المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/journal_contribution/S1_Table_-/14271832

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.s001

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/journal_contribution/S2_Table_-/14271835

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.s002

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/figure/Heat_map_of_up-_and_down-regulated_transcripts_mapped_with_a_dendrogram_red_up-regulated_n_348_blue_down-regulated_n_430_grey_unchanged_n_10590_/14271841

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.g001

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/S1_Data_-/14271838

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.s003

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/figure/Principal_component_analysis_PCA_depicts_some_variation_amongst_Non-loaded_controls_blue_possibly_related_to_animal_age_or_body_mass_yet_reveals_a_noteworthy_and_distinct_segregation_of_Non-loaded_controls_from_Hyperloaded_red_samples_/14271844

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.g002

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/figure/PANTHER_GO-Slim_results_for_up-regulated_and_down-regulated_genes_analyses_for_functional_networks_of_biological_processes_molecular_function_and_cellular_component_/14271847

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.g003

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/Over-_and_under-representation_of_PANTHER_Gene_Ontology_GO_activities_compared_to_background_/14271868

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.t004

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/figure/Cluster_dendrogram_with_dissimilarity_based_on_topological_overlap_together_with_assigned_module_colors_in_this_case_blue_and_turquoise_calculated_by_WGCNA_/14271850

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.g004

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/figure/Module-trait_associations_with_each_row_corresponding_to_a_module_eigengene_each_column_to_a_trait_/14271853

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.g005

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/DAVID_Top_20_clusters_of_differentially_expressed_RNA_transcripts_/14271865

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.t003

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/figure/Flowsheet_of_overall_experimental_design_/14271856

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.g006

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/WGCNA_module_enrichment_interfaced_with_Gene_Ontology_/14271871

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.t005

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/Normalized_fold-change_in_Hyperloaded_discs_of_select_RT-PCR_targets_/14271862

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.t002

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/PCR_primer_sequences_for_select_RNA_transcripts_/14271874

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.t006

المؤلفون: John Robert Matyas (10358272), Claudia Klein (1906330), Dragana Ponjevic (10358275), Neil A. Duncan (10358278), Gregory N. Kawchuk (9250290)

مصطلحات موضوعية: Microbiology, Cell Biology, Genetics, Molecular Biology, Immunology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, gene ontology, studies support, intervertebral disc cell mechanotra., gene targets, pericellular activities, ventral annuli fibrosi, loading, Weighted Gene Co-expression Network., response, future work, porcine annuli fibrosi, porcine intervertebral disc cell me., annuli fibrosi, pathway analyses, spine, therapy interventions, vivo, intervertebral disc degeneration, intervertebral discs, RNA, low-amplitude loads

Relation: https://figshare.com/articles/dataset/Twenty_selected_transcripts_with_differential_expression_possibly_relevant_to_IVD_pathobiology_/14271859

الاتاحة: https://doi.org/10.1371/journal.pone.0248104.t001