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1Academic Journal
المؤلفون: Tobias Puengel, Sander Lefere, Jana Hundertmark, Marlene Kohlhepp, Christian Penners, Frederique Van de Velde, Bruno Lapauw, Anne Hoorens, Lindsey Devisscher, Anja Geerts, Stephanie Boehm, Qihong Zhao, John Krupinski, Edgar D. Charles, Bradley Zinker, Frank Tacke
المصدر: International Journal of Molecular Sciences; Volume 23; Issue 12; Pages: 6696
مصطلحات موضوعية: macrophages, monocytes, treatment strategies, chemokines, inflammation, fibroblast growth factor (FGF), nonalcoholic steatohepatitis (NASH), fibrosis, nonalcoholic fatty liver disease (NAFLD), metabolism
جغرافية الموضوع: agris
وصف الملف: application/pdf
Relation: Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms23126696
الاتاحة: https://doi.org/10.3390/ijms23126696
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2
المؤلفون: Yan Shi, Ying Wang, Wei Meng, Robert P. Brigance, Denis E. Ryono, Scott Bolton, Hao Zhang, Sean Chen, Rebecca Smirk, Shiwei Tao, Joseph A. Tino, Kristin N. Williams, Richard Sulsky, Laura Nielsen, Bruce Ellsworth, Michael K. Y. Wong, Jung-Hui Sun, Leslie W. Leith, Dawn Sun, Dauh-Rurng Wu, Anuradha Gupta, Richard Rampulla, Arvind Mathur, Bang-Chi Chen, Aiying Wang, Helen G. Fuentes-Catanio, Lori Kunselman, Michael Cap, Jacob Zalaznick, Xiaohui Ma, Heng Liu, Joseph R. Taylor, Rachel Zebo, Beverly Jones, Stephen Kalinowski, Joann Swartz, Ada Staal, Kevin O’Malley, Lisa Kopcho, Jodi K. Muckelbauer, Stanley R. Krystek, Steven A. Spronk, Jovita Marcinkeviciene, Gerry Everlof, Xue-Qing Chen, Carrie Xu, Yi-Xin Li, Robert A. Langish, Yanou Yang, Qi Wang, Kamelia Behnia, Aberra Fura, Evan B. Janovitz, Nicola Pannacciulli, Steven Griffen, Bradley A. Zinker, John Krupinski, Mark Kirby, Jean Whaley, Robert Zahler, Joel C. Barrish, Jeffrey A. Robl, Peter T. W. Cheng
المصدر: Journal of Medicinal Chemistry. 65:4291-4317
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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3
المؤلفون: Susheel J. Nara, Srinivas Jogi, Srinivas Cheruku, Sarkunam Kandhasamy, Firoz Jaipuri, Pavan Kalyan Kathi, Subba Reddy, Sanket Sarodaya, Erica M. Cook, Tao Wang, Doree Sitkoff, Karen A. Rossi, Max Ruzanov, Susan E. Kiefer, Javed A. Khan, Mian Gao, Satyanarayana Reddy, Sankara Sivaprasad LVJ, Ramola Sane, Kathy Mosure, Xiaoliang Zhuo, Gary G. Cao, Milinda Ziegler, Anthony Azzara, John Krupinski, Matthew G. Soars, Bruce A. Ellsworth, Dean A. Wacker
المصدر: Journal of medicinal chemistry. 65(13)
مصطلحات موضوعية: Non-alcoholic Fatty Liver Disease, Drug Discovery, Molecular Medicine, Humans, Receptors, Cytoplasmic and Nuclear
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4
المؤلفون: Tobias Puengel, Sander Lefere, Jana Hundertmark, Christian Penners, Frederique Van de Velde, Bruno Lapauw, Lindsey Devisscher, Anja Geerts, Stephanie Boehm, Zhao Qihong, John Krupinski, Edgar Charles, Bradley Zinker, Frank Tacke
المصدر: Journal of Hepatology. 73:S13
مصطلحات موضوعية: Hepatology
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5
المؤلفون: Gary G. Cao, Min Zhou, Ramya Jayaram, Douglas B. Moore, Andres S. Hernandez, Tao Wang, Jean M. Whaley, Yue-Zhong Shu, Carrie Xu, Lori Kunselman, Atsu Apedo, William R. Ewing, Reshma Panemangalore, Qi Gao, Arvind Mathur, Richard Rampulla, Bradley A. Zinker, Lauren Haque, Mary Ellen Cvijic, Marta Dabros, Arun Kumar Gupta, Heng Liu, Jeffrey A. Robl, Bruce A. Ellsworth, Jun Shi, Zhengxiang Gu, Jason J. Wilkes, Akin H. Davulcu, Kristin N. Williams, Elizabeth A. Dierks, John Krupinski, Zhenqiu Hong, Edward J. Brady, Ximao Wu, Qin Sun, Hong Cai, Chunshan Xie, Elizabeth A. Jurica, Kimberly A. Foster
المصدر: Journal of medicinal chemistry. 61(3)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, endocrine system, Pyrrolidines, medicine.drug_class, medicine.medical_treatment, Molecular Conformation, Incretin, Administration, Oral, Biological Availability, Pharmacology, 01 natural sciences, Receptors, G-Protein-Coupled, 03 medical and health sciences, Mice, In vivo, Free fatty acid receptor 1, Drug Discovery, medicine, Animals, Humans, Secretion, Receptor, 010405 organic chemistry, Chemistry, Drug discovery, Insulin, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine, Pyrazoles
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6
المؤلفون: Gerry Everlof, Chen-Pin Hung, Bradley A. Zinker, Ginger Wu, Steven C. Griffen, Stephanie Boehm, Hong Cai, Larisa Sereda, Li Xin, Matthias Broekema, Linda LaMarre, Sarah E. Malmstrom, Randolph P. Ponticiello, Cuixia Chu, Anjaneya Chimalakonda, Jeffrey A. Robl, Chiuwa Emily Luk, Michelle Lee, Steven O’Connor, Rachel Zebo, Keith J. Miller, Ying Wang, Richard L. Wong, John Krupinski, Zhenqiu Hong, Lisa Zhang, Jacob Zalaznick, Songping Han, Chunyu K. Wu, Yi-Xin Li, Karen A. Rossi, Dean A. Wacker
المصدر: Journal of Medicinal Chemistry. 57:7499-7508
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Pyridones, medicine.medical_treatment, Incretin, Enteroendocrine cell, Pharmacology, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Mice, In vivo, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Molecular Targeted Therapy, Sulfones, Receptor, Clinical Trials as Topic, Gastrointestinal tract, Chemistry, Insulin, Rats, medicine.anatomical_structure, GPR119, Diabetes Mellitus, Type 2, Drug Design, Molecular Medicine, Pancreas
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7
المؤلفون: Li Xin, Ming Lei, Claudio Mapelli, Tasir Shamsul Haque, Ge Zhang, John Krupinski, Sarah E. Malmstrom, Ving G. Lee, Douglas James Riexinger, Songping Han, William R. Ewing, Cooper Christopher B
المصدر: Peptides. 31:950-955
مصطلحات موضوعية: Blood Glucose, Agonist, endocrine system, Physiology, medicine.drug_class, Molecular Sequence Data, CHO Cells, Biochemistry, Glucagon-Like Peptide-1 Receptor, Mice, Cellular and Molecular Neuroscience, Cricetulus, Endocrinology, In vivo, Cricetinae, Receptors, Glucagon, medicine, Animals, Amino Acid Sequence, Receptor, Glucagon-like peptide 1 receptor, chemistry.chemical_classification, Molecular Structure, Aminobutyrates, Photo-reactive amino acid analog, In vitro, Amino acid, chemistry, Hyperglycemia, Functional activity, Peptides
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8
المؤلفون: Claudio Mapelli, Ramakrishna Seethala, Songping Han, Ellen Sieber-McMaster, William R. Ewing, Ashish Khanna, Keith L. Constantine, Douglas James Riexinger, Daniel Longhi, John Krupinski, Zhengping Ma, Constance Smith-Monroy, Bastos Margarita M, Dan Shi, Michael S. Bernatowicz, Joseph R. Taylor, Christine Huang, Rajasree Golla, Gordon William Robinson, Jelka Pluscec, Jean M. Whaley, Sesha Natarajan, Jean-Philippe Meyer, Robert H. Stoffel, Li Xin, Ving G. Lee, Barry Koplowitz, Cecilia L Chi, Ildiko Antal-Zimanyi
المصدر: Journal of Medicinal Chemistry. 52:7788-7799
مصطلحات موضوعية: Male, Models, Molecular, endocrine system, Protein Conformation, Molecular Sequence Data, Peptide, CHO Cells, Glucagon-Like Peptide-1 Receptor, Mice, chemistry.chemical_compound, Cricetulus, Dogs, Cricetinae, Drug Discovery, Receptors, Glucagon, Peptide synthesis, Animals, Humans, Hypoglycemic Agents, Glucose homeostasis, Amino Acid Sequence, Receptor, Peptide sequence, Glucagon-like peptide 1 receptor, chemistry.chemical_classification, Dipeptide, Dose-Response Relationship, Drug, digestive, oral, and skin physiology, Amino acid, chemistry, Biochemistry, Molecular Medicine, Oligopeptides
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9
المؤلفون: Laurie Seliger, Jian Wang, Ronald Pongrac, Helen J. Mason, Bruce Beyer, Andrew Henwood, John Krupinski, Ximao Wu, John E. Macor, Saeho Chong, Rongan Zhang, Pam Ferrer, Diane E. Normandin, Guixue Yu, Leonard P. Adam, William G. Humphrey, Bin He
المصدر: Journal of Medicinal Chemistry. 46:457-460
مصطلحات موضوعية: Male, medicine.medical_specialty, Sildenafil, Administration, Oral, Biological Availability, Blood Pressure, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Erectile Dysfunction, Pharmacokinetics, 3',5'-Cyclic-GMP Phosphodiesterases, Oral administration, In vivo, Internal medicine, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Adverse effect, Cyclic Nucleotide Phosphodiesterases, Type 5, biology, medicine.disease, In vitro, Rats, Pyridazines, Erectile dysfunction, Endocrinology, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Rabbits, Penis
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10
المؤلفون: Evan B. Janovitz, Karen Granaldi, Julia Li, Paul Levesque, Lei Zhao, Lisa Berman-Booty, John Krupinski, James K. Hennan, Paul G. Sleph, Michael Basso
المصدر: Journal of Pharmacological and Toxicological Methods. 88:207
مصطلحات موضوعية: Pharmacology, Drug, medicine.medical_specialty, Exacerbation, business.industry, media_common.quotation_subject, Cardiomyopathy, Toxicology, medicine.disease, Atrial thrombosis, Pathogenesis, Internal medicine, Cardiology, Medicine, business, media_common
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11
المؤلفون: Atsu Apedo, Xiang-Yang Ye, Christian L. Morales, John Krupinski, Mojgan Abousleiman, Dean A. Wacker, Karen A. Rossi, Keith J. Miller, Sarah E. Malmstrom, Ying Wang, Jeffrey A. Robl, Larisa Sereda
المصدر: Bioorganicmedicinal chemistry letters. 24(11)
مصطلحات موضوعية: Agonist, Models, Molecular, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Cell Line, Receptors, G-Protein-Coupled, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Humans, Molecular Biology, Benzofurans, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Metabolic stability, Piperazine, GPR119, chemistry, Ion channel activity, Molecular Medicine, Piperidine
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12
المؤلفون: John E. Macor, Ronald Pongrac, Zhong Sun, David P. Rotella, Yeheng Zhu, John Krupinski, Diane E. Normandin, Laurie Seliger
المصدر: Journal of Medicinal Chemistry. 43:1257-1263
مصطلحات موضوعية: Male, Purinones, Phosphodiesterase Inhibitors, medicine.drug_class, Sildenafil, Carboxamide, In Vitro Techniques, Pharmacology, Piperazines, Sildenafil Citrate, Structure-Activity Relationship, chemistry.chemical_compound, Erectile Dysfunction, 3',5'-Cyclic-GMP Phosphodiesterases, Drug Discovery, medicine, Animals, Potency, Sulfones, Adverse effect, Cyclic Nucleotide Phosphodiesterases, Type 5, biology, Chemistry, Imidazoles, Biological activity, medicine.disease, respiratory tract diseases, Erectile dysfunction, Purines, Enzyme inhibitor, cGMP-specific phosphodiesterase type 5, Quinazolines, cardiovascular system, biology.protein, Molecular Medicine, Rabbits, Penis
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13
المؤلفون: Ronald Taussig, Laurent Désaubry, Glen Bianchi, Peter A. Watson, John Krupinski, Edward Lyons, Roger A. Johnson, Ravi Iyengar, Joseph P. Pieroni, James J. Cali, Ilana Shoshani
المصدر: Journal of Biological Chemistry. 272:8962-8966
مصطلحات موضوعية: Adenosine, Stereochemistry, Nerve Tissue Proteins, Biochemistry, Isozyme, Adenylyl Cyclase Inhibitors, ADCY10, Adenylyl cyclase, Structure-Activity Relationship, chemistry.chemical_compound, Calmodulin, GTP-Binding Protein alpha Subunits, Gs, Animals, Enzyme Inhibitors, Molecular Biology, Oncogene Proteins, ADCY6, Binding Sites, Chemistry, ADCY9, Brain, Membrane Proteins, Cell Biology, Adenine nucleoside, Recombinant Proteins, Rats, Isoenzymes, Dideoxyadenosine, Calcium, Cattle, Nucleoside, Adenylyl Cyclases
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14
المؤلفون: John Krupinski, Rannade S. Parekh, James J. Cali
المصدر: Journal of Biological Chemistry. 271:1089-1095
مصطلحات موضوعية: chemistry.chemical_classification, Glycosylation, Calmodulin, Base pair, Cell Biology, Biology, Biochemistry, Molecular biology, Adenylyl cyclase, chemistry.chemical_compound, Enzyme, chemistry, Cytoplasm, hemic and lymphatic diseases, Complementary DNA, Extracellular, biology.protein, Molecular Biology
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15
المؤلفون: Jing Du, Kenneth M. Baker, John C. Zwaagstra, Kathleen Conrad, Thomas J. Thekkumkara, John Krupinski
المصدر: Molecular and Cellular Biochemistry. 152:77-86
مصطلحات موضوعية: Clinical Biochemistry, Gi alpha subunit, Phosphodiesterase 3, CHO Cells, Biology, chemistry.chemical_compound, Cricetinae, Cyclic AMP, Animals, Vasoconstrictor Agents, Protein kinase A, Molecular Biology, Protein kinase B, Protein kinase C, Receptors, Angiotensin, Forskolin, Angiotensin II, Gene Transfer Techniques, Tyrosine phosphorylation, Cell Biology, General Medicine, Molecular biology, chemistry, Phosphorylation, Cell Division, Signal Transduction
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16
المؤلفون: John Krupinski, Saeho Chong, Andrew Henwood, Ximao Wu, Leonard P. Adam, Guixue Yu, Jian Wang, Ronald Pongrac, John E. Macor, Bin He, Gary Dorough, Diane E. Normandin, Helen J. Mason, Laurie Seliger
المصدر: Journal of Medicinal Chemistry. 44:1025-1027
مصطلحات موضوعية: Male, Phosphodiesterase Inhibitors, Pyridines, Muscle Relaxation, Administration, Oral, In Vitro Techniques, Pharmacology, Structure-Activity Relationship, Dogs, Erectile Dysfunction, 3',5'-Cyclic-GMP Phosphodiesterases, Drug Discovery, Pyrazolopyridine, medicine, Animals, Cyclic Nucleotide Phosphodiesterases, Type 5, biology, Chemistry, Phosphoric Diester Hydrolases, Muscle, Smooth, medicine.disease, Rats, Erectile dysfunction, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Rabbits, Penis
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17
المؤلفون: Yeheng Zhu, David P. Rotella, John E. Macor, Ronald Pongrac, Diane E. Normandin, Laurie Seliger, Zhong Sun, John Krupinski
المصدر: ChemInform. 31
مصطلحات موضوعية: chemistry.chemical_classification, Sildenafil, General Medicine, Pharmacology, medicine.disease, Isozyme, In vitro, respiratory tract diseases, chemistry.chemical_compound, Enzyme, Erectile dysfunction, chemistry, cGMP-specific phosphodiesterase type 5, cardiovascular system, medicine, Potency, Adverse effect
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18
المؤلفون: Laurie Seliger, John Krupinski, John E. Macor, Ron Pongrac, Bin He, Leonard P. Adam, Andrew Watson, Patrick Stoy, Yingzhi Bi, Diane E. Normandin
المصدر: ChemInform. 32
مصطلحات موضوعية: Scaffold, chemistry.chemical_compound, Chemistry, Sildenafil, General Medicine, PDE1, Pharmacology, IC50
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19
المؤلفون: Ving G. Lee, Tasir Shamsul Haque, Ming Feng, Douglas G. Riexinger, Rogelio L. Martinez, Claudio Mapelli, William R. Ewing, Cooper Christopher B, Ming Lei, Ge Zhang, Barry Koplowitz, John Krupinski, Christine Huang
المصدر: Peptides. 31(7)
مصطلحات موضوعية: Functional assay, Agonist, Models, Molecular, endocrine system, Physiology, medicine.drug_class, Stereochemistry, Molecular Sequence Data, Peptide, CHO Cells, Biochemistry, Glucagon-Like Peptide-1 Receptor, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Structure-Activity Relationship, Endocrinology, Cricetulus, Dogs, Biosynthesis, Peptide Library, Cricetinae, medicine, Receptors, Glucagon, Animals, Humans, Amino Acid Sequence, Receptor, Glucagon-like peptide 1 receptor, chemistry.chemical_classification, In vitro, Amino acid, chemistry, Peptides
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20
المؤلفون: John Krupinski, Ron Pongrac, John E. Macor, Andrew Watson, Patrick Stoy, Yingzhi Bi, Diane E. Normandin, Bin He, Leonard P. Adam, Laurie Seliger
المصدر: Bioorganicmedicinal chemistry letters. 14(6)
مصطلحات موضوعية: Male, Stereochemistry, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Erectile Dysfunction, 3',5'-Cyclic-GMP Phosphodiesterases, Drug Discovery, medicine, Potency, Humans, Molecular Biology, IC50, chemistry.chemical_classification, Cyclic Nucleotide Phosphodiesterases, Type 5, Bicyclic molecule, biology, Organic Chemistry, Quinoline, medicine.disease, Erectile dysfunction, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Quinolines, Molecular Medicine