha Gupta, Virna Borowski, Peng Li, Kevin Stefanski, Sridharan Ramlingam, Myra Beaudoin-Bertrand, Nageswara Maddala, Sridhar Vanteru, Percy H. Carter, Arvind Mathur, Aberra Fura, Max Ruzanov, John Hynes, Dauh-Rurng Wu, Jinhong Wang, Luisa Salter-Cid, John S. Sack, Cornelius Lyndon A M, Anurag S. Srivastava, Robert J. Cherney, Kumaravel Selvakumar, Mushkin Basha, Arun Kumar Gupta, Douglas G. Batt, Rex Denton, Sukhen Karmakar, Qing Shi, Ananta Karmakar, Naveen Manjunath, Javed Khan, Jenny Xie, Joseph A. Tino, T. G. Murali Dhar

المصدر: Journal of Medicinal Chemistry. 62:9931-9946

مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Drug Inverse Agonism, Protein Conformation, Pharmacology, 01 natural sciences, Jurkat Cells, Mice, Structure-Activity Relationship, 03 medical and health sciences, Psoriatic arthritis, RAR-related orphan receptor gamma, In vivo, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Structure–activity relationship, Tissue Distribution, 030304 developmental biology, 0303 health sciences, Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, medicine.disease, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Nuclear receptor, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eeada291586349dd371c5b816894adb
https://doi.org/10.1021/acs.jmedchem.9b01369

المؤلفون: Zhonghui Lu, James J.-W. Duan, Haiyun Xiao, James Neels, Dauh-Rurng Wu, Carolyn A. Weigelt, John S. Sack, Javed Khan, Max Ruzanov, Yongmi An, Melissa Yarde, Ananta Karmakar, Sureshbabu Vishwakrishnan, Venkata Baratam, Harisha Shankarappa, Sridhar Vanteru, Venkatesh Babu, Mushkin Basha, Arun Kumar Gupta, Selvakumar Kumaravel, Arvind Mathur, Qihong Zhao, Luisa M. Salter-Cid, Percy H. Carter, T.G. Murali Dhar

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:2265-2269

مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Dose-Response Relationship, Drug, Drug Inverse Agonism, Molecular Structure, Organic Chemistry, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Nuclear Receptor Subfamily 1, Group F, Member 3, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Molecular Medicine, Sulfones, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9735d752f4623c3770abdd535d7b6097
https://doi.org/10.1016/j.bmcl.2019.06.036

المؤلفون: Doree F. Sitkoff, Alice Y. Chen, Hongwei Zhang, Anne Rose, Xue-Qing Chen, Cailan Wang, Leonard P. Adam, Mimi L. Quan, Nathan L. Cheadle, Zilun Hu, Lisa Zhang, David S. Taylor, Ruth R. Wexler, Songmei Xu, John S. Sack, Joseph E. Myers, Victor R. Guarino, James Hennan, Peter W. Glunz, Chunhong Yan, Julia Li

المصدر: Bioorganicmedicinal chemistry letters. 30(21)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Blood Pressure, Crystallography, X-Ray, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Amide, Drug Discovery, Molecule, Potency, Animals, Humans, Kinome, Molecular Biology, Protein Kinase Inhibitors, rho-Associated Kinases, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Rho kinase inhibitor, Molecular Medicine, Pyrazoles, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995bf0c5f6f2e8dbdc6c12fb55d1327a
https://pubmed.ncbi.nlm.nih.gov/32798651

المؤلفون: Bin Jiang, Sylwia Stachura, T. G. Murali Dhar, Carolyn A. Weigelt, Dauh Rurng Wu, Jingwu Duan, Luisa M. Salter–Cid, Javed Khan, Ding Ren Shen, Melissa Yarde, Qihong Zhao, Zhonghui Lu, Percy H. Carter, John S. Sack, Max Ruzanov

المصدر: Bioorganicmedicinal chemistry letters. 30(19)

مصطلحات موضوعية: Pyrrolidines, Drug Inverse Agonism, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ether, Alcohol, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Sulfone, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Stability, In vivo, Drug Discovery, Moiety, Inverse agonist, Animals, Humans, Sulfones, Binding site, Molecular Biology, Pregnane X receptor, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Hep G2 Cells, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Microsomes, Liver, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d78507decbe1c2b5ea2335c53b8ab6
https://pubmed.ncbi.nlm.nih.gov/32736080

المؤلفون: Yanling Huang, Jingwu Duan, Carolyn A. Weigelt, Cullen L. Cavallaro, Javed Khan, Brian E. Fink, Muthoni G. Kamau, Zheming Ruan, Lan-Ying Qin, Sylwia Stachura, Cliff Chen, Murali Gururajan, Lalgudi S. Harikrishnan, Tram N. Huynh, John S. Sack, Anwar Murtaza, Daniel O'malley, Zhuyin Li, Melissa Yarde, Max Ruzanov, Virna Borowski, Patrice Gill, Huadong Sun, Zhonghui Lu, Jessica J. Wong

المصدر: Bioorganicmedicinal chemistry letters. 30(12)

مصطلحات موضوعية: Agonist, Drug, medicine.drug_class, Receptors, Retinoic Acid, media_common.quotation_subject, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Pharmacology, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, RAR-related orphan receptor gamma, Heterocyclic Compounds, Drug Discovery, Benzyl Compounds, medicine, Animals, Molecular Biology, media_common, Orphan receptor, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Pharmacodynamics, Molecular Medicine, Female, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28391368dbe9fe0275182d85ed69ba6
https://pubmed.ncbi.nlm.nih.gov/32334911

المؤلفون: Celia D’Arienzo, Ananta Karmakar, Marta Dabros, Michael Galella, Jingwu Duan, John S. Sack, Dhanya Kumar Raut, David S. Weinstein, Andrew T. Pudzianowski, Ding-Ren Shen, Sylwia Stachura, Joel C. Barrish, Arun Kumar Gupta, Huadong Sun, William R. Foster, Javed Khan, Melissa Yarde, Dan Camac, Lauren Haque, Qihong Zhao, Dauh-Rurng Wu, Carolyn A. Weigelt, Faye Wang, Percy H. Carter, Luisa Salter-Cid, Hemalatha Hemagiri, Jenny Xie, T. G. Murali Dhar, Zhonghui Lu, Virna Borowski, Hua Gong, John E. Somerville

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:85-93

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Receptors, Steroid, Propanols, Receptors, Retinoic Acid, Clinical Biochemistry, Pharmaceutical Science, Benzothiazine, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, Animals, Humans, Inverse agonist, Liver X receptor, Receptor, Molecular Biology, Liver X Receptors, Orphan receptor, Mice, Inbred BALB C, Sulfonamides, Pregnane X receptor, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Pregnane X Receptor, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Retinoic acid receptor, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1f582e5622499ffe28a2c4e0122b0d
https://doi.org/10.1016/j.bmcl.2017.12.006

المؤلفون: Qingjie Liu, Mary T. Obermeier, John S. Sack, Carolyn A. Weigelt, Georgia Cornelius, Percy H. Carter, David J. Shuster, Luisa Salter-Cid, Aberra Fura, Virna Borowski, Jingwu Duan, Purnima Khandelwal, Qing Shi, Robert J. Cherney, Cornelius Lyndon A M, Jinhong Wang, Jenny Xie, Max Ruzanov, Kevin Stefanski, Rex Denton, T. G. Murali Dhar, David Marcoux, Shiuhang Yip, Melissa Yarde, Douglas G. Batt, Javed Khan, Joseph A. Tino, Qihong Zhao, Anurag S. Srivastava, Arvind Mathur, Mary Ellen Cvijic, John E. Macor, Sha Li, Dauh-Rurng Wu

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: chemistry.chemical_classification, 010405 organic chemistry, Chemistry, Organic Chemistry, Inflammation, Acanthosis, Pharmacology, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Pharmacokinetics, Pharmacodynamics, Drug Discovery, medicine, Inverse agonist, medicine.symptom, Whole blood, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c0984e9b1636552c6620f1a6235555
https://pubmed.ncbi.nlm.nih.gov/32551004

المؤلفون: Yanling Huang, Murali Gururajan, Cullen L. Cavallaro, Zhuyin Li, Ashok V. Purandare, Jessica J. Wong, Jenny Xie, Sylwia Stachura, Huadong Sun, Lalgudi S. Harikrishnan, Javed Khan, Brian E. Fink, Carolyn A. Weigelt, Honghe Wan, Peter K. Park, Daniel O'malley, Michele Agler, Cliff Chen, John S. Sack, Donna D. Wei, Zheming Ruan, Melissa Yarde, Heidi L. Perez, Monique Anthony, Virna Borowski, Max Ruzanov

المصدر: Bioorganic & Medicinal Chemistry Letters. 35:127778

مصطلحات موضوعية: Models, Molecular, Agonist, medicine.drug_class, Clinical Biochemistry, Retinoic acid, Pharmaceutical Science, Tretinoin, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, RAR-related orphan receptor gamma, Drug Discovery, medicine, Animals, Humans, Potency, Molecular Biology, Orphan receptor, Diaryl ether, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Th17 Cells, Molecular Medicine, Lead compound, Ethers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bcbeb08e68c5a36002135e73f0931e
https://doi.org/10.1016/j.bmcl.2021.127778

المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Stacey Skala, Paul Davies, Jenny Xie, John S. Sack, T. G. Murali Dhar, Melissa Yarde-Chinn, James Neels, Michael A. Poss, Stefan Ruepp, Robert J. Cherney, Christine Goldstein, Joseph A. Tino, Luisa Salter-Cid, Kevin Stefanski, Vojkan Susulic, Rajeev S. Bhide, Xiaoxia Yang, Anurag S. Srivastava, Zheming Ruan, Lan-Ying Qin, Cornelius Lyndon A M, Ruth Bosnius

المصدر: Bioorganic & Medicinal Chemistry Letters. 27:855-861

مصطلحات موضوعية: 0301 basic medicine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Piperazines, Autoimmune Diseases, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, In vivo, Drug Discovery, Animals, Humans, Protein Isoforms, Amines, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Amine derivatives, Binding Sites, Triazines, Organic Chemistry, Alternative treatment, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62fd58c8612f99a2829596d8b0690e5
https://doi.org/10.1016/j.bmcl.2017.01.016

المؤلفون: Dianlin Xie, Jing Chen, Celia D’Arienzo, Jodi K. Muckelbauer, Nelly Aranibar, John S. Sack, Jeffrey Tredup, Christine Huang, Charu Chaudhry, Joann Strnad, Percy H. Carter, John S. Tokarski, Adriana Zupa-Fernandez, Joseph B. Santella, Yuval Blat, Gardner Daniel S, James R. Burke, James Lin, David S. Weinstein, Moslin Ryan M, Yifan Zhang, Lihong Cheng, Chong-Hwan Chang, Donna L. Pedicord, Chunjian Liu, J. V. Duncia, Huadong Sun

المصدر: MedChemComm. 8:700-712

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Allosteric regulation, Pharmaceutical Science, Biochemistry, Pyridazine, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Signalling, Enzyme, chemistry, Tyrosine kinase 2, Drug Discovery, Molecular Medicine, Transferase, Selectivity, Tyrosine kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::552547d736fc9e5ccc4dd8b6c4e38854
https://doi.org/10.1039/c6md00560h

المؤلفون: Carolyn A. Weigelt, Xiaomei Gu, Lan-Ying Qin, Christine B. Goldstine, Sylwia Stachura, Jenny Xie, Zheming Ruan, T. G. Murali Dhar, Donna L. Pedicord, Michael A. Poss, Luisa Salter-Cid, Rajeev S. Bhide, Percy H. Carter, James Neels, John S. Sack, Stefan Ruepp, Kevin Stefanski, Paul Davies, Stacey Skala

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4256-4260

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, chemical and pharmacologic phenomena, Phosphatidylinositol 3-Kinases, Biochemistry, PI3K signaling, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Animals, Protein Isoforms, Structure–activity relationship, Amines, Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Binding Sites, biology, Triazines, Chemistry, Arthritis, Organic Chemistry, Protein Structure, Tertiary, Molecular Docking Simulation, Disease Models, Animal, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Keyhole limpet hemocyanin, Protein Binding, Collagen-induced arthritis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdaa3a62c46009198cffe25f36688ef7
https://doi.org/10.1016/j.bmcl.2016.07.047

المؤلفون: Georgia Cornelius, Carolyn A. Weigelt, Sha Li, Dauh-Rurng Wu, David Marcoux, Luisa Salter-Cid, Aberra Fura, Melissa Yarde, Shiuhang Yip, Peng Li, John Hynes, Tara Sherry, Max Ruzanov, Rex Denton, Robert J. Cherney, Yue-Zhong Shu, Jinhong Wang, Mary Ellen Cvijic, Zili Xiao, David J. Shuster, Jenny Xie, Purnima Khandelwal, Kevin Stefanski, T. G. Murali Dhar, Qing Shi, Yang Michael G, Mary T. Obermeier, Silvi A. Chacko, Javed Khan, John S. Sack, Joseph A. Tino, Qihong Zhao

المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127521

مصطلحات موضوعية: Male, Drug Inverse Agonism, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Melanosis, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, Animals, Inverse agonist, Sulfones, Molecular Biology, chemistry.chemical_classification, Mice, Inbred BALB C, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Interleukin-18, Late stage, Regioselectivity, Nuclear Receptor Subfamily 1, Group F, Member 3, Combinatorial chemistry, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Female, Heterocyclic Compounds, 3-Ring, Protein Binding, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea96801b270e44f686650249c45be29
https://doi.org/10.1016/j.bmcl.2020.127521

المؤلفون: Javed Khan, Dhanya Kumar Raut, Sylwia Stachura, Qihong Zhao, Jingwu Duan, Melissa Yarde, Bin Jiang, Hemalatha Hemagiri, Arvind Mathur, Ananta Karmakar, Michael Galella, T. G. Murali Dhar, John S. Sack, Percy H. Carter, Luisa Salter-Cid, Arun Kumar Gupta, Carolyn A. Weigelt, Dauh-Rurng Wu, Ding-Ren Shen

المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127392

مصطلحات موضوعية: Pyrrolidines, Drug Inverse Agonism, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Pyrrolidine, Mice, Structure-Activity Relationship, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, medicine, Animals, Humans, Inverse agonist, Molecular Biology, chemistry.chemical_classification, Pregnane X receptor, Binding Sites, Bicyclic molecule, 010405 organic chemistry, Organic Chemistry, Pregnane X Receptor, Nuclear Receptor Subfamily 1, Group F, Member 3, 0104 chemical sciences, Sulfonamide, 010404 medicinal & biomolecular chemistry, Binding conformation, chemistry, Drug Design, Microsomes, Liver, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7bcbc80bdfe799857c1dc059bd62be3
https://doi.org/10.1016/j.bmcl.2020.127392