المؤلفون: James A. H. Inkster, Anna W. Sromek, Vamsidhar Akurathi, John L. Neumeyer, Alan B. Packard

المصدر: Chemistry, Vol 3, Iss 3, Pp 1047-1056 (2021)

مصطلحات موضوعية: fluorine-18, aporphines, dopamine D2 agonist, high-affinity state, PET, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2624-8549/3/3/75; https://doaj.org/toc/2624-8549

URL الوصول: https://doaj.org/article/5a1916e91d404f2aa0245d4f9b0a550a

المؤلفون: Youbai Chen, Alan B. Packard, John L. Neumeyer, Anna W. Sromek, Vamsidhar Akurathi, James A. H. Inkster

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

مصطلحات موضوعية: Multidisciplinary, 010405 organic chemistry, Elution, Chemistry, lcsh:R, lcsh:Medicine, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Solvent, chemistry.chemical_compound, Perchlorate, Nucleophile, Basic solution, Anhydrous, lcsh:Q, Acetonitrile, lcsh:Science, Fluoride

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077b79cbd9506167828faee6438141e5
http://link.springer.com/article/10.1038/s41598-020-61845-y

المؤلفون: Sivan, Subburaju, Anna W, Sromek, Philip, Seeman, John L, Neumeyer

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: Apomorphine, Raclopride, Receptors, Dopamine D2, Dopamine, Dopamine Agonists, Receptors, Dopamine D3, Animals, Nervous System Diseases, Corpus Striatum, Article, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::7f813fd6204b12b4423e55ec16e37b51
https://pubmed.ncbi.nlm.nih.gov/33844498

المؤلفون: John L. Neumeyer, Yulong Xu, Anna W. Sromek

المصدر: Bioorganic & Medicinal Chemistry Letters. 29:230-233

مصطلحات موضوعية: 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, High selectivity, Pharmaceutical Science, 01 natural sciences, Biochemistry, 0104 chemical sciences, 5-HT2C receptor, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Drug Discovery, Molecular Medicine, Serotonin, Aporphine, Binding site, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::96b833cc72f602d444ab8ba4a6b456d2
https://doi.org/10.1016/j.bmcl.2018.11.050

المؤلفون: Philip Seeman, Sivan Subburaju, Anna W. Sromek, John L. Neumeyer

المصدر: ACS Chem Neurosci

مصطلحات موضوعية: 0301 basic medicine, Agonist, Apomorphine, Physiology, medicine.drug_class, Dopamine, Cognitive Neuroscience, Binding, Competitive, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dopamine receptor D2, medicine, Animals, Aporphine, Receptor, Raclopride, Receptors, Dopamine D2, Chemistry, Antagonist, Cell Biology, General Medicine, Ligand (biochemistry), Corpus Striatum, 030104 developmental biology, Dopamine Agonists, Schizophrenia, Biophysics, Dopamine Antagonists, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac8ae3a2d925a203e60932a1dfd9de6
https://doi.org/10.1021/acschemneuro.8b00096

المؤلفون: Xue-Qin Chen, Jing Zhang, John L Neumeyer, Guo-Zhang Jin, Guo-Yuan Hu, Ao Zhang, Xuechu Zhen

المصدر: PLoS ONE, Vol 4, Iss 6, p e5811 (2009)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC2690691?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/7508d982aa0449b3b4b8a817edb57a18

المؤلفون: Peter Jenner, Anna W. Sromek, Andrew J. Lees, Louise Lincoln, Sarah Rose, Michael J. Jackson, John L. Neumeyer, Ria Fisher

المصدر: Movement Disorders. 31:1381-1388

مصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, business.industry, MPTP, Pharmacology, medicine.disease, Dopamine agonist, Effective dose (pharmacology), Apomorphine, 03 medical and health sciences, Subcutaneous injection, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Neurology, chemistry, Dyskinesia, Oral administration, medicine, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c604e38f427589e5c64738425d70de04
https://doi.org/10.1002/mds.26626

المؤلفون: Yulong, Xu, Anna W, Sromek, John L, Neumeyer

المصدر: Bioorganicmedicinal chemistry letters. 29(2)

مصطلحات موضوعية: Aporphines, Halogenation, Molecular Structure, Receptor, Serotonin, 5-HT2C, Humans, Ligands

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::86c2b56a495db415b9249cb1264d3891
https://pubmed.ncbi.nlm.nih.gov/30545651

المؤلفون: David Alagille, Gilles Tamagnan, Shaohui Zhang, John L. Neumeyer, R. M. Baldwin, Thomas J. Morley, Vamsidhar Akurathi, Wei Li, Anna W. Sromek, Alan B. Packard

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 57:725-729

مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Leaving group, Stereoisomerism, Aporphines, Biochemistry, In vitro, Analytical Chemistry, chemistry.chemical_compound, Tosyl, Drug Discovery, Radiology, Nuclear Medicine and imaging, Specific activity, Receptor, Protecting group, Spectroscopy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2536422dcef868d9cf3930f360342093
https://doi.org/10.1002/jlcr.3246

المؤلفون: Vladimir Stepanov, Cathrine Jonsson, Lars Farde, Michael G. Stabin, Christer Halldin, Sjoerd J. Finnema, Tangzhi Zhang, Philip Seeman, Anna W. Sromek, Ryuji Nakao, John L. Neumeyer, Susan R. George

المصدر: Journal of Nuclear Medicine. 55:1164-1170

مصطلحات موضوعية: Agonist, Apomorphine, medicine.drug_class, Dopamine, Pharmacology, Medicinal chemistry, Article, chemistry.chemical_compound, Column chromatography, Dopamine receptor D3, Dopamine receptor D2, medicine, Trifluoroacetic acid, Animals, Radiology, Nuclear Medicine and imaging, Radiometry, Radiochemistry, Receptors, Dopamine D2, Chemistry, Receptors, Dopamine D3, Thin-layer chromatography, Solvent, Kinetics, Macaca fascicularis, Isotope Labeling, Positron-Emission Tomography, Yield (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b7a2971e22c901e91529127ee73ebd
https://doi.org/10.2967/jnumed.113.133876

المؤلفون: Shayla Russell, Anna W. Sromek, Elena H. Chartoff, Jean M. Bidlack, John L. Neumeyer, Brian I. Knapp, Brian A. Provencher

المصدر: ACS Chemical Neuroscience. 5:93-99

مصطلحات موضوعية: Male, N-Methylaspartate, Physiology, Stereochemistry, medicine.drug_class, Cognitive Neuroscience, Sigma receptor, Pharmacology, Morphinans, Biochemistry, Rats, Sprague-Dawley, Opioid receptor, medicine, Animals, Humans, Receptors, sigma, Receptor, Chemistry, Cell Biology, General Medicine, Affinities, Rats, Opioid, Receptors, Opioid, NMDA receptor, Enantiomer, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2df7a8eaee6dc826e0dbec5619aa04
https://doi.org/10.1021/cn400205z

المؤلفون: Wei Li, Shayla Russell, Elena H. Chartoff, John L. Neumeyer, Brian I. Knapp, Anna W. Sromek, Jean M. Bidlack, Brian A. Provencher

المصدر: Journal of Medicinal Chemistry. 56:8872-8878

مصطلحات موضوعية: Male, Agonist, Morphinan, medicine.drug_class, Molecular Conformation, Receptors, Opioid, mu, CHO Cells, Pharmacology, κ-opioid receptor, Article, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Aminothiazole, Opioid receptor, Drug Discovery, medicine, Animals, Humans, Dose-Response Relationship, Drug, Receptors, Opioid, kappa, Cyclorphan, Stereoisomerism, Rats, Gtpγs binding, Thiazoles, Morphinans, chemistry, Opioid, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02059c738de4599bf09258a0ddb056ca
https://doi.org/10.1021/jm401290y

المؤلفون: Ross J. Baldessarini, John L. Neumeyer, Xuechu Zhen, Na Ye, Ao Zhang

المصدر: Chemical Reviews. 113:PR123-PR178

مصطلحات موضوعية: Chemistry, Mental Disorders, Dopamine Agents, General Chemistry, Pharmacology, Subtype selective, Receptors, Dopamine, Dopamine receptor, Drug Discovery, Animals, Humans, Nervous System Diseases, Dopamine metabolism, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038e3234e60f09c775640129fcf53bc7
https://doi.org/10.1021/cr300113a

المؤلفون: Tangzhi Zhang, Brian I. Knapp, Jean M. Bidlack, Thomas Scrimale, Zhaohua Yan, Anna W. Sromek, John L. Neumeyer

المصدر: Journal of Medicinal Chemistry. 54:1903-1913

مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Receptors, Opioid, mu, Stereoisomerism, CHO Cells, Morphinans, Article, Radioligand Assay, Structure-Activity Relationship, Cricetulus, Opioid receptor, Cricetinae, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Receptor, Chemistry, Receptors, Opioid, kappa, Affinities, Thiazoles, Opioid, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37643bddbb5c1ff864be4bc9d82d1048
https://doi.org/10.1021/jm101542c

المؤلفون: Ewa D. Marczak, Lawrence H. Lazarus, Severo Salvadori, John L. Neumeyer, Jean M. Bidlack, Yu Gui Si, Xuemei Peng, Gianfranco Balboni, Brian I. Knapp

المصدر: European Journal of Medicinal Chemistry. 46:799-803

مصطلحات موضوعية: Stereochemistry, Narcotic Antagonists, Molecular Conformation, Stereoisomerism, CHO Cells, Ligands, Article, Bifunctional ligands, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Cricetinae, Tetrahydroisoquinolines, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Bifunctional, Receptor, Pharmacology, Morphine, biology, Organic Chemistry, Esters, Dmt-Tic pharmacophore, Opioid receptors, Dipeptides, General Medicine, biology.organism_classification, chemistry, Opioid, Pharmacophore, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b3ce90c579642adddc9a79101d457d
https://doi.org/10.1016/j.ejmech.2010.12.001

المؤلفون: Yu-Gui Si, Tangzhi Zhang, Susan R. George, Philip Seeman, Anna W. Sromek, John L. Neumeyer

المصدر: ACS Medicinal Chemistry Letters. 2:189-194

مصطلحات موضوعية: Catechol, Organic Chemistry, Aporphines, Pharmacology, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, chemistry, Dopamine receptor, Dopamine, Dopamine receptor D2, Drug Discovery, medicine, Aporphine, Receptor, Selectivity, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72db43736e1f1f187ab7665f93e5bab5
https://doi.org/10.1021/ml1001689

المؤلفون: Jie Chen, Yun Cheng, John L. Neumeyer, Gang Lu, Yu-hua Wang, Ao Zhang, Fuying Li, Yi-Min Tao, Jing-Gen Liu, Xue-Jun Xu, Zhi-Qiang Chi, Jian-feng Sun

المصدر: Acta Pharmacologica Sinica. 31:1547-1552

مصطلحات موضوعية: Male, Narcotics, Agonist, Hot Temperature, medicine.drug_class, Narcotic Antagonists, Receptors, Opioid, mu, Physical dependence, (+)-Naloxone, Motor Activity, Pharmacology, Mice, medicine, Animals, Pharmacology (medical), Hot plate test, Sensitization, Pain Measurement, Behavior, Animal, Dose-Response Relationship, Drug, Morphine, Naloxone, Chemistry, Receptors, Opioid, kappa, General Medicine, medicine.anatomical_structure, Morphinans, Opioid, Original Article, μ-opioid receptor, medicine.symptom, Morphine Dependence, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6f34df9e20b2b0c5c39fb4d781f5b2
https://doi.org/10.1038/aps.2010.164

المؤلفون: Raymond G. Booth, Ross J. Baldessarini, John L. Neumeyer

المصدر: Burger's Medicinal Chemistry and Drug Discovery

مصطلحات موضوعية: Aromatic L-amino acid decarboxylase, Levodopa, Parkinson's disease, Pramipexole, Dopamine, Parkinsonism, medicine, Decarboxylase inhibitor, Pharmacology, medicine.disease, Dopamine agonist, nervous system diseases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf78926682849be5bfadb173aac35c12
https://doi.org/10.1002/0471266949.bmc105.pub2

المؤلفون: John L. Neumeyer, Brian I. Knapp, Jean M. Bidlack, Michael Decker, Yu-Gui Si

المصدر: Journal of Medicinal Chemistry. 53:402-418

مصطلحات موضوعية: Morphinan, Binding Sites, Stereochemistry, medicine.drug_class, Narcotic Antagonists, Molecular Conformation, Morphinans, Ligands, Affinities, Chemical synthesis, Article, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Opioid receptor, Opioid Receptor Binding, Drug Discovery, medicine, Molecular Medicine, Levorphanol, Binding site, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444d7bec2d87c936b748c7349a534f5e
https://doi.org/10.1021/jm9013482

المؤلفون: Bin Zhang, Jean M. Bidlack, Brian I. Knapp, Michael Decker, Brian S. Fulton, John L. Neumeyer

المصدر: Journal of Medicinal Chemistry. 52:7389-7396

مصطلحات موضوعية: Morphinan, medicine.drug_class, Stereochemistry, GTPgammaS, CHO Cells, Ligands, κ-opioid receptor, Article, Bivalent (genetics), chemistry.chemical_compound, Cricetulus, Opioid receptor, Cricetinae, Drug Discovery, medicine, Animals, Humans, Receptor, Chemistry, Hydrolysis, Ligand binding assay, Ligand (biochemistry), Morphinans, Receptors, Opioid, Molecular Medicine, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebaedc91f9d4a192b4c572ba5c58bb80
https://doi.org/10.1021/jm900379p