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1Academic Journal
المؤلفون: Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2Academic Journal
المؤلفون: Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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المؤلفون: Jeffrey Y.K. Wong, Steven E. Kirberger, Ryan Qiu, Arunika I. Ekanayake, Payam Kelich, Susmita Sarkar, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, John J. Dwyer, John M. Nuss, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C.K. Pomerantz, Ratmir Derda
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المؤلفون: Wei Shu, Sean P. Brown, Allan S. Wagman, Kirk W. Johnson, Dane Goff, Eric Fang, Vincent P. Le, Keith B. Pfister, Zhi-Jie Ni, Rustum S. Boyce, Paul A. Renhowe, Dirksen E. Bussiere, Stephen D. Harrison, Xiaohui A. Zhou, Barry Levine, David B. Ring, Cynthia M. Shafer, Savithri Ramurthy, Johanna M. Jansen, Sharadha Subramanian, Simon Ng, John M. Nuss
المصدر: Journal of Medicinal Chemistry. 60:8482-8514
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Proton Magnetic Resonance Spectroscopy, medicine.medical_treatment, CHO Cells, Crystallography, X-Ray, 01 natural sciences, Mass Spectrometry, Structure-Activity Relationship, 03 medical and health sciences, Cricetulus, GSK-3, Drug Discovery, medicine, Animals, Humans, Hypoglycemic Agents, Structure–activity relationship, Enzyme Inhibitors, Glycogen synthase, Chromatography, High Pressure Liquid, biology, 010405 organic chemistry, Chemistry, Chinese hamster ovary cell, Insulin, Glycogen Synthase Kinases, biology.organism_classification, Rats, 0104 chemical sciences, Pyrimidines, 030104 developmental biology, biology.protein, Molecular Medicine, Amine gas treating, Linker
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المؤلفون: James C. Collins, John M. Nuss, Antoine Henninot
المصدر: Journal of Medicinal Chemistry. 61:1382-1414
مصطلحات موضوعية: 0301 basic medicine, Drug Industry, 010405 organic chemistry, business.industry, Chemistry, Drug discovery, Nanotechnology, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Risk analysis (engineering), Drug Design, Drug Discovery, Humans, Molecular Medicine, Peptides, business, Peptide drug, Drug industry, Forecasting, Pharmaceutical industry
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المؤلفون: Robert Lester, Allison Luo, MiRa Huyghe, Kathleen M. Ogilvie, John M. Nuss, Raju Mohan, Robert Schwab, William J. Sandborn
المصدر: Gastroenterology. 158:S-1188
مصطلحات موضوعية: Hepatology, Pharmacokinetics, business.industry, Gastroenterology, Medicine, Pharmacology, business, Highly selective
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المؤلفون: David B. Ring, Eric Fang, Allan S. Wagman, Rustum S. Boyce, Simon Ng, Wei Shu, Manoj C. Desai, Keith B. Pfister, Sean P. Brown, Savithri Ramurthy, Dirksen E. Bussiere, Abran Costales, Levine Barry Haskell, John M. Nuss, Sharada Subramanian, Haixia Wang, Cynthia M. Shafer
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:126930
مصطلحات موضوعية: Pyridines, medicine.medical_treatment, Clinical Biochemistry, Cell, Drug Evaluation, Preclinical, Pharmaceutical Science, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Glycogen Synthase Kinase 3, Inhibitory Concentration 50, Structure-Activity Relationship, GSK-3, Drug Discovery, medicine, Animals, Humans, Transferase, Protein kinase A, Glycogen synthase, Protein Kinase Inhibitors, Molecular Biology, Cyclin-dependent kinase 1, Binding Sites, biology, 010405 organic chemistry, Kinase, Chemistry, Insulin, Organic Chemistry, Protein Structure, Tertiary, Rats, 0104 chemical sciences, Metabolic pathway, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: John Woolfrey, Craig Stacy Takeuchi, Arthur Plonowski, Kyoko Yamaguchi, Ron Aoyama, Byung Gyu Kim, Anagha Abhijit Joshi, Paul Foster, Sunghoon Ma, Sharmila Rajan, Tae Gon Baik, Naing Aay, Arlyn Arcalas, Charles M. Blazey, Jonah Cannoy, Peter Lamb, Isabelle Lehoux, Chris A. Buhr, Narsimha Munagala, Matthew Sangyup Lee, John M. Nuss, James W. Leahy, Jae Lee, Sergey Epshteyn, Neel Kumar Anand, Nicole Miller, Longcheng Wang, Katherine Lara, Henry Johnson
المصدر: Journal of Medicinal Chemistry. 56:2218-2234
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Administration, Oral, Biological Availability, Pharmacology, Binding, Competitive, Substrate Specificity, Mice, Adenosine Triphosphate, Dogs, Pharmacokinetics, Oral administration, Cell Line, Tumor, Drug Discovery, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Drug discovery, Chemistry, Kinase, TOR Serine-Threonine Kinases, Benzoxazines, Rats, Bioavailability, Cell culture, Molecular Medicine, Phosphorylation, Female
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المؤلفون: Sunghoon Ma, Julie Lougheed, Christopher Jaeger, Scott W. Womble, Jean-Claire Limun Manalo, Chris A. Buhr, Longcheng Wang, Wentao Zhang, Kenneth D. Rice, Steven Charles Defina, Abigail R. Kennedy, Timothy S. Heuer, Michael Yakes, Neel Kumar Anand, Tae-Gon Baik, Curtis Jeff Kimo, Joerg Bussenius, Angie I. Kim, Jonathan C. Li, Michael Pack, Csaba J. Peto, Monique Nicoll, Naing Aay, Simona Costanzo, Jae Lee, Garth Joseph Mcgrath, Charles M. Blazey, Tsze H. Tsang, Shiva Malek, Anagha Abhijit Joshi, Arlyn Arcalas, Ping Huang, Larisa Dubenko, Jean-Francois Martini, Katherine Lara, John M. Nuss, Owen Joseph Bowles
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5396-5404
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Phthalic Acids, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Biochemistry, Protein content, Mice, chemistry.chemical_compound, Mouse xenograft, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Tumor regression, Animals, Humans, HSP90 Heat-Shock Proteins, Molecular Biology, Cell Proliferation, biology, Chemistry, Drug discovery, Organic Chemistry, Tropane, Hsp90, Small molecule, biology.protein, Molecular Medicine, Azabicyclo Compounds
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المؤلفون: Erick Wang Co, John M. Nuss, Stefan Engst, Monica Rodriquez, Jason Chen, Xiang Wu, Moon Hwan Kim, Peiwen Yu, Fawn Qian, Yeping Zhao, Morrison B. Mac, Peter Lamb, Wei Cheng, Wei Xu, Kwang-Ai Won, Frauke Bentzien, Wentao Zhang, Thomas J. Stout, Dana T. Aftab, Jason Jevious Parks, Jeffrey H. Till, Amy Lew Tsuhako, Rhett Ronald Klein, Levina Goon, Donna T. Le, F. Michael Yakes
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4979-4985
مصطلحات موضوعية: Indoles, Transplantation, Heterologous, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, Biochemistry, Receptor tyrosine kinase, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Cytochrome P-450 CYP3A, Humans, Transferase, Structure–activity relationship, Oxindole, Lung, Protein Kinase Inhibitors, Molecular Biology, ADME, Binding Sites, biology, Organic Chemistry, Receptor Protein-Tyrosine Kinases, Protein Structure, Tertiary, Rats, Transplantation, chemistry, Drug Design, biology.protein, Molecular Medicine, Female, Piperidine, Platelet-derived growth factor receptor, Half-Life
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المؤلفون: Arlyn Arcalas, Richards Steven J, Amy Lew Tsuhako, Naing Aay, Kim Ferguson, Arthur Plonowski, Gordon Mark Stott, Wei Xu, Jenny Young, Peiwen Yu, Wentao Zhang, Charles R. Holst, Kevin Noson, Cristiana A. Zaharia, Brown S David, Hongwang Du, Manisha Mohan, Ping Huang, Thomas J. Stout, Adam A. Galan, Patrick Kearney, David W. Markby, Stefan Engst, Maurizio Franzini, Peiwen Zhou, John M. Nuss, Brian Kane, Kenneth J. Shaw, Elena S. Koltun, Scott Robertson, Moon Hwan Kim, Vicky Chan, Jia Li
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3727-3731
مصطلحات موضوعية: Cell cycle checkpoint, Transplantation, Heterologous, Clinical Biochemistry, Pharmaceutical Science, Cell Cycle Proteins, Pyrimidinones, Protein Serine-Threonine Kinases, Biochemistry, Serine, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Computer Simulation, Threonine, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, Kinase, Chemistry, Organic Chemistry, DNA replication, Cell Cycle Checkpoints, In vitro, Protein Structure, Tertiary, Rats, Up-Regulation, Cell biology, Cell culture, Molecular Medicine
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المؤلفون: John M. Nuss, Gordon Mark Stott, Hongwang Du, E.S. Koltun, A.D Laird, I Ngan, Amy Lew Tsuhako, Adam A. Galan, Ping Huang, Thomas J. Stout, Patrick Kearney, Chan, Stuart Johnston, W. Zhang, R Lin, Stefan Engst, Peiwen Zhou, L Mock, Maurizio Franzini, Brown S David, Moon Hwan Kim, Brian Kane, Naing Aay, Arlyn Arcalas, Wei Xu, Michael Pack, Peiwen Yu, Cristiana A. Zaharia
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3732-3738
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Transferase, Computer Simulation, Furans, Protein Kinase Inhibitors, Molecular Biology, Cell permeability, Alkyl, Biological evaluation, chemistry.chemical_classification, Binding Sites, Kinase, Aryl, Organic Chemistry, Combinatorial chemistry, Protein Structure, Tertiary, chemistry, Design synthesis, Drug Design, Molecular Medicine, Selectivity
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المؤلفون: Danny Tam, Amanda Harrison, Jason August Nachtigall, Fawn Qian, Ron Aoyama, Jon Rosen, Peter Lamb, Tao Wang, Artur Plonowski, Belinda Cancilla, Naing Aay, Elena S. Koltun, Patrick Kearney, Adam A. Galan, Arlyn Arcalas, Kwang-Ai Won, Wentao Zhang, Raju Mohan, Hongwang Du, Vicky Chan, Art Hanel, Patricia Finn, Michael Yakes, Jeff Zhang, Richards Steven J, Frauke Bentzien, John M. Nuss, Kathy Ogilvie, Christopher J. Larson
المصدر: Journal of Medicinal Chemistry. 55:4322-4335
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Adipose Tissue, White, Phenylalanine, Mice, Nude, Glucosylceramide synthase, Pharmacology, Mass Spectrometry, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, In vivo, Gangliosides, Drug Discovery, Animals, Humans, Dosing, Enzyme Inhibitors, IC50, Triglycerides, Gene knockdown, Chemistry, Glucose Tolerance Test, Zdf rats, Rats, Rats, Zucker, Mice, Inbred C57BL, Diabetes Mellitus, Type 2, Liver, Biochemistry, Metabolic regulation, Glucosyltransferases, Decreased plasma triglycerides, Molecular Medicine, Female, hormones, hormone substitutes, and hormone antagonists
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14
المؤلفون: Jeffry Kimo Curtis, Julie Lougheed, Stefan Engst, Peiwen Yu, Anagha Abhijit Joshi, Elena S. Koltun, Csaba J. Peto, Neel Kumar Anand, Jean-Claire Limun Manalo, Stuart Johnston, Steven Charles Defina, Abigail R. Kennedy, Naing Aay, Kenneth D. Rice, Larisa Dubenko, Tsze H. Tsang, Jean-Francois Martini, Simona Costanzo, John M. Nuss, Angie I. Kim, Owen Joseph Bowles, Joerg Bussenius, Charles M. Blazey
المصدر: ACS Medicinal Chemistry Letters. 3:416-421
مصطلحات موضوعية: MAPK/ERK pathway, business.industry, MEK inhibitor, Organic Chemistry, Allosteric regulation, Cancer, Pharmacology, medicine.disease, Biochemistry, Phenotype, In vitro, Downregulation and upregulation, In vivo, Drug Discovery, medicine, Cancer research, business
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المؤلفون: Kenneth D. Rice, Neel Kumar Anand, Moon Hwan Kim, Jason Jevious Parks, Tsze H. Tsang, Donna T. Le, Larisa Dubenko, Erick Wang Co, Steven Charles Defina, Joerg Bussenius, Lynne Canne-Bannen, David J. Matthews, John M. Nuss, Stefan Engst, Simona Costanzo, Richard George Khoury, A. Douglas Laird, Diva Sze-Ming Chan, Wei Xu, Owen Joseph Bowles, Maurizio Franzini, Vasu Jammalamadaka, Ping Huang, Amy Lew Tsuhako, Yong Wang, David W. Markby, Baili Chen, Morrison B. Mac, Rhett Ronald Klein, Nicole Miller, Charles M. Blazey
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2693-2697
مصطلحات موضوعية: Models, Molecular, Pyridines, Proto-Oncogene Proteins c-akt, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Enzyme activator, Dogs, In vivo, Microsomes, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Molecular Structure, Kinase, Chemistry, Akt/PKB signaling pathway, Organic Chemistry, Ribosomal Protein S6 Kinases, 70-kDa, Cancer, Haplorhini, medicine.disease, Enzyme Activation, Cancer research, Pyrazoles, Molecular Medicine
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المؤلفون: Patricia Finn, Jeff Zhang, Patrick Kearney, Raju Mohan, Tao Wang, Peter Lamb, Vicky Chan, Danny Tam, Christopher J. Larson, Kwang-Ai Won, Adam A. Galan, Amanda Harrison, Jason August Nachtigall, Art Hanel, Jon Rosen, Richards Steven J, John M. Nuss, Naing Aay, Fawn Qian, Kevin Noson, Kathleen M. Ogilvie, Hongwang Du, Elena S. Koltun
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6773-6777
مصطلحات موضوعية: Glucosylceramide Synthase Inhibitors, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Inflammation, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Oral administration, In vivo, Drug Discovery, medicine, Animals, Humans, Potency, Tissue distribution, Enzyme Inhibitors, Molecular Biology, ADME, Chemistry, Organic Chemistry, In vitro, Mice, Inbred C57BL, Glucosyltransferases, Molecular Medicine, medicine.symptom
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17Academic Journal
المؤلفون: TAKEUCHI CRAIG, Craig Takeuchi, Byung Gyu Kim, Charles M. Blazey, Sunghoon Ma, Henry W. B. Johnson, Neel K. Anand, Arlyn Arcalas, Tae Gon Baik, Chris A. Buhr, Jonah Cannoy, Sergey Epshteyn, Anagha Joshi, Katherine Lara, Matthew S. Lee, Longcheng Wang, James W. Leahy, John M. Nuss, Naing Aay, Ron Aoyama, Paul Foster, Jae Lee, Isabelle Lehoux, Narsimha Munagala, Arthur Plonowski, Sharmila Rajan, John Woolfrey, Kyoko Yamaguchi, Peter Lamb, Nicole Miller
Relation: http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100685042; oai:t2r2.star.titech.ac.jp:50269996
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18Academic Journal
المؤلفون: Timothy Forsyth, Patrick C. Kearney, Byung Gyu Kim, Henry W. B. Johnson, Naing Aay, Arlyn Arcalas, David S. Brown, Vicky Chan, Jeff Chen, Hongwang Du, Sergey Epshteyn, Adam A. Galan, Tai P. Huynh, Mohamed A. Ibrahim, Brian Kane, Elena S. Koltun, Grace Mann, Lisa E. Meyr, Matthew S. Lee, Gary L. Lewis, Robin T. Noguchi, Michael Pack, Brian H. Ridgway, Xian Shi, TAKEUCHI CRAIG, Craig Takeuchi, Peiwen Zu, James W. Leahy, John M. Nuss, Ron Aoyama, Stefan Engst, Steven B. Gendreau, Robert Kassees, Jia Li, Shwu-Hwa Lin, Jean-Francois Martini, Thomas Stout, Philip Tong, John Woolfrey, Wentao Zhang, Peiwen Yu
Relation: http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100685045; oai:t2r2.star.titech.ac.jp:50270003
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المؤلفون: Allan S. Wagman, John M. Nuss
المصدر: Current Pharmaceutical Design. 7:417-450
مصطلحات موضوعية: medicine.medical_specialty, Pyruvate dehydrogenase kinase, medicine.medical_treatment, Population, Pharmaceutical Science, Receptors, Cytoplasmic and Nuclear, Pharmacology, Biology, Glucagon, Diabetes Therapy, Diabetes Complications, Impaired glucose tolerance, Insulin resistance, Internal medicine, Diabetes mellitus, Drug Discovery, Diabetes Mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Obesity, Enzyme Inhibitors, education, education.field_of_study, business.industry, Genetic Therapy, medicine.disease, Glucose, Sulfonylurea Compounds, Endocrinology, Postprandial, Liver, Molecular Medicine, business, Transcription Factors
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المؤلفون: John M. Nuss, Allan S. Wagman, Liang Wang
المصدر: The Journal of Organic Chemistry. 65:9103-9113
مصطلحات موضوعية: chemistry.chemical_classification, Annulation, medicine.drug_class, Aryl, Organic Chemistry, Carboxamide, Sulfonamide, Catalysis, chemistry.chemical_compound, Acetic acid, Malonate, chemistry, medicine, Organic chemistry, Acetophenone
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