المؤلفون: Gordon L. Amidon, Chandrasekharan Ramachandran, John M. Hilfinger, Christopher P. Landowski, Jing Sun, Balvinder S. Vig, Yasuhiro Tsume

المصدر: Molecules, Vol 13, Iss 7, Pp 1441-1454 (2008)

مصطلحات موضوعية: 5-FU, floxuridine, prodrugs, Caco-2 permeability, cell proliferation assays, oligopeptide transporter 1 (PEPT1), Organic chemistry, QD241-441

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1420-3049/13/7/1441/; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/a04c8d0bdff94aefb074988bf52ef410

المؤلفون: Xueqin Song, Gordon L. Amidon, Yasuhiro Tsume, Tuba Incecayir, John M. Hilfinger

المصدر: European Journal of Pharmaceutics and Biopharmaceutics. 86:514-523

مصطلحات موضوعية: Antimetabolites, Antineoplastic, Cell Membrane Permeability, Membrane permeability, Administration, Oral, Pharmaceutical Science, Deoxycytidine, Article, Mice, Enzyme Stability, medicine, Animals, Humans, Prodrugs, Amino Acids, Thymidine phosphorylase, chemistry.chemical_classification, Mice, Inbred BALB C, Chemistry, Stereoisomerism, General Medicine, Metabolism, Prodrug, Gemcitabine, Amino acid, Enzyme, Biochemistry, Caco-2, Female, Caco-2 Cells, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33aa779ac7533f5f1388562a1ec78e1
https://doi.org/10.1016/j.ejpb.2013.12.009

المؤلفون: Jae-Seung Kim, John M. Hilfinger, Wei Shen

المصدر: Synthetic Communications. 42:358-374

مصطلحات موضوعية: chemistry.chemical_classification, chemistry, Organic Chemistry, Toxicity, Total synthesis, Nucleotide, Prodrug, Pharmacology, Cytotoxicity, Tricyclic, Bioavailability, Amino acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2caae0409db0b343ff8ddd82c21ef7ef
https://doi.org/10.1080/00397911.2010.524342

المؤلفون: Deepak Gupta, John M. Hilfinger, Jing Sun, Gordon L. Amidon, Arik Dahan, Sheeba Varghese Gupta, Kyung Dall Lee, Yasuhiro Tsume

المصدر: Molecular Pharmaceutics. 8:2358-2367

مصطلحات موضوعية: Cell Membrane Permeability, Membrane permeability, viruses, Pharmaceutical Science, Article, HeLa, Zanamivir, Drug Stability, Drug Discovery, medicine, Animals, Humans, Prodrugs, Intestinal Mucosa, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Drug Carriers, Molecular Structure, biology, Membrane transport protein, virus diseases, biochemical phenomena, metabolism, and nutrition, Prodrug, biology.organism_classification, Combinatorial chemistry, Rats, respiratory tract diseases, Amino acid, Intestines, chemistry, Biochemistry, Caco-2, biology.protein, Molecular Medicine, Caco-2 Cells, Drug carrier, HeLa Cells, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff777ffbead5c3f7b1287885b807ee85
https://doi.org/10.1021/mp200291x

المؤلفون: John C. Drach, Boris A. Kashemirov, Michaela Serpi, Charles E. McKenna, John M. Hilfinger, Valeria M. Zakharova, Mindy Collins, Ivan S. Krylov, Katherine Z. Borysko, Julie M. Breitenbach, Larryn W. Peterson

المصدر: Journal of Medicinal Chemistry. 54:5680-5693

مصطلحات موضوعية: Cell Survival, Stereochemistry, Organophosphonates, Biological Availability, Cytomegalovirus, Vaccinia virus, Herpesvirus 1, Human, Antiviral Agents, Article, Cytosine, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Prodrugs, Tyrosine, Cowpox virus, IC50, Cells, Cultured, Active metabolite, Dipeptide, Molecular Structure, Adenine, Fibroblasts, Prodrug, In vitro, Rats, Models, Chemical, chemistry, Area Under Curve, Molecular Medicine, Cidofovir

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b88218740170ce8c2178cb525db1f6
https://doi.org/10.1021/jm2001426

المؤلفون: Boris A. Kashemirov, Jae-Seung Kim, Paul Kijek, Kathy Borysko, John M. Hilfinger, Stefanie Mitchell, Larryn W. Peterson, John C. Drach, Charles E. McKenna, Julie M. Breitenbach

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4045-4049

مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Organophosphonates, Administration, Oral, Cytomegalovirus, Pharmaceutical Science, Pharmacology, Antiviral Agents, Biochemistry, Chemical synthesis, Article, Cytosine, Inhibitory Concentration 50, chemistry.chemical_compound, Oral administration, Valine, Drug Discovery, Serine, Animals, Humans, Prodrugs, Molecular Biology, Cells, Cultured, Alanine, Dipeptide, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Biological activity, Prodrug, In vitro, Rats, Disease Models, Animal, chemistry, Molecular Medicine, Peptides, Cidofovir

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870ce9adb2499fb30f5b310a780cbec8
https://doi.org/10.1016/j.bmcl.2011.04.126

المؤلفون: Gordon L. Amidon, Yasuhiro Tsume, John M. Hilfinger

المصدر: Pharmaceutical Research. 28:2575-2588

مصطلحات موضوعية: Drug, media_common.quotation_subject, Cell, Pharmaceutical Science, Permeability, chemistry.chemical_compound, Drug Delivery Systems, Drug Stability, Floxuridine, Cell Line, Tumor, Neoplasms, Enzyme Stability, Monolayer, medicine, Humans, Prodrugs, Pharmacology (medical), Amino Acids, Cell Proliferation, media_common, Pharmacology, chemistry.chemical_classification, Dipeptide, Chemistry, Organic Chemistry, Cancer, Dipeptides, Prodrug, medicine.disease, Amino acid, medicine.anatomical_structure, Biochemistry, Delayed-Action Preparations, Molecular Medicine, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d5ab0e1229353ce234e98a013211f0
https://doi.org/10.1007/s11095-011-0485-7

المؤلفون: Charles E. McKenna, John C. Drach, Katherine Z. Borysko, Stefanie Mitchell, Jae Seung Kim, Larryn W. Peterson, Ulrika Eriksson, Boris A. Kashemirov, John M. Hilfinger, Julie M. Breitenbach, Paul Kijek

المصدر: Molecular Pharmaceutics. 5:598-609

مصطلحات موضوعية: Male, Models, Molecular, Human cytomegalovirus, Static Electricity, Organophosphonates, Cytomegalovirus, Pharmaceutical Science, Peptide, Antiviral Agents, Article, Cytosine, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Serine, medicine, Animals, Humans, Prodrugs, Intestinal Mucosa, chemistry.chemical_classification, Dipeptide, Esterification, Molecular Structure, Hydrolysis, Prodrug, medicine.disease, Rats, Bioavailability, chemistry, Biochemistry, Molecular Medicine, Vaccinia, Peptides, Cidofovir

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a939a351f5cbb3b511f4bd0c3695b38
https://doi.org/10.1021/mp8000099

المؤلفون: Marija Tubic-Grozdanis, Jae Seung Kim, Paul Kijek, Peter Langguth, Gordon L. Amidon, John M. Hilfinger, Petra Staubach

المصدر: Pharmaceutical Research. 25:1591-1600

مصطلحات موضوعية: Adult, Male, Drug, Simvastatin, media_common.quotation_subject, Acrylic Resins, Biological Availability, Pharmaceutical Science, Capsules, Pharmacology, Dosage form, Intestinal absorption, Excipients, Pharmacokinetics, medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Chromatography, High Pressure Liquid, media_common, Cross-Over Studies, biology, Chemistry, Organic Chemistry, Hydroxymethylglutaryl-CoA reductase, Bioavailability, Intestinal Absorption, Solubility, Area Under Curve, Delayed-Action Preparations, HMG-CoA reductase, biology.protein, Molecular Medicine, Female, Spectrophotometry, Ultraviolet, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Algorithms, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f6f931bd7c9bc1746078d7499f62c3
https://doi.org/10.1007/s11095-007-9519-6

المؤلفون: Elke Lipka, Tuba Incecayir, Gordon L. Amidon, Yasuhiro Tsume, Tomoka Gose, Hao Xu, John M. Hilfinger, Jing Sun, Takeo Nakanishi, Ikumi Tamai

مصطلحات موضوعية: Male, 0301 basic medicine, Cell Membrane Permeability, Membrane permeability, medicine.drug_class, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Antiviral Agents, 030226 pharmacology & pharmacy, Article, Mice, Xenopus laevis, 03 medical and health sciences, Oseltamivir, 0302 clinical medicine, medicine, Animals, Humans, Prodrugs, Mice, Knockout, chemistry.chemical_classification, Drug Carriers, Oligopeptide, Neuraminidase inhibitor, Chemistry, Diastereomer, Hep G2 Cells, Prodrug, Amino acid, Bioavailability, 030104 developmental biology, Biochemistry, Caco-2, Female, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f6f10c5d834d6cd3fde43bc18237f6
https://avesis.gazi.edu.tr/publication/details/1d969e7b-b4ae-42db-8483-1b05addea914/oai

المؤلفون: Charles E. McKenna, Boris A. Kashemirov, Ulrika Eriksson, Gordon L. Amidon, Phillip E. Kish, Stefanie Mitchell, Jae-Seung Kim, John M. Hilfinger

المصدر: Journal of Organometallic Chemistry. 690:2673-2678

مصطلحات موضوعية: chemistry.chemical_classification, Dipeptide, Chemistry, animal diseases, viruses, Organic Chemistry, virus diseases, Peptide, Transporter, Tripeptide, biochemical phenomena, metabolism, and nutrition, respiratory system, Prodrug, Biochemistry, Bioavailability, Amino acid, Inorganic Chemistry, chemistry.chemical_compound, Materials Chemistry, Physical and Theoretical Chemistry, Cidofovir

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b8fb703f6d1751bd26340ad3d6a14dd7
https://doi.org/10.1016/j.jorganchem.2005.03.004

المؤلفون: Xueqin Song, Philip L. Lorenzi, Christopher P. Landowski, Balvinder S. Vig, John M. Hilfinger, Gordon L. Amidon

المصدر: Song, X, Lorenzi, P L, Landowski, C P, Vig, B S, Hilfinger, J M & Amidon, G L 2005, ' Amino acid ester prodrugs of the anticancer agent gemcitabine : Synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport ', Molecular Pharmaceutics, vol. 2, no. 2, pp. 157-167 . https://doi.org/10.1021/mp049888e

مصطلحات موضوعية: Peptide transporter, Membrane permeability, Amino acid esters, Metabolite, Pharmaceutical Science, Antineoplastic Agents, Deoxycytidine, Peptide Transporter 1, Inhibitory Concentration 50, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Humans, Prodrugs, Amino Acids, Prodrug, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Symporters, Cytidine deaminase, Hydrolysis, Biological Transport, Dipeptides, Gemcitabine, Amino acid, chemistry, Biochemistry, Mediated transport, Molecular Medicine, Caco-2 Cells, Drug Screening Assays, Antitumor, Peptides, Nucleoside, HeLa Cells, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232db4b6cca0dacc1f8cfd38d2f903ea
https://doi.org/10.1021/mp049888e

المؤلفون: David Kritchevsky, Yasuhiro Tsume, Bryan Delaney, Wade N. Schmelzer, Steve McCurry, Luke A. Stevens, Jae Seung Kim, John M. Hilfinger, Gordon L. Amidon, James Haworth

المصدر: The Journal of Nutritional Biochemistry. 15:289-295

مصطلحات موضوعية: food.ingredient, Endocrinology, Diabetes and Metabolism, Campesterol, Clinical Biochemistry, Biochemistry, Soybean oil, Absorption, Rats, Sprague-Dawley, chemistry.chemical_compound, food, Blood serum, Animals, Molecular Biology, Chromatography, High Pressure Liquid, Micelles, Mouth, Nutrition and Dietetics, Chromatography, Stigmasterol, beta-Sitosterol, Esterification, Cholesterol, Phytosterol, Phytosterols, Water, Sitosterols, Diet, Rats, Bioavailability, Kinetics, Solubility, chemistry, Phosphatidylcholines, Emulsions

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4729d4c86b378fd53c69fdff4e80c7b6
https://doi.org/10.1016/j.jnutbio.2003.08.013

المؤلفون: Balvinder S. Vig, Gordon L. Amidon, Henry I. Mosberg, Philip L. Lorenzi, Sachin Mittal, John M. Hilfinger, Ho-Chul Shin, Christopher P. Landowski

المصدر: Pharmaceutical Research. 20:1381-1388

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Stereoisomerism, Prodrug, Amino acid, Hydrolysis, Enzyme, chemistry, Floxuridine, medicine, Molecular Medicine, Structure–activity relationship, Pharmacology (medical), Proline, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9399b87d739a03306fdb9b343375cf92
https://doi.org/10.1023/a:1025745824632

المؤلفون: C B Matthews, John M. Hilfinger, Beverly L. Davidson, G Jenkins

المصدر: Gene Therapy. 6:1558-1564

مصطلحات موضوعية: Polymers, viruses, Genetic Vectors, Gene Expression, Biocompatible Materials, Polyethylene glycol, Biology, medicine.disease_cause, Mass Spectrometry, Adenoviridae, chemistry.chemical_compound, Polylactic Acid-Polyglycolic Acid Copolymer, In vivo, PEG ratio, Genetics, medicine, Humans, Polylysine, Lactic Acid, Molecular Biology, Genetic transfer, Gene Transfer Techniques, technology, industry, and agriculture, Genetic Therapy, beta-Galactosidase, Molecular biology, Biodegradable polymer, Microspheres, PLGA, chemistry, Molecular Medicine, Polyglycolic Acid, Chromatography, Liquid, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325b8dc4631fd6ff68add1c549514987
https://doi.org/10.1038/sj.gt.3300978

المؤلفون: Steven J. Beer, Brian D. Ross, Beverly L. Davidson, C B Matthews, John M. Hilfinger, Colleen S. Stein

المصدر: Gene Therapy. 5:740-746

مصطلحات موضوعية: viruses, Genetic enhancement, Genetic Vectors, Biology, medicine.disease_cause, Adenoviridae, law.invention, chemistry.chemical_compound, In vivo, law, Genetics, medicine, Humans, Polyglactin 910, Molecular Biology, Glycolic acid, Brain Neoplasms, Immunogenicity, Brain, Genetic Therapy, Virology, Molecular biology, Microspheres, In vitro, PLGA, Biodegradation, Environmental, chemistry, Microscopy, Electron, Scanning, Recombinant DNA, Molecular Medicine, Glioblastoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0c42425aea807a95e202a82da6b35a
https://doi.org/10.1038/sj.gt.3300647

المؤلفون: Blake J. Roessler, Gordon L. Amidon, Elke Walter, Cheng Pang Hsu, Hans P. Merkle, John M. Hilfinger

المصدر: Pharmaceutical Research. 15:1376-1381

مصطلحات موضوعية: Pharmacology, Oligopeptide, biology, Organic Chemistry, Pharmaceutical Science, Transporter, medicine.disease_cause, biology.organism_classification, Epithelium, In vitro, Cell biology, Adenoviridae, HeLa, Transduction (genetics), medicine.anatomical_structure, Caco-2, Immunology, medicine, Molecular Medicine, Pharmacology (medical), Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::63c31ac8a5fcd0b04d5444a7faacd382
https://doi.org/10.1023/a:1011993303397

المؤلفون: Beverly L. Davidson, Gordon L. Amidon, Blake J. Roessler, John M. Hilfinger, Maria A. Croyle

المصدر: Pharmaceutical Development and Technology. 3:373-383

مصطلحات موضوعية: Recombination, Genetic, HEPES, food.ingredient, Cryoprotectant, Pharmaceutical Science, Genetic Therapy, General Medicine, Hydrogen-Ion Concentration, Trehalose, Gelatin, Adenoviridae, chemistry.chemical_compound, Freeze-drying, Freeze Drying, food, chemistry, Biochemistry, Freezing, medicine, Humans, Ethanesulfonic acid, Sorbitol, Mannitol, Cell Line, Transformed, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffec29cdbb418be288a1d61327a0db1
https://doi.org/10.3109/10837459809009865

المؤلفون: John M. Hilfinger, Steven J. Beer, Beverly L. Davidson

المصدر: Advanced Drug Delivery Reviews. 27:59-66

مصطلحات موضوعية: Gene product, Adenoviridae, Helper virus, Genetic enhancement, Genetic transfer, medicine, Pharmaceutical Science, Cytotoxic T cell, Biology, medicine.disease_cause, Recombinant virus, Virology, Viral vector

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::39368dbe8d0a6a40aa23010ade29b55a
https://doi.org/10.1016/s0169-409x(97)00022-7

المؤلفون: Maria A. Croyle, Beverly L. Davidson, John M. Hilfinger, Blake J. Roessler, Gordon L. Amidon, Elke Walter

المصدر: Journal of Controlled Release. 46:75-87

مصطلحات موضوعية: Reporter gene, Genetic enhancement, Pharmaceutical Science, Transfection, Biology, medicine.disease_cause, Gastrointestinal epithelium, Intestinal epithelium, Virology, Cell biology, Viral vector, Adenoviridae, medicine, Secretion

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::28b8a818894885decc4fc97fb62e148e
https://doi.org/10.1016/s0168-3659(96)01584-2